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    Heat generation tool
    11.
    发明专利
    Heat generation tool 有权
    热发电工具

    公开(公告)号：JP2012239651A

    公开(公告)日：2012-12-10

    申请号：JP2011112778

    申请日：2011-05-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ODA HIDESHI ,  SAKAMOTO ICHIRO ,  SAKASAI MITSUYOSHI ,  SUZUKI YASUTO

    IPC: A61F7/03

    Abstract: PROBLEM TO BE SOLVED: To provide a heat generation tool for continuously giving a sufficient warm sensation to a user.SOLUTION: Heat generation temperature measured based on JIS S4000 is 37-60°C in the heat generation tool. The heat generation tool includes on a skin abutment surface, a water-absorbing fiber sheet which retains 0.1-100μg/cmof a heating agent to be expressed by general formula (1) and 0.1-50μg/cmof water. It is preferable that the water retention ratio of the water-absorbing fiber sheet is 200-2,000 mass%. It is also preferable that the basis weight of the water-absorbing fiber sheet is 10-100g/m. It is also preferable that the heat generation tool includes: a body part having a heat generation part for enclosing a heat generation composition and a storage body which stores the heat generation part and at least partially has ventilation property; and a water-absorbing fiber sheet which constitutes a part of the storage body and is arranged on the outer surface of a first sheet positioned on the skin abutment surface side of the storage body. (In the formula, X indicates -CHCO-, NHCO-, or -O-. R indicates a 2-15C linear or branched alkyl group, a 2-15C linear or branched hydroxyalkyl group, or a 2-15C linear or branched alkenyl group.).

    Abstract translation: 要解决的问题：提供一种用于对用户持续给予足够的温暖感觉的发热工具。

    解决方案：在发热工具中，基于JIS S4000测量的发热温度为37-60℃。 发热工具在皮肤邻接表面上包含保持通式（1）表示的加热剂的0.1-100μg/ cm 2的吸水性纤维片， 和0.1-50μg/ cm 2的水。 吸水性纤维片的保水率优选为200〜2000质量％。 另外，吸水性纤维片的单位面积重量也优选为10〜100g / m 2。 还优选的是，发热体具有：主体部，具有用于封闭发热体组合物的发热部和存储发热部的储存体，至少部分具有透气性; 以及构成储存体的一部分并且设置在位于储存体的皮肤抵接表面侧的第一片材​​的外表面上的吸水性纤维片材。 （在该式中，X表示-CH

    Trpv3 activating agent
    12.
    发明专利
    Trpv3 activating agent 有权
    TRPV3激活剂

    公开(公告)号：JP2012153618A

    公开(公告)日：2012-08-16

    申请号：JP2011011748

    申请日：2011-01-24

    Applicant: Kao Corp ,  花王株式会社

    Inventor： KUMIHASHI KENTARO ,  KUSUOKU HIROSHI ,  SAKASAI MITSUYOSHI

    IPC: A61K8/97 ,  A61K36/18 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide a TRPV3 activating agent for imparting warm feeling to cosmetics, pharmaceuticals or compositions for oral cavity application.SOLUTION: The TRPV3 activating agent contains an extract of a plant of genus Curcuma as an active component. Preferably, the plant of genus Curcuma of the TRPV3 activating agent is one or more plants selected from among Curcuma xanthorrhiza, Curcuma zedoaria, Curcuma aromatica and Curcuma longa.

