公开(公告)号：US07290013B2

公开(公告)日：2007-10-30

申请号：US10688070

申请日：2003-10-17

Applicant: Douglas P. Doucette ,  Blake Lewis ,  John Edwards

Inventor： Douglas P. Doucette ,  Blake Lewis ,  John Edwards

IPC: G06F17/30 ,  G06F17/00

CPC classification number: G06F3/0605 ,  G06F3/0608 ,  G06F3/0631 ,  G06F3/0643 ,  G06F3/0644 ,  G06F3/0689 ,  G06F17/30067 ,  Y10S707/99943 ,  Y10S707/99952 ,  Y10S707/99953 ,  Y10S707/99956

Abstract: The invention provides a method and system for improving data access of a reliable file system. In a first aspect of the invention, the file system determines the relative vacancy of a collection of storage blocks, herein called an “allocation area”. This is accomplished by recording an array of binary numbers. Each binary number in the array describes the vacancy of a collection of storage blocks. The file system examines these binary numbers when attempting to record file blocks in relatively contiguous areas on a storage medium, such as a hard disk. When a request to write to disk occurs, the system determines the average vacancy of all the allocation areas and queries the allocation areas for individual vacancy rates such as sequentially. The system preferably writes file blocks to the allocation areas that are above a threshold related to the average storage block vacancy of the file system. If the file in the request to write is larger than the selected allocation area, the next allocation area above the threshold is preferably used to write the remaining blocks of the file.

Abstract translation: 本发明提供了一种用于改善可靠文件系统的数据访问的方法和系统。 在本发明的第一方面，文件系统确定存储块集合的相对空位，这里称为“分配区域”。 这是通过记录二进制数字的数组来实现的。 阵列中的每个二进制数字描述了存储块集合的空位。 当尝试在诸如硬盘的存储介质上的相对连续的区域中记录文件块时，文件系统检查这些二进制数。 当写入磁盘的请求发生时，系统确定所有分配区域的平均空缺，并查询单个空缺率的分配区域，如顺序。 系统优选地将文件块写入高于与文件系统的平均存储块空缺相关的阈值的分配区域。 如果写入请求中的文件大于所选择的分配区域，则优选地使用高于阈值的下一个分配区域来写入文件的剩余块。

公开(公告)号：USD540943S1

公开(公告)日：2007-04-17

申请号：US29231450

申请日：2005-06-03

Applicant: John Edwards

Designer： John Edwards

公开(公告)号：US20070077256A1

公开(公告)日：2007-04-05

申请号：US11327197

申请日：2006-01-06

Applicant: John Edwards ,  Ashraf Ibrahim ,  Brad Spellberg ,  Yue Fu ,  Scott Filler ,  Michael Yeaman

Inventor： John Edwards ,  Ashraf Ibrahim ,  Brad Spellberg ,  Yue Fu ,  Scott Filler ,  Michael Yeaman

IPC: A61K39/02

CPC classification number: A61K39/0002 ,  A61K39/085 ,  A61K2039/5156 ,  A61K2039/58 ,  C07K16/14 ,  C07K2317/76

Abstract: The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.

Abstract translation: 本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。 本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。 该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。 还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。 还提供了治疗或预防金黄色葡萄球菌感染的方法。 该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

公开(公告)号：US20070043697A1

公开(公告)日：2007-02-22

申请号：US11207055

申请日：2005-08-18

Applicant: Robert Driesch ,  John Edwards ,  Michael Faunce ,  Brian Muras

Inventor： Robert Driesch ,  John Edwards ,  Michael Faunce ,  Brian Muras

IPC: G06F17/30

CPC classification number: G06F17/30469

Abstract: An apparatus, program product and method generate at least one statistic for a temporary table during optimization of a database query before the temporary table is created. By doing so, optimization can proceed on a database query irrespective of the fact that the temporary table may not be materialized until the database query is ultimately executed.

Abstract translation: 在创建临时表之前，在优化数据库查询期间，设备，程序产品和方法生成临时表的至少一个统计量。 通过这样做，可以在数据库查询上进行优化，而不管在最终执行数据库查询之前临时表可能未被实现的事实。

公开(公告)号：US20070012469A1

公开(公告)日：2007-01-18

申请号：US11043017

申请日：2005-01-24

Applicant: Craig McCarthy ,  Stanley Dunaway ,  G. Saunders ,  John Edwards

Inventor： Craig McCarthy ,  Stanley Dunaway ,  G. Saunders ,  John Edwards

IPC: H02G3/04

CPC classification number: H02G3/0412 ,  H02G3/00

Abstract: A conduit includes an elongate member with an outer surface and an inner surface defining an inner passage for enclosing one or more electrical signal conductors therein, and an electromagnetic shield disposed coaxially with the elongate member to block electromagnetic radiation emitted by the one or more electrical signal conductors.

Abstract translation: 导管包括具有外表面的细长构件和限定用于封闭其中的一个或多个电信号导体的内部通道的内表面，以及与细长构件同轴地设置以阻挡由一个或多个电信号发射的电磁辐射的电磁屏蔽 导体

公开(公告)号：US20060222125A1

公开(公告)日：2006-10-05

申请号：US11095173

申请日：2005-03-31

Applicant: John Edwards ,  Jeffrey Somers ,  Tim Wegner

Inventor： John Edwards ,  Jeffrey Somers ,  Tim Wegner

IPC: H04L7/00

CPC classification number: H04L7/00 ,  H04L7/02

Abstract: Systems and methods are disclosed for facilitating synchronous communications over an asynchronous communications link. Specifically, embodiments of the present invention provide systems and methods for transmitting high-speed signals while maintaining lock-step determinism using remote clock phase adjustments. Embodiments of the present invention also provide systems and methods for maintaining determinism through the use of synchronized time slice counters within the various components.

