公开(公告)号：WO2008060091A1

公开(公告)日：2008-05-22

申请号：PCT/KR2007/005704

申请日：2007-11-14

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  GREEN OPTICS CO., LTD. ,  KIM, Geonhee ,  YANG, Sunchoel ,  KIM, Dongkyun ,  KIM, Youngjoo ,  PARK, Hakjoo

Inventor： KIM, Geonhee ,  YANG, Sunchoel ,  KIM, Dongkyun ,  KIM, Youngjoo ,  PARK, Hakjoo

IPC: B24B13/00

CPC classification number: B24B13/01 ,  B24B41/002 ,  B24B49/16

Abstract: Disclosed is an automatic constant pressure polishing apparatus. The automatic constant pressure polishing apparatus comprises a housing having a hollow section therein, a rubber pad installed in the housing and having superior expansion and contraction characteristics, a pressure fixture having a male screw section, which is formed on an outer peripheral surface thereof in order to press and fix the rubber pad, and a central hole formed at a central portion thereof, a slider screw-coupled into the housing to adjust pressure in the housing according to a rotational degree of the rotating shaft, and a polishing pad installed at a front end portion of the housing.

Abstract translation: 公开了一种自动恒压抛光装置。 所述自动恒压抛光装置包括其中具有中空部分的壳体，安装在所述壳体中并且具有优异的膨胀和收缩特性的橡胶垫，具有阳螺纹部分的压力夹具，其按顺序形成在其外周表面上 按压和固定橡胶垫，以及形成在其中心部分的中心孔，螺丝连接到壳体中的滑块，以根据旋转轴的转动程度来调节壳体中的压力;以及抛光垫，其安装在 外壳的前端部分。

公开(公告)号：WO2008007821A1

公开(公告)日：2008-01-17

申请号：PCT/KR2006/003261

申请日：2006-08-18

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

Inventor： KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G06F17/30

CPC classification number: G06F19/28 ,  G06F19/18 ,  G06F19/22

Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database comprising the steps of i) Grouping proteins having a required homology by using the clustering software from the primary database which minimizes the overlapping of proteins and then recording sequence information of each protein group on a recording system of a computer; and ii) Designating a representative protein in each protein group and then constructing the representative protein database composed of the representative proteins, followed by recording the results containing sequence information on a recording system of a computer, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.

Abstract translation: 本发明涉及一种用于重建用于鉴定蛋白质的蛋白质数据库的方法和使用该蛋白质筛选蛋白质的方法，更准确地说，一种重建蛋白质数据库的方法，包括以下步骤：i）通过使用聚类分组具有所需同源性的蛋白质 来自主数据库的软件，其最小化蛋白质的重叠，然后在计算机的记录系统上记录每个蛋白质组的序列信息; 和ii）指定每个蛋白质组中的代表性蛋白质，然后构建由代表性蛋白质组成的代表性蛋白质数据库，然后将含有序列信息的结果记录在计算机的记录系统上，以及用于鉴定使用其的蛋白质的方法 。 重组蛋白质数据库的方法和鉴定本发明蛋白质的方法对于内源蛋白质及其功能和相互作用的研究非常有用，并且进一步有效地用于各种疾病的诊断和治疗剂的开发。

公开(公告)号：WO2007091754A1

公开(公告)日：2007-08-16

申请号：PCT/KR2006/003618

申请日：2006-09-12

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hyun Sik ,  CHOI, Myoung Choul ,  YOO, Jong Shin

Inventor： KIM, Hyun Sik ,  CHOI, Myoung Choul ,  YOO, Jong Shin

IPC: G01N27/62

CPC classification number: G01N27/62

Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT- ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method. Also, a high resolution and hith sensitivity measurement can be achieved. Moreover, when a reagent gas instead of a collision gas in the collision cell is injected, the gas phase reaction of the selected ions and the reagent gas can be observed, and the mass of the ions generated in the gas phase reaction can be measured.

Abstract translation: 提供了一种串联傅里叶变换离子回旋共振质谱仪。 在质谱仪中，可以进行离子选择处理的FT-ICR质量分析器选择的离子和在处理之间的时间间隔的质量测量过程通过离子导向器传输到位于 距离FT-ICR质量分析器预定的距离，以分裂为碎片离子。 碎片离子传输到测量碎片离子质量的FT-ICR质量分析仪。 在根据质谱仪与FT-ICR质量分析器40分开设置的碰撞单元60中产生碎片离子。 因此，可以使用常规的串联质量分析方法来解决在串联质谱仪中发生的各种问题（例如，产生碰撞离子的回旋加速器运动的半径减小或产生碎片离子之后的外围气体的去除）。 此外，可以实现高分辨率和高灵敏度测量。 此外，当注入反应气体代替碰撞气体中的碰撞气体时，可以观察到所选择的离子和反应气体的气相反应，并且可以测量在气相反应中产生的离子的质量。

