公开(公告)号：WO2008059434A3

公开(公告)日：2008-07-24

申请号：PCT/IB2007054593

申请日：2007-11-12

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  ZIEGLER ANDY ,  KOEHLER THOMAS ,  NIELSEN TIM ,  VAN DER MARK MARTINUS B ,  VAN BEEK MICHAEL C

Inventor： ZIEGLER ANDY ,  KOEHLER THOMAS ,  NIELSEN TIM ,  VAN DER MARK MARTINUS B ,  VAN BEEK MICHAEL C

IPC: A61B5/00 ,  G01J3/44

CPC classification number: A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

Abstract: The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

Abstract translation: 本发明涉及一种用于对混浊介质（25）的内部进行成像的系统，医学图像采集系统和方法。 本发明还涉及用于对混浊介质（25）的内部进行成像的方法中使用的标记（60）。 该系统，医学图像采集系统和方法可以用于通过以下操作来获得混浊介质（25）的内部的图像：在容纳体积（20）内容纳混浊介质（25）; 用来自光源的光照射接收体积（20） 作为通过使用光电探测器单元以来自光源的光照射接收体积（20）的结果检测从接收体积（20）发出的光。 然后使用检测到的光重建混浊介质（25）内部的图像。 根据本发明，系统，医疗采集系统和方法适于使得在测量期间，接收容积（20）包括至少一个包含预定浓度的所选荧光剂的标记（60）。 光源被设置用于产生在标记（60）中引起荧光发射的激发光，并且光检测器被设置为检测由于用激发光照射接收体积（20）而从接收体积（20）发出的光。 根据本发明使用标记（60）能够获得与浑浊介质（25）的几何形状有关的信息。 如果混浊介质（25）包含未知浓度的第二荧光剂，并且光源和光电检测器单元被设置为分别在第二荧光剂中引起荧光并检测所得到的荧光，则使用标记（ 60）根据本发明能够校准由该荧光产生的信号。

公开(公告)号：WO2006109227A3

公开(公告)日：2006-12-07

申请号：PCT/IB2006051068

申请日：2006-04-07

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  ZIEGLER ANDY

Inventor： ZIEGLER ANDY

IPC: G01V5/00 ,  G01T1/164 ,  G01T1/29

CPC classification number: G01T1/2985

Abstract: The reconstruction of the energy distribution at a detector with a detector element that consists of many small pixels, which count the number of photons above certain thresholds, is performed with a Maximum Likelihood analysis, according to an aspect of the present invention. Thus, the reconstruction scheme may use the redundancy in the measurement and may treat the Poisson statistics accordingly.

Abstract translation: 根据本发明的一个方面，用具有由许多小像素组成的检测器元件的检测器上的能量分布的重建是根据本发明的一个方面用最大似然分析来执行的，所述检测器元件对超过特定阈值的光子数进行计数。 因此，重建方案可以使用测量中的冗余并且可以相应地处理泊松统计。

公开(公告)号：WO2006109233A2

公开(公告)日：2006-10-19

申请号：PCT/IB2006051086

申请日：2006-04-10

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  KOEHLER THOMAS ,  PROKSA ROLAND ,  ZIEGLER ANDY

Inventor： KOEHLER THOMAS ,  PROKSA ROLAND ,  ZIEGLER ANDY

IPC: G06T11/00

CPC classification number: G06T11/008 ,  G06T11/006

Abstract: The invention relates to an examination apparatus with an X-ray device (10) for circular or helical cone-beam CT acquisition of projections images (P i (E 1 ), P i (E 2 )) of a patient (1) with different energy spectra (E 1 , E 2 ) and/or with an energy -resolved detection. By a combination of the projections, images (I bone , i , I tissue , i ) can be calculated that show predominantly the bone structure and the soft tissue, respectively. Therefore, a 3D model (M bone ) of the bone structure and a 3D model (M tissue ) of the tissue can be reconstructed separately. After removal of artifacts from the bone- structure model (M bone ), both separate 3D models can be integrated to a combined model (M) of the body volume with a high image quality.

Abstract translation: 本发明涉及一种具有X射线装置（10）的检查装置，用于对投影图像进行圆形或螺旋锥束CT采集（P 1） 具有不同能量谱的患者（1）的患者（1）的患者（E 2） >）和/或用能量分辨检测。 通过投影的组合，可以计算出图像（I ，，I ，SUB> i） 主要分别显示骨骼结构和软组织。 因此，可以分别重建组织的骨骼结构的3D模型（M＆gt;骨头）和3D模型（M＆gt;组织）。 在从骨结构模型（骨骼）中去除人造物之后，两个分开的3D模型可以被集成到具有高图像质量的身体体积的组合模型（M）上。

公开(公告)号：WO2006097867A8

公开(公告)日：2008-05-29

申请号：PCT/IB2006050699

申请日：2006-03-07

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  ZIEGLER ANDY ,  KOEHLER THOMAS ,  PROKSA ROLAND

Inventor： ZIEGLER ANDY ,  KOEHLER THOMAS ,  PROKSA ROLAND

IPC: G06T11/00

CPC classification number: G06T11/006 ,  G06T2211/424