公开(公告)号：WO1996025098A1

公开(公告)日：1996-08-22

申请号：PCT/US1995006425

申请日：1995-05-24

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BOVA, Frank, J. ,  FRIEDMAN, William, A.

IPC: A61B05/05

CPC classification number: A61B6/08 ,  A61B6/035 ,  A61B34/20 ,  A61B90/14 ,  A61B90/16 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/101 ,  A61B2090/363 ,  A61B2090/3945 ,  A61B2090/3983 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1059

Abstract: Repeat fixation for medical procedures is accomplished using a non-invasive locator, specifically a bite plate (26). The bite plate (26) has at least three fiducial markers (38) on it. The fiducial markers (38) may be LEDs, radiopaque markers for angiography or computerized tomography (CT) imaging or magnetic resonance markers for magnetic resonance (MR) imaging. By detecting the position of the markers (38), the position of features within the patient (14) (such as a brain tumor or other intracranial target to which radiation is to be applied) can be determined with great precision. Since the bite plate (26) has been molded to uniquely fit to the patient's teeth, it may be removed after an initial imaging of the patient (14). The bite plate (26) may then be re-attached one or more times to the teeth and the location of the features will be in a known position relative to the sensed markers.

Abstract translation: 用于医疗程序的重复固定使用非侵入性定位器，特别是咬合板（26）来实现。 咬合板（26）上具有至少三个基准标记（38）。 基准标记（38）可以是LED，用于血管造影或计算机断层摄影（CT）成像的不透射线标记物或用于磁共振（MR）成像的磁共振标记物。 通过检测标记（38）的位置，可以很高的精度确定患者（14）内的特征位置（例如脑瘤或其他应用辐射的颅内靶）。 由于咬合板（26）已经模制成唯一地适合患者的牙齿，所以可以在患者（14）的初始成像之后去除它。 然后可以将咬合板（26）重新连接到牙齿上一次或多次，并且特征的位置将相对于感测到的标记处于已知位置。

公开(公告)号：WO1995008297A1

公开(公告)日：1995-03-30

申请号：PCT/US1994001725

申请日：1994-02-25

Applicant: ABELA LASER SYSTEMS, INC. ,  UNIVERSITY OF FLORIDA

Inventor： ABELA LASER SYSTEMS, INC. ,  UNIVERSITY OF FLORIDA ,  ABELA, George, S. ,  FRIEDL, Stephan, E. ,  MATHEWS, Eric, D.

IPC: A61B17/36

CPC classification number: A61B18/24 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2018/00196

Abstract: A catheter (10) uses a steerable outer catheter (12) with an inner catheter (14) rotatable and extendable with respect to the outer catheter (12). The outer catheter (12) may be positioned within a patient's heart and a portion of the outer catheter (12) may provide movement like that of a windshield wiper by manipulation of a spring. By combining a windshield-wiper-type movement with the extension and rotation of the inner catheter (14) relative to the outer catheter (12), a large area within a patient's heart may be readily mapped for conduction tissue and be subjected to laser ablation if appropriate. Various configurations provide flexibility in relatively positioning of windows used to apply laser energy and ring electrodes (20F and 20S) used to sense conduction tissue.

Abstract translation: 导管（10）使用具有可相对于外导管（12）旋转和延伸的内导管（14）的可操纵外导管（12）。 外导管（12）可以定位在患者的心脏内，并且外导管（12）的一部分可以通过操纵弹簧来提供类似于挡风玻璃刮水器的运动。 通过将挡风玻璃刮水器型运动与内导管（14）相对于外导管（12）的延伸和旋转相结合，患者心脏内的大面积可以容易地映射到传导组织并进行激光消融 如果合适的话。 各种配置在用于施加用于感测传导组织的激光能量和环形电极（20F和20S）的窗口的相对定位中提供灵活性。

公开(公告)号：WO1994017186A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000581

申请日：1994-01-21

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GUY, Charles, L. ,  HASKELL, Dale, W. ,  HOFIG, Andrea ,  NEVEN, Lisa, Gail

IPC: C12N15/29

CPC classification number: C12N15/8273 ,  A01H1/00 ,  A01N3/00 ,  C07K14/415 ,  C12N1/04

Abstract: Described are proteins having molecular weights of 85 and 160 kDa, which proteins are responsive to cold acclimation or drought stress in plants. The cDNA for the 85 and 160 kDa proteins, designated CAP85 and CAP160, are disclosed. Transgenic cells, including microorganisms and plants, can be produced which express the CAP85 and CAP160 proteins and thereby advantageously enhance the cold or water stress tolerance in the transgenic organism. Freeze and desiccation damage can also be prevented by applying a cold acclimation protein to the organism needing such protection.

