公开(公告)号：US10544161B2

公开(公告)日：2020-01-28

申请号：US16249024

申请日：2019-01-16

Applicant: INTERMUNE, INC.

Inventor： Johnnie Y. Ramphal ,  Brad Owen Buckman ,  Kumaraswamy Emayan ,  John Beamond Nicholas ,  Scott D. Seiwert

IPC: C07D401/14 ,  C07D401/02 ,  A61K31/437 ,  A61K31/4353 ,  C07D498/04 ,  C07D221/04 ,  C07C225/20 ,  C07D471/04 ,  C07D495/04 ,  C07D209/34 ,  C07D513/04 ,  C07D211/76 ,  C07D405/14 ,  C07D213/74 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D213/64 ,  C07D213/69 ,  C07C25/18 ,  C07D405/02 ,  C07D413/02 ,  C07D417/10 ,  C07D487/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US10233195B2

公开(公告)日：2019-03-19

申请号：US15128061

申请日：2015-03-31

Applicant: InterMune, Inc.

Inventor： Johnnie Y. Ramphal ,  Brad Owen Buckman ,  Kumaraswamy Emayan ,  John Beamond Nicholas ,  Scott D. Seiwert

IPC: C07D401/14 ,  C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D498/04 ,  C07D221/04 ,  C07C225/20 ,  C07D471/04 ,  C07D495/04 ,  C07D209/34 ,  C07D513/04 ,  C07D211/76 ,  C07D405/14 ,  C07D213/74 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D213/64 ,  C07D213/69 ,  C07C25/18 ,  C07D405/02 ,  C07D413/02 ,  C07D417/10 ,  C07D487/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20180064692A1

公开(公告)日：2018-03-08

申请号：US15492828

申请日：2017-04-20

Applicant: INTERMUNE, INC.

Inventor： Brad O. Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: A61K31/437 ,  C07D498/04 ,  C07D401/14 ,  C07D401/04 ,  C07D495/04 ,  C07D513/04 ,  C07D295/125 ,  C07D221/04 ,  C07D211/86 ,  A61K9/00 ,  C07D217/24 ,  C07D213/64 ,  C07D417/04 ,  C07D413/04 ,  C07D409/14 ,  C07D405/04 ,  C07D223/10 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K9/007 ,  C07D211/86 ,  C07D213/64 ,  C07D217/24 ,  C07D221/04 ,  C07D223/10 ,  C07D295/125 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US09290450B2

公开(公告)日：2016-03-22

申请号：US14263822

申请日：2014-04-28

Applicant: InterMune, Inc.

Inventor： Karl Kossen ,  Scott D. Seiwert ,  Vladimir Serebryany ,  Donald Ruhrmund ,  Leonid D. Beigelman ,  Luca Francesco Mario Raveglia ,  Stefania Vallese ,  Ivana Bianchi ,  Tao Hu

IPC: C07D213/22 ,  C07D241/18 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D213/63 ,  C07D213/64 ,  C07D213/71 ,  C07D237/14 ,  C07D417/14 ,  C07D471/04 ,  C07D213/69 ,  C07D213/85 ,  C07D239/36 ,  C07D239/54 ,  C07D251/10 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14

CPC classification number: C07D213/63 ,  C07D213/22 ,  C07D213/64 ,  C07D213/69 ,  C07D213/71 ,  C07D213/85 ,  C07D237/14 ,  C07D239/36 ,  C07D239/54 ,  C07D241/18 ,  C07D251/10 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

公开(公告)号：US08969347B2

公开(公告)日：2015-03-03

申请号：US13652247

申请日：2012-10-15

Applicant: Intermune, Inc.

