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公开(公告)号：US07980180B2
公开(公告)日：2011-07-19
申请号：US10590461
申请日：2005-02-23
Applicant: John MacDougall
Inventor： John MacDougall
IPC: F42B10/00
Abstract: A jacketed projectile having one-piece steel core provides good performance regarding chamber pressure, barrel wear and accuracy by separating the jacket from a central tapered portion of the core by providing an encircling air gap that facilitates engraving of the jacket during firing.
Abstract translation: 具有一体式钢芯的护套弹丸通过提供一种环绕的空气间隙来提供外壳与中心锥形部分之间的分离，从而提高了室内压力，滚筒磨损和精度。
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公开(公告)号：US20100297118A1
公开(公告)日：2010-11-25
申请号：US12762008
申请日：2010-04-16
Applicant: John MacDougall , Kip A. West
Inventor： John MacDougall , Kip A. West
IPC: A61K39/395 , A61K31/4355 , A61K31/517 , A61K31/5377 , A61P35/00
CPC classification number: A61K31/00 , A61K31/282 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , C07D491/048 , A61K2300/00
Abstract: Provided are methods for treating non-small cell lung cancer by administering a therapeutically effective amount of a hedgehog inhibitor.
Abstract translation: 提供了通过施用治疗有效量的刺猬蛋白抑制剂治疗非小细胞肺癌的方法。
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公开(公告)号：US20080171046A1
公开(公告)日：2008-07-17
申请号：US10844295
申请日：2004-05-12
Applicant: Corine Vermet , Elma Fernandes , Richard Shimkets , John Herrmann , Kumud Majumder , John MacDougall , Vishnu Mishra , Peter S. Mezes , Luca Rastelli
Inventor： Corine Vermet , Elma Fernandes , Richard Shimkets , John Herrmann , Kumud Majumder , John MacDougall , Vishnu Mishra , Peter S. Mezes , Luca Rastelli
IPC: A61K39/395 , C07K14/435 , C07H21/00 , C12N15/00 , C07K16/18 , C12N5/00 , A61K38/17 , A61P25/00 , A61P11/00 , A61P37/00 , A61P15/00 , A61P35/04 , A61K31/70 , G01N33/566 , C12Q1/68 , G01N33/00 , C12Q1/02
CPC classification number: C07K14/705 , A61K38/00 , C07K14/47 , C07K14/54 , C07K14/70571 , Y02A50/423 , Y10T436/143333
Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract translation: 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
Applicant: Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
Inventor： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
CPC classification number: C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050049192A1
公开(公告)日：2005-03-03
申请号：US10635149
申请日：2003-08-06
Applicant: Mei Zhong , Weizhen Ji , Xiaojia Guo , Daniel Rieger , Muralidhara Padigaru , Rachel Malcolm , Kimberly Spytek , David Anderson , Linda Gorman , Elina Catterton , John MacDougall , David Stone , Shlomit Edinger
Inventor： Mei Zhong , Weizhen Ji , Xiaojia Guo , Daniel Rieger , Muralidhara Padigaru , Rachel Malcolm , Kimberly Spytek , David Anderson , Linda Gorman , Elina Catterton , John MacDougall , David Stone , Shlomit Edinger
CPC classification number: C07H21/04 , A61K38/00 , G01N33/68 , G01N2500/04 , G01N2500/10
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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Patent Agency Ranking
公开(公告)号：US20220387619A2
公开(公告)日：2022-12-08
申请号：US17395369
申请日：2021-08-05
Applicant: Elisabet de los Pinos , John Todd Schiller , Rhonda C. Kines , John MacDougall
Inventor： Elisabet de los Pinos , John Todd Schiller , Rhonda C. Kines , John MacDougall
IPC: A61K47/69 , A61K41/00 , A61K39/12 , A61K47/64 , C07K1/13 , C07K14/025 , C07K16/08 , C07K16/32 , A61N5/06 , C12N7/00
Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
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公开(公告)号：US20070163459A1
公开(公告)日：2007-07-19
申请号：US10590461
申请日：2005-02-23
Applicant: John MacDougall
Inventor： John MacDougall
IPC: F42B10/00
Abstract: A jacketed projectile having one-piece steel core provides good performance regarding chamber pressure, barrel wear and accuracy by separating the jacket from a central tapered portion of the core by providing an encircling air gap that facilitates engraving of the jacket during firing.
Abstract translation: 具有一体式钢芯的护套弹丸通过提供一种环绕的空气间隙来提供外壳与中心锥形部分之间的分离，从而提高了室内压力，滚筒磨损和精度。
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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
Applicant: John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
Inventor： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract translation: 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060013813A1
公开(公告)日：2006-01-19
申请号：US11054281
申请日：2005-02-08
Applicant: Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
Inventor： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
IPC: C12Q1/68 , G01N33/53 , C07H21/04 , A61K39/395 , C07K14/705 , C07K16/18
CPC classification number: C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050183617A1
公开(公告)日：2005-08-25
申请号：US10783032
申请日：2004-02-23
Applicant: John MacDougall
Inventor： John MacDougall
Abstract: A jacketed projectile, preferably with a unique geometry one-piece steel core to improve penetration of hard targets, provides good performance regarding chamber pressure, barrel wear and accuracy by separating the jacket from a central tapered portion of the core by providing an encircling air gap.
Abstract translation: 优选具有独特几何形状的单件钢芯以提高硬目标的穿透性的护套弹丸通过将套管与芯的中心锥形部分分开来提供腔室压力，筒磨损和精度的良好性能，通过提供环绕气隙 。
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