公开(公告)号：WO2006065027A1

公开(公告)日：2006-06-22

申请号：PCT/KR2005/004030

申请日：2005-11-29

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  LEE, Byoung-Seob ,  KIM, Dong-Lak ,  KIM, Hyun-Sik ,  YOO, Jong-Shin

Inventor： LEE, Byoung-Seob ,  KIM, Dong-Lak ,  KIM, Hyun-Sik ,  YOO, Jong-Shin

IPC: H01F6/00

CPC classification number: G01R33/3815

Abstract: Disclosed is a method for designing a superconducting magnet for generating high magnetic fields with high uniformity for controlling a stray field to be within an allowable range and acquiring structural and magnetic stability by optimizing the arrangement of positions and shapes of coils configuring the superconducting magnet. Volumes of a main coil and a shielding coil are set to be variables, and the critical value of a wires related on the current and magnetic field, the heat transfer depth, and the quench strain are defined to be restriction conditions so that linear programming is applied to determine an initial shape of the shielding coil and division of the main coil based on the sum of total volumes, that is, an objective function. The initial shapes of the main coil and the shielding coil determined through the linear programming are revised and the shape of a shimming coil is determined by using non-linear programming based on the objective function.

Abstract translation: 公开了一种设计用于产生高均匀性的高磁场的超导磁体的方法，用于通过优化构成超导磁体的线圈的位置和形状的布置来优化将杂散磁场控制在允许范围内并获得结构和磁稳定性。 主线圈和屏蔽线圈的体积被设置为变量，并且将与电流和磁场相关的导线的临界值，传热深度和骤冷应变定义为限制条件，使得线性规划是 用于确定屏蔽线圈的初始形状和基于总体积的总和即目标函数的主线圈的划分。 修改通过线性规划确定的主线圈和屏蔽线圈的初始形状，并且通过使用基于目标函数的非线性规划来确定匀场线圈的形状。

公开(公告)号：TWI471894B

公开(公告)日：2015-02-01

申请号：TW101145940

申请日：2012-12-07

Applicant: 韓國基礎科學支援研究所 ,  KOREA BASIC SCIENCE INSTITUTE

Inventor： 俞席在 ,  YOO, SUK JAE ,  金聖鳳 ,  KIM, SEONG BONG

IPC: H01J37/34 ,  H01J27/02 ,  C23C14/34 ,  C23C14/46

公开(公告)号：WO2011081329A2

公开(公告)日：2011-07-07

申请号：PCT/KR2010/008988

申请日：2010-12-15

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

Inventor： PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

IPC: G01N30/72 ,  G01N33/15 ,  B01D15/08

CPC classification number: G01N30/06 ,  G01N30/8686 ,  G01N30/96 ,  G01N33/6848 ,  G01N2030/8809 ,  G01N2030/8813 ,  G01N2500/00 ,  Y10T436/174614 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.

Abstract translation: 公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性曲线; 基于通过质谱法分析样品产生的质谱获得质量分布图; 并通过比较和分析活性曲线和质量曲线来确定药理活性物质的分子量。 所公开的方法通过对包含在天然产物的提取物样品中的许多组分进行高分辨质谱并且与活性测试数据进行比较而允许药理活性物质的快速发现。 有关天然产物药理活性物质活性强度的信息可以有效利用天然产物。

公开(公告)号：WO2011078544A3

公开(公告)日：2011-06-30

申请号：PCT/KR2010/009141

申请日：2010-12-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  CHOI, Myoung Choul ,  KIM, Hyun Sik ,  YOO, Jong Shin

Inventor： CHOI, Myoung Choul ,  KIM, Hyun Sik ,  YOO, Jong Shin

IPC: H01J37/30 ,  H01J49/26

Abstract: An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.

公开(公告)号：WO2011068350A2

公开(公告)日：2011-06-09

申请号：PCT/KR2010/008543

申请日：2010-12-01

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  LEE, Byoung Seob ,  WON, Mi Sook ,  KIM, Jong Pil ,  YOON, Jang Hee ,  BAE, Jong Seong ,  LEE, Hyo Sang ,  PARK, Jin Yong ,  PARK, Gyu Jun ,  LIM, Jung Hwan

Inventor： LEE, Byoung Seob ,  WON, Mi Sook ,  KIM, Jong Pil ,  YOON, Jang Hee ,  BAE, Jong Seong ,  LEE, Hyo Sang ,  PARK, Jin Yong ,  PARK, Gyu Jun ,  LIM, Jung Hwan

IPC: H05G1/00 ,  H05H1/24

CPC classification number: H05G2/003

Abstract: An apparatus for generating X-ray may include: a plasma chamber; a magnet unit for applying a magnetic field to the plasma chamber, the magnet unit configured to allow the control of the magnitude of the minimum magnetic field in the plasma chamber without change in structure; a microwave generator for applying microwaves to the plasma chamber; a reaction gas injected into the plasma chamber for generating X-ray through electron cyclotron resonance by the magnetic field and the microwaves; a variable guide for focusing the generated X-ray; and a variable extractor for outputting the focused X-ray from the plasma chamber.

