公开(公告)号：WO2008056290A9

公开(公告)日：2009-03-05

申请号：PCT/IB2007054354

申请日：2007-10-26

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  HOFFMANN RALF ,  HUMMEL HELGA ,  WEILER VOLKER

Inventor： HOFFMANN RALF ,  HUMMEL HELGA ,  WEILER VOLKER

IPC: C07F5/02 ,  G01N33/68

CPC classification number: G01N33/6812 ,  C07F5/025 ,  C07K14/00 ,  G01N33/532 ,  G01N33/58 ,  G01N33/6851 ,  G06F19/28 ,  Y10T436/13

Abstract: The present invention relates to the tagging of Histidine in polypeptides with arylboronic acid tagging reagents. The present invention further describes methods and devices to identify proteins in a sample by isolating and identifying Histidine-comprising peptides from one protein sample or a pool of protein samples. The present invention further describes databases of Histidine-comprising peptides from in silico cleaved proteins and their use in the identification of proteins.

Abstract translation: 本发明涉及用芳基硼酸标记试剂在多肽中标记组氨酸。 本发明还描述了通过从一个蛋白质样品或一组蛋白质样品中分离和鉴定含有组氨酸的肽来鉴定样品中蛋白质的方法和装置。 本发明进一步描述了来自硅片切割的蛋白质的组氨酸肽的数据库及其在鉴定蛋白质中的用途。

公开(公告)号：WO2008007290A2

公开(公告)日：2008-01-17

申请号：PCT/IB2007052557

申请日：2007-07-02

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  RONDA CORNELIS REINDER ,  HUMMEL HELGA ,  JUESTEL THOMAS

Inventor： RONDA CORNELIS REINDER ,  HUMMEL HELGA ,  JUESTEL THOMAS

IPC: A61K41/00 ,  A61K9/14 ,  A61K49/00 ,  A61P35/00

CPC classification number: A61K41/0057 ,  A61K49/1881 ,  A61K51/1244 ,  B82Y5/00

Abstract: The invention relates to nanoparticles coated with an inorganic nanoscale material herein referred to as core-shell nanoparticle, in which the core material has a wider band gap than the shell material. The described core-shell nanoparticles are very suitable for the application in photodynamic therapy due to their enhanced energy transfer ability.

Abstract translation: 本发明涉及用本文称为核 - 壳纳米颗粒的无机纳米级材料涂覆的纳米颗粒，其中核材料具有比壳材料更宽的带隙。 所描述的核 - 壳纳米颗粒由于其增强的能量转移能力而非常适用于光动力治疗。

公开(公告)号：WO2006131853A3

公开(公告)日：2007-03-15

申请号：PCT/IB2006051750

申请日：2006-06-01

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  HOFFMANN RALF ,  HUMMEL HELGA ,  WENDT MATTHIAS

Inventor： HOFFMANN RALF ,  HUMMEL HELGA ,  WENDT MATTHIAS

IPC: G01N33/50 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/5091 ,  G01N33/6842

Abstract: The present invention relates to in vivo expression profiling using a plurality of specific targeting moieties each labelled with a different compound which allows to identify simultaneously the binding of each targeting moiety to a target.

Abstract translation: 本发明涉及使用多个特异性靶向部分的体内表达谱，每个特异性靶向部分用不同的化合物标记，其允许同时鉴定每个靶向部分与靶标的结合。

公开(公告)号：WO2006064451A3

公开(公告)日：2007-03-01

申请号：PCT/IB2005054185

申请日：2005-12-12

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  HUMMEL HELGA ,  WEILER VOLKER U ,  HOFFMANN RALF

Inventor： HUMMEL HELGA ,  WEILER VOLKER U ,  HOFFMANN RALF

IPC: A61K49/00 ,  A61K51/00

CPC classification number: A61K49/0067 ,  A61K51/0402 ,  A61K51/1255 ,  B82Y5/00 ,  B82Y10/00 ,  Y10T428/2984

Abstract: This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use.

Abstract translation: 本发明公开了一种合成靶向造影剂用于分子成像和靶向诊断和治疗，靶向造影剂和靶向治疗剂及其用途的方法。