    Abstract translation: 要解决的问题：提供TRPV3活化剂，以赋予用于口腔应用的化妆品，药​​物或组合物温暖的感觉。 解决方案：TRPV3活化剂含有姜黄属植物的提取物作为活性成分。 优选地，TRPV3活化剂的姜黄属植物是选自姜黄，姜黄，姜黄和姜黄的一种或多种植物。 版权所有（C）2012，JPO＆INPIT

    Composition for oral cavity
    13.
    发明专利
    Composition for oral cavity 有权
    口腔用组合物

    公开(公告)号：JP2011136953A

    公开(公告)日：2011-07-14

    申请号：JP2009298304

    申请日：2009-12-28

    Applicant: Kao Corp ,  花王株式会社

    Inventor： YAMASHIRO TAKAHISA ,  SAKASAI MITSUYOSHI

    IPC: A61K8/34 ,  A61K8/97 ,  A61Q11/00

    Abstract: PROBLEM TO BE SOLVED: To provide a composition for the oral cavity that contains menthol in a level of an amount not causing sharp irritation and pain and yet gives refreshing feel equal to or stronger as if the amount of menthol added were increased. SOLUTION: The composition for the oral cavity includes 0.2-0.8 mass% of (A) menthol, and (B) refined ginger oleoresin in which the content of zingiberene to 1 pts.mass of shogaol is less than 1 pt.mass by weight of solid. The mass ratio of (A) to (B) (A/B) is 2-80. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供含有不引起急性刺激和疼痛的量的含有薄荷醇的口腔组合物，并且如同加入的薄荷醇的量增加一样，具有等同于或更强的清爽感觉。 解决方案：口腔用组合物包含（A）薄荷醇的0.2-0.8质量％和（B）精制姜油树脂，其中姜黄素含量为1磅以下的冰果糖含量小于1重量％ 的固体。 （A）〜（B）（A / B）的质量比为2-80。 版权所有（C）2011，JPO＆INPIT

    Hair growing agent
    14.
    发明专利
    Hair growing agent 有权
    头发生长剂

    公开(公告)号：JP2010100536A

    公开(公告)日：2010-05-06

    申请号：JP2008271069

    申请日：2008-10-21

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NAGASAWA AZUMI

    IPC: A61K8/49 ,  A61K31/352 ,  A61P17/14 ,  A61Q7/00 ,  C07D493/04

    Abstract: PROBLEM TO BE SOLVED: To identify an active ingredient showing hair-growing activity in a plant or a plant extract. SOLUTION: The active ingredient showing hair-growing activity is identified in an extract of Angelica atropurpurea. The active ingredient has an angular furocoumarin skeleton having a prescribed structure. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：鉴定在植物或植物提取物中显示毛发生长活性的活性成分。 解决方案：在当归提取物中鉴定显示毛发生长活性的活性成分。 活性成分具有规定结构的角状呋喃香豆素骨架。 版权所有（C）2010，JPO＆INPIT

    Processed nutmeg product and method for producing the same
    15.
    发明专利
    Processed nutmeg product and method for producing the same 有权
    加工的NUTMEG产品及其制造方法

    公开(公告)号：JP2014031366A

    公开(公告)日：2014-02-20

    申请号：JP2013140593

    申请日：2013-07-04

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SHIRAI TOMOHIRO ,  KUMIHASHI KENTARO ,  KUSUOKU HIROSHI ,  SAKASAI MITSUYOSHI ,  HASHIMOTO CHU

    IPC: A61K8/97 ,  A23L27/10 ,  A61Q11/00

    Abstract: PROBLEM TO BE SOLVED: To provide a processed plant product that has excellent TRPM8 activity, a method for producing the same, and an agent that produces a cold sensation and a TRPM8 activator using the processed plant product.SOLUTION: A method for producing a processed nutmeg product is characterized by including a step for simultaneously treating nutmeg or an extract thereof with one or more substances selected from an alcohol or a 25% (v/v) or higher aqueous alcohol solution, a protonic acid, and an H-type cation exchange resin.