Abstract translation: 用于产生X射线的设备可以包括：等离子体室; 磁体单元，用于向所述等离子体腔室施加磁场，所述磁体单元被配置为允许控制所述等离子体腔室中的最小磁场的大小而不改变结构; 微波发生器，用于向等离子体室施加微波; 注入到等离子体室中用于通过磁场和微波通过电子回旋共振产生X射线的反应气体; 用于聚焦所产生的X射线的可变指导; 以及用于从等离子体室输出聚焦X射线的可变提取器。

公开(公告)号：WO2010144811A1

公开(公告)日：2010-12-16

申请号：PCT/US2010/038328

申请日：2010-06-11

Applicant: FLORIDA STATE UNIVERSITY ,  KOREA BASIC SCIENCE INSTITUTE ,  PAINTER, Andrew ,  CHOI, Yeon Suk ,  KIM, Dong Lak ,  BAI, Hongyu

Inventor： PAINTER, Andrew ,  CHOI, Yeon Suk ,  KIM, Dong Lak ,  BAI, Hongyu

IPC: F25B9/00 ,  F25B19/00

CPC classification number: F25D19/006

Abstract: An apparatus for transferring cryogenic refrigeration includes a cryocooler interface, a housing, a working fluid, a heat exchanger, a flexible thermal link, and a remote cartridge cold head. The cryocooler interface is thermally connected to a cryocooler providing a source of refrigeration. The refrigeration is passed from the crycooler into the heat exchanger via the cryocooler interface. The remote cartridge cold head is attached to a remote location. Heat is drawn from the remote location through the remote cartridge cold head and into the heat exchanger via the working fluid within the flexible thermal link and housing. Within the heat exchanger, heat is transferred from the working fluid to the refrigeration source, such as a cryocooler; accordingly, the remote location is cooled.

Abstract translation: 用于转移低温制冷的设备包括低温冷却器接口，壳体，工作流体，热交换器，柔性热连接器和远程冷库冷头。 低温冷却器界面热连接到提供冷冻源的低温冷却器。 制冷从冷冻机通过低温冷却器接口进入热交换器。 远程墨盒冷头连接到远程位置。 热量从远程位置通过远程墨盒冷头抽出，并通过柔性热连接件和外壳内的工作流体进入热交换器。 在热交换器内，热量从工作流体传递到制冷源，例如低温冷却器; 因此，远程位置被冷却。

公开(公告)号：WO2009110655A1

公开(公告)日：2009-09-11

申请号：PCT/KR2008/002379

申请日：2008-04-25

Applicant: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  KOREA BASIC SCIENCE INSTITUTE ,  FOOD SCIENCE CO., LTD. ,  RYU, Do Hyun ,  HWANG, Geum Sook ,  KIM, Kun Hong ,  PARK, Jin Hyun ,  KIM, Hwa Jin

Inventor： RYU, Do Hyun ,  HWANG, Geum Sook ,  KIM, Kun Hong ,  PARK, Jin Hyun ,  KIM, Hwa Jin

IPC: C07C69/52

CPC classification number: C07C67/31 ,  C07B2200/09 ,  C07C67/343 ,  C07C69/73 ,  C07C69/732 ,  C07C69/738 ,  C07C255/57 ,  C07C311/19 ,  C07F7/1852

Abstract: Provided are β-substituted Morita-Baylis-Hillman (MBH) derivatives, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof. The derivatives may be prepared by preparing β-iodo-MBH esters from a variety of carbonyl compounds such as aldehydes and ketones, or imines in the presence of a Lewis acid as a basic backbone, and substituting iodide on a vinyl position with a variety of substituents. In addition, the β-substituted MBH derivatives have an excellent pharmaceutical effect in preventing and treating cancer.

Abstract translation: 提供的是取代的Morita-Baylis-Hillman（MBH）衍生物，其药学上可接受的盐，水合物，溶剂化物和立体异构体。 衍生物可以通过在路易斯酸作为碱性主链的存在下由各种羰基化合物如醛和酮或亚胺制备β-碘-MBH酯来制备，并且在乙烯基位置用各种各样的 取代。 此外，β取代的MBH衍生物在预防和治疗癌症中具有优异的药物作用。