公开(公告)号：JP2004317661A

公开(公告)日：2004-11-11

申请号：JP2003109371

申请日：2003-04-14

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KATO NORIKO ,  HARADA MITSUO ,  KOBAYASHI SAYOKO

IPC: G02B21/00

Abstract: PROBLEM TO BE SOLVED: To efficiently clean an objective in spite of simple constitution.
SOLUTION: A cleaning part 23 is provided at a position corresponding to the base of a well 24 on a base 18 inside the frame 25 of the microplate 12. By arranging the cleaning part 23 on an immersion objective 11 or making the cleaning part 23 pass through the lens 11, the lens 11 is cleaned when it comes into contact with the cleaning part 23.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：为了有效地清洁目标，尽管结构简单。 解决方案：清洁部件23设置在对应于微孔板12的框架25内的基座18上的孔24的底部的位置。通过将清洁部件23布置在浸没物体11上或使清洁 部分23穿过透镜11，当透镜11与清洁部分23接触时，透镜11被清洁。版权所有：（C）2005，JPO＆NCIPI

公开(公告)号：JP2009151023A

公开(公告)日：2009-07-09

申请号：JP2007327789

申请日：2007-12-19

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： TSUTSUI AKIRA ,  MATSUO YUICHIRO ,  HARADA MITSUO ,  SHIMADA YOSHIHIRO

IPC: G02B21/06 ,  F21V9/40 ,  G01N21/64 ,  H01L33/00 ,  H01L33/50 ,  H01L33/58 ,  H01L33/60

CPC classification number: G01N21/6428 ,  A61B5/0059 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0624 ,  G01N2201/0627 ,  G02B21/06

Abstract: PROBLEM TO BE SOLVED: To provide an illumination apparatus for the cellular analysis apparatus in which the loss of light is kept to a minimum, the amount of light of the LED light sources is automatically maintained constant, and changes of the location, shape, and intensity of fluorescent light of a substance for its object can be quantitatively obtained. SOLUTION: The illumination apparatus for the cellular analysis apparatus includes: a plurality of LEDs 11R, 11G, 11B of different center emission wavelengths; a photodetector 12; a path sharing means for introducing light emitted from the plurality of LEDs into the common optical path; a light-introducing device located on the common optical path to introduce part of the light emitted from the plurality of LEDs passing through the common optical path into the photodetector; a feedback controller 15 controlling turning-on states of the LEDs over preset states in accordance with the amount of light emitted from the plurality of LEDs detected by the photodetector; and an illumination light supplying device 16 which is located on the common optical path and supplies light which is emitted from the plurality of LEDs to pass through the common optical path and is not introduced into the photodetector through the light-introducing device, as illumination light for a cellular analysis. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：为了提供将光损失保持在最小值的细胞分析装置的照明装置，LED光源的光量自动保持恒定，并且位置的变化， 可以定量地获得物体的荧光的形状和强度。 解决方案：用于细胞分析装置的照明装置包括：具有不同中心发射波长的多个LED 11R，11G，11B; 光电检测器12; 用于将从所述多个LED发射的光引入所述公共光路中的路径共享装置; 位于公共光路上的光引入装置，用于将从通过公共光路的多个LED发射的光的一部分引入光电检测器; 反馈控制器15，根据由光检测器检测到的多个LED发出的光量，控制LED的预置状态的接通状态; 以及照明光供给装置16，其位于公共光路上，并且供给从多个LED射出的光，以通过公共光路，并且不通过光导入装置引入到光检测器中作为照明光 用于细胞分析。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009003093A

