公开(公告)号：JP2008122341A

公开(公告)日：2008-05-29

申请号：JP2006309560

申请日：2006-11-15

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： OIKAWA YUKIO

IPC: G01N30/88

Abstract: PROBLEM TO BE SOLVED: To simultaneously form macro holes and meso holes, using a single stage of gelation reaction.
SOLUTION: This method includes a solation step for preparing an aqueous sol solution, containing tetramethoxy silane, trimethoxy (methyl) silane, a polyethylene glycol and ammonium acetate, a gelation step for heating a sol to be converted into a gel, a washing step for washing the gel with water, and a baking step for firing the gel after washed with water.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：同时形成大孔和中孔，使用单阶段凝胶化反应。 解决方案：该方法包括用于制备含有四甲氧基硅烷，三甲氧基（甲基）硅烷，聚乙二醇和乙酸铵的水溶胶溶液的溶胶步骤，用于加热待转化成凝胶的溶胶的凝胶化步骤， 用水洗涤凝胶的洗涤步骤，以及用水洗涤之后烧结凝胶的烘烤步骤。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2003144401A

公开(公告)日：2003-05-20

申请号：JP2001348445

申请日：2001-11-14

Applicant: SHIMADZU CORP ,  ONISHI KANEHISA ,  ISOBE KENICHI ,  KUSAKA TAKASHI

Inventor： KONISHI IKUO ,  TAKEUCHI SADAO ,  OIKAWA YUKIO ,  ONISHI KANEHISA ,  ISOBE KENICHI ,  KUSAKA TAKASHI

IPC: A61B5/0275 ,  A61B5/026

Abstract: PROBLEM TO BE SOLVED: To easily measure a blood stream such as the bloodstream and bloodstream distribution in an organism, and also the bloodstream of an artery and a vein. SOLUTION: This bloodstream measuring device 1 is provided with a light source for irradiating an organism with light; a light measuring means 2 comprising a light transmitter-receiver for detecting light of a plurality of wavelength emitted from the organism; an aging effect measuring means 3 for obtaining the aging effect of a specific component included in blood from the light intensity change of a plurality of wavelength; and a bloodstream computing means 4 for computing the bloodstream from the aging effect of the specific component and the ratio of the specific component in the blood. The aging effect measuring means 3 obtains the aging effect of a plurality of wavelength components detected by the light measuring means 2, and that of the specific component in the blood obtained by computing the wavelength components. The bloodstream computing means 4 obtains the blood volume from the amount of components and the ratio of the specific component included in the blood, when the aging effect of the specific component included in the blood is stabilized, and computes the bloodstream of the artery and vein using the ratio of a pulse wave component.

公开(公告)号：JPH04229195A

公开(公告)日：1992-08-18

申请号：JP40712490

申请日：1990-12-27

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: C12Q1/25 ,  C12Q1/37

Abstract: PURPOSE:To provide an easily operable process for the determination of an amino acid sequence. CONSTITUTION:Amino acids are successively eliminated from the carboxyl terminal of a peptide fragment by carboxypeptidase treatment. The eliminated amino acid is made to react with t-RNA specific to said amino acid in the presence of an aminoacyl t-RNA synthetase and the synthesized aminoacyl t-RNA is detected to easily determine the amino acid sequence.

公开(公告)号：JPH03282353A

公开(公告)日：1991-12-12

申请号：JP8560890

申请日：1990-03-30

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: G01N21/33

Abstract: PURPOSE:To quantitatively determine DNA and RNA by subjecting a soln. consisting of two-chain DNA and single-chain RNA to a heating treatment and/or alkaline treatment and measuring the absorbance of the soln. before and after the treatment. CONSTITUTION:The heating treatment is required to be heated to the temp, where the hydrogen bond of the DNA having the two-chain structure is broken to the single-chain by heating. The heating is preferably executed in an about 93 to 100 deg.C range. The alkaline treatment may be executed under the conditions necessary for decreasing the chains of the DNA of the two chains to the single chain by the alkanline treatment. The alkaline treatment is executed at 65 to 80&oC by using NaOH, etc., normally. The wavelength suitable for the determination of necleic acid is used for measuring the absorbance and the measurement at about 260nm is exemplified. The absorbance before the treatment is usually satisfactory if it is from room temp. to about 75 deg.C. The DNA and RNA are calculated from the difference in the absorbance obtd. by the measurement before and after the treatment.

