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Patent Agency Ranking11.发明申请
公开(公告)号：WO2019191770A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025211
申请日：2019-04-01
Inventor： FOSTER, Alexander Brett , BARMAN, Arghya , KENNEDY, Jonathan , PEARLMAN, Paul S.
Abstract: Provided herein are novel, synthetic polypeptides having, for example, acyl-acyl carrier protein (ACP) thioesterase (TE) activity, including polypeptides that convert pimeloyl-ACP to pimelic acid. In some aspects, the synthetic polypeptides have advantageous enzymatic activity and/or improved substrate specificity relative to a wild type acyl-ACP TE.
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12.发明申请
公开(公告)号：WO2019191761A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025189
申请日：2019-04-01
Inventor： SMITH, Gary J. , PEARLMAN, Paul S. , KIRBY, Gregory S.
Abstract: Disclosed are materials and methods for managing aerobic biosynthesis. The materials include a fermenter system comprising a fermenter, a microorganism provided to the fermenter, and at least two control loops. The methods are directed to measuring and controlling different oxygen concentrations within the fermenter.
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13.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS 审中-公开通过C1碳链延伸生产碳 - 碳化合物的方法与乙酰乙酸乙酯合成相关
公开(公告)号：WO2014105790A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077413
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 该文件描述了通过形成一个或两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径，所述末端官能团各自包含羧基，胺 或羟基，在C7脂族主链底物中。 这里描述的这些途径，代谢工程和培养策略依赖于C1延伸酶或与辅酶B生物合成相关的同源物。
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14.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS 审中-公开通过碳环化合物合成生成碳碳化合物通过碳链延伸的方法
公开(公告)号：WO2014105788A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077411
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P13/001 , C12N9/0008 , C12N9/1096 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/002 , C12Y102/99006 , C12Y301/02002
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
Abstract translation: 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于与酸性营养不良食物或2-氨基己二酸赖氨酸生物合成的环己烷羧酸盐生物合成相关的碳链延长酶或其同系物。
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15.发明公开METHODS OF PRODUCING 7-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION 审中-公开用于生产7-CARBON化学BY METHYLESTERABGESCHIRMTE碳链延长
公开(公告)号：EP2938733A2
公开(公告)日：2015-11-04
申请号：EP13824255.7
申请日：2013-12-23
Applicant: Invista North America S.a.r.l.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P13/001 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
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