公开(公告)号：US09513303B2

公开(公告)日：2016-12-06

申请号：US14214190

申请日：2014-03-14

Applicant: Abbott Laboratories

Inventor： Joseph P. Donohue

IPC: G01N35/04 ,  G01N35/00 ,  G01N21/00 ,  G01N35/02

CPC classification number: G01N35/021 ,  G01N21/76 ,  G01N35/0099 ,  G01N35/02 ,  G01N35/04 ,  G01N2035/0429 ,  G01N2201/0642 ,  G01N2201/0648 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.

Abstract translation: 诊断分析仪包括轨道，遮光构件，电动机和光学测试装置。 轨道移动由轨道保持的反应容器。 遮光构件邻近轨道设置。 遮光构件从远离轨道的第一位置移动到靠近轨道的第二位置。 当遮光构件设置在第一位置时，容纳在由轨道保持的反应容器内的样品暴露于光。 当遮光构件设置在第二位置时，包含在由轨道保持的反应容器内的样品被阻挡以暴露于光。 电动机在第一和第二位置之间移动遮光构件。 当所述至少一个遮光构件设置在所述第二位置时，所述光学测试装置邻近所述轨道设置用于光学地测试由所述轨道保持的所述反应容器内的样本。

公开(公告)号：US09395238B2

公开(公告)日：2016-07-19

申请号：US14020730

申请日：2013-09-06

Applicant: John W. Runcie

Inventor： John W. Runcie

IPC: G01J1/04 ,  G01N21/64 ,  G01N21/63

CPC classification number: G01J1/044 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/635 ,  G01N2201/0627 ,  G01N2201/0648

Abstract: An automated shutter for dark acclimating a sample, comprising a base and a head mounted to the base and movable between an open and closed position. The automated shutter further comprises one or more artificial light sources and one or more optical detectors disposed in said head or base, and wherein the head is contiguous with the sample when moved into the closed position. Another embodiment comprises an enclosure placed over a sample to be dark acclimatized, with one or more artificial light sources and optical detectors disposed within or closely adjacent to said enclosure which is configured to be transformed between an optically transparent state and an optically opaque state.

公开(公告)号：US20140001348A1

公开(公告)日：2014-01-02

申请号：US14020730

申请日：2013-09-06

Applicant: John W. Runcie

Inventor： John W. Runcie

IPC: G01J1/04

CPC classification number: G01J1/044 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/635 ,  G01N2201/0627 ,  G01N2201/0648

Abstract: An automated shutter for dark acclimating a sample, comprising a base and a head mounted to the base and movable between an open and closed position. The automated shutter further comprises one or more artificial light sources and one or more optical detectors disposed in said head or base, and wherein the head is contiguous with the sample when moved into the closed position. Another embodiment comprises an enclosure placed over a sample to be dark acclimatised, with one or more artificial light sources and optical detectors disposed within or closely adjacent to said enclosure which is configured to be transformed between an optically transparent state and an optically opaque state.

Abstract translation: 一种用于暗适应样品的自动快门，包括基座和安装在基座上的头部，可在打开和关闭位置之间移动。 自动快门还包括一个或多个人造光源和设置在所述头部或底座中的一个或多个光学检测器，并且其中当移动到关闭位置时，头部与样品邻接。 另一个实施例包括放置在样本上以适于深色适应的外壳，其中一个或多个人造光源和光学检测器设置在所述外壳内或紧邻所述外壳中，该检测器被配置为在光学透明状态和光学不透明状态之间转换。

公开(公告)号：EP2734833A2

公开(公告)日：2014-05-28

申请号：EP12783659.1

申请日：2012-07-20

Applicant: Biosensia Patents Limited

Inventor： MOYNIHAN, Shane ,  FLAVIN, Diarmuid

IPC: G01N21/64 ,  G01N3/44 ,  G01N33/53 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N21/6486 ,  G01N21/278 ,  G01N21/645 ,  G01N21/6452 ,  G01N33/5302 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/0648 ,  G01N2201/0693

Abstract: The present disclosure, among other things, describes a reader system comprising a casing, an optical system, en electromechanical motor system, and one or more digital processors.

