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11.发明申请PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLES AND THEIR USE AS CONTRAST AGENTS. 审中-公开PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLE AND AND THE USE as CONTRAST AGENTS。
公开(公告)号：WO2013053042A1
公开(公告)日：2013-04-18
申请号：PCT/CA2012/000937
申请日：2012-10-11
Applicant: UNIVERSITY HEALTH NETWORK , ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
Abstract translation: 本发明涉及包含单层卟啉 - 磷脂缀合物的微泡，所述微泡封装在其中，以及所述微泡在受试者的靶区域的超声成像中的用途。
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公开(公告)号：EP3157509A1
公开(公告)日：2017-04-26
申请号：EP15809455.7
申请日：2015-06-18
Applicant: University Health Network
Inventor： CHEN, Juan , ZHENG, Gang , CUI, Liyang
CPC classification number: B82Y5/00 , A61K9/1075 , A61K9/5169 , A61K31/337 , A61K31/404 , A61K41/0071 , A61K41/0076 , A61K47/42 , A61K47/544 , A61K47/6907 , A61K49/0036 , Y10S977/773 , Y10S977/801 , Y10S977/906 , Y10S977/915
Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.
Abstract translation: 本文提供了包含单层磷脂，卟啉 - 磷脂缀合物和包封疏水核心的肽的纳米囊泡，其中所述肽包含能够形成至少一个两亲性α-螺旋的氨基酸序列; 卟啉 - 磷脂缀合物包含一种卟啉，卟啉衍生物或卟啉类似物，其共价连接至一个磷脂的脂质侧链，优选在sn-1或sn-2位; 卟啉 - 磷脂结合物与磷脂的摩尔百分比为35％或更少; 纳米囊泡的直径为35nm或更小。
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公开(公告)号：EP2717857B1
公开(公告)日：2018-07-11
申请号：EP12796842.8
申请日：2012-05-25
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , LOVELL, Jonathan
IPC: A61K9/127 , A61K31/704 , A61K47/22 , A61K49/00 , A61K51/12 , A61K9/14 , B01J13/02 , C12P17/18 , C12P41/00 , C07F9/6561 , A61K8/55 , A61K41/00 , A61K47/54 , A61K8/14 , C07F9/10 , C09B67/02 , C09B69/10 , A61Q19/00
CPC classification number: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
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14.发明公开PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLES AND THEIR USE AS CONTRAST AGENTS. 审中-公开卟啉PHOSPHOLIPIDKONJUGAT微小气泡及其作为造影剂
公开(公告)号：EP2766051A1
公开(公告)日：2014-08-20
申请号：EP12840663.4
申请日：2012-10-11
Applicant: University Health Network
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
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公开(公告)号：EP2488206A1
公开(公告)日：2012-08-22
申请号：EP10822941.0
申请日：2010-10-05
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , LOVELL, Jonathan F.
CPC classification number: A61K41/0071 , A61K47/544 , A61K49/0036 , A61K49/0084 , Y10T428/2991
Abstract: The application relates to a nanovesicle comprising a bilayer of at least 15 mol% porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.
Abstract translation: 本申请涉及包含至少15摩尔％卟啉 - 磷脂缀合物的双层的纳米囊泡，其中所述缀合物包含共价连接至磷脂侧链的卟啉，卟啉衍生物或卟啉类似物。 纳米囊泡可用于光热疗法，光声成像和荧光成像。 该申请还公开了制备所述纳米囊泡的方法。
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Patent Agency Ranking
公开(公告)号：EP2488206B1
公开(公告)日：2018-03-21
申请号：EP10822941.0
申请日：2010-10-05
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , LOVELL, Jonathan F.
CPC classification number: A61K41/0071 , A61K47/544 , A61K49/0036 , A61K49/0084 , Y10T428/2991
Abstract: The application relates to a nanovesicle comprising a bilayer of at least 15 mol % porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.
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17.发明公开PORPHYRIN-LIPID STABILIZED NANOPARTICLES FOR SURFACE ENHANCED RAMAN SCATTERING BASED IMAGING 审中-公开卟啉 - 脂质纳米粒稳定化成像基于表面增强拉曼散射
公开(公告)号：EP2841112A1
公开(公告)日：2015-03-04
申请号：EP13780691.5
申请日：2013-04-19
Applicant: University Health Network
Inventor： ZHENG, Gang , TAM, Natalie
CPC classification number: G01N21/658 , G01N33/57423 , G01N33/587
Abstract: Herein are provided nanoparticles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering.
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18.发明公开TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME 审中-公开TEXAPHYRIN-PHOSPHIPIPUJUCATES及其制备方法
公开(公告)号：EP3283493A1
公开(公告)日：2018-02-21
申请号：EP16779355.3
申请日：2016-04-14
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , KECA, Joseph
IPC: C07F9/10 , A61K41/00 , A61K49/00 , A61K49/10 , A61K9/14 , A61K9/51 , C07D487/22 , C07F9/6561 , C12P17/18
Abstract: There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.
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">19.发明公开HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD ("HPPS") NANOPARTICLES 审中-公开高密度脂蛋白样肽 - 磷脂酰胆碱（HPPS-）纳米脂
公开(公告)号：EP2229411A1
公开(公告)日：2010-09-22
申请号：EP08859772.9
申请日：2008-12-12
Applicant: University Health Network
Inventor： ZHENG, Gang , ZHANG, Zhihong , CORBIN, Ian , CHEN, Juan
IPC: C07K17/02 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/04 , A61P35/00 , C12N15/10 , C12N15/11 , G01N33/566 , G01N33/574 , C07K14/485 , C07K14/71 , C12N15/87
CPC classification number: A61K49/0082 , A61K47/6917 , A61K47/6919 , A61K49/0002 , A61K49/0032 , A61K49/0056 , B82Y5/00 , G01N33/54346 , G01N33/587 , G01N2800/00
Abstract: The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a-helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.
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公开(公告)号：EP4370158A1
公开(公告)日：2024-05-22
申请号：EP22840900.9
申请日：2022-07-12
Applicant: University Health Network
Inventor： ZHENG, Gang , CHEN, Juan , HO, Tiffany , BU, Jiachuan , DING, Lili
CPC classification number: A61K41/0071 , A61K47/544 , A61K47/6911 , A61K49/0036 , A61K49/0084 , A61K49/0002 , A61K49/227 , A61K51/1234 , A61K9/5123
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