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11.发明申请
公开(公告)号：WO1996001143A1
公开(公告)日：1996-01-18
申请号：PCT/US1995009046
申请日：1995-06-26
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , NIERMEYER, J., Karl
IPC: B01D63/02
CPC classification number: B29D99/005 , B01D63/02 , B01D63/022 , B01D63/023 , B29C47/00 , B29C47/0021 , B29C53/562 , B29C53/8041 , B29K2023/0683 , B29K2023/12 , B29K2027/18 , B29L2031/755
Abstract: A hollow fiber membrane module and its method of manufacture are disclosed wherein the module is fabricated utilizing superior hollow fiber materials, namely high molecular weight (i.e. molecular weight > 500,000 Daltons) polymers. In a preferred embodiment, the hollow fibers are fabricated from ultrahigh molecular weight polyethylene (UPE). An array of UPE hollow fiber membranes is contacted with an extrusion of molten thermoplastic polymer at a contact temperature which is higher than the UPE membrane polymer. This high temperature application of sealing polymer does not collapse or otherwise deform the lumen of the hollow fiber, while assuring that the polymer can thus be applied with sufficiently low viscosity to provide adequate penetration around the individual fibers of the array to form an integral seal thereabout.
Abstract translation: 公开了一种中空纤维膜组件及其制造方法，其中模块采用优质中空纤维材料制成，即高分子量（即分子量> 500,000道尔顿）聚合物。 在优选实施例中，中空纤维由超高分子量聚乙烯（UPE）制成。 UPE中空纤维膜阵列与熔融热塑性聚合物的挤出物接触温度高于UPE膜聚合物。 密封聚合物的这种高温应用不会使中空纤维的内腔破裂或变形，同时确保聚合物因此可以施加足够低的粘度，以提供围绕阵列的各个纤维的足够的渗透，从而在其周围形成一体的密封 。
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公开(公告)号：WO1995035146A1
公开(公告)日：1995-12-28
申请号：PCT/US1995007821
申请日：1995-06-20
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , SNOW, James, T. , PLANTE, Walter , ZELLER, Robert, S.
IPC: B01D39/20
CPC classification number: B01D67/0041 , B01D39/2034 , B01D39/2044 , B01D53/228 , B01D53/46 , B01D69/12 , B01D71/02 , B01D2323/08 , B01D2323/12 , B01D2325/04 , B22F7/002 , H01J7/183 , Y10S55/05
Abstract: A getter-filter composite membrane element, comprising a sinterable getter material and a sinterable metal filter material, the composite element defining a matrix of substantially interconnected pores. Membrane elements may be comprised of at least three alternating layers of a first sinterable getter material layer and a second sinterable metal filter material layer, the first getter layer being located between the second filter layers, the second layers acting to hold the getter layer, and to retain the getter particles. Also disclosed is a method of making the getter-filter element.
Abstract translation: 一种吸气过滤器复合膜元件，其包括可烧结的吸气剂材料和可烧结金属过滤材料，所述复合元件限定基本相互连接的孔的基体。 膜元件可以由至少三个交替层的第一可烧结吸气材料层和第二可烧结金属过滤材料层组成，第一吸气剂层位于第二过滤层之间，第二层用于保持吸气剂层，以及 以保留吸气剂颗粒。 还公开了制造吸气剂过滤元件的方法。
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公开(公告)号：WO1993011829A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010660
申请日：1992-12-10
Applicant: BAXTER INTERNATIONAL INC. , MILLIPORE CORPORATION
Inventor： BAXTER INTERNATIONAL INC. , MILLIPORE CORPORATION , BUCCHIANERI, Richard , DAVIS, Ralph , LUEDERS, Arthur , SENNINGER, Mark
IPC: A61M39/00
CPC classification number: F16L33/00 , A61M1/1656 , A61M1/1662 , A61M1/1668 , A61M1/28 , A61M39/18
Abstract: An apparatus and a system are provided for preparing and delivering a peritoneal dialysis solution to a patient under filtered conditions. Means are provided for filtering potable water and mixing it with concentrate solutions under sanitary conditions for delivery through a final sterilizing filter to a patient. An interface apparatus between the patient and the means for making the filtered peritoneal dialysis solution is provided to permit delivery of concentrate solutions for admixture with the filtered water delivery of the dialysis solution to the patient and drainage of the dialysis solution from the patient. Means are also provided for testing the sterility integrity of the system. The interface apparatus permits delivery of a plurality of fluid streams without cross contamination of the fluid streams.