    Abstract translation: 要解决的问题：提供具有优异TRPM8活性的加工植物产品，其制备方法和产生冷感觉的试剂和使用加工的植物产品的TRPM8活化剂。解决方案：一种生产加工过的 肉豆蔻产品的特征在于包括用一种或多种选自醇或25％（v / v）或更高的醇水溶液，质子酸和H型阳离子的物质同时处理肉豆蔻或其提取物的步骤 交换树脂。

    Cool feeling agent, and trpm8 activator
    16.
    发明专利
    Cool feeling agent, and trpm8 activator 有权
    冷却感觉剂和TRPM8激活剂

    公开(公告)号：JP2013136733A

    公开(公告)日：2013-07-11

    申请号：JP2012253512

    申请日：2012-11-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SHIRAI TOMOHIRO ,  KUSUOKU HIROSHI ,  SAKASAI MITSUYOSHI ,  KUMIHASHI KENTARO

    IPC: C09K3/00 ,  A61K8/34 ,  C07C43/23

    CPC classification number: C07C43/23 ,  A61K8/33 ,  A61K8/347 ,  A61K2201/054 ,  A61K2800/10 ,  A61K2800/244 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide a cool feeling agent, a TRPM8 activator and a method for imparting cool feeling, excellent in activation action of TRPM8 as a receptor exhibiting response to menthol and cold stimulus, and a novel compound useful for imparting cool feeling.SOLUTION: The cool feeling agent has as an effective ingredient a compound represented by formula (1) wherein Ris a hydrogen atom; Ris a hydrogen atom, a hydroxy group or a 1-3C alkoxy group; Ris a hydrogen atom or a hydroxy group; Ris a hydrogen atom, a 1-6C alkyl group, a 2-6C alkenyl group or a 1-3C alkoxy group; Ris a hydrogen atom or a 1-3C alkoxy group; and Ris a hydrogen atom, a hydroxy group, a 1-14C alkoxy group, an alkoxyalkoxy group having 2 to 12 total carbon atoms, a 3-12C cycloalkoxy group, a 6-12C aryloxy group, an aralkyloxy group having 7 to 14 total carbon atoms, or an alkanoyloxy group having 2 to 12 total carbon atoms.

    Abstract translation: 要解决的问题：提供凉爽感觉剂，TRPM8活化剂和赋予凉爽感觉的方法，作为显示对薄荷醇和冷刺激的反应的受体的TRPM8的活化作用优异，以及用于赋予凉爽感觉的新型化合物。 解决方案：凉爽感觉剂作为有效成分，由式（1）表示的化合物，其中R为氢原子; R 1为氢原子，羟基或1-3C烷氧基; R是氢原子或羟基; R 1为氢原子，1-6C烷基，2-6C烯基或1-3C烷氧基; R是氢原子或1-3C烷氧基; R 1为氢原子，羟基，1-14C烷氧基，碳原子数为2〜12的烷氧基烷氧基，3-12C环烷氧基，6-12C芳氧基，芳烷氧基共7-14个 碳原子或碳原子数为2〜12的烷酰氧基。

    Fructosyl dipeptide or salt thereof
    17.
    发明专利
    Fructosyl dipeptide or salt thereof 有权
    果糖或其盐

    公开(公告)号：JP2010180240A

    公开(公告)日：2010-08-19

    申请号：JP2010095789

    申请日：2010-04-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SUGIYAMA MITSURU ,  SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

    IPC: C07K5/062 ,  A61K8/64 ,  A61Q7/02 ,  A61Q19/08

    Abstract: PROBLEM TO BE SOLVED: To provide a skin care preparation for external use having efficacy for preventing or improving skin aging such as wrinkles and also having efficacy for inhibiting hair growth.
    SOLUTION: There are provided fructosyl dipeptide represented by general formula (1): Fru-A-B-R or its salt, as well as a skin care preparation for external use, a hair growth inhibitor and a wrinkle-preventing or improving agent, each containing the same. In the general formula (1), Fru represents a fructosyl residue; A represents a valine residue or an isoleucine residue; B represents a tyrosine residue, a phenylalanine residue, a valine residue or an isoleucine residue; R represents a hydroxy group or a methoxy group.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种具有用于预防或改善皮肤老化如皱纹的功效的外用护肤品，并且还具有抑制头发生长的功效。 提供由通式（1）表示的果糖基二肽：Fru-ABR或其盐，以及外用护肤品，毛发生长抑制剂和防皱或改善剂，每种 含有相同的 在通式（1）中，Fru表示果糖基残基; A代表缬氨酸残基或异亮氨酸残基; B代表酪氨酸残基，苯丙氨酸残基，缬氨酸残基或异亮氨酸残基; R表示羟基或甲氧基。 版权所有（C）2010，JPO＆INPIT

