公开(公告)号：EP4161952A1

公开(公告)日：2023-04-12

申请号：EP21736092.4

申请日：2021-06-03

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  PANNUCCI, James ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  BROWNE, Cecille D.

IPC: C07K14/47 ,  C07K14/705

公开(公告)号：EP4188947A2

公开(公告)日：2023-06-07

申请号：EP21769534.5

申请日：2021-07-28

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  PANNUCCI, James ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  BROWNE, Cecille D.

IPC: C07K14/705 ,  A61K39/39 ,  A61P25/28 ,  A61P35/00

公开(公告)号：EP3972696A1

公开(公告)日：2022-03-30

申请号：EP20732028.4

申请日：2020-05-21

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  PANNUCCI, James ,  MANSOUR, Marc

IPC: A61P35/00 ,  C07K7/00 ,  A61P25/28

公开(公告)号：EP3795167A1

公开(公告)日：2021-03-24

申请号：EP20204314.7

申请日：2017-09-15

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PANNUCCI, James ,  AYALA, Ramses

IPC: A61K38/10 ,  C07K7/08 ,  A61P35/00 ,  A61P31/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

公开(公告)号：EP3630807A1

公开(公告)日：2020-04-08

申请号：EP18733407.3

申请日：2018-05-25

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy ,  PANNUCCI, James

IPC: C07K14/705 ,  A61K38/17