公开(公告)号：JPS63170396A

公开(公告)日：1988-07-14

申请号：JP25398786

申请日：1986-10-24

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: C12N15/09 ,  C07H1/08 ,  C07H21/04 ,  C12N15/00

Abstract: PURPOSE:To readily carry out deproteinization treatment in short time, by adding a bivalent heavy metal ion having chelating property to DNA-containing aqueous solution containing a protein as an impurity, heat-treating the mixture and removing the formed precipitation. CONSTITUTION:A bivalent heavy metal ion (preferably Cu Or Zn ) having cheleting property is added to a DNA-containing aqueous solution (preferably cell ground liquid) containing a protein as an impurity and the mixture is heat- treated preferably at 65-100 deg.C for several minutes and cooled to room temperature or below and precipitation formed in the above mentioned solution is treated, for example, by a density gradient method by cesium chloride accompanied by ultracentrifugation treatment, dialysis treatment or the like to remove the protein.

公开(公告)号：JP2013195301A

公开(公告)日：2013-09-30

申请号：JP2012064332

申请日：2012-03-21

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： OIKAWA YUKIO ,  SAKAMOTO KATSUMASA ,  KASHIHARA MINORU ,  ABE HIROHISA

IPC: G01N30/02 ,  G01N30/64

CPC classification number: G01N30/96 ,  G01N2030/965

Abstract: PROBLEM TO BE SOLVED: To simplify assembly of a suppressor.SOLUTION: A first electrode 13 comprises a plurality of first electrode salients 13a on a surface facing a first ion exchange membrane 5. A first resin layer 15 consisting of materials which are softer than the materials of the electrode 13 is formed at an end face of the electrode salient 13a. A space surrounded by the surface on which the electrode salient 13a of the electrode 13 is formed, a side face of the electrode salient 13a, a side face of the resin layer 15 and the ion exchange membrane 5 forms a first regenerating solution passage 3a. A second electrode 17 comprises a plurality of second electrode salients 17a on a surface facing a second ion exchange membrane 9. A second resin layer 19 consisting of materials which are softer than the materials of the electrode 17 is formed at an end face of the electrode salient 17a. A space surrounded by the surface on which the electrode salient 17a of the electrode 17 is formed, a side face of the electrode salient 17a, a side face of the resin layer 19 and the ion exchange membrane 9 forms a second regenerating solution passage 11a.

Abstract translation: 要解决的问题：简化抑制器的组装。解决方案：第一电极13包括在面向第一离子交换膜5的表面上的多个第一电极极13a。第一树脂层15由比第 电极13的材料形成在电极突出部13a的端面。 由形成有电极13的电极凸部13a的表面包围的空间，电极凸部13a的侧面，树脂层15的侧面和离子交换膜5形成第一再生溶液通路3a。 第二电极17包括在面向第二离子交换膜9的表面上的多个第二电极极17a。由比电极17的材料更软的材料构成的第二树脂层19形成在电极的端面 显着的 由形成有电极17的电极凸部17a的表面所包围的空间，电极凸部17a的侧面，树脂层19的侧面和离子交换膜9形成第二再生溶液通道11a。

公开(公告)号：JP2006098211A

公开(公告)日：2006-04-13

申请号：JP2004284611

申请日：2004-09-29

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： OIKAWA YUKIO ,  NISHIMOTO HISAHIRO

IPC: G01N21/27 ,  G01Q30/08 ,  G01Q30/20 ,  G02B5/08

Abstract: PROBLEM TO BE SOLVED: To provide a substrate with a satisfactory manufacture yield and suitable for use as a substrate for microscopic observation.
SOLUTION: A glass plate of high surface flatness is employed in stead of natural mica so far used as a base material. A break groove is formed in advance in one surface of the glass plate of an S grade, and thereafter, a gold thin film is formed by vapor deposition on the reverse surface. A substrate for specimen observation of a scanning probe microscope or a substrate, of 10 mm square for example, suitable for a reflector for reflectance spectrum analysis, is cut out by only applying a small amount of force to the break groove by means of a pair of tweezers, etc. The substrate thus obtained is resistant to exfoliation, etc. of the gold thin film, easy to handle, excellent in durability and corrosion resistance, and free from slowly releasing humidity like mica. This substrate is used for forming a suitable specimen observation substrate, etc.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：为了提供令人满意的制造成品并适合用作显微镜观察用基板的基板。 解决方案：采用高表面平整度的玻璃板代替目前用作基材的天然云母。 预先在S级玻璃板的一个表面形成断裂槽，然后通过气相沉积在反面上形成金薄膜。 扫描探针显微镜或例如适用于反射光谱分析的反射器的例如10mm见方的基板的样品观察用基板，仅通过一对施加少量的力而切断断裂槽 镊子等。由此获得的基材对金薄膜的剥离等具有抗剥落性，易于处理，耐久性和耐腐蚀性优异，并且不会像云母那样缓慢释放湿度。 该基板用于形成合适的样品观察基板等。版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JPH07103941A

