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    NUCLEIC ACID PROBE
    12.
    发明专利
    NUCLEIC ACID PROBE 失效

    公开(公告)号：JP2000316587A

    公开(公告)日：2000-11-21

    申请号：JP2000063374

    申请日：2000-03-03

    Applicant: TOSOH CORP

    Inventor： HORIE RYUICHI ,  ISHIGURO NORIHIKO ,  TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  SAITO JUICHI ,  TAYA TOSHITAKA

    IPC: G01N33/53 ,  C07H21/04 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/58

    Abstract: PROBLEM TO BE SOLVED: To obtain a new nucleic acid probe having a base sequence complementary to a specific nucleic acid sequence, comprising a single-stranded nucleic acid labeled so as to exhibit a measurable fluorescence signal when bound to a nucleic acid having the nucleic acid sequence and useful for analysis of existence and amount of a specific nucleic acid or the like. SOLUTION: There is described a new nucleic acid probe having a base sequence complementary to a specific nucleic acid sequence, comprising a single- stranded nucleic acid labeled so as to exhibit a measurable luminescence signal when bound to a nucleic acid having the nucleic acid sequence and having 3'-terminal end modified as shown by the formula R is COOH, CONH2, (CH2)nOH (n is one or more integer), CH(OH)-CH2OH, CH(CH2)n-NHR1] (R1 is a protective group for amino group, a coloring material or H)}. The probe is used for a method for analyzing existence or amount of a target nucleic acid such as DNA or RNA having a specific nucleic acid sequence or the like, utilization in a field of clinical diagnosis such as gene diagnosis, search of an unknown gene.

    PRODUCTION OF 3-AMINOTHIOPHENE DERIVATIVE
    13.
    发明专利
    PRODUCTION OF 3-AMINOTHIOPHENE DERIVATIVE 失效

    公开(公告)号：JP2000026457A

    公开(公告)日：2000-01-25

    申请号：JP19394998

    申请日：1998-07-09

    Applicant: TOSOH CORP

    Inventor： YAMAMOTO TAKASHI ,  TOKUNAGA TAKUMI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO

    IPC: C07D333/36 ,  B01J23/72 ,  B01J27/122 ,  C07B61/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a 3-aminothiophene derivative useful as a synthetic intermediate of a medicine, an agrochemical, etc., by reacting each specific thienyl halide derivative with an amine derivative in the presence of a copper catalyst, simply at a low cost in a high purity and in a high yield. SOLUTION: This new 3-aminothiophene derivative expressed by formula III is obtained by reacting a 3-thienyl halide derivative expressed by formula I (R1, R2 are each H, F, a lower alkyl, a lower alkoxy, a lower alkoxycarbonyl or a lower acyl; X is a halogen) with an amine derivative expressed by formula II (R3 is H or a lower alkyl; R4 is H, a lower alkyl or a lower alkyl substituted with hydroxyl) in the presence of a copper catalyst (amount of use is preferably 0.001-1 equivalent based on the derivative of formula I) consisting of a single substance or a mixture of two or more kinds selected from a metallic copper powder, metallic copper granules, a metallic copper wire, cuprous (I) oxide, cuprous (I) chloride, cuprous (I) bromide and cuprous (I) iodide, under a pressure of normal pressure to 1 MPa.

    TRIAMINE DERIVATIVE AND PRODUCTION THEREOF
    15.
    发明专利
    TRIAMINE DERIVATIVE AND PRODUCTION THEREOF 失效

    公开(公告)号：JP2000026454A

    公开(公告)日：2000-01-25

    申请号：JP19394698

    申请日：1998-07-09

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO

    IPC: C07D333/20 ,  C07D333/36

    Abstract: PROBLEM TO BE SOLVED: To obtain a new triamine derivative useful as an organic intermediate, etc., of a medicine, an agrochemical material or the like. SOLUTION: This new triamine derivative is a compound of formula I [R1 is H, a lower alkyl or a lower cycloalkyl; R2 is H, a lower acyl or the like; R3 is H or a lower alkyl; R4 is H, a lower alkyl or a lower acyl; R3 and R4 form a ring by bonding each other; X, Y and Z are each H, a lower alkyl, a lower alkoxy or the like; (m), (n) are each 0, 1; E is carbonyl, CR5R6 (R5, R6 are each H or a lower alkyl); F is carbonyl or the like; provided that E and F can not be carbonyl simultaneously], e.g. 2-[3-(formylamino)phenylamino]- N-methyl-N-(3-thienylmethyl)acetamide. Further the compound the formula I is obtained by reacting a compound of formula II (E' is CR5R6; E7 is H, a lower alkyl or a lower acyl; V is a halogen) with a compound of formula III (R9 is H or a lower alkyl) in an inert solvent in the presence of a base.

