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    DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN WHOLE BLOOD
    11.
    发明公开
    DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN WHOLE BLOOD 审中-公开

    公开(公告)号：EP4134657A1

    公开(公告)日：2023-02-15

    申请号：EP22193163.7

    申请日：2018-06-07

    Applicant: Siemens Healthcare Diagnostics Inc.

    Inventor： DUBEY, Satish Kumar ,  LAL, Ashish Kumar ,  PRABHU, Vishal Manjanath ,  LEDDEN, David J.

    IPC: G01N21/05 ,  G01N21/552 ,  G01N21/47 ,  G01N33/49 ,  G01N21/03

    Abstract: A device for determining the concentration of an analyte in whole blood is disclosed. A plasma layer (302, 308) is generated in the whole blood sample. Furthermore, the the plasma layer (302) is exposed to light (303, 304). Light (305) reflected from the plasma layer (302) is captured. Additionally, the reflected light (305) is analyzed to determine the concentration of the analyte. A device for determining the concentration of an analyte in a whole blood sample comprises a channel (309) configured to carry whole blood; a light source configured to direct light (303) on the channel (309); and an optical fiber (301), wherein within the optical fiber (301) the light (303) is reflected multiple times to form reflected light (304), the optical fiber (301) being located inside the channel (309) and extending in parallel with the channel (309).

    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD
    12.
    发明公开
    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD 审中-公开
    NACHWEIS VONHÄMOLYSEMITHILEL EINES CHROMATOGRAPHISCHEN NACHWEISPADS

    公开(公告)号：EP3155430A1

    公开(公告)日：2017-04-19

    申请号：EP15807510.1

    申请日：2015-06-08

    Applicant: Siemens Healthcare Diagnostics Inc.

    Inventor： LEDDEN, David J. ,  COX, Janine A. ,  JASPERSE, Jeffrey R.

    IPC: G01N33/558 ,  G01N33/72

    CPC classification number: G01N33/725 ,  G01N33/558 ,  G01N33/721 ,  G01N33/726

    Abstract: In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path for capillary fluid flow. The chromatographic detection pad has a pore size. The sample application site on the chromatographic detection pad is for application of a portion of the whole blood sample. The detection site on the chromatographic detection pad is spaced apart from the application site and is downstream of the sample application site. The chromatographic detection pad is devoid of a compound located downstream of the application site that is reactive to the whole blood sample.

    Abstract translation: 在一个方面，本文公开的发明概念涉及用于检测全血样品中游离血红蛋白的存在的色谱测定装置。 该装置包括具有样品施加位点和检测侧的色谱检测垫。 色谱检测垫定义了毛细管流体流动的路径。 色谱检测垫具有孔径。 色谱检测垫上的样品应用位点是用于全血样品的一部分的应用。 色谱检测垫上的检测位置与应用场所间隔开，位于样品应用场所的下游。 色谱检测垫没有位于应用位点下游的化合物，其对全血样品具有反应性。

    LUMINESCENT OXYGEN CHANNELING IMMUNOASSAY UTILIZING THREE ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF
    13.
    发明公开
    LUMINESCENT OXYGEN CHANNELING IMMUNOASSAY UTILIZING THREE ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
    与三种抗体发光氧通道化免疫分析方法进行生产及其用途

    公开(公告)号：EP3123151A1

    公开(公告)日：2017-02-01

    申请号：EP15767906.9

    申请日：2015-03-24

    Applicant: Siemens Healthcare Diagnostics Inc.

    Inventor： LI, Jay J. ,  LEDDEN, David J. ,  COWDEN, Eric Scott ,  LU, Donglai

    IPC: G01N21/76

    CPC classification number: G01N33/5308 ,  G01N21/76 ,  G01N33/542 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/582 ,  G01N2800/32 ,  G01N2800/325

    Abstract: A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in accordance with the presently disclosed and claimed inventive concept(s). For example, each of the first, second, and third antibodies/binding fragments may be a polyclonal antibody/binding fragment or a monoclonal antibody/binding fragment.

    Abstract translation: 化学发光检测系统，以及含有相同的试剂盒和微流体装置中，游离缺失光盘。 因此，使用该系统，试剂盒和设备的方法是游离缺失盘。 其可以以任何形式提供的第一，第二和第三抗体或其结合片段确实允许论文抗体/结合片段在雅舞蹈与当前盘和游离缺失要求保护的发明构思的功能。 对于实施例中，每个第一，第二和第三抗体/结合片段可以是结合片段的多克隆抗体/结合片段或单克隆抗体/。

    LUMINESCENT OXYGEN CHANNELING IMMUNOASSAYS UTILIZING ELECTROCHEMICAL DISCHARGE OF SINGLET OXYGEN AND METHODS OF PRODUCTION AND USE THEREOF
    20.
    发明公开
    LUMINESCENT OXYGEN CHANNELING IMMUNOASSAYS UTILIZING ELECTROCHEMICAL DISCHARGE OF SINGLET OXYGEN AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开

    公开(公告)号：EP3418743A1

    公开(公告)日：2018-12-26

    申请号：EP18182375.8

    申请日：2014-03-14

    Applicant: Siemens Healthcare Diagnostics Inc.

    Inventor： LEDDEN, David J.

    IPC: G01N33/543 ,  G01N33/542 ,  G01N27/327

    CPC classification number: G01N27/3275 ,  G01N33/542 ,  G01N33/5438

    Abstract: Chemiluminescent detection systems, kits, and microfluidics devices containing same, as well as methods of production and use thereof, are disclosed. They involve an induced luminescence immunoassay (LOCI), in which the electrode generates singlet oxygen upon reaction with a singlet oxygen generator such as methylene blue or phtalocyanine. The singlet oxygen reacts with a singlet oxygen activatable chemiluminescent compound with a dioxetan or luminol moiety. This compound is either capable of binding a target analyte or analog thereof (1) or is attached thereto (2). The electrode can have a target analyte or analog thereof attached thereto in assay format (1) or can be capable of binding to the target analyte or analog thereto in assay format (2). In assay format (2) the singlet oxygen activatable chemiluminescent compound is attached to an analyte or its analog. Both assay format are competitive assays in which there is competition for binding to the analyte from the sample and binding to its analog or analyte attached to electrode (1) or attached to the singlet oxygen activatable chemiluminescent compound (2) . When the singlet oxygen-activatable chemiluminescent compound upon binding is brought in close proximity to electrode, it can react with the singlet oxygen generated by electrode and singlet oxygen generator to cause chemiluminescence, which is detected to be inversely proportional to the amount of target analyte in the sample.

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