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    METHODS FOR SCREENING VIRAL LIKE PARTICLES AND IDENTIFYING NEUTRALIZING EPITOPES AND RELATED VACCINES, CONSTRUCTS, AND LIBRARIES
    11.
    发明申请
    METHODS FOR SCREENING VIRAL LIKE PARTICLES AND IDENTIFYING NEUTRALIZING EPITOPES AND RELATED VACCINES, CONSTRUCTS, AND LIBRARIES 审中-公开
    筛选病毒样颗粒和鉴定中和表位及相关疫苗，构建体和文库的方法

    公开(公告)号：WO2013063366A2

    公开(公告)日：2013-05-02

    申请号：PCT/US2012/062073

    申请日：2012-10-26

    Applicant: STC.UNM

    Inventor： HJELLE, Brian L. ,  PEABODY, David S. ,  CHACKERIAN, Bryce

    IPC: G01N33/68 ,  G01N33/569 ,  C12Q1/68

    CPC classification number: G01N33/6878 ,  G01N33/56983 ,  G01N33/6845 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/58 ,  Y02A50/60

    Abstract: The invention is directed to methods of screening immunogenic viral like particles and related immunogenic compositions and diagnostic techniques. In one embodiment, the invention provides methods of screening immunogenic viral like particles containing peptides corresponding to epitope regions of a wide variety of pathogens, including viruses, bacteria, parasites, and microbes. Non-infectious antigens and allergens of interest can also be screened as described herein. Immunization, therapeutic and diagnostic applications are also described for the compositions and methods according to the invention. In another embodiment, the invention provides novel methods of identifying a cryptic neutralizing epitope and related vaccines, constructs, and libraries. In some embodiments, these methods use high-throughput formats that are facilitated by in silica or in vitro steps.

    Abstract translation: 本发明涉及筛选免疫原性病毒样颗粒和相关免疫原性组合物和诊断技术的方法。 在一个实施方案中，本发明提供筛选含有对应于各种病原体（包括病毒，细菌，寄生虫和微生物）的表位区域的肽的免疫原性病毒样颗粒的方法。 如本文所述也可以筛选感兴趣的非感染性抗原和过敏原。 还描述了根据本发明的组合物和方法的免疫，治疗和诊断应用。 在另一个实施方案中，本发明提供了鉴定隐蔽中和表位和相关疫苗，构建体和文库的新方法。 在一些实施方案中，这些方法使用通过二氧化硅或体外步骤促进的高通量形式。

    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS, CONSTRUCTS, AND THERAPEUTIC METHODS
    13.
    发明申请
    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS, CONSTRUCTS, AND THERAPEUTIC METHODS 审中-公开
    免疫原性HPV L2含有VLPS及相关组合物，构造和治疗方法

    公开(公告)号：WO2011100234A2

    公开(公告)日：2011-08-18

    申请号：PCT/US2011/024030

    申请日：2011-02-08

    Applicant: STC.UNM ,  CHACKERIAN, Bryce ,  PEABODY, David, S.

    Inventor： CHACKERIAN, Bryce ,  PEABODY, David, S.

    IPC: A61K38/17 ,  A61K38/16 ,  A61K47/48 ,  A61K47/30 ,  A61P31/12 ,  A61P31/00

    CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2795/18123

    Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related ompositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.

    Abstract translation: 本发明提供了可用于治疗和预防人乳头状瘤病毒（HPV）感染和相关疾病（包括宫颈癌和与HPV相关的持续感染）的免疫治疗和预防性噬菌体病毒样颗粒（VLP）。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLPs和相关症状诱导针对HPV L2的高滴度抗体应答，并在体内防止HPV挑战。 VLP，含VLP的组合物和本发明的治疗方法诱导针对HPV感染的免疫原性应答，赋予HPV感染免疫力，防止HPV感染，并降低HPV感染感染的可能性。

    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS
    16.
    发明申请
    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS 审中-公开
    免疫原性HPV L2含有VLPS及相关组合物及方法

    公开(公告)号：WO2013106525A1

    公开(公告)日：2013-07-18

    申请号：PCT/US2013/020960

    申请日：2013-01-10

    Applicant: STC.UNM ,  CHACKERIAN, Bryce ,  PEABODY, David ,  TUMBAN, Ebenezer

    Inventor： CHACKERIAN, Bryce ,  PEABODY, David ,  TUMBAN, Ebenezer

    IPC: A61K39/12 ,  C12N7/01 ,  A61P31/20

    CPC classification number: A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  C12N2710/20034 ,  C12N2795/18142 ,  C12N2795/18143

    Abstract: In one aspect, the invention provides immunogenic HPV L2-containing viral-like particles (VLPs). Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. In certain aspects, the VLPs are comprised of a coat polypeptide of the bacteriophages PP7 or MS2, wherein the coat protein is modified by insertion of peptide antigens derived from HPV L2, and wherein the HPV L2 peptide is displayed on the VLP and encapsidates PP7 or MS2 mRNA. Specifically, VLPs of the invention display L2 peptides at the N- terminus of the bacteriophage coat protein. Surprisingly, these L2-displaying VLPs induce more broadly neutralizing antibody responses than when the same peptide is displayed in the AB-loop such that the immunogenic response is enhanced by a factor of at least 10. Immunogenic VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo.

    Abstract translation: 一方面，本发明提供了含免疫原性的含有HPV L2的病毒样颗粒（VLP）。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 在某些方面，VLP由噬菌体PP7或MS2的外壳多肽组成，其中通过插入衍生自HPV L2的肽抗原修饰外壳蛋白，并且其中HPV L2肽显示在VLP上并且包裹PP7或 MS2 mRNA。 具体地，本发明的VLP在噬菌体外壳蛋白的N-末端显示L2肽。 令人惊讶的是，这些L2显示的VLP诱导比在AB环中显示相同的肽更广泛的中和抗体应答，使得免疫原性应答增加至少10倍。本发明的免疫原性VLP和相关组合物诱导高 针对HPV L2的滴度抗体应答和在体内防止HPV挑战。

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