    PYRIMIDINE DERIVATIVE AND ITS PRODUCTION
    16.
    发明专利
    PYRIMIDINE DERIVATIVE AND ITS PRODUCTION 失效

    公开(公告)号：JP2000026432A

    公开(公告)日：2000-01-25

    申请号：JP19394798

    申请日：1998-07-09

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO

    IPC: C07D239/34 ,  C07F7/10

    Abstract: PROBLEM TO BE SOLVED: To obtain a new compound useful as a synthetic intermediate of a thiocarbamate derivative expected as medical and agricultural chemicals and an organic intermediate, especially as a treating agent for hyperlipidemia. SOLUTION: This compound is expressed by formula I (R1 is H, a lower alkyl or a lower alkoxyalkyl; R2 and R3 are each a lower alkyl; X is O or S; Y is C or Si; V is a halogen), e.g. (2-tert-butylpyrimidin-5-yl)= chlorothioformate. The compound of formula I is obtained by reacting a compound of formula II (e.g. 2-tert-butylpyrimidin-5-ol) with a halocarbonylation agent such as thiophosgene in a solvent such as cyclohexane in the presence of a base such as sodium hydroxide preferably at from -5 deg.C to 40 deg.C for 2-10 hrs.

    PYRIDINE DERIVATIVE AND PYRIDONE DERIVATIVE
    17.
    发明专利
    PYRIDINE DERIVATIVE AND PYRIDONE DERIVATIVE 失效

    公开(公告)号：JP2000026419A

    公开(公告)日：2000-01-25

    申请号：JP19394898

    申请日：1998-07-09

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO

    IPC: C07D213/64

    Abstract: PROBLEM TO BE SOLVED: To obtain a new compound comprising a specific pyridine derivative and useful as an intermediate for medicines and agrochemicals and an organic intermediate. SOLUTION: This new compound is represented by formula I (R1 and R2 are each a lower alkyl; X is O or S; Z1 is a group CR3 or a group SiR4; R3 and R4 are each H, a lower alkyl, a lower alkoxy or the like; V1 is a halogen), e.g. (5-trimethylsilylpyridin-2-yl) chlorothioformate. The compound represented by formula I is obtained by reacting a compound represented by formula II [e.g. 5-trimethylsilyl-2(1h)-pyridinone] with a halocarbonylating agent such as thiophosgene in the presence of a base such as sodium hydroxide without or in a solvent such as water, preferably at -10 to +100 deg.C for several min to 24 h.

    PHENYLSILANE DERIVATIVE, ITS PRODUCTION AND FUNGICIDE CONTAINING THE DERIVATIVE AS ACTIVE COMPONENT
    18.
    发明专利
    PHENYLSILANE DERIVATIVE, ITS PRODUCTION AND FUNGICIDE CONTAINING THE DERIVATIVE AS ACTIVE COMPONENT 失效

    公开(公告)号：JPH069654A

    公开(公告)日：1994-01-18

    申请号：JP19170592

    申请日：1992-06-25

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI

    IPC: A01N55/00 ,  C07F7/10 ,  C07F7/18

    Abstract: PURPOSE:To provide a new compound applicable without causing environmental problem and useful as a fungicide, especially an agricultural and horticultural fungicide free from the development of resistant fungi. CONSTITUTION:The compound of formula I (R is 1-5C alkyl, 2-5C alkenyl or 2-5C alkynyl; R to R are H, 1-10C alkyl, 2-10C alkenyl or 2-10C alkynyl; R is H, 1-10C alkyl, 2-10C alkenyl, 2-10C alkynyl, etc.), e.g. 2-methyl-3-(4- trimethylsilylphenyl)-1,2,3,4-tetrahydroisoquinoline. The compound of formula I can be produced by reacting a lactam derivative of formula II with a hydrogenation agent (e.g. lithium aluminum hydride) in a solvent (e.g. THF) at -10 to +200 deg.C. The amount of the hydrogenation agent is 0.2-20mol-equivalent based on 1mol-equivalent of the compound of formula II. The compound has excellent fungicidal activity against plant pathogens of powdery mildew of wheat, rust of wheat, powdery mildew of cucumber, etc.

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