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    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    12.
    发明公开
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开

    公开(公告)号：EP4513175A2

    公开(公告)日：2025-02-26

    申请号：EP24204956.7

    申请日：2014-02-24

    Applicant: Life Technologies Corporation

    Inventor： CHEN, Mingsong ,  AGUANNO, Mauro ,  BOO, Kuan Moon ,  SOH, Woon Liang Terence ,  FREUDENTHAL, Jacob ,  MARKS, Jeffrey

    IPC: G01N21/64

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    METHODS AND SYSTEMS FOR INSTRUMENT VALIDATION
    17.
    发明公开
    METHODS AND SYSTEMS FOR INSTRUMENT VALIDATION 审中-公开
    用于仪器验证的方法和系统

    公开(公告)号：EP3254080A1

    公开(公告)日：2017-12-13

    申请号：EP16706289.2

    申请日：2016-02-05

    Applicant: Life Technologies Corporation

    Inventor： WESSEL, Thomas ,  CHU, Yong ,  FREUDENTHAL, Jacob ,  WOO, David

    IPC: G01N21/27 ,  G01N21/64 ,  C12Q1/68 ,  G06F19/26

    CPC classification number: G01N21/6428 ,  G01N21/274 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6439 ,  G06F19/24

    Abstract: In one exemplary embodiment, a method for validating an instrument is provided. The method includes receiving amplification data from a validation plate to generate a plurality of amplification curves. The validation plate includes a sample of a first quantity and a second quantity, and each amplification curve includes an exponential region. The method further includes determining a set of fluorescence thresholds based on the exponential regions of the plurality of amplification curves and determining, for each fluorescence threshold of the set, a first set of cycle threshold (Ct) values of amplification curves generated from the samples of the first quantity and a second set of Ct values of amplification curves generated from the samples of the second quantity. The method includes calculating if the first and second quantities are sufficiently distinguishable based on Ct values at each of the plurality of fluorescence thresholds.

    SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    18.
    发明公开
    SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
    系统和生物分析方法

    公开(公告)号：EP2760583A2

    公开(公告)日：2014-08-06

    申请号：EP12787175.4

    申请日：2012-09-28

    Applicant: Life Technologies Corporation

    Inventor： DANEHY, Ronald ,  LIM, Gary ,  FREUDENTHAL, Jacob

    IPC: B01L3/00 ,  C12M1/00

    Abstract: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    19.
    发明公开
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开

    公开(公告)号：EP4513175A3

    公开(公告)日：2025-05-07

    申请号：EP24204956.7

    申请日：2014-02-24

    Applicant: Life Technologies Corporation

    Inventor： CHEN, Mingsong ,  AGUANNO, Mauro ,  BOO, Kuan Moon ,  SOH, Woon Liang Terence ,  FREUDENTHAL, Jacob ,  MARKS, Jeffrey

    IPC: G01N21/27 ,  G01N21/64

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

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