公开(公告)日：1995-04-21

申请号：JP24427793

申请日：1993-09-30

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: G01N27/447

Abstract: PURPOSE:To obtain an apparatus which is hardly affected by Joule heat and which can treat samples in large quantities by a method wherein a voltage is applied across the inner peripheral edge and the outer peripheral edge of a capillary disk which is provided with many capillary structures which are extended radially. CONSTITUTION:A required sample and a required reagent are poured into capillaries, capillary disks 6 which have been housed inside an electrophoretic tank 1 are then arranged in a state that they have been stacked between electrodes 3, 4, and the capillaries are immersed in an electrolyte buffer solution 2. In this state, a high voltage is applied across the electrodes 3, 4 by a high-voltage power-supply device 5, and an electrophoretic operation is started. A DNA synthesized substance in the sample is moved inside a gel, it is separated according to the magnitude or the like of its molecular weight, and a DNA band is produced. After the electrophoretic operation has been completed, every disk 6 is set in a fluorescence readout device, and the arrangement of bases in DNA is decided. Since the electrophoretic operation is treated by using many capillary structures which are installed on every disk 6 and which are extended radially, samples in large quantities can be treated, and the electrophoretic operation is hardly affected by Joule heat.

公开(公告)号：JPH03146852A

公开(公告)日：1991-06-21

申请号：JP28549889

申请日：1989-10-31

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: G01N21/27

Abstract: PURPOSE:To dispense with a complicated filter switching mechanism and to monitor plural lines with one device by branching one line to plural passages, and forming a flow cell at every passage. CONSTITUTION:One line of chemical facility is branched to the pipes 4-1 to 4-n of the plural passages, and the pipes 4-1 to 4-n are connected to the flow cells 6-1 to 6-n in a light-shielded measuring box 8, respectively. Measuring light from a light source 16 is introduced with an optical fiber 20, and is radiated in the directions of the flow cells 6-1 to 6-n. The tip of the optical fiber 20 is moved with a motor. Since detectors 34-1 to 34-n always detect incident light, when light irradiating from the tip of the optical fiber 20 traverses the flow cells 6-1 to 6-n, a traversed detector detects transmission light. The detection signal of each of the detectors 34-1 to 34-n is introduced to a data processor, and the peak detection of the signal that is the output of the detector is performed, then absorbance can be found.

公开(公告)号：JPH01174958A

公开(公告)日：1989-07-11

申请号：JP33569987

申请日：1987-12-29

Applicant: SHIMADZU CORP

Inventor： OIKAWA YUKIO

IPC: G01N27/26 ,  G01N27/447

Abstract: PURPOSE:To achieve a higher detection sensitivity, by providing an orifice section at a part where a DAN sample is detected at the low end of a capillary- like migration tube. CONSTITUTION:DAN samples are placed at the upper end of migration tube 10 as labeled by fluorescent substance varied with four kinds of terminal bases. Then, a voltage of 500-1,000V is applied across the vibration tube 10 from a power source section 14, to cause an electrophoresis in the among the DAN samples 18. Here, as an orifice section 11 is irradiated with a laser light from an argon laser 2 being selected to a single wavelength with a filter 3, a fluorescent 5 is generated from the fluorescent substance as labeled for the DAN samples as the DAN samples passes the orifice section 11. The fluorescence is selected with a filter 7 to be detected with a photomultiplier tube 8 and analyzed by a CPU 16 while being displayed on a CRT 17. In this manner, a base sequence can be determined at one time by causing an electrophoresis with the labeling by fluorescent substances varied with terminal bases.