公开(公告)号：CA2588760A1

公开(公告)日：2006-06-15

申请号：CA2588760

申请日：2005-12-06

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： HOORNAERT GEORGES JOSEPH CORNE ,  KOUKNI MOHAMED ,  COMPERNOLLE FRANS JOSEF CORNEL ,  KOZLECKI TOMASZ ,  MEGENS ANTONIUS ADRIANUS HENDR ,  JHA SUSHIL CHANDRA ,  CID-NUNEZ JOSE MARIA ,  TRABANCO-SUAREZ ANDRES AVELINO ,  MAO HUA ,  FERNANDEZ-GADEA FRANCISCO JAVI

IPC: C07D209/70 ,  A61K31/343 ,  A61K31/352 ,  A61K31/381 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/496 ,  A61K31/4985 ,  C07D221/18 ,  C07D307/93 ,  C07D311/94 ,  C07D333/80 ,  C07D487/04 ,  C07D491/044

Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.