公开(公告)号：US20020142480A1

公开(公告)日：2002-10-03

申请号：US10056808

申请日：2002-01-25

Applicant: SURROMED, INC.

Inventor： Michael J. Natan

IPC: G01N021/62 ,  G01J003/44

CPC classification number: G01N21/658 ,  G01J3/44 ,  Y10T436/10 ,  Y10T436/13

Abstract: Surface-enhanced Raman spectroscopy (SERS) uses nanoscale metal particles (SERS-active particles) or surface roughness to enhance the Raman signal of Raman-active analytes contacting the surface. SERS sandwich particles contain SERS-active particles sandwiching a Raman-active substance and serve as optical tags. Preferably, the particles are rod-shaped, with each layer (SERS-active and Raman-active) formed as a distinct stripe of the particle. These freestanding particles can be derivatized with surface ligands capable of associating with analytes of interest in, for example, a biological sample. The acquired Raman spectrum of the particle encodes the identity of the ligand. Because of the simplicity and intensity of Raman spectra, highly multiplexed assays are capable using SERS particles with different Raman-active species.

Abstract translation: 表面增强拉曼光谱（SERS）使用纳米级金属颗粒（SERS-活性颗粒）或表面粗糙度来增强与表面接触的拉曼活性分析物的拉曼信号。 SERS夹心颗粒含有夹带拉曼活性物质的SERS活性颗粒并用作光学标签。 优选地，颗粒是棒状的，每个层（SERS-活性和拉曼活性）形成为颗粒的不同条纹。 这些独立颗粒可以用能够与例如生物样品中的感兴趣的分析物结合的表面配体进行衍生化。 所获得的该粒子的拉曼光谱编码配体的同一性。 由于拉曼光谱的简单性和强度，高度多重测定能够使用具有不同拉曼活性物质的SERS颗粒。

公开(公告)号：US20020123050A1

公开(公告)日：2002-09-05

申请号：US09876298

申请日：2001-06-07

Inventor： Vladimir Poponin

IPC: C12Q001/68 ,  C12M001/34 ,  G01J003/44

CPC classification number: C12Q1/6825 ,  C12Q2565/632

Abstract: The invention generally relates to a new gene probe biosensor employing near field surface enhanced Raman scattering (NFSERS) for direct spectroscopic detection of hybridized molecules (such as hybridized DNA) without the need for labels, and the invention also relates to methods for using the biosensor.

Abstract translation: 本发明一般涉及使用近场表面增强拉曼散射（NFSERS）的新型基因探针生物传感器，用于直接光谱检测杂交分子（如杂交DNA）而不需要标记，本发明还涉及使用生物传感器的方法 。

公开(公告)号：US20040169938A1

公开(公告)日：2004-09-02

申请号：US10795512

申请日：2004-03-09

Inventor： Yoshitaka Nakamura ,  Naoki Hikishima

IPC: G02B009/04 ,  G02B009/00 ,  G01J003/44

CPC classification number: H04M1/67 ,  G06K9/00046 ,  H04M1/0214

Abstract: A portable information terminal device comprising: an enclosure 180 of the portable information terminal device, an imaging element 143 provided within the enclosure 180, a first lens 141 provided within the enclosure 180 for the imaging element 143, a second lens 142, which focal length is shorter than that of the first lens, provided within the enclosure 180 for the imaging element 143, a lens selection means 180, provided within the enclosure 180, for selecting one of the first lens 141 and the second lens 142 so that a focal point of a selected lens is at the imaging element 143, and a transparent plate 122 for pressing a tip of a finger 131 of an user of the portable information terminal device, wherein the imaging element 143 captures fingerprint of the tip of the finger 131 on the transparent plate 122 by the second lens 142 selected by the lens selection means 180.

Abstract translation: 一种便携式信息终端设备，包括：便携式信息终端设备的外壳180，设置在外壳180内的成像元件143，设置在用于成像元件143的外壳180内的第一透镜141，第二透镜142， 比设置在用于成像元件143的外壳180内的第一透镜的透镜选择装置180短，该透镜选择装置180设置在外壳180内，用于选择第一透镜141和第二透镜142中的一个，使得焦点 所选择的透镜的位置在成像元件143处，以及用于按压便携式信息终端装置的用户的手指131的尖端的透明板122，其中成像元件143捕获手指131的尖端的指纹 透明板122由透镜选择装置180选择的第二透镜142。

