公开(公告)号：US20200058367A1

公开(公告)日：2020-02-20

申请号：US16672601

申请日：2019-11-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel FLEISHMAN ,  Adi GOLDENZWEIG ,  Dan S. TAWFIK

IPC: G16B15/00 ,  G16B15/20 ,  G16C20/60 ,  G16C20/10 ,  G16B35/00 ,  G16B30/00 ,  C12N9/10 ,  C12N9/16 ,  C12N9/18

Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.