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公开(公告)号：WO2020178739A1
公开(公告)日：2020-09-10
申请号：PCT/IB2020/051808
申请日：2020-03-03
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12 , A61K35/17 , A61K38/20 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/55 , C12N15/867 , C12N5/0783 , C12N5/10 , G01N33/566
Abstract: The present disclosure is directed recombinant T cell receptors capable of binding an NY-ESO-1 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.
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公开(公告)号：EP4004217A1
公开(公告)日：2022-06-01
申请号：EP20845977.6
申请日：2020-07-29
Applicant: University Health Network
Inventor： HIRANO, Naoto , SUGATA, Kenji , SASO, Kayoko
IPC: C12N15/867 , A61K35/17 , A61P35/00 , C07K14/725
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公开(公告)号：EP4004218A1
公开(公告)日：2022-06-01
申请号：EP20847664.8
申请日：2020-07-29
Applicant: University Health Network
Inventor： HIRANO, Naoto , SUGATA, Kenji , SASO, Kayoko
IPC: C12N15/867 , A61K35/17 , A61P35/00 , C07K14/725 , C12N15/113 , C12N15/12 , C12N15/63
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公开(公告)号：EP3935174A1
公开(公告)日：2022-01-12
申请号：EP20765783.4
申请日：2020-03-03
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12 , A61K35/17 , A61K38/20 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/55 , C12N15/867 , C12N5/0783 , C12N5/10 , G01N33/566
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公开(公告)号：EP3947688A1
公开(公告)日：2022-02-09
申请号：EP20776939.9
申请日：2020-03-24
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12 , A61K35/17 , A61K38/20 , A61K39/00 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/85 , C12N5/0783 , C12N5/10 , G01N33/566
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Patent Agency Ranking
公开(公告)号：EP3935177A1
公开(公告)日：2022-01-12
申请号：EP20767178.5
申请日：2020-03-03
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12 , A61K35/17 , A61K38/20 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/55 , C12N15/867 , C12N5/078 , C12N5/0783 , C12N5/10 , C12N5/12 , G01N33/566
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公开(公告)号：EP3935176A1
公开(公告)日：2022-01-12
申请号：EP20767177.7
申请日：2020-03-03
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12
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公开(公告)号：EP3935173A1
公开(公告)日：2022-01-12
申请号：EP20765782.6
申请日：2020-03-03
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K31/12 , A61K35/15 , A61K35/17 , A61K38/20 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/55 , C12N15/867 , C12N5/078 , C12N5/0783 , C12N5/10 , G01N33/566
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公开(公告)号：EP3935172A1
公开(公告)日：2022-01-12
申请号：EP20765650.5
申请日：2020-03-03
Applicant: University Health Network
Inventor： HIRANO, Naoto , MURATA, Kenji , SASO, Kayoko
IPC: C12N15/62 , A61K31/675 , A61K31/7076 , A61K35/12 , A61K35/17 , A61K38/20 , A61P35/00 , C07F9/6584 , C07K14/705 , C07K14/725 , C07K14/74 , C07K19/00 , C12N15/113 , C12N15/12 , C12N15/55 , C12N15/867 , C12N5/0783 , C12N5/10 , G01N33/566
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公开(公告)号：EP4004219A1
公开(公告)日：2022-06-01
申请号：EP20848269.5
申请日：2020-07-29
Applicant: University Health Network
Inventor： HIRANO, Naoto , SUGATA, Kenji , SASO, Kayoko
IPC: C12N15/867 , A61K35/17 , A61P35/00 , C07K14/725 , C12N15/113 , C12N15/12 , C12N15/63 , C12N5/0783
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