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    SYSTEMS AND METHODS FOR PERFORMING DIGITAL PCR
    11.
    发明公开
    SYSTEMS AND METHODS FOR PERFORMING DIGITAL PCR 审中-公开

    公开(公告)号：EP3356555A1

    公开(公告)日：2018-08-08

    申请号：EP16782341.8

    申请日：2016-09-29

    Applicant: Life Technologies Corporation

    Inventor： KEYS, David ,  MAJUMDAR, Nivedita Sumi ,  STRAUB, Theodore

    IPC: C12Q1/68 ,  B01L3/00

    CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/024 ,  B01L2300/0829 ,  C12Q1/6851 ,  C12Q2527/107 ,  C12Q2545/114 ,  C12Q2561/113 ,  C12Q2563/159

    Abstract: Systems and methods are described for quantifying a target nucleic acid. A sample comprising a target nucleic acid is segregated into a first plurality of the reaction volumes containing at least one target nucleic acid molecule and a second plurality of the reaction volumes containing no target nucleic acid molecules. The reaction volumes are subjected to an amplification assay, wherein the amplification assay is configured to amplify the target nucleic acid. An indicator of amplification is detected or measured in at least some of the plurality of reaction volumes. The target nucleic acid is quantified based on the detection or measurement. After discontinuing the amplification assay, the plurality of reaction volumes may be heated and changes in the indicators of amplification of two or more of the at least some of the reaction volumes may be detected or measured.

    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE
    12.
    发明公开
    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE 审中-公开
    住房和住房支持的生物样品和使用相关方法

    公开(公告)号：EP3003558A1

    公开(公告)日：2016-04-13

    申请号：EP14733021.1

    申请日：2014-05-27

    Applicant: Life Technologies Corporation

    Inventor： PALLAS, Michael ,  FOSTER, Evan ,  FONSECA, Jorge ,  NURSE, James ,  STRAUB, Theodore

    IPC: B01L3/00

    CPC classification number: B01L3/50851 ,  B01L3/50857 ,  B01L7/52 ,  B01L9/523 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/18 ,  C12Q1/686 ,  G01N21/6452

    Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.

    Abstract translation: 一种用于处理生物样品的所述多个系统包含一个支撑和一个温度控制器。 支撑被构造为保持确实包括位于内部腔室的情况下，以及位于所述内室中的基质，包含含有一种或多种生物样品中分离的反应位点的多个基板。 温度控制器被配置为维持或上的一个或多个生物样品的测定或反应过程中控制支撑中的至少一个的情况下，或所述一种或多种生物样品的温度。 因此，该支撑件被配置以保持衬底的表面中的至少一个在正向相对水平面的测定或反应过程中的角度。

    SYSTEMS AND METHODS FOR ANALYSIS OF NUCLEIC ACIDS
    18.
    发明公开
    SYSTEMS AND METHODS FOR ANALYSIS OF NUCLEIC ACIDS 审中-公开

    公开(公告)号：EP3353323A1

    公开(公告)日：2018-08-01

    申请号：EP16777855.4

    申请日：2016-09-22

    Applicant: Life Technologies Corporation

    Inventor： LI, Shifeng ,  DONG, Shoulian ,  STRAUB, Theodore ,  KEYS, David

    IPC: C12Q1/68

    CPC classification number: C12Q1/6825 ,  C12Q1/6837 ,  C12Q1/6851 ,  G01N27/301 ,  G01N27/4145 ,  C12Q2531/113 ,  C12Q2563/116 ,  C12Q2563/159 ,  C12Q2565/607

    Abstract: A system for detecting one or more target molecules includes a reaction device and a temperature controller. The reaction device comprises a plurality of reaction sites and plurality of field effect transistors corresponding to the plurality of reaction sites. At least two of the reaction sites may receive a reaction solution including two target molecules. The temperature controller is configured to control a temperature of at least one of the reaction sites or the reaction solution received by the at least one reaction site. At least some of the reaction sites may receive a reagent supporting an amplification reaction. When the reaction is subjected to an amplification assay, an amplified product is produced in the at least some of the reaction sites. The plurality of field effect transistors are configured to detect at least one of the amplified products.

    SYSTEMS AND METHODS FOR LOADING LIQUID SAMPLES
    19.
    发明公开
    SYSTEMS AND METHODS FOR LOADING LIQUID SAMPLES 审中-公开
    系统和方法用于装载液体样品

    公开(公告)号：EP3071331A1

    公开(公告)日：2016-09-28

    申请号：EP14821331.7

    申请日：2014-11-18

    Applicant: Life Technologies Corporation

    Inventor： LIM, Gary ,  STRAUB, Theodore

    IPC: B01L3/02

    CPC classification number: B01L3/0293 ,  B01L3/50857 ,  B01L2200/026 ,  B01L2200/0642 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2400/0406 ,  C12Q1/686

    Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85 +/- 15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action. The first and second blade may dispense the liquid by laterally moving over the plurality of reaction sites, where a motor laterally moves the first and second blade.

    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS
    20.
    发明公开
    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS 审中-公开
    涂布底材对生物反应系统

    公开(公告)号：EP2825311A1

    公开(公告)日：2015-01-21

    申请号：EP13716895.1

    申请日：2013-03-15

    Applicant: Life Technologies Corporation

    Inventor： GHENCIU, Eliodor ,  FOSTER, Evan ,  STRAUB, Theodore ,  PALLAS, Michael C.

    IPC: B01L3/00 ,  C40B60/14 ,  B01L3/02

    Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.

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