公开(公告)号：WO1993003726A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006842

申请日：1992-08-12

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： THE UNIVERSITY OF TOLEDO ,  DUNBAR, Philip, G. ,  DURANT, Graham, J. ,  HOSS, Wayne ,  MESSER, William, S., Jr.

IPC: A61K31/505

CPC classification number: C07D239/06 ,  C07D211/78 ,  C07D405/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04

Abstract: Substituted 1,4,5,6-tetrahydropyrimidine compositions, substituted 1,2,3,6-tetrahydropyrimidine compositions and substituted 3,4,5,6-tetrahydropyrimidine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for example, treating the symptoms of cognitive disorders, especially impaired memory, which are associated with decreased acetylcholine synthesis and cholinergic cell degeneration.

公开(公告)号：WO1987004071A1

公开(公告)日：1987-07-16

申请号：PCT/US1986002824

申请日：1986-12-31

Applicant: THE UNIVERSITY OF TOLEDO ,  THE MEDICAL COLLEGE OF OHIO ,  SAINT VINCENT MEDICAL CENTER ,  MORGAN, Alan, R. ,  SELMAN, Steven, H. ,  KREIMER-BIRNBAUM, Martha

Inventor： THE UNIVERSITY OF TOLEDO ,  THE MEDICAL COLLEGE OF OHIO ,  SAINT VINCENT MEDICAL CENTER

IPC: A61K31/40

CPC classification number: C07D487/22 ,  A61K31/40 ,  C07D519/00

Abstract: A family of chlorins, a family of purpurins and metal complexes thereof are disclosed. The purpurins have the formula of Fig. 5 of the attached drawings; their metal complexes have the formula of Fig. 1. The chlorins have the formula of Fig. 6 of the attached drawings; their metal complexes have the formula of Fig. 2. Solutions of the purpurins, chlorins and metal complexes which are physiologically acceptable for intravenous administration are also disclosed, as are emulsions or suspensions of the solutions. The solvent for the solutions can be a product of the reaction of ethylene oxide with castor oil. A method for detecting and treating tumors in human and animal patients is also disclosed. The method comprises administering one of the purpurins, chlorins or metal complexes to the patient. For detection, the tumor area is then illuminated with ultra violet light; for treatment, the tumor area is illuminated with visible light of a wavelength at which the purpurin, chlorin or complex administered shows an absorption peak.

Abstract translation: 公开了一系列的二氢卟酚，一类紫红素及其金属络合物。 紫杉素具有图1的公式。 附图5; 它们的金属络合物具有图1的公式。 二氢卟酚具有图1的公式。 附图6; 它们的金属络合物具有图1的公式。 还公开了用于静脉内给药的生理学可接受的紫嘌呤，二氢卟酚和金属络合物的溶液，以及溶液的乳液或悬浮液。 溶液的溶剂可以是环氧乙烷与蓖麻油反应的产物。 还公开了一种用于在人和动物患者中检测和治疗肿瘤的方法。 该方法包括向患者施用紫杉醇，二氢卟酚或金属络合物之一。 为了检测，用紫外线照射肿瘤区域; 为了治疗，用可见光照射肿瘤区域，其中紫外线素，二氢卟酚或复合物给药显示出吸收峰。