公开(公告)日：2009-01-08

申请号：JP2007162590

申请日：2007-06-20

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO ,  SHIMADA YOSHIHIRO

IPC: G02B21/24

CPC classification number: G02B21/26 ,  G02B21/0088 ,  G02B21/362

Abstract: PROBLEM TO BE SOLVED: To provide a box type motor-driven microscope which achieves miniaturization of an entire device by suppressing the operation range of an opening/closing member for changing a sample container to the utmost, which accurately maintains observing and measuring accuracy by suppressing wear in opening/closing operation, which excels in operability and safety, and additionally, for which observing and measuring conditions are easily changed, and further which achieves instantaneous observation and measurement of the change of the sample by manual injection of a reagent and confirmation of the operation circumstances inside the microscope.
SOLUTION: The box type motor-driven microscope includes: a motor-driven microscope part 10 having a transmissive illumination optical system 11, a motor-driven stage 12 and an image-formation optical system 14; and a housing 20. The housing has a fixed housing 21 and a movable housing 22, and the movable housing can parallel displace in an oblique direction relative to the fixed housing while holding an optical element above the motor-driven stage, so as to change the sample container 40 placed on the motor-driven stage, hermetically seal the motor-driven microscope part and shield it from light in cooperation with the fixed housing, and also nearly match the optical axis of the transmissive illumination optical system and the optical axis of the image-formation optical system.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种盒式电动显微镜，其通过抑制用于更换样品容器的开闭部件的操作范围来实现整个装置的小型化，从而精确地维持观察和测量 通过抑制打开/关闭操作中的磨损的精度，其操作性和安全性优异，另外，观察和测量条件容易改变，并且进一步通过手动注射试剂来实现对样品的变化的瞬时观察和测量 并确认显微镜下的操作情况。 盒式电动显微镜包括：具有透射照明光学系统11的电动显微镜部分10，电机驱动台12和成像光学系统14; 壳体20具有固定壳体21和可动壳体22，并且可动壳体能够相对于固定壳体在倾斜方向上平行移动，同时将光学元件保持在电动驱动平台上方，以便改变 放置在马达驱动平台上的样本容器40与电动驱动显微镜部分密封地密封，并与固定壳体协调地遮蔽光，并且几乎与透射照明光学系统的光轴和光轴 图像形成光学系统。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008224992A

公开(公告)日：2008-09-25

申请号：JP2007062423

申请日：2007-03-12

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO ,  SHIMADA YOSHIHIRO

IPC: G02B7/04 ,  G02B7/16 ,  G02B21/02 ,  G02B21/32

CPC classification number: G02B27/0068 ,  G02B21/0088 ,  G02B21/241 ,  G02B21/248

Abstract: PROBLEM TO BE SOLVED: To provide a corrector ring driving device of a microscopic objective lens provided with a corrector ring in which the exchange of a corrector ring mounting objective lens and the introduction of the objective lens into the observation optical path can be facilitated even in a state where the corrector ring mounting objective lens is mounted to a revolver, the working load of a viewer is lessened, and the corrector ring can be automatically driven. SOLUTION: A device driving the corrector ring 4a of the corrector ring mounting objective lens 4 mounted to an objective mounting and dismounting section 3a of the revolver 3 includes a rotation driving mechanism 1 having a motor 1a and a torque transmitting section 1b which transmits a torque of the motor 1a to the corrector ring 4a of the corrector ring mounting objective lens 4 mounted to the revolver 3 to drive the corrector ring 4a; and a connection means 2 for connecting the torque transmitting section 1b to the corrector ring 4a of the corrector ring mounting objective lens 4 introduced into an observation optical path in association with a switching operation performed by the revolver 3 and disconnecting the torque transmitting section 1b from the corrector ring 4a of the corrector ring mounting objective lens 4 removed from the observation optical path. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：为了提供一种具有校正环的微观物镜的校正环驱动装置，其中校正器环安装物镜的更换和物镜在观察光路中的引入可以是 即使在校正器环安装物镜安装到旋转枪的状态下，观察者的工作负荷减轻，并且校正环可以被自动驱动。 解决方案：驱动安装在旋转枪3的目标安装和拆卸部分3a上的校正器环安装物镜4的校正环4a的装置包括具有马达1a和转矩传递部分1b的旋转驱动机构1， 将马达1a的转矩传递到安装在转轮3上的校正器环安装物镜4的校正环4a，驱动校正环4a; 以及连接装置2，用于将转矩传递部分1b连接到引导到观察光路中的校正器环安装物镜4的校正环4a，与由转轮3执行的切换操作相关联，并将扭矩传递部分1b从 校正器环安装物镜4的校正环4a从观察光路去除。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2005195878A

公开(公告)日：2005-07-21

申请号：JP2004002107

申请日：2004-01-07

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO

IPC: G02B21/00 ,  G02B21/33

CPC classification number: G02B21/0088 ,  G02B21/33

Abstract: PROBLEM TO BE SOLVED: To provide an objective lens, a microscope and an optical analyzer which can surely prevent the objective lens, an object to be measured, a plate on which the object is placed, or a container in which the object is stored, from being damaged. SOLUTION: An elastic member 33 supports a top end lens 31 and a lens frame 32 supporting the top end lens 31, by applying biased force in a central axis direction of the lens frame 32. The top end of the lens frame 32 is located outside a top end surface 31a of the top end lens 31 in the center axis direction of the top end lens 31. An immersion objective lens 11 is moved by an objective lens moving device 23 in the central axis direction and is brought into contact with a bottom surface 18 of a microplate 12. A stage 13 supports the microplate 12 and is moved only within a plane vertical to the central axis direction, while its movement in the center axis direction is being regulated. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：为了提供一种物镜，显微镜和光学分析器，其可以可靠地防止物镜，待测物体，被放置物体的板或其中物体的容器 被储存，不被损坏。 解决方案：通过在透镜框架32的中心轴线方向施加偏压力，弹性构件33支撑顶端透镜31和支撑顶端透镜31的透镜框架32.透镜框架32的顶端 在顶端透镜31的中心轴方向上位于顶端透镜31的顶端面31a的外侧。浸没物镜11由物镜移动装置23沿中心轴方向移动并与之接触 具有微板12的底表面18.阶段13支撑微板12，并且仅在垂直于中心轴线方向的平面内移动，同时其在中心轴线方向上的移动被调节。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004070307A