Inventor： Karl Kossen ,  Scott D. Seiwert ,  Vladimir Serebryany ,  Donald Ruhrmund ,  Leonid Beigelman ,  Luca Francesco Mario Raveglia ,  Stefania Vallese ,  Ivana Bianchi ,  Tao Hu

IPC: A61K31/44 ,  C07D213/64 ,  C07D401/04 ,  C07D213/63 ,  C07D213/22 ,  C07D213/71 ,  C07D237/14 ,  C07D241/18 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D213/69 ,  C07D213/85 ,  C07D239/36 ,  C07D239/54 ,  C07D251/10 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14

CPC classification number: C07D213/63 ,  C07D213/22 ,  C07D213/64 ,  C07D213/69 ,  C07D213/71 ,  C07D213/85 ,  C07D237/14 ,  C07D239/36 ,  C07D239/54 ,  C07D241/18 ,  C07D251/10 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

Abstract translation: 公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。 还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。

公开(公告)号：US20140107110A1

公开(公告)日：2014-04-17

申请号：US14043121

申请日：2013-10-01

Applicant: InterMune, Inc.

Inventor： Brad Owen Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: C07D513/04 ,  C07D211/86 ,  C07D295/125 ,  C07D221/04 ,  C07D471/04 ,  C07D498/04 ,  C07D495/04 ,  C07D401/04

CPC classification number: A61K31/437 ,  A61K9/007 ,  C07D211/86 ,  C07D213/64 ,  C07D217/24 ,  C07D221/04 ,  C07D223/10 ,  C07D295/125 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20190321343A1

公开(公告)日：2019-10-24

申请号：US16454623

申请日：2019-06-27

Applicant: INTERMUNE, INC.

Inventor： Brad Owen Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: A61K31/437 ,  C07D498/04 ,  C07D401/14 ,  C07D401/04 ,  C07D495/04 ,  C07D513/04 ,  C07D295/125 ,  C07D221/04 ,  C07D211/86 ,  A61K9/00 ,  C07D217/24 ,  C07D213/64 ,  C07D417/04 ,  C07D413/04 ,  C07D409/14 ,  C07D405/04 ,  C07D223/10 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US10376497B2

公开(公告)日：2019-08-13

申请号：US15492828

申请日：2017-04-20

Applicant: INTERMUNE, INC.

Inventor： Brad O. Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: C07D213/02 ,  A61K31/437 ,  C07D513/04 ,  C07D495/04 ,  C07D211/86 ,  C07D401/04 ,  C07D221/04 ,  C07D471/04 ,  C07D498/04 ,  C07D295/125 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D223/10 ,  C07D405/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D213/64 ,  C07D217/24 ,  A61K9/00

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20190144467A1

公开(公告)日：2019-05-16

申请号：US16249024

申请日：2019-01-16

Applicant: INTERMUNE, INC.

Inventor： Johnnie Y. Ramphal ,  Brad Owen Buckman ,  Kumaraswamy Emayan ,  John Beamond Nicholas ,  Scott D. Seiwert

IPC: C07D498/04 ,  C07D487/04 ,  C07C25/18 ,  C07D413/02 ,  C07D417/10 ,  C07D213/69 ,  C07D213/64 ,  C07D417/12 ,  C07D417/04 ,  C07D413/04 ,  C07D405/04 ,  C07D401/12 ,  C07D401/04 ,  C07D213/75 ,  C07D213/74 ,  C07D405/14 ,  C07D401/14 ,  C07D211/76 ,  C07D513/04 ,  C07D209/34 ,  C07D495/04 ,  C07D471/04 ,  C07C225/20 ,  C07D221/04 ,  C07D405/02

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US10010536B2

公开(公告)日：2018-07-03

申请号：US15387537

申请日：2016-12-21

Applicant: InterMune, Inc.

Inventor： Lawrence M. Blatt ,  Scott D. Seiwert ,  Leonid D. Beigelman ,  Ramachandran Radhakrishnan ,  Karl Kossen ,  Vladimir Serebryany

IPC: A61K31/4412 ,  A61K31/44 ,  A61K31/444

CPC classification number: A61K31/4412 ,  A61K31/44 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4704 ,  A61K31/7052 ,  A61K47/56 ,  A61K47/58 ,  C07D213/16 ,  C07D213/26 ,  C07D213/63 ,  C07D213/64 ,  C07D213/69 ,  C07D215/227 ,  C07H15/26 ,  C07K1/1077 ,  C08F289/00 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

Abstract: Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.