公开(公告)号：US20040057040A1

公开(公告)日：2004-03-25

申请号：US10296581

申请日：2003-09-26

Inventor： Konrad Beckenkamp ,  Oliver Mandal ,  Karl Molt

IPC: G01J003/44 ,  G01N021/00

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/65

Abstract: The invention relates to a method for identifying chemical substances, comprising the following steps: analyzing a group of reference substances using a first method of analysis and a second, different method of analysis, especially NIR and Raman spectroscopy; storing the first and second sets of characteristic properties obtained for each reference substance and the combined sets of characteristic properties obtained by combining said first set and said second set, in a reference data base; analyzing the substance to be analyzed with the first and second methods of analysis; comparing the combined set of characteristic properties of the substance to be analyzed with the combined sets of the reference substances; identifying the substance to be analyzed with one of the reference substances when the similarity between the combined set of the substance to be analyzed and the combined set of exactly one reference substance, as established according to a set scale, exceeds a predetermined threshold value.

Abstract translation: 本发明涉及一种用于鉴定化学物质的方法，包括以下步骤：使用第一种分析方法和第二种不同的分析方法，特别是NIR和拉曼光谱分析一组参考物质; 存储对于每个参考物质获得的第一组和第二组特征特性以及通过组合所述第一组和所述第二组获得的组合的特征特征集合在参考数据库中; 用第一种和第二种分析方法分析待分析物质; 将待分析物质的特征性质的组合与参考物质的组合进行比较; 当要分析的物质的组合集合与根据设定比例确定的正好一个参考物质的组合集合之间的相似度超过预定阈值时，用其中一个参考物质鉴定待分析物质。

公开(公告)号：US20040042006A1

公开(公告)日：2004-03-04

申请号：US10450403

申请日：2003-06-13

Inventor： Peter Chen ,  Candace C. Joyner ,  Sheena T. Patrick ,  Dean R. Guyer

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2021/651 ,  G01N2021/653 ,  G01N2021/655

Abstract: A multiplex coherent Raman spectrometer (10) and spectroscopy method rapidly detects and identifies individual components of a chemical mixture separated by a separation technique, such as gas chromatography. The spectrometer (10) and method accurately identify a variety of compounds because they produce the entire gas phase vibrational Raman spectrum of the unknown gas. This is accomplished by tilting a Raman cell (20) to produce a high-intensity, backward-stimulated, coherent Raman beam of 683 nm, which drives a degenerate optical parametric oscillator (28) to produce a broadband beam of 1100-1700 nm covering a range of more than 3000 wavenumber. This broadband beam is combined with a narrowband beam of 532 nm having a bandwidth of 0.003 wavenumbers and focused into a heated windowless cell (38) that receives gases separated by a gas chromatograph (40). The Raman radiation scattered from these gases is filtered and sent to a monochromator (50) with multichannel detection.

公开(公告)号：US20030231306A1

公开(公告)日：2003-12-18

申请号：US10411193

申请日：2003-04-11

Inventor： Igor B. Gornushkin ,  James D. Winefordner ,  Ben W. Smith

IPC: G01J003/44 ,  G01J003/30

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N21/718

Abstract: The present invention approximates and automatically subtracts continuum backgrounds in laser-induced breakdown (LIBS) and Raman spectra measured by non-gated detectors. Significantly, reference spectra are not used to determine background positioning in the present invention. The present invention approximates a spectral continuum by determining a plurality of minima in the spectral data; splitting the spectral data into a predetermined number of groups N; for each group of spectral data, determining major minima for the group, and calculating an average and a standard deviation for the determined major minima; determining a polynomial function that can be drawn through the major minima of all groups; for each group of spectral data, determining minor minima; calculating an average deviation (nullN) between this polynomial function and the determined minor minima; reducing the number of groups, and repeating this process for the reduced number of groups until a minimum number of groups is reached. Then, the least nullN corresponding to an optimal number of groups Nopt is determined. The spectral data is split into Nopt groups; and a polynomial function that can be drawn through both the major minima and minor minima is determined for Nopt groups. This polynomial function approximates the spectral continuum.