Abstract translation: 描述了分子量为85和160 kDa的蛋白质，这些蛋白质对植物中的冷驯化或干旱胁迫有反应。 公开了85和160kDa蛋白质的标记为CAP85和CAP160的cDNA。 可以产生转基因细胞，包括微生物和植物，其表达CAP85和CAP160蛋白质，从而有利地增强转基因生物体中的冷胁迫或水胁迫耐受性。 还可以通过将寒冷适应性蛋白质应用于需要这种保护的生物体来防止冷冻和干燥损伤。

公开(公告)号：WO1994003107A1

公开(公告)日：1994-02-17

申请号：PCT/US1993006888

申请日：1993-07-26

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BRIGGS, Richard, W. ,  LIEBIG, Thomas ,  ROS, Pablo ,  BALLINGER, J., Ray

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/1806

Abstract: A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.

Abstract translation: 用于成像包含在可接受的培养基中的悬浮液的样品的造影剂（a）具有顺磁特性的造影剂颗粒和（b）具有抗磁特性的造影剂颗粒。 还公开了一种对样品成像的方法，其包括向样品中引入上述造影剂并产生其基本上无伪影的图像。 一个悬浮液中的抗磁性硫酸钡和超顺磁性氧化铁（SPIO）的组合产生了正和负磁化率成分的宏观消除，即使使用梯度回波脉冲序列也消除了敏感性伪影。 使SPIO悬浮液成为有用的负造影剂的松弛性能得以保留。

公开(公告)号：WO1992015306A1

公开(公告)日：1992-09-17

申请号：PCT/US1992001451

申请日：1992-02-27

Applicant: UNIVERSITY OF FLORIDA ,  ZOLTEWICZ, John, A. ,  KEM, William, R. ,  MEYER, Edwin, M.

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K31/445

CPC classification number: C07D401/04 ,  A61K31/44 ,  A61K31/445

Abstract: Method of using anabaseine, DMAB-anabaseine, and anabasine for stimulating brain cholinergic transmission and a method of making anabaseine.

Abstract translation: 使用anabaseine，DMAB-anabaseine和anabasine刺激脑胆碱能传播的方法和制备anabaseine的方法。

公开(公告)号：WO1992011056A1

公开(公告)日：1992-07-09

申请号：PCT/US1991009594

申请日：1991-12-18

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  MILLER, Gary, J. ,  MELKER, Richard, J.

IPC: A61M25/00

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2065

Abstract: A fluid transfer device (20) for safely transferring fluid from a needleless collection device (28) to a separate container (32). The device includes a housing (10) having a passage (16) therethrough and an integral needle (22). A first, connection section (18) of the housing is adapted to connect to a needleless collection device (28) from which fluid is to be transferred and a second, shield section (20) of the housing is adapted to accept the container (32) into which fluid is to be transferred. One end (24) of the needle is formed integrally with the connection section (18) of the housing. The penetration end (26) of the needle extends into the shield section (20) of the housing (10) and is fully covered by the shield section (20). When a container (32) is inserted into the shield section (20) of the housing (10) the needle enters the container and fluid may be transferred from a collection device (28) connected to the connection section (18) of the housing.

Abstract translation: 一种用于将流体从无针收集装置（28）安全地传送到单独的容器（32）的流体输送装置（20）。 该装置包括具有穿过其中的通道（16）和整体针（22）的壳体（10）。 壳体的第一连接部分（18）适于连接到待传送流体的无针收集装置（28），并且壳体的第二屏蔽部分（20）适于容纳容器（32 ）流体将被转移到其中。 针的一端（24）与壳体的连接部（18）一体地形成。 针的穿透端（26）延伸到壳体（10）的屏蔽部分（20）中并被屏蔽部分（20）完全覆盖。 当容器（32）插入到壳体（10）的屏蔽部分（20）中时，针进入容器，并且流体可以从连接到壳体的连接部分（18）的收集装置（28）传送。

公开(公告)号：WO1992003733A1

公开(公告)日：1992-03-05

申请号：PCT/US1991005920

申请日：1991-08-16

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  ATKINSON, Mark, A. ,  MACLAREN, Noel, K. ,  KASTERN, William

IPC: G01N33/564

CPC classification number: C07K14/72 ,  A61K38/00 ,  A61K39/00 ,  A61K47/62 ,  C07K16/40 ,  C12N9/88 ,  G01N33/564 ,  G01N33/573 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/042

Abstract: The subject invention concerns a novel process for the early detection of insulin dependent diabetes (IDD). The novel process described here enables the detection of the onset of IDD before clinical symptoms appear. The novel process involves the detection, in a sample of biological fluid, of an autoantibody which is highly specific to individuals who will later develop the clinical manifestations of IDD. Novel treatments for the prevention of IDD are also described.

Abstract translation: 本发明涉及早期检测胰岛素依赖性糖尿病（IDD）的新方法。 这里描述的新颖方法使得能够在出现临床症状之前检测IDD的发作。 该新方法涉及在生物流体样品中检测对随后发展IDD的临床表现的个体高度特异性的自身抗体。 还描述了防治IDD的新型治疗方法。

公开(公告)号：WO1990009806A2

公开(公告)日：1990-09-07

申请号：PCT/US1990001122

申请日：1990-03-01

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BAZER, Fuller, W. ,  JOHNSON, Howard, M.