公开(公告)日：2004-03-04

申请号：JP2003166750

申请日：2003-06-11

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO

IPC: G01N21/64 ,  G01N1/00 ,  G01N1/28 ,  G01N21/01 ,  G02B21/26

CPC classification number: C12M41/14 ,  C12M41/46

Abstract: PROBLEM TO BE SOLVED: To provide a maceration medium supply apparatus, a fluorescent analytic inspecting device, and an incubation microscope which can stably perform temperature control over a sample and have simple constitution, and are reduced in cost.
SOLUTION: The maceration medium 13 charged between an observation sample and a maceration objective 12, a temperature controller 26 which controls the maceration medium 13 at specified temperature, and a maceration medium supply part (22 to 25) which supplies the maceration medium 13 whose temperature is controlled by the temperature controller 26 to the maceration objective 12, are included.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2010217930A

公开(公告)日：2010-09-30

申请号：JP2010154102

申请日：2010-07-06

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO ,  NANBA AKIHIRO ,  FUKUOKA MORINAO

IPC: G02B21/00 ,  G02B21/33

CPC classification number: G02B21/33 ,  Y10T29/49826 ,  Y10T436/25

Abstract: PROBLEM TO BE SOLVED: To provide a retention mechanism for an immersion objective lens or an immersion medium, which is configured such that when a specimen is observed and measured, the immersion medium supplied to the tip of an objective lens is hindered from dripping from the tip of the objective lens even if the measurement involves a large amount of movement and takes a long time, and also to provide a method of manufacturing the same. SOLUTION: The retention mechanism for the immersion medium includes: an immersion objective lens 10; a bottom plate 41 with an opening for engaging with the immersion objective lens; a wall 42 disposed around the bottom plate 41; an immersion medium supply section 34 for supplying an immersion medium to the tip of the objective lens; and a droplet discharge part 35 which is disposed near the wall of the bottom plate and discharges a droplet of the immersion medium from the tip of the objective lens. The bottom plate has a first ring member (α portion ) made of a first material for holding the immersion medium, which is disposed so as to surround the opening. The bottom plate inclines so that the opening side is higher than the wall side. The affinity of the first ring member with the immersion medium is lower than that of an inside member of the first ring member with it. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：为了提供一种浸没物镜或浸没介质的保持机构，其被配置为使得当观察和测量样本时，供应到物镜的尖端的浸没介质被阻止 即使测量涉及大量运动并且需要很长时间，也从物镜的尖端滴下，并且还提供其制造方法。 浸渍介质的保持机构包括：浸没物镜10; 具有用于与浸没物镜接合的开口的底板41; 围绕底板41设置的壁42; 浸没介质供给部34，用于将浸没介质供给到物镜的前端; 以及液滴排出部35，其设置在底板的壁附近，并从物镜的前端排出浸没介质的液滴。 底板具有由用于保持浸没介质的第一材料制成的第一环构件（α部分），该第一环构件围绕开口设置。 底板倾斜使开口侧高于壁面。 第一环构件与浸渍介质的亲合力低于第一环构件与浸没介质的内部构件的亲和性。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2012198236A

公开(公告)日：2012-10-18

申请号：JP2012130406

申请日：2012-06-08

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： YAMAGUCHI MITSUSHIRO ,  HARADA MITSUO

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0289 ,  G01J3/06 ,  G01J3/08 ,  G01J3/10 ,  G01J3/42 ,  G01J2003/123 ,  G01N21/6428 ,  G01N21/6445

Abstract: PROBLEM TO BE SOLVED: To provide an optical measuring device which promptly and efficiently carries out a dynamic optical analysis method of a sample.SOLUTION: An optical measuring device includes a laser light source 1, an object lens 10, an optical detector 2, a sample container 22, an optical element, a beam scanning mechanism 9 composed of an eccentric rotation mirror 40 and a motor 41 for rotating the eccentric rotation mirror 40, and a beam scanning mechanism control portion for generating a control signal and carrying out the drive control of the beam scanning mechanism 9; and carries out measurement corresponding to plural kinds of measuring items about physical properties of a biological sample in a solution held in the sample container. When carrying out FIDA measurement, the eccentric rotation mirror 40 is rotated to optically scan a condensing spot of a laser beam in a generally elliptical shape at a focus position in the solution held in the sample container. When carrying out FCS measurement, a mirror surface of the eccentric rotation mirror is fixed in an orientation in which light passing through an optical axis passes through the object lens along the optical axis, and confocal illumination is carried out in the solution by the light passing through the optical axis.