Abstract translation: 本发明近似并且自动地减去激光诱发击穿（LIBS）中的连续谱和由非门控检测器测量的拉曼光谱。 重要的是，参考光谱不用于确定本发明的背景定位。 本发明通过确定光谱数据中的多个最小值近似光谱连续谱; 将光谱数据分解成预定数量的组N; 对于每组光谱数据，确定组的主要最小值，并计算所确定的主要最小值的平均值和标准偏差; 确定可以通过所有组的主要最小值绘制的多项式函数; 对于每组光谱数据，确定次要最小值; 计算该多项式函数与确定的次要最小值之间的平均偏差（PhiN）; 减少组的数量，并重复此过程以减少组数，直到达到最小组数。 然后，确定对应于组Nopt的最佳数量的最小PhiN。 光谱数据分为Nopt组; 并且可以为Nopt组确定可以通过主要最小值和次要最小值绘制的多项式函数。 该多项式函数近似于光谱连续谱。

公开(公告)号：US20030147066A1

公开(公告)日：2003-08-07

申请号：US10339584

申请日：2003-01-09

Inventor： Richard David Bruce

IPC: G01N021/00 ,  G01J003/44

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2021/656 ,  Y10S977/853 ,  Y10S977/881

Abstract: This invention relates to a method and apparatus for the analysis of pharmaceutical specimens by nondestructively obtaining the molecular data for a chemical component on the surface or within the matrix of a pharmaceutical specimen.

Abstract translation: 本发明涉及一种用于通过非破坏性地获得药物样品表面或基质内的化学成分的分子数据来分析药物样品的方法和装置。

公开(公告)号：US20030142302A1

公开(公告)日：2003-07-31

申请号：US10346540

申请日：2003-01-17

Inventor： Yanan Jiang

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/65 ,  G01N21/6458 ,  G01N2021/656 ,  G01N2201/0221 ,  G02B21/241

Abstract: A portable spectral imaging microscope includes a probe head coupled via fiber optic cabling to a laser source and to a spectrograph. The probe head is coupled to a position controller that is mounted on a base suitable for positioning adjacent to a sample. The position controller has five degrees of freedom that permits one to adjust the position and direction of the probe head relative to the sample over a wide range of dimensions and angles. The entire probe head can be easily moved in order to precisely align the objective lens to stationary samples for simultaneous viewing and spectral analysis.

Abstract translation: 便携式光谱成像显微镜包括通过光纤布线耦合到激光源和光谱仪的探头。 探针头连接到位置控制器，该位置控制器安装在适于邻近样品定位的基座上。 位置控制器具有五个自由度，允许在宽范围的尺寸和角度上相对于样品调节探头的位置和方向。 可以容易地移动整个探针头，以便将物镜精确地对准固定的样品，以便同时进行观察和光谱分析。

公开(公告)号：US20030123057A1

公开(公告)日：2003-07-03

申请号：US10235922

申请日：2002-09-06

Inventor： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Orn Almarsson ,  Christopher McNulty

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

Abstract: Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

Abstract translation: 描述了允许高通量制备，处理和研究样品阵列的系统和方法，每个样品包含至少一种化合物。 本发明的具体实施方案允许在由毫克或微克数量的化合物上的一种或多种化合物组成的样品上并行进行大量实验。 本发明的其它实施例包括用于快速筛选这些实验的结果的方法和装置，以及用于快速确定阵列中的样品组之间是否存在相似性的方法和装置。 本发明的具体实施方案包括用于高通量制备不同形式的化合物（例如不同结晶形式）的方法和装置，用于发现新形式的旧化合物，以及发现生产此类形式的新方法。 本发明的实施方案还允许高通量测定当化合物或形式的化合物在暴露于其它化学物质或环境条件时的表现。

公开(公告)号：US20030081205A1

公开(公告)日：2003-05-01

申请号：US10247269

申请日：2002-09-18

Applicant: Deutsches Zentrum fuer Luft-und Raumfahrt e.V.

Inventor： Manfred Klose

IPC: G01J003/44

CPC classification number: G01N21/65

Abstract: In order to improve a method of analyzing SinullGe alloys, with which a Raman spectrum of a sample is recorded and Raman frequencies and Raman intensities of the SinullSi modes and the SinullGe modes of the alloy layer are evaluated, such that any strain and any Ge portion in an alloy layer can be ascertained in a simple and as exact a manner as possible, it is provided for one or more spectrum contributions lying outside the SinullGe modes and the SinullSi modes to be evaluated as oscillation modes.

Abstract translation: 为了改进分析记录样品的拉曼光谱的Si-Ge合金的分析方法，并评价合金层的Si-Si模式和Si-Ge模式的拉曼频率和拉曼强度，使得 可以以简单且尽可能准确的方式确定合金层中的任何应变和任何Ge部分，提供位于Si-Ge模式之外的一个或多个光谱贡献，并且Si-Si模式被评估为 振荡模式。