Abstract translation: 提供了一种用于将腹膜透析溶液输送给患者的装置和系统。 包含第一组导管段和包含第二组导管段的装载器的连接器配合在一起，例如配合一组轨道和槽，使得两组导管段形成多个导管，每个导管各自密封 其他管道。 装载机设置有用于以密封的关系将导管段配合在一起的装置，例如偏心安装的可旋转气缸和与气缸接触的压板。 该装置允许将透析溶液递送至患者并随后从患者移除溶液。
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公开(公告)号：WO1992005814A1
公开(公告)日：1992-04-16
申请号：PCT/US1991007130
申请日：1991-09-27
Applicant: BAXTER INTERNATIONAL INC. , MILLIPORE CORPORATION
Inventor： BAXTER INTERNATIONAL INC. , MILLIPORE CORPORATION , SENNINGER, Mark , KENLEY, Rodney , WITSOE, David , BUCCHIANERI, Richard , DEMING, Laura , GARCIA, Ben
IPC: A61M01/14
CPC classification number: A61M1/1656 , A61M1/1668 , A61M1/287 , B01F3/088
Abstract: An apparatus (10) for proportioning solutions from at least first and second constituent solutions connected to separate inlet ports (26) of the apparatus (10) first detects which constituent solution is being supplied to which port and then properly proportions the finished solution from the constituent solutions irrespective of which constituent solution is connected to which inlet port.
Abstract translation: 用于将来自连接到装置（10）的分离的入口（26）的至少第一和第二组分溶液的溶液配比的装置（10）首先检测哪个构成溶液被供应到哪个端口，然后将成品溶液从 无论哪个成分溶液与哪个入口连接在一起。
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公开(公告)号：WO1997035657A1
公开(公告)日：1997-10-02
申请号：PCT/US1997004252
申请日：1997-03-18
Applicant: MILLIPORE CORPORATION
IPC: B01D63/08
CPC classification number: B01D63/082 , B01D63/081 , B01D63/084 , B01D65/003 , Y10S264/48
Abstract: A filtration apparatus is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, a filtrate port and, optionally, a retentate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feel liquid to be filtered to form a filtrate such that the filtrate is not mixed with either the feed or a retentate.
Abstract translation: 提供了一种过滤装置，其由嵌入成型在一起的多层预剥离元件和单层元件形成。 该装置设置有进料口，滤液口和任选的滞留物口。 预先密封的元件和由嵌件成型步骤提供的密封件的密封结构影响密封结构，其使得感觉液体被过滤以形成滤液，使得滤液不与进料或渗余物混合。
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Patent Agency Ranking
公开(公告)号：WO1996021851A2
公开(公告)日：1996-07-18
申请号：PCT/US1996000485
申请日：1996-01-02
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , RISING, Donald, B.
IPC: G01N00/00
CPC classification number: B01L3/50853 , B01L3/50255 , B01L2200/0684 , B01L2300/0829 , B01L2400/0688 , C12M23/04 , C12M23/12 , C12M25/04 , Y10S435/809 , Y10S436/809
Abstract: A device for conducting biological analysis, such as cell culture, is disclosed having improved contamination prevention features. In a preferred embodiment, a microwell membrane plate for cell analysis is adapted to be inserted into a shallow rectangular tray with elevated side walls which form a single large reservoir for holding an appropriate liquid used in cell growth and analysis. The side surfaces of the tray include a raised ridge extending about the entire periphery of the tray. A series of uniform-height steps formed on the ridge serve as support for the microwell membrane plate when inserted into the tray and also create a narrow capillary gap between the plate and the tray. A ledge extending laterally from the base of the ridge forms a second, wider gap when the microwell membrane plate is inserted into the tray. The height of the first capillary gap is less than the height of the second gap formed within the zone of space extending to the exterior of the device, thus when the tray and plate are tilted, as when jostled during handling, liquid from the reservoir will preferentially remain in the space formed by the first capillary gap. Liquid which does spill into the second gap will run back into the reservoir when the device is leveled.
Abstract translation: 公开了用于进行生物分析的装置，例如细胞培养，其具有改进的防污染特征。 在优选实施例中，用于细胞分析的微孔膜片适于插入具有升高的侧壁的浅矩形托盘中，所述侧壁形成用于保持用于细胞生长和分析的适当液体的单个大贮存器。 托盘的侧表面包括围绕托盘的整个周边延伸的凸脊。 在脊上形成的一系列均匀高度的台阶在插入托盘时用作微孔膜板的支撑，并且还在板和托盘之间产生窄的毛细管间隙。 当微孔膜片插入托盘时，从脊的基部横向延伸的凸缘形成第二较宽的间隙。 第一毛细管间隙的高度小于在延伸到装置外部的空间区域内形成的第二间隙的高度，因此当托盘和板倾斜时，如在处理期间推挤时，来自储存器的液体将 优先保留在由第一毛细管间隙形成的空间中。 当装置平整时，会溅入第二间隙的液体将流回到储存器中。
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公开(公告)号：WO1996003202A1
公开(公告)日：1996-02-08
申请号：PCT/US1995010080
申请日：1995-07-25
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , MOYA, Wilson
IPC: B01D69/12
CPC classification number: B01D67/0088 , B01D69/125 , Y10T428/249958 , Y10T428/249978 , Y10T428/249979 , Y10T428/24998 , Y10T428/249981
Abstract: A composite porous membrane is provided which comprises a porous membrane substrate having an average pore size between 0.01 and 10 microns formed of a first polymer which is coated over its entire surface with a crosslinked second polymer. The second polymer is dissolved in a solvent with a free radical polymerization initiator in the absence of a crosslinking agent. The second polymer is crosslinked in situ and rendered insoluble by mild heating and/or exposure to ultraviolet light.
