公开(公告)号：WO1995022046A1

公开(公告)日：1995-08-17

申请号：PCT/US1995001556

申请日：1995-02-07

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  OHIO UNIVERSITY ,  SMALL, Gary, W. ,  ARNOLD, Mark

Inventor： UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  OHIO UNIVERSITY

IPC: G01N21/35

CPC classification number: G01J3/45 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7257 ,  G01N21/35 ,  G01N21/359

Abstract: Non-invasive measurements of physiological chemicals such as glucose are made using infrared radiation and a signal processing system that permits the construction of a device suited for home use. The level of a selected physiological chemical in a test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The data collected may be in the form of an absorbance spectrum, i.e., a representation of the variation in absorbance as a function of wavelength; a single beam spectrum or in the form of an interferogram, i.e., a representation of infrared light intensity as a function of the retardation of the moving mirror in the interferometer, and thus of time.

Abstract translation: 使用红外辐射和信号处理系统制造生物化学品如葡萄糖的非侵入性测量，其允许构造适于家庭使用的装置。 通过包括以下步骤的方法以非侵入性和定量的方式测定受检对象中所选择的生理化学物质的水平：（a）用近红外辐射照射被测物体的一部分，使得辐射被传输 通过或反映在考试科目; （b）使用检测器收集关于发射或反射的红外辐射的数据; （c）对所收集的数据进行数字滤波以分离指示生理化学品的数据的一部分; 和（d）通过将定义的数学模型应用于数字滤波数据来确定测试对象中生理化学物质的量。 收集的数据可以是吸收光谱的形式，即作为波长的函数的吸光度变化的表示; 单波束光谱或干涉图形式，即作为干涉仪中的移动镜的延迟的函数的红外光强度的表示，并且因此表示时间。

公开(公告)号：WO1994016032A1

公开(公告)日：1994-07-21

申请号：PCT/US1993012713

申请日：1993-12-29

Applicant: OHIO UNIVERSITY

Inventor： OHIO UNIVERSITY ,  BUTCHER, Jared, A., Jr.

IPC: C10G01/10

CPC classification number: C07C4/22 ,  C07C4/00 ,  C10G1/10

Abstract: The present invention is a method for depolymerizing or "cracking" polymeric materials. The method of the present invention may be used in the disposal and/or recycling of such materials. Products of the degradation of polymeric materials using the present method may be recycled or more easily treated for disposal. The present invention is a process for degrading, depolymerizing or "cracking" a polymeric material, otherwise amenable to cracking by alkali fusion, comprising the steps of: (a) preparing a molten reaction mixture comprising: (i) a basic material; (ii) a source of copper; and (iii) said polymeric material; and (b) maintaining said molten mixture at a temperature sufficient to reflux said molten mixture for sufficient time to depolymerize said polymeric material. Preferred basic materials include NaOH, KOH, Na2B4O7.10H2O, Na3BO3, Na2SiO3, K2SiO3, and materials thereof. The preferred copper sources include copper metal and copper in the I or II oxidation state.

Abstract translation: 本发明是解聚或“开裂”聚合材料的方法。 本发明的方法可用于处理和/或回收这些材料。 使用本发明方法降解聚合材料的产物可以被再循环或更容易处理以便处理。 本发明是一种降解，解聚或“裂解”聚合材料的方法，否则易于碱熔融破裂，包括以下步骤：（a）制备熔融反应混合物，其包括：（i）碱性材料; （ii）铜源; 和（iii）所述聚合物材料; 和（b）将所述熔融混合物保持在足以使所述熔融混合物回流足够时间以解聚所述聚合材料的温度。 优选的碱性物质包括NaOH，KOH，Na2B4O7.10H2O，Na3BO3，Na2SiO3，K2SiO3及其材料。 优选的铜源包括处于I或II氧化态的铜金属和铜。

公开(公告)号：WO1997036477A1

公开(公告)日：1997-10-09

申请号：PCT/US1997005318

申请日：1997-03-28

Applicant: OHIO UNIVERSITY ,  HARVARD MEDICAL SCHOOL ,  MASSACHUSETTS GENERAL HOSPITAL ,  HOMEY, Charles, J. ,  VATNER, Stephen, F. ,  WAGNER, Thomas, E. ,  ISHIKAWA, Yoshihiro