Abstract translation: 要解决的问题：提供一种能够及时有效地进行样品的动态光学分析方法的光学测量装置。 光学测量装置包括激光光源1，物镜10，光学检测器2，样本容器22，光学元件，由偏心旋转镜40和电动机构成的光束扫描机构9 41，用于旋转偏心旋转镜40;以及光束扫描机构控制部分，用于产生控制信号并执行光束扫描机构9的驱动控制; 并且对于保持在样本容器中的溶液中的生物样品的物理性质的多种测量项目进行测量。 当进行FIDA测量时，偏心旋转镜40被旋转以在保持在样品容器中的溶液中的聚焦位置处以大致椭圆形状的光学扫描激光束的聚光点。 当执行FCS测量时，偏心旋转镜的镜面被固定在通过光轴的光沿着光轴穿过物镜的方向上，并且通过光通过在溶液中进行共聚焦照明 通过光轴。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2010271537A

公开(公告)日：2010-12-02

申请号：JP2009123287

申请日：2009-05-21

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO

IPC: G02B21/06 ,  G02B21/36

Abstract: PROBLEM TO BE SOLVED: To solve a problem on phase difference observation due to deviation of phase difference ring illumination in observation by an inverted type phase contrast microscope. SOLUTION: The phase contrast microscope includes a light source 1, an illumination optical system 3 guiding light from the light source to an object to be observed 2, and an imaging optical system 4 for enlarging an image of the object to be observed, wherein a pupil image detector 48 is arranged between the imaging lens 42 and an imaging position 432 in the imaging optical system, and an optical element 32, shaping phase difference ring illumination shape by controlling a ring-like aperture 33, is arranged at a position conjugate to an objective lens pupil position in transmission illumination of the illumination optical system. Thus, phase film shape at the objective lens pupil position and the phase difference ring illumination shape are detected by the pupil image detector, and operation is performed based on coordinate data of the phase film shape and the phase difference ring illumination shape detected by the pupil image detector, and then the ring-like aperture of the optical element is controlled to shape the phase difference ring illumination shape. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 解决问题：为了解决由反相型相差显微镜的观察中的相位差环光照射的偏差观察的问题。 相位差显微镜包括：光源1，将来自光源的光引导到待观察物体2的照明光学系统3;以及用于放大待观察对象的图像的成像光学系统4 ，其中在成像光学系统中的成像透镜42和成像位置432之间布置有光瞳图像检测器48，并且通过控制环状孔33将成形相位差环形照明形状的光学元件32布置在 位置与照明光学系统的透射照明中的物镜光瞳位置共轭。 因此，通过瞳孔图像检测器检测物镜光瞳位置处的相位膜形状和相位差环形照明形状，并且基于由瞳孔检测到的相位膜形状和相位差环照明形状的坐标数据进行操作 图像检测器，然后控制光学元件的环状孔径以形成相位差环形照明形状。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010243838A

公开(公告)日：2010-10-28

申请号：JP2009093079

申请日：2009-04-07

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： HARADA MITSUO

IPC: G02B21/00 ,  G02B7/04

Abstract: PROBLEM TO BE SOLVED: To provide a microscope device that enables an observer to manually operate an optical adjustment correction ring for objective lenses, while confirming it from outside a shielding object, separated from an optical axis and that completely blocks a microscope portion, at observation.
SOLUTION: In the microscope of box type in which a microscope portion 1 covered with the shielding object 3 has a conversion section mounted with the plurality of objective lenses, there is provided a remote drive mechanism 2 for operating the optical adjustment correction ring for the objective lenses on the optical axis, from outside the shielding object separated from the optical axis.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供一种显微镜装置，其使得观察者能够手动操作用于物镜的光学调节校正环，同时从与光轴分离的屏蔽物体外部确认，并完全阻挡显微镜部分 ，观察。 解决方案：在显示器部分1被屏蔽物体3覆盖的显示器部分1具有安装有多个物镜的转换部分的盒式显微镜中，设置有用于操作光学调节校正环的远程驱动机构2 对于光轴上的物镜，从屏蔽物体的外侧与光轴分离。 版权所有（C）2011，JPO＆INPIT