Abstract:
PROBLEM TO BE SOLVED: To provide a cell image analyzer that precisely extracts the total number of cells or the characteristic quantity of an individual cell. SOLUTION: The cell image analyzer is equipped with: a cell image acquiring means 55 for imaging a plurality of cells developed in color by different dyes under different conditions to acquire a plurality of images; and an image analyzing means 80 for extracting predetermined element contained in the respective cells in a plurality of images. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a fluorescent imaging method and a fluorescent imaging apparatus by which an excellent fluorescence image can be obtained by maintaining an excellent liquid pouring state without forcing an observer to continuously monitor the liquid pouring state over a long term in long-term observation such as time lapse observation. SOLUTION: The fluorescent imaging method, in which an inverted fluorescence imaging apparatus provided with an immersion objective is used to image fluorescent observation object for a fixed term, includes: a step S1 of locating a preset well in a vessel having a plurality of wells storing the fluorescent observation object at the imaging position of the fluorescent imaging apparatus; a liquid pouring step S2 of pouring a preset amount of liquid between the top portion of the immersion objective in the fluorescent imaging apparatus and the preset well; an imaging step S3 of imaging the fluorescent observation object in the preset well in a state where a space between the top portion of the immersion objective and the preset well is filled with the liquid; and a control step S4 of repeating a series of operations including the liquid pouring step S2 of a single operation and the imaging step S3 of a preset number of times of operations performed after the liquid pouring step S2 of the single operation, at preset time intervals. COPYRIGHT: (C)2008,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a microscope illumination apparatus configured so that the loss of the amount of light is kept to a minimum and the light can be efficiently supplied to the microscope body, even in the case of light to be emitted, in particular, from any of at least three kinds of light sources, each of a different emission wavelength region and a different figure and size of the light emitting section, including a light source using an ultraviolet wavelength region as the emission wavelength. SOLUTION: The microscope illumination apparatus includes: at least three kinds of light sources 21 to 24, each of a different emission wavelength region and a different figure and size of the light-emitting section; collimator lenses 25 to 28; a means 29 introducing light emitted from the collimator lenses into a common optical path; an imaging lens 30 placed on the common optical path; and an optical fiber 31 placed so that the entrance end face 31a of the optical fiber is located at a position where the images of the individual light sources are formed through the imaging lens. The collimator lenses are constructed to have different optical properties so that an angle of incidence of light on the optical fiber through the imaging lens may become smaller than a critical angle of the optical fiber and each of images of the light sources formed through the imaging lens has the maximum size to such an extent that the image is not larger than the entrance end face of the optical fiber. COPYRIGHT: (C)2008,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an analyzer for detecting the presence of liquid penetration, and to provide its program. SOLUTION: The analyzer is equipped with a light source (1), a sample tank (17) for housing a sample, a lens (3) for condensing the light from the light source toward the sample tank, a photodetector (14) for detecting the reflected light from the sample tank and a medium determining means (20) for determining whether the gap between the lens and the sample tank is filled with a medium for enhancing optical dissolving power on the basis of the output signal of the photodetector. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To provide a liquid supplying and discharging device for an immersion objective lens which do not exert adverse influence on aiming accuracy, whose reliability is high and whose maintainability is good. SOLUTION: The liquid discharging device for the immersion objective lens is equipped with 1st liquid receiving parts (3 and 3a) attached to the immersion objective lens (2) and receiving liquid overflowing from the edge of the immersion objective lens and dropping it downward by gravity, a 2nd liquid receiving part (4) receiving the liquid dropped from the 1st liquid receiving parts by gravity, and a discharged liquid storage means (8) located under the 2nd liquid receiving part and storing the liquid discharged from the 2nd liquid receiving part. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To provide a photodetection device and a photodetection method, capable of simply and inexpensively coping with the changes in a medium temperature, without impeding measuring work on a test sample. SOLUTION: This photodetection device has a holding means 4 for holding the test sample and a known sample, a light source means 2 for irradiating the test sample and the known sample with light, a photodetection means 12 for detecting light from the test sample and the known sample, a means 13 for holding the relation between the physical properties and the temperature of the known sample acquired beforehand, and a means 13 for performing the correction operation of the physical properties of the test sample, relative to the temperature from the relation between the physical property and the temperature of the known sample. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To provide an illumination apparatus for the cellular analysis apparatus in which the loss of light is kept to a minimum, the amount of light of the LED light sources is automatically maintained constant, and changes of the location, shape, and intensity of fluorescent light of a substance for its object can be quantitatively obtained. SOLUTION: The illumination apparatus for the cellular analysis apparatus includes: a plurality of LEDs 11R, 11G, 11B of different center emission wavelengths; a photodetector 12; a path sharing means for introducing light emitted from the plurality of LEDs into the common optical path; a light-introducing device located on the common optical path to introduce part of the light emitted from the plurality of LEDs passing through the common optical path into the photodetector; a feedback controller 15 controlling turning-on states of the LEDs over preset states in accordance with the amount of light emitted from the plurality of LEDs detected by the photodetector; and an illumination light supplying device 16 which is located on the common optical path and supplies light which is emitted from the plurality of LEDs to pass through the common optical path and is not introduced into the photodetector through the light-introducing device, as illumination light for a cellular analysis. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a cell analysis method, apparatus and program that can increase the accuracy of evaluation of drug reactions of cells. SOLUTION: The cell analysis method includes an imaging step of imaging each cell group cultured under a different condition, a luminance measurement step of measuring the luminance of each cell from the cell image acquired in the imaging step, a distribution characteristic creation step of creating distribution characteristics of the luminance data under each condition, and a normalization step of normalizing the distribution characteristics created under each condition. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a box type motor-driven microscope which achieves miniaturization of an entire device by suppressing the operation range of an opening/closing member for changing a sample container to the utmost, which accurately maintains observing and measuring accuracy by suppressing wear in opening/closing operation, which excels in operability and safety, and additionally, for which observing and measuring conditions are easily changed, and further which achieves instantaneous observation and measurement of the change of the sample by manual injection of a reagent and confirmation of the operation circumstances inside the microscope. SOLUTION: The box type motor-driven microscope includes: a motor-driven microscope part 10 having a transmissive illumination optical system 11, a motor-driven stage 12 and an image-formation optical system 14; and a housing 20. The housing has a fixed housing 21 and a movable housing 22, and the movable housing can parallel displace in an oblique direction relative to the fixed housing while holding an optical element above the motor-driven stage, so as to change the sample container 40 placed on the motor-driven stage, hermetically seal the motor-driven microscope part and shield it from light in cooperation with the fixed housing, and also nearly match the optical axis of the transmissive illumination optical system and the optical axis of the image-formation optical system. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a corrector ring driving device of a microscopic objective lens provided with a corrector ring in which the exchange of a corrector ring mounting objective lens and the introduction of the objective lens into the observation optical path can be facilitated even in a state where the corrector ring mounting objective lens is mounted to a revolver, the working load of a viewer is lessened, and the corrector ring can be automatically driven. SOLUTION: A device driving the corrector ring 4a of the corrector ring mounting objective lens 4 mounted to an objective mounting and dismounting section 3a of the revolver 3 includes a rotation driving mechanism 1 having a motor 1a and a torque transmitting section 1b which transmits a torque of the motor 1a to the corrector ring 4a of the corrector ring mounting objective lens 4 mounted to the revolver 3 to drive the corrector ring 4a; and a connection means 2 for connecting the torque transmitting section 1b to the corrector ring 4a of the corrector ring mounting objective lens 4 introduced into an observation optical path in association with a switching operation performed by the revolver 3 and disconnecting the torque transmitting section 1b from the corrector ring 4a of the corrector ring mounting objective lens 4 removed from the observation optical path. COPYRIGHT: (C)2008,JPO&INPIT