Inventor： OHIO UNIVERSITY ,  HARVARD MEDICAL SCHOOL ,  MASSACHUSETTS GENERAL HOSPITAL

IPC: A01K67/00

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0375 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/705 ,  C12N2830/008

Abstract: The present invention relates to transgenic models of heart failure and, more particularly, to transgenic animals and methods for testing the usefulness of chemical compounds in treating or preventing heart failure. A transgenic mouse was developed wherein Gs alpha is selectively overexpressed approximately three-fold in the heart. Although steady state adenylyl cyclase activities are not altered, both the percent of agonist high affinity beta -adrenergic receptors as well as the rate of catalyst activation are increased. In addition, physiological and pathological studies revealed that chronically-facilitated sympathetic stimulation causes adverse cardiac effects.

Abstract translation: 本发明涉及心力衰竭的转基因模型，更具体地涉及用于测试化合物在治疗或预防心力衰竭中的有用性的转基因动物和方法。 开发了转基因小鼠，其中Gsα在心脏中选择性地过表达约三倍。 虽然稳态腺苷酸环化酶活性没有改变，但激动剂高亲和力β-肾上腺素能受体的百分比以及催化剂活化的速率都增加。 此外，生理和病理学研究表明，慢性交感神经刺激会引起不良心脏的影响。

公开(公告)号：WO1997024585A1

公开(公告)日：1997-07-10

申请号：PCT/US1996020231

申请日：1996-12-24

Applicant: OHIO UNIVERSITY

Inventor： OHIO UNIVERSITY ,  JEPSON, William, Paul ,  GOPAL, Madan

IPC: G01F01/66

CPC classification number: G01F1/74 ,  G01F1/24 ,  G01F1/662 ,  G01F1/667 ,  G01F1/668 ,  G01N29/032 ,  G01N2291/0222 ,  G01N2291/02433 ,  G01N2291/02836 ,  G01N2291/105

Abstract: An ultrasonic measuring system is provided including a plurality of upstream and downstream ultrasonic transducers coupled to a multiflow pipeline and positioned along first and second cross-sectional portions of the multiflow pipeline. A transducer control system is coupled to the upstream and downstream ultrasonic transducers for selective activation of the transducers. In one embodiment, the ultrasonic measuring system is utilized to determine a flow velocity of a selected fluid in a multiflow pipeline by generating and detecting velocimetric ultrasonic pulses in the selected fluid. In another embodiment, the ultrasonic measuring system is utilized to determine film heights of fluids flowing within the pipeline.

Abstract translation: 提供了一种超声波测量系统，其包括多个上游和下游超声波换能器，所述多个上游和下游超声波换能器耦合到多路管线并且沿着所述多路管线的第一和第二横截面部分定位。 传感器控制系统耦合到上游和下游超声换能器，用于选择性地激活换能器。 在一个实施例中，超声波测量系统用于通过在所选择的流体中产生和检测速度超声波脉冲来确定多通道流水线中选定流体的流速。 在另一个实施例中，超声波测量系统用于确定在管道内流动的流体的膜高度。

公开(公告)号：WO1995008625A1

公开(公告)日：1995-03-30

申请号：PCT/US1993008878

申请日：1993-09-22

Applicant: OHIO UNIVERSITY ,  POLISH ACADEMY OF SCIENCES INSTITUTE OF GENETICS AND ANIMAL BREEDING

Inventor： OHIO UNIVERSITY ,  POLISH ACADEMY OF SCIENCES INSTITUTE OF GENETICS AND ANIMAL BREEDING ,  REED, Michael, A. ,  WAGNER, Thomas, Edward ,  MODLINSKI, Jacek, A.

IPC: C12N15/00

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  C12N15/90

Abstract: The present invention is generally directed to a process for multiplying (cloning) embryos and specifically directed to a process for producing large numbers of identical mammalian embryos by transplanting embryonic stem cell nuclei into enucleated recipient oocytes, enucleated two cell embryos, or replacing the inner cell mass of a mammalian blastocyst with donor mammalian embryonic stem cells. Accordingly, the present invention is also generally directed to a process for cloning live animals by transplanting embryonic stem cell nuclei into enucleated recipient oocytes, enucleated two cell embryos, or replacing the inner cell mass of a mammalian blastocyst with donor mammalian embryonic stem cells.