Abstract translation: 公开了用于促进异步通信链路上的同步通信的系统和方法。 具体地，本发明的实施例提供用于在使用远程时钟相位调整保持锁定阶段确定性的同时传输高速信号的系统和方法。 本发明的实施例还提供了通过在各种组件内使用同步的时间片计数器来维持确定性的系统和方法。

公开(公告)号：US20060168409A1

公开(公告)日：2006-07-27

申请号：US11393543

申请日：2006-03-28

Applicant: Andy Kahn ,  Kayuri Patel ,  Raymond Chen ,  John Edwards

Inventor： Andy Kahn ,  Kayuri Patel ,  Raymond Chen ,  John Edwards

IPC: G06F12/00 ,  G06F12/14

CPC classification number: G06F17/3015 ,  Y10S707/99931 ,  Y10S707/99942 ,  Y10S707/99952 ,  Y10S707/99953

Abstract: A method for reducing duplicate data of an active file system, where the data is stored on a storage device of a storage system, is disclosed. A persistent image of the active file system is generated at a first point in time. At a later time, a sequence of steps to compare the active file system with the persistent image is initiated. Then, if a block of data of the active file system is identical to the data in the persistent image, the active file system is directed to refer to the persistent image for data of the file. Alternatively, if the block of data of the active file system is not identical to the data in the persistent image, the active file system is directed to refer to the data of the active file system. A file folding command may be issued to start the comparison.

Abstract translation: 公开了一种用于减少存储在存储系统的存储设备上的活动文件系统的重复数据的方法。 在第一时间点生成活动文件系统的持久图像。 稍后，启动将活动文件系统与持久性映像进行比较的一系列步骤。 然后，如果活动文件系统的数据块与持久性图像中的数据相同，则活动文件系统被引导以引用文件数据的持久图像。 或者，如果活动文件系统的数据块与持久图像中的数据不相同，则活动文件系统被引导以参考活动文件系统的数据。 可以发出文件折叠命令来开始比较。

公开(公告)号：US20050182799A1

公开(公告)日：2005-08-18

申请号：US11057409

申请日：2005-02-14

Applicant: David Hitz ,  John Edwards ,  Blake Lewis

Inventor： David Hitz ,  John Edwards ,  Blake Lewis

IPC: G06F12/00 ,  G06F17/30

CPC classification number: G06F17/30067 ,  G06F2201/84 ,  Y10S707/99931 ,  Y10S707/99938 ,  Y10S707/99952 ,  Y10S707/99953

Abstract: Maintenance of plural active file systems, wherein each of the active file systems initially access data shared with another of the active file systems, and wherein changes made to each of the active file systems are not reflected in other active file systems. When a second active file system is created based on a first active file system, the first active file system and the second active file system initially share data. When changes are made to the first active file system, modified data is recorded in the first active file system in a location that is not shared with the second active file system. When changes are made to the second active file system, modified data is recorded in the second active file system in a location that is not shared with the first active file system. Also, creation of the plural active file systems.

Abstract translation: 维护多个活动文件系统，其中每个活动文件系统最初访问与另一个活动文件系统共享的数据，并且其中对每个活动文件系统所做的更改不会反映在其他活动文件系统中。 当基于第一活动文件系统创建第二活动文件系统时，第一活动文件系统和第二活动文件系统最初共享数据。 当对第一活动文件系统进行改变时，修改的数据被记录在不与第二活动文件系统共享的位置的第一活动文件系统中。 当对第二活动文件系统进行改变时，修改的数据被记录在不与第一活动文件系统共享的位置的第二活动文件系统中。 另外，创建多个活动文件系统。

公开(公告)号：US20050114297A1

公开(公告)日：2005-05-26

申请号：US11024184

申请日：2004-12-28

Applicant: John Edwards

Inventor： John Edwards

IPC: G06F17/30 ,  G06F7/00

CPC classification number: G06F17/30067 ,  Y10S707/99931 ,  Y10S707/99952 ,  Y10S707/99953 ,  Y10S707/99955

Abstract: A system and method for performing an on-line check of a file system modifies various function calls within a file system layer of a storage operating system so that each time the particular inode is retrieved using the modified function calls, a check is performed on the inode and associated buffer trees before returning the requested inode to the calling process.

公开(公告)号：US5978431A

公开(公告)日：1999-11-02

申请号：US417

申请日：1998-03-30

Applicant: John Edwards

Inventor： John Edwards

IPC: G21C3/62

CPC classification number: G21C3/623 ,  G21C3/62 ,  Y02E30/38

Abstract: A method of producing mixed oxide fuel pellets. The method uses oxides of at least two fissile elements and includes a mixing, milling, spheroidising and sintering step to produce a fuel pellet incorporating a neutron poison.

Abstract translation: PCT No.PCT / GB96 / 01828 Sec。 371日期1998年3月30日 102（e）1998年3月30日PCT PCT 1996年7月26日PCT公布。 出版物WO97 / 06535 日期：1997年2月20日制造混合氧化物燃料粒料的方法。 该方法使用至少两种裂变元素的氧化物，并且包括混合，研磨，球化和烧结步骤以产生包含中子毒物的燃料颗粒。