公开(公告)号：EP1163497A1

公开(公告)日：2001-12-19

申请号：EP00915795.9

申请日：2000-02-18

Applicant: Packard Instrument Company, Inc.

Inventor： DUEBENDORFER, Juerg ,  JONES, Donald ,  NEUMANN, Kenneth ,  WANG, Chang

IPC: G01J3/30 ,  G01J1/58 ,  G01N21/25 ,  G01N21/64

CPC classification number: G01N21/6452 ,  G01N2201/0648

Abstract: An apparatus for measuring light in samples using a high intensity light source (12), is presented. The system utilizes bifurcated fiber bundle (26) to transmit light at the excitation and emission wavelength bands. It also uses a band-pass filter (36) for eliminating extraneous light, including that which corresponds to the excitation wavelength range, while permitting the emitted light to pass to a detector (41) for quantitation. The system employs a shutter (39) to shield the detector (41) while the laser light source is activated, and a controller to intermittently activate the laser light and close the shutter. The apparatus preferably includes lenses (16, 17, 37) for better illumination and read out conditions. The apparatus is employed in Luminescence Oxygen Channeling Immunoassays. The method has high sensitivity, accuracy and precision, and the apparatus is highly compact. Accordingly, the analyzer can perform assays in nanoliter to microliter sample volumes in standard microplates having at least 96, 384 or 1536 wells.

公开(公告)号：US20170045540A1

公开(公告)日：2017-02-16

申请号：US15339433

申请日：2016-10-31

Applicant: Abbott Laboratories

Inventor： Joseph P. Donohue

IPC: G01N35/02 ,  G01N35/04 ,  G01N35/00 ,  G01N21/76

CPC classification number: G01N35/021 ,  G01N21/76 ,  G01N35/0099 ,  G01N35/02 ,  G01N35/04 ,  G01N2035/0429 ,  G01N2201/0642 ,  G01N2201/0648 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.

Abstract translation: 诊断分析仪包括轨道，遮光构件，电动机和光学测试装置。 轨道移动由轨道保持的反应容器。 遮光构件邻近轨道设置。 遮光构件从远离轨道的第一位置移动到靠近轨道的第二位置。 当遮光构件设置在第一位置时，容纳在由轨道保持的反应容器内的样品暴露于光。 当遮光构件设置在第二位置时，包含在由轨道保持的反应容器内的样品被阻挡以暴露于光。 电动机在第一和第二位置之间移动遮光构件。 当所述至少一个遮光构件设置在所述第二位置时，所述光学测试装置邻近所述轨道设置用于光学地测试由所述轨道保持的所述反应容器内的样本。

公开(公告)号：US08530826B2

公开(公告)日：2013-09-10

申请号：US12921445

申请日：2009-03-13

Applicant: John W. Runcie

Inventor： John W. Runcie

IPC: G01N21/64 ,  G01N21/01

CPC classification number: G01J1/044 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/635 ,  G01N2201/0627 ,  G01N2201/0648

Abstract: An automated shutter for dark acclimating a sample, comprising a base and a head mounted to the base and movable between an open and closed position. The automated shutter further comprises one or more artificial light sources and one or more optical detectors disposed in said head or base, and wherein the head is contiguous with the sample when moved into the closed position. Another embodiment comprises an enclosure placed over a sample to be dark acclimatized, with one or more artificial light sources and optical detectors disposed within or closely adjacent to said enclosure which is configured to be transformed between an optically transparent state and an optically opaque state.

Abstract translation: 一种用于暗适应样品的自动快门，包括基座和安装在基座上的头部，可在打开和关闭位置之间移动。 自动快门还包括一个或多个人造光源和设置在所述头部或底座中的一个或多个光学检测器，并且其中当移动到关闭位置时，头部与样品邻接。 另一个实施例包括放置在样本上以适应暗处的外壳，其中一个或多个人造光源和光学检测器设置在所述外壳内或紧邻所述外壳中，所述外壳被配置为在光学透明状态和光学不透明状态之间转换。

公开(公告)号：US06538735B1

公开(公告)日：2003-03-25

申请号：US09512707

申请日：2000-02-25

Applicant: Juerg Duebendorfer ,  Donald Jones ,  Kenneth Neumann ,  Chang Jin Wang