Abstract translation: 本发明一般涉及通过将胚胎干细胞核移植到去核的受体卵母细胞，去核的两个细胞胚胎或替换内部细胞的方法来扩增（克隆）胚胎并且特异性地涉及产生大量相同的哺乳动物胚胎的方法 具有供体哺乳动物胚胎干细胞的哺乳动物胚泡的质量。 因此，本发明还通常涉及通过将胚胎干细胞核移植到去核的受体卵母细胞，去核的两个细胞胚胎或用供体哺乳动物胚胎干细胞代替哺乳动物胚泡的内细胞团来克隆活动物的方法。

公开(公告)号：WO1994022469A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003005

申请日：1994-03-22

Applicant: OHIO UNIVERSITY

Inventor： OHIO UNIVERSITY ,  PORTANOVA, Ronald, B. ,  PATTERSON, Michael, M. ,  WAGNER, Thomas, E.

IPC: A61K37/36

CPC classification number: A61K38/27

Abstract: The ability of an individual to learn and remember is improved by administering somatotropin to the individual before the task or information is first taught or presented to the individual. The present invention is the use of somatotropin (growth hormone) and related compounds for enhancing the mental abilities of normal, defective and deficient individual. Somatotropin is particularly useful for people with brain injury, mental retardation, and degenerative diseases such as Alzheimer's disease.

Abstract translation: 通过在任务或信息首先被教导或呈现给个体之前，向个体施用生长激素来改善个体学习和记忆的能力。 本发明是使用生长激素（生长激素）和相关化合物来增强正常，缺陷和缺乏个体的精神能力。 生长激素对脑损伤，精神发育迟滞和退行性疾病如阿尔茨海默氏病尤其有用。

公开(公告)号：WO1987000561A1

公开(公告)日：1987-01-29

申请号：PCT/US1986001473

申请日：1986-07-08

Applicant: OHIO UNIVERSITY

Inventor： OHIO UNIVERSITY ,  COLLIER, John, R. ,  COLLIER, Billie, J.

IPC: D01F08/00

CPC classification number: D01F8/02 ,  D01F8/00

Abstract: A sheath core fiber having an inner core (10) made from an oriented thermoplastic material, such as polyester, nylon, acrylic, and olefin, and a sheath (18) made of a nonthermoplastic material, such as regenerated cellulose and protein. The fiber maintains the crease and tear resistance of the core material, yet has the water sorptivity and dyeability of the sheath material. A method of manufacturing such a fiber is also disclosed.

Abstract translation: 具有由定向热塑性材料制成的内芯（10）的护套芯纤维，例如聚酯，尼龙，丙烯酸和烯烃，以及由非热塑性材料（例如再生纤维素和蛋白质）制成的护套（18）。 纤维保持芯材的折痕和抗撕裂性，但具有护套材料的吸水性和染色性。 还公开了制造这种纤维的方法。

公开(公告)号：WO1985003122A1

公开(公告)日：1985-07-18

申请号：PCT/US1984002134

申请日：1984-12-27

Applicant: OHIO UNIVERSITY

Inventor： OHIO UNIVERSITY ,  WILLIAMS, Ronald, R.

IPC: G01B09/02

CPC classification number: G01J3/4531 ,  G01J3/2803 ,  G01J9/02

Abstract: An interferometric spectrometer utilizing a multiple array detector (22). When the spectrometer utilizes visible light a photodiode array detector (22) is utilized and a fixed tilted mirror (17) and vertical mirror (16) in combinations with a beamsplitter (15) are utilized to produce a Michaelson interferometer with no moving parts.

Abstract translation: 一种利用多阵列检测器（22）的干涉光谱仪。 当光谱仪利用可见光时，利用光电二极管阵列检测器（22）并与分束器（15）组合使用固定的倾斜镜（17）和垂直镜（16）来产生没有移动部件的迈克尔逊干涉仪。