公开(公告)号：CA2231170A1

公开(公告)日：1997-03-13

申请号：CA2231170

申请日：1996-09-06

Applicant: PATHOGENESIS CORP

Inventor： TOWELL J ANDREW ,  BAKER WILLIAM R ,  HARNESS JAMES R

IPC: C12N15/09 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C08F2/00 ,  C12M1/00 ,  C40B60/14 ,  C07H21/00 ,  C07K1/00

Abstract: A method and device (2) for the simultaneous production of chemical compounds in an array which is capable of providing a very broad range of reaction environments including reaction temperatures of -40 ~C to 150 ~C, reflux condensation, and a selective gas environment. The invention also allows the addition of several reagents (4) during the course of the production process. The device (2) is comprised of a number of different block sections (6, 24, 18) which are fastened together to provide the required reaction environment.

公开(公告)号：CA2225822A1

公开(公告)日：1997-01-16

申请号：CA2225822

申请日：1996-06-25

Applicant: PATHOGENESIS CORP

Inventor： SHAOPEI CAI ,  BAKER WILLIAM R ,  KEELER ERIC L

IPC: A61K31/535 ,  A61K31/55 ,  A61P31/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/505 ,  A61K31/54

Abstract: Method, compounds and compositions are provided for inhibiting the growth of pathogenic microbes in vitro and of treatment of pathogenic bacterial infections, such as mycobacterial, Clostridium, Cryptosporidium and Helicobacter infections, in vivo using bicyclic nitroimidazole compounds. The methods, compounds and compositions are particularly useful for inhibiting the growth of Mycobacterium tuberculosis, Clostridium difficile, Cryptosporidium parvum, and Helicobacter pylori, and may be used alone, or in combination with other antimicrobial agents.