公开(公告)号：AT363283T

公开(公告)日：2007-06-15

申请号：AT02006356

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445 ,  C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：DE69334008T2

公开(公告)日：2006-10-19

申请号：DE69334008

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445 ,  A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：NO310644B1

公开(公告)日：2001-08-06

申请号：NO950374

申请日：1995-02-01

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  A61K31/137 ,  C07D211/22 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU5191100A

公开(公告)日：2000-10-12

申请号：AU5191100

申请日：2000-08-09

Applicant: UNIV GEORGETOWN ,  SEPRACOR INC

Inventor： GRAY NANCY ,  WOOSLEY RAYMOND L

IPC: A61K31/495 ,  A61P17/00

公开(公告)号：AU687746B2

公开(公告)日：1998-03-05

申请号：AU4848093

申请日：1993-09-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： WOOSLEY RAYMOND L ,  ABERG A K GUNNAR

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P31/12 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising the compound of formula I: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in a treatment of allergic rhinitis which does not induce any significant cardiac arrhythmia, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient.

公开(公告)号：ES2086270T3

公开(公告)日：1998-03-01

申请号：ES93918584

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：GB2285219B

公开(公告)日：1996-09-11

申请号：GB9504329

申请日：1993-09-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： WOOSLEY RAYMOND L ,  ABERG A K GUNNAR

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P31/12 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising the compound of formula I: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in a treatment of allergic rhinitis which does not induce any significant cardiac arrhythmia, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient.

公开(公告)号：CZ27495A3

公开(公告)日：1996-09-11

申请号：CZ27495

申请日：1995-02-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：HUT71889A

公开(公告)日：1996-02-28

申请号：HU9500313

申请日：1993-08-03

Applicant: UNIV GEORGETOWN ,  SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：NO950374D0

公开(公告)日：1995-02-01

申请号：NO950374

申请日：1995-02-01

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00 ,  A61K

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.