IPC: A61K45/02

CPC classification number: A61K38/212 ,  C07K2319/02

Abstract: Use of ovine trophoblast protein-1 (-OTP-1) or fragments thereof to inhibit viral activity and tumor formation and growth. OTP-1 exhibits potent antiviral activity but, advantageously, does not have cytotoxic effects.

Abstract translation: 使用养殖滋养层蛋白-1（-OTP-1）或其片段来抑制病毒活性和肿瘤形成和生长。 OTP-1显示出有效的抗病毒活性，但是有利地，没有细胞毒性作用。

公开(公告)号：WO1990002799A1

公开(公告)日：1990-03-22

申请号：PCT/US1989003643

申请日：1989-08-28

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BALABAN, Murat, O. ,  MARSHALL, Maurice, R. ,  WICKER, Louise

IPC: C12N09/99

CPC classification number: A23B7/144 ,  A23B4/12 ,  A23B4/16 ,  A23B7/10 ,  A23C9/1524 ,  A23L2/44 ,  A23L3/0155 ,  A23L3/3409 ,  A23L5/276 ,  C12N9/99

Abstract: A method for the inactivation of undesirable enzymes in food products which contain an aqueous phase comprising exposing the food product to an atmosphere having a partial pressure of CO2 so as to dissolve CO2 in the aqueous phase of the food product to produce a carbonic acid solution having a pH sufficiently low to irreversibly inactivate the undesirable enzymes.

Abstract translation: 一种用于灭活含有水相的食品中不期望的酶的方法，包括将食品暴露于具有分压CO 2的气氛中，以便将CO 2溶解在食品的水相中以产生具有 足够低的pH以不可逆地灭活不需要的酶。

公开(公告)号：WO1989005171A2

公开(公告)日：1989-06-15

申请号：PCT/US1988004303

申请日：1988-12-02

Applicant: UNIVERSITY OF FLORIDA ,  BOVA, Frank, J. ,  FRIEDMAN, William, A.

Inventor： UNIVERSITY OF FLORIDA

IPC: A61N05/10

CPC classification number: A61N5/1049 ,  A61B2017/00707 ,  A61B2017/00712 ,  A61B2090/101 ,  A61B2090/363 ,  A61N5/10 ,  A61N5/103 ,  A61N5/1031

Abstract: Stereotactic radiosurgery apparatus for eliminating misalignments due to mechanical inaccuracies and sag of a linear accelerator radiation-emitting head which is swung through an arc comprises a guiding and support structure (54) with a first bearing system for accurately rotating a collimator (32) through a precise arc in a vertical plane (30) with respect to a predetermined center point (34) in the plane corresponding to a treatment location, a second gimbal bearing system (70) for coupling the collimator (32) to the head (16) so that the rotating head can drive the collimator (32) through its arc while mechanically uncoupling the head from the collimator by eliminating torques and forces on the collimator which would be exerted by mechanical inaccuracies or sag of the head, and a third bearing system (86) for rotatably supporting a stereotactic floorstand (28) for rotation about a vertical axis (30) which intersects the center point. Since the movement of the collimator (32) and the rotation of the floorstand are precisely controlled with respect to the center point, the apparatus ensures that radiation from the head will be accurately focused at the center point (34) for all rotational positions of the head and floorstand. Mechanical linking arrangements are shown for allowing the floorstand to rotate automatically upon rotation of a patient treatment table (20). Although the linking arrangements are used to drive the rotation of the floorstand, the linkage arrangements prevent the introduction of positional inaccuracies in the floorstand rotation.

Abstract translation: 用于消除由于通过电弧摆动的线性加速器辐射发射头的机械不准确和下垂引起的不对准的立体定向放射外科手术包括具有第一轴承系统的引导和支撑结构（54），用于将准直器（32）精确地旋转通过 在对应于处理位置的平面中相对于预定中心点（34）的垂直平面（30）中的精确电弧;用于将准直器（32）耦合到头部（16）的第二万向节轴承系统（70） 旋转头可以通过其弧线驱动准直器（32），同时通过消除由准直器产生的机械不准确或下垂造成的扭矩和力，同时机械地将头部与准直器分离，以及第三轴承系统（86 ），用于可旋转地支撑用于围绕与中心点相交的垂直轴线（30）旋转的立体定向底座（28）。 由于准直器（32）的移动和底板的旋转相对于中心点被精确地控制，因此该装置确保来自头部的辐射将精确地聚焦在中心点（34）处，用于所有的旋转位置 头和地板。 示出了机械连接装置，用于允许地板架在患者治疗台（20）旋转时自动旋转。 虽然连接装置用于驱动地板架的旋转，但是连杆装置防止在地板座旋转中引入位置不准确。