Abstract translation: 提供一种复合多孔膜，其包括由第一聚合物形成的平均孔径为0.01至10微米的多孔膜基材，其在其整个表面上用交联的第二聚合物涂覆。 第二聚合物在不存在交联剂的情况下用自由基聚合引发剂溶解在溶剂中。 第二聚合物原位交联并通过温和加热和/或暴露于紫外光使其变得不溶。
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公开(公告)号：WO1995003842A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008506
申请日：1994-07-27
Applicant: MILLIPORE CORPORATION
IPC: A61M05/165
CPC classification number: A61M5/38 , A61M5/165 , A61M5/36 , A61M5/385 , A61M2005/1657 , A61M2205/7527 , A61M2205/7536 , B01D19/0031 , B01D36/001 , B01D63/08 , B01D63/082
Abstract: A self-priming filter holder for filtration of intravenous liquids is provided and is formed of one or two housing portions sealed to a core portion. The core portion has one or two ribbed surfaces forming a plurality of flow paths sealed at one end and open at a second end and at least one channel preferably larger than the flow paths. The channel(s) is in fluid communication with the flow paths and an outlet. An inlet is provided to the interior of the housing portion(s) which are sealed from the ribbed surfaces by hydrophilic membranes. The housing portion(s) can be provided with gas vents sealed with hydrophobic membranes. Fluids pass through the flow paths in one direction and through the channel(s) in an opposite direction to remove gas from the flow paths and channels prior to use.
Abstract translation: 提供了用于过滤静脉注射液体的自吸过滤器保持器，并且由一个或两个密封到芯部的壳体部分形成。 芯部分具有一个或两个肋状表面，其形成在一端密封并在第二端处开口的多个流动路径以及优选地大于流动路径的至少一个通道。 通道与流路和出口流体连通。 入口被提供到壳体部分的内部，其通过亲水膜与肋表面密封。 壳体部分可以设置有用疏水膜密封的气体通风口。 流体在一个方向上通过流动路径并且沿相反方向穿过通道，以在使用之前从流动路径和通道中除去气体。
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公开(公告)号：WO1991016968A1
公开(公告)日：1991-11-14
申请号：PCT/US1991002967
申请日：1991-04-29
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , DILEO, Anthony, J. , ALLEGREZZA, Anthony, F., Jr. , BURKE, Edmund, Tracy
IPC: B01D69/12
CPC classification number: B01D61/145 , A61L2/0017 , A61L2/022 , B01D61/142 , B01D69/02 , B01D69/12 , C07K1/34
Abstract: A composite membrane and process utilizing the membrane which is capable of selectively removing particles such as viral particles from a solution such as a protein solution is provided. The membrane comprises a porous membrane substrate, a surface skin having ultrafiltration separation properties and an intermediate porous zone between the substrate and the skin which intermediate zone has an average pore size smaller than that of the substrate. The intermediate zone is free of voids which break the skin and which directly fluid communicate with the substrate. The composite is capable of a log reduction value of at least 3 (99.9 % removal) of particles selectively from solution.
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公开(公告)号：WO1990010718A1
公开(公告)日：1990-09-20
申请号：PCT/US1990001316
申请日：1990-03-09
Applicant: MILLIPORE CORPORATION
Inventor： MILLIPORE CORPORATION , BECK, Stephan , COULL, James, M. , KOESTER, Hubert , O'KEEFFE, Thomas, J.
IPC: C12Q01/68
CPC classification number: C12Q1/6869 , C12Q2563/103
Abstract: This invention pertains to methods of detecting nucleic acids by chemiluminescence and to methods of sequencing nucleic acids using chemiluminescence detection. Nucleic acids are covalently or non-covalently linked to a compound that can generate chemiluminescence. Preferably the nucleic acid is linked to an enzyme and the substrate for the enzyme is a stable but enzymatically triggerable substituted 1,2-dioxetane.
Abstract translation: 本发明涉及通过化学发光检测核酸的方法和使用化学发光检测对核酸进行测序的方法。 核酸与可以产生化学发光的化合物共价或非共价连接。 优选地，核酸连接到酶，并且酶的底物是稳定但酶促触发的取代的1,2-二氧环乙烷。
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