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公开(公告)号：US20210350725A1
公开(公告)日：2021-11-11
申请号：US17193910
申请日：2021-03-05
Applicant: Massachusetts Institute of Technology
Inventor： Clara Park , Xuanhe Zhao , Hyunwoo Yuk , Christopher Tam Nguyen , Ellen T. Roche
Abstract: A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.
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公开(公告)号：US11884845B2
公开(公告)日：2024-01-30
申请号：US17110841
申请日：2020-12-03
Applicant: Massachusetts Institute of Technology , Mayo Foundation for Medical Education and Research
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Xinyu Mao , Christoph Nabzdyk
IPC: C09J105/08 , C09J133/02 , A61L24/00 , C09J11/06 , C09J9/00 , C09J151/00
CPC classification number: C09J105/08 , A61L24/0042 , A61L24/0094 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/003 , A61L2400/04 , C09J2483/00
Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
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公开(公告)号：US20240009346A1
公开(公告)日：2024-01-11
申请号：US17669442
申请日：2022-02-11
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Heejung Roh , Aristidis Veves , Georgios Theocharidis
CPC classification number: A61L26/008 , C09J11/06 , A61L26/0052 , A61L26/0038 , A61L26/0033 , A61L26/0066 , A61L26/0095 , A61L2430/34 , A61L2400/16
Abstract: A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
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公开(公告)号：US20220259463A1
公开(公告)日：2022-08-18
申请号：US17666642
申请日：2022-02-08
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Heejung Roh
Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
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15.发明申请公开(公告)号：US20220110619A1
公开(公告)日：2022-04-14
申请号：US17497497
申请日：2021-10-08
Applicant: Massachusetts Institute of Technology , Mayo Foundation for Medical Education and Research
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Sarah J Wu , Christoph Nabzdyk
IPC: A61B17/00 , A61L24/06 , A61B17/072
Abstract: Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials.
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Patent Agency Ranking
公开(公告)号：US11148389B2
公开(公告)日：2021-10-19
申请号：US16085692
申请日：2016-06-27
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk
IPC: A61L27/52 , A61L31/12 , A61L31/14 , B32B7/04 , B32B7/10 , B32B25/04 , B32B25/14 , B32B3/30 , B32B3/08 , B32B27/06 , B32B5/32 , B32B25/20 , B32B3/20 , A61L27/44 , A61L27/60 , B32B27/08 , B32B37/18
Abstract: Hydrogel-elastomer hybrids with interfacial bonding tougher than epidermis-dermis interfaces and functional micro-channels and micro-patterns can be created by pre-shaping both elastomers and hydrogels before bonding to conserve their micro-structures, modifying cured elastomer surfaces with benzophenone for chemical bonding with hydrogels, and harnessing dissipative properties of tough hydrogels to achieve robust interfaces.
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17.发明申请公开(公告)号：US20200368962A1
公开(公告)日：2020-11-26
申请号：US16761643
申请日：2018-12-03
Applicant: Massachusetts Institute of Technology
Inventor： Hyunwoo Yuk , Xuanhe Zhao
IPC: B29C64/118 , B29C64/393 , B33Y10/00 , B33Y50/02 , B33Y70/00 , B33Y30/00 , B29C64/209
Abstract: Systems and methods for three-dimensionally printing different configurations of a printed fiber using a single nozzle are provided. The provided systems and methods harness deformation, instability, and fracture of viscoelastic materials to adjust dimensionless parameters related to a speed of extrusion and a height of a nozzle to create the different configurations. A controller of the system can operate to create these different configurations using the single nozzle without having to change out hardware during the process. Instead, the dimensionless parameters can be adjusted while the printing is occurring to achieve the different configurations. The disclosure provides various systems for carrying out the printing, and methods of using the same.
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公开(公告)号：US20190125934A1
公开(公告)日：2019-05-02
申请号：US15794432
申请日：2017-10-26
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , German Alberto Parada Hernandez , Hyunwoo Yuk
Abstract: Hydrogel-substrate laminate structures and tough biocompatible hydrogel coatings for various equipment such as medical devices and underwater equipment, in which robust interfaces are formed between the hydrogel coatings and the substrate/equipment surface(s). The hydrogel coatings provide a highly-hydrated, ultra-low friction structure that does not rupture or delaminate under stress. The hydrogel coatings may further incorporate a variety of therapeutic agents and/or sensing mechanisms to provide for environmental sensing and therapeutic agent release.
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公开(公告)号：US09878506B2
公开(公告)日：2018-01-30
申请号：US14970704
申请日：2015-12-16
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Shaoting Lin , Hyunwoo Yuk
IPC: A61K9/00 , B29C71/00 , A61K49/22 , A61B8/00 , C08J3/075 , C08J3/24 , B29K105/00 , A61B17/225
CPC classification number: B29C71/0009 , A61B8/4281 , A61B2017/2253 , A61K49/226 , B29K2105/0061 , B29K2995/0078 , C08J3/075 , C08J3/246 , C08J2300/14 , C08J2300/208 , C08J2333/26
Abstract: Method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy. The precursor hydrogel is stretched to a multiple of its original length to form a pre-stretched hydrogel. The pre-stretched hydrogel is allowed to relax and is soaked in a biocompatible solvent to reach equilibrium swelling of the pre-stretched hydrogel whereby shear modulus of the hydrogel is reduced.
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公开(公告)号：US20170226339A1
公开(公告)日：2017-08-10
申请号：US15172131
申请日：2016-06-02
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Xuanhe Zhao , Shaoting Lin , Hyunwoo Yuk , Teng Zhang , German Alberto Parada
IPC: C08L33/26 , C09D133/26 , C08L35/00 , B05D3/04 , C09D135/00 , H01B1/12 , B05D3/10 , C09J133/26 , C09J135/00
CPC classification number: C08L33/26 , B05D3/044 , B05D3/10 , B32B27/04 , B32B27/308 , C08L35/00 , C08L2205/04 , C09D133/26 , C09D135/00 , C09D201/02 , C09J133/26 , C09J135/00 , H01B1/122
Abstract: Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm−2.
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