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    PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE
    12.
    发明专利
    PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE 未知

    公开(公告)号：CA2599498C

    公开(公告)日：2011-06-21

    申请号：CA2599498

    申请日：2006-02-23

    Applicant: UCB FARCHIM SA

    Inventor： PALACIO MAGALI ,  ATES CELAL

    IPC: C07D295/088 ,  C07D207/28

    Abstract: The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide - (R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

    13.
    发明专利
    未知

    公开(公告)号：NO20053910D0

    公开(公告)日：2005-08-22

    申请号：NO20053910

    申请日：2005-08-22

    Applicant: UCB FARCHIM SA

    Inventor： ATES CELAL ,  CAVOY EMILE ,  BOUVY DIDIER

    IPC: C07D201/00 ,  C07D271/06 ,  C07D271/07 ,  C07D295/15 ,  C07D

    Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

    PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE
    15.
    发明专利
    PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE 未知

    公开(公告)号：CA2599498A1

    公开(公告)日：2006-09-14

    申请号：CA2599498

    申请日：2006-02-23

    Applicant: UCB FARCHIM SA

    Inventor： ATES CELAL ,  PALACIO MAGALI

    IPC: C07D295/088 ,  C07D207/28

    Abstract: The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

    17.
    发明专利
    未知

    公开(公告)号：NO330989B1

    公开(公告)日：2011-08-29

    申请号：NO20053910

    申请日：2005-08-22

    Applicant: UCB FARCHIM SA

    Inventor： ATES CELAL ,  CAVOY EMILE ,  BOUVY DIDIER

    IPC: C07D295/15 ,  C07D201/00 ,  C07D271/06 ,  C07D271/07

    Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

    ПИРОГЛЮТАМАТЫ И ИХ ПРИМЕНЕНИЕ ДЛЯ РАЗДЕЛЕНИЯ ОПТИЧЕСКИХ ИЗОМЕРОВ ПРОМЕЖУТОЧНЫХ ПРОДУКТОВ СИНТЕЗА ДЕКСТРОЦЕТИРИЗИНА И ЛЕВОЦЕТИРИЗИНА
    18.
    发明专利
    ПИРОГЛЮТАМАТЫ И ИХ ПРИМЕНЕНИЕ ДЛЯ РАЗДЕЛЕНИЯ ОПТИЧЕСКИХ ИЗОМЕРОВ ПРОМЕЖУТОЧНЫХ ПРОДУКТОВ СИНТЕЗА ДЕКСТРОЦЕТИРИЗИНА И ЛЕВОЦЕТИРИЗИНА 未知

    公开(公告)号：EA014248B1

    公开(公告)日：2010-10-29

    申请号：EA200900359

    申请日：2006-02-23

    Applicant: UCB FARCHIM SA

    Inventor： PALASCIO MAGALI ,  ATES CELAL

    IPC: C07D295/088 ,  C07D207/28

    Abstract: Визобретенииописанысоль (S)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамидас (S)-пирролидон-5-карбоновойкислотой; соль (R)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамидас (S)-пирролидон-5-карбоновойкислотой; соль (S)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамидас (R)-пирролидон-5-карбоновойкислотойи соль (R)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамидас (R)-пирролидон-5-карбоновойкислотой. Визобретениитакжеописанспособполучения (S)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамида (I) и (R)-2-[4-(4-хлорбензгидрил)пиперазин-1-ил]этоксиацетамида (II) путемхимическогоразделениясмеси. Этисоединенияявляютсяпромежуточнымипродуктамидлясинтезадекстроцетиризинаи левоцетиризинасоответственно.

    Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
    19.
    发明专利
    Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine 未知

    公开(公告)号：NZ556580A

    公开(公告)日：2009-08-28

    申请号：NZ55658006

    申请日：2006-02-23

    Applicant: UCB FARCHIM SA

    Inventor： PALACIO MAGALI ,  ATES CELAL

    IPC: C07D295/088 ,  C07D207/28

    Abstract: The disclosure relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The disclosure also relates to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

    SALES DE PIROGLUTAMATO Y SU USO EN LA RESOLUCION OPTICA DE INTERMEDIARIOS PARA LA SINTESIS DE DEXTROCETIRIZINA Y LEVOCETIRIZINA.
    20.
    发明专利
    SALES DE PIROGLUTAMATO Y SU USO EN LA RESOLUCION OPTICA DE INTERMEDIARIOS PARA LA SINTESIS DE DEXTROCETIRIZINA Y LEVOCETIRIZINA. 未知

    公开(公告)号：MX2007010455A

    公开(公告)日：2007-11-08

    申请号：MX2007010455

    申请日：2006-02-23

    Applicant: UCB FARCHIM SA

    Inventor： PALACIO MAGALI ,  ATES CELAL

    IPC: C07D295/088 ,  C07D207/28

    Abstract: La presente invencion se relaciona con la sal de acido (S)-2-[4-[4- clorobenzhidril)piperazin-1-il]-etoxiacetamida-(S)-pirrolidona- 5-carboxilico, sal de acido (R)-2-[4-[4-clorobenzhidril) piperazin-1-il]-etoxiacetamida-(S)- pirrolidona-5-carboxilico, sal de acido (S)-2-[4-[4-clorobenzhidril)piperazin-1-il]- etoxiacetamida-(R)- pirrolidona-5-carboxilico, sal de acido (R)-2-[4-[4-clorobenzhidril)piperazin-1-il]-etoxiacetamida-(R)- pirrolidona-5-carboxilico. La presente invencion se relaciona tambien con un proceso para preparar (S)-2-[4-[4-clorobenzhidril) piperazin-1-il]-etoxiacetamida-(I) y (R)-2-[4-[4-clorobenzhidril) piperazin-1-il]-etoxiacetamida-(II) por la resolucion quimica de una mezcla. Estos compuestos son compuestos intermediarios respectivamente para la sintesis de la dextrocetirizina y levocetirizina.

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