    Fructosyl dipeptide or salt thereof
    19.
    发明专利
    Fructosyl dipeptide or salt thereof 有权
    果糖或其盐

    公开(公告)号：JP2005170930A

    公开(公告)日：2005-06-30

    申请号：JP2004325500

    申请日：2004-11-09

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SUGIYAMA MITSURU ,  SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/64 ,  A61Q9/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07K9/00 ,  A61K7/00 ,  A61K7/155 ,  A61K7/48

    Abstract: PROBLEM TO BE SOLVED: To provide a skin care preparation for external use having efficacy for preventing or improving the aging of skin such as the development of wrinkles and for inhibiting hair growth.
    SOLUTION: There is provided fructosyl dipeptide represented by general formula (1): Fru-A-B-R (1) or a salt thereof, and also provided a skin care preparation for external use, a hair growth inhibitor and a wrinkle-preventing or improving agent, each containing the same. In general formula (1), Fru denotes a fructosyl residue; A denotes a valine residue or an isoleucine residue; B denotes a tyrosine residue, a phenylalanine residue, a valine residue or an isoleucine residue; and R denotes a hydroxy group or a methoxy group.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种具有用于预防或改善皮肤老化的效果的外用护肤品，例如皱纹的发展和抑制毛发生长。 提供由通式（1）表示的果糖基二肽：Fru-ABR（1）或其盐，并且还提供用于外用的护肤制剂，毛发生长抑制剂和抗皱纹或 改善剂，每种含量相同。 通式（1）中，Fru表示果糖基残基; A表示缬氨酸残基或异亮氨酸残基; B表示酪氨酸残基，苯丙氨酸残基，缬氨酸残基或异亮氨酸残基; R表示羟基或甲氧基。 版权所有（C）2005，JPO＆NCIPI

    β-GLUCURONIDASE INHIBITORY AGENT
    20.
    发明专利
    β-GLUCURONIDASE INHIBITORY AGENT 有权
    - GLUCURONIDASE抑制剂

    公开(公告)号：JP2013255834A

    公开(公告)日：2013-12-26

    申请号：JP2013177699

    申请日：2013-08-29

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKASAI MITSUYOSHI ,  MORI ICHIRO

    IPC: A61L9/01 ,  A61F13/15 ,  A61F13/472 ,  A61F13/49 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61P13/00 ,  A61P35/00 ,  A61P43/00 ,  A61Q15/00 ,  C12N9/99

    Abstract: PROBLEM TO BE SOLVED: To provide an agent persistently suppressing the generation of a bad smell derived from urine by making a bad smell component having higher contribution to uraroma than ammonia in living environment clear and inhibiting an enzyme related to the generation thereof.SOLUTION: A new β-glucuronidase inhibitory agent includes Lindera strychnifolia or an extract thereof. An environmental sanitation product and a sanitary product contain the β-glucuronidase inhibitory agent. A uraroma generation-suppressing composition and a method for suppressing the generation of uraroma use the β-glucuronidase inhibitory agent.

    Abstract translation: 要解决的问题：提供一种通过在生活环境中制备具有比氨在尿素中具有较高贡献的不利气味组分来持续地抑制来自尿的不良气味的产生，并且抑制与其生成有关的酶。解决方案：A 新葡萄糖醛酸苷酶抑制剂包括林鞭草或其提取物。 环境卫生用品和卫生用品含有葡萄糖醛酸苷酶抑制剂。 尿糖代谢抑制组合物和抑制尿红蛋白的产生的方法使用葡萄糖醛酸苷酶抑制剂。

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