Inventor： Juerg Duebendorfer ,  Donald Jones ,  Kenneth Neumann ,  Chang Jin Wang

IPC: G01J330

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N2201/0648

Abstract: An apparatus for measuring light in samples using a high intensity light source, is presented. The system utilizes bifurcated fiber bundles to transmit light at the excitation and emission wavelength bands. It also uses a band-pass filter for eliminating extraneous light, including that which corresponds to the excitation wavelength range, while permitting the emitted light to pass to a detector for quantitation. The system employs a shutter to shield the detector while the laser light source is activated, and a controller to intermittently activate the laser light and close the shutter. The apparatus preferably includes lenses for better illumination and read out conditions. The apparatus is employed in Luminescence Oxygen Channeling Immunoassays. The method has high sensitivity, accuracy and precision, and the apparatus is highly compact. Accordingly, the analyzer can perform assays in nanoliter to microliter sample volumes in standard microplates having at least 96, 384 or 1536 wells.

Abstract translation: 提出了一种使用高强度光源测量样品中的光的装置。 该系统利用分叉光纤束在激发和发射波长带发射光。 它还使用带通滤波器来消除外来光，包括对应于激发波长范围的光，同时允许发射的光通过检测器进行定量。 该系统在激活激光光源时使用快门屏蔽检测器，并且控制器间歇地激活激光并关闭快门。 该装置优选地包括用于更好照明和读出条件的透镜。 该装置用于发光氧通道免疫测定。 该方法灵敏度高，精度高，精度高，装置高度紧凑。 因此，分析仪可以在具有至少96个，384个或1536个孔的标准微孔板中进行纳升至微升样品体积的测定。

公开(公告)号：US5223218A

公开(公告)日：1993-06-29

申请号：US179645

申请日：1988-04-08

Applicant: Masayoshi Fukuoka ,  Akira Matsuyuki

Inventor： Masayoshi Fukuoka ,  Akira Matsuyuki

IPC: G01N21/03 ,  G01N21/76

CPC classification number: G01N21/76 ,  G01N2021/0375 ,  G01N2201/0231 ,  G01N2201/0253 ,  G01N2201/0648

Abstract: An instrument for quantitative analysis includes two shutters, one of which prevents light from being introduced into a black box housing a cell holder from the outside through a port in which a cell may be placed in and taken out the black box, and the other of which prevents light from impinging on a photomultiplier tube which is in communication with the black box. The shutters are controlled by a control unit so that one of the shutters opens when the other closes. The instrument also includes detectors which detect whether or not the cell holder and the cell are disposed at predetermined positions, respectively. The detectors output signals to the control unit. The control unit controls an automatic pipetting device to restrict a sample from being introduced into the cell when both the cell holder and the cell are not disposed at the predetermined position.

公开(公告)号：US4213703A

公开(公告)日：1980-07-22

申请号：US910819

申请日：1978-05-30

Applicant: Otto Haunold ,  Malbone W. Greene

Inventor： Otto Haunold ,  Malbone W. Greene

IPC: G01N21/76 ,  G01N21/64 ,  G01N21/01

CPC classification number: G01N21/0332 ,  G01N21/763 ,  G01N2201/0648

Abstract: A sample holder and shutter assembly for photometers is disclosed in which a stationary sample chamber body is mounted in close proximity to a photosensitive device. A light path is provided from the sample chamber to the photosensitive device and shutter means is provided for selectively interrupting and opening the light path between the photosensitive device and the sample chamber without moving the sample chamber. Heat exchange means including a heat pump and a heat reservoir are provided for maintaining a desired temperature in the sample chamber. The sample chamber body is thermally connected to said heat pump and is preferably thermally isolated from the means mounting it. In one embodiment, the heat pump and heat reservoir are flexibly connected.

Abstract translation: 公开了一种用于光度计的样本保持器和快门组件，其中固定的样品室主体安装在感光装置附近。 从样品室到感光装置提供光路，并且提供快门装置，用于选择性地中断和打开感光装置和样品室之间的光路，而不移动样品室。 提供了包括热泵和储热器的热交换装置，用于保持样品室中所需的温度。 样品室主体热连接到所述热泵，并且优选地与安装它的装置热隔离。 在一个实施例中，热泵和储热器灵活地连接。