公开(公告)号：EP0642325B1

公开(公告)日：1998-01-21

申请号：EP93915127.0

申请日：1993-05-26

Applicant: RAM, Michael J. ,  Kalb, Irvin M. ,  SHAW, Robert H.

Inventor： RAM, Michael J. ,  Kalb, Irvin M. ,  SHAW, Robert H.

IPC: A61F2/00

CPC classification number: A61B5/14539 ,  A61B5/14507 ,  A61B5/201 ,  A61B5/202 ,  A61F2/0009

Abstract: A system for controlling drainage of the female bladder comprising a valved catheter (10), a stylet for placing the catheter in the female urethra (30), and a spike (60) for opening the valve (24) in the catheter to allow voiding of the contents of the bladder. The system also includes a sizing device (50) for determining the length of the urethra so that the proper fitting catheter is used. The catheter (10) comprises a hollow shaft (12) with an extendable sealing portion (18) on one end for placement through the urethra and a crown (18) on the other end for placement external of the body. The valve (24, 90) may be integral with the shaft or insertable after the catheter is placed in the urethra.

公开(公告)号：EP0656762A4

公开(公告)日：1996-10-30

申请号：EP94918206

申请日：1994-06-03

Applicant: PRINCE MARTIN R

Inventor： PRINCE MARTIN R

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/201 ,  A61B5/411 ,  A61B5/7285 ,  A61K49/18 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of a magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate.

公开(公告)号：EP0364216B1

公开(公告)日：1996-01-17

申请号：EP89310355.6

申请日：1989-10-10

Applicant: GYRUS MEDICAL LIMITED

Inventor： Goble, Nigel Mark ,  Goble, Colin Charles Owen

IPC: A61B5/20

CPC classification number: A61B5/201 ,  A61B5/14507

公开(公告)号：EP0118066A1

公开(公告)日：1984-09-12

申请号：EP84101670.2

申请日：1984-02-17

Applicant: Sterimed Gesellschaft für medizinischen Bedarf mbH

Inventor： Nagorski, Klaus-Peter ,  Kramann, Bernhard, Prof. Dr.

IPC: A61F5/44 ,  A61B5/00

CPC classification number: A61B5/201 ,  A61B5/208 ,  A61F5/44

Abstract: Es wird ein Sekretbeutel für medizinische Zwecke mit Einlaufröhrchen beschrieben, dessen Beutel (1) eine oder mehrere Meßkammern (4,4a, 4b ...) mit Feinmeßgraduierungen (7, 7a, 7b, ...) aufweist, wobei diese Meßkammern so angeordnet sind, daß sie bei Sekretzulauf nacheinander beschickt werden. Der Sekretzufluß pro Zeiteinheit kann so ohne besondere zusätzliche Einrichtungen einfach bestimmt werden.

Abstract translation: 所述袋（1）设置有具有精密测量刻度（7,7a，7b ...）的一个或多个测量室（4,4a，4b ...）; 这些测量室被布置成在分泌物到达时一个接一个地供应。 因此，可以容易地确定每个时间单位的分泌物的附着，而不使用任何特定的附加装置。

公开(公告)号：EP0073156A1

公开(公告)日：1983-03-02

申请号：EP82304426.8

申请日：1982-08-23

Applicant: Leveen, Eric G. ,  LeVeen, Robert F.

Inventor： Leveen, Eric G. ,  LeVeen, Robert F.

IPC: A61B5/20

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61B5/208 ,  G01F3/38

Abstract: There is disclosed an apparatus which measures the output of urine optically, may totalize it and may print it on a seif-adherent,paper which can easily be affixed to the hospital chart.
The apparatus (10) comprises a collection means (30) and a control means (20), said collection means comprising catheter coupler means (35), said catheter coupler means ' being adapted to couple to said catheter; measurement column means (40) coupled to said catheter coupler means, said measurement column means being adapted to retain said urinary output for optical measurement; optical sensor means (41, 42, 43, 44) positioned adjacent to said measurement column means, said optical sensor means being adapted to determine when said measurement column means has a predetermined amount of liquid therein; pump means (50) coupled to said measurement column means, said pump means being adapted to remove urinary output from the measurement column means at a known rate of flow; collection bag means (90) communicating with said measurament column means, said control means comprising control logic means and clock means, said control logic means being coupled to said optical sensor means, said pump means and said clock means, said control logic means being adapted to periodically empty said measurement column means by operation of said pump means to compute the periodic flow of urinary output and to direct the output of said pump means to said collection bag means.

Abstract translation: 公开了一种以光学方式测量尿液输出的装置，可以将其整合并将其印刷在可以容易地固定在医院图表上的自粘纸上。 装置（10）包括收集装置（30）和控制装置（20），所述收集装置包括导管联接装置（35），所述导管联接装置适于联接到所述导管; 测量柱装置（40），耦合到所述导管耦合装置，所述测量柱装置适于保持所述尿液输出用于光学测量; 位于邻近所述测量柱装置的光学传感器装置（41,42,43,44），所述光学传感器装置适于确定何时所述测量柱装置在其中具有预定量的液体; 耦合到所述测量柱装置的泵装置（50），所述泵装置适于以已知的流量从测量柱装置中去除尿液输出; 收集袋装置（90）与所述测量列装置通信，所述控制装置包括控制逻辑装置和时钟装置，所述控制逻辑装置耦合到所述光学传感器装置，所述泵装置和所述时钟装置，所述控制逻辑装置适于 通过所述泵装置的操作来周期性地清空所述测量柱装置，以计算尿液输出的周期性流量并将所述泵装置的输出引导到所述收集袋装置。

公开(公告)号：WO2018058077A1

公开(公告)日：2018-03-29

申请号：PCT/US2017/053337

申请日：2017-09-25

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： BIRD, Victoria Y. ,  ANDERSEN, Brandey L. ,  ZIEGLER, Kirk ,  KULKARNI, Anniruddah

IPC: A61B5/145 ,  A61B10/00 ,  G01N33/84 ,  G01N21/80 ,  G01N33/553

CPC classification number: G01N33/84 ,  A61B5/14507 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/207 ,  A61B10/007 ,  A61B2010/0006 ,  G01N21/554 ,  G01N21/80 ,  G01N33/587 ,  G01N2021/775 ,  G01N2021/7763

Abstract: Devices equipped with one or more sensors to detect pH changes or presence of nitrite in a fluid are disclosed herein. Specifically exemplified, are urinary catheter systems that are capable of detection pH and nitrite concentration changes in urine. Also disclosed are new hydrogel compositions that are capable of providing colorimetric changes in response to pH and nitrite concentration levels in a fluid to which the compositions are exposed.

Abstract translation: 本文公开了配备有一个或多个传感器以检测流体中的pH变化或亚硝酸盐的存在的装置。 具体例示的是能够检测尿液中的pH和亚硝酸盐浓度变化的导尿管系统。 还公开了新的水凝胶组合物，其能够响应组合物暴露于其中的流体中的pH和亚硝酸盐浓度水平而提供比色变化。

公开(公告)号：WO2017136362A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/015887

申请日：2017-01-31

Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

Inventor： TRUDEL, Julia ,  HETTRICK, Douglas

IPC: A61B5/00 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/053 ,  A61B5/01 ,  A61B5/20 ,  G06F19/00 ,  A61N1/36

CPC classification number: A61B5/4848 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0285 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/6851 ,  A61B5/7232 ,  A61B18/1492 ,  A61B2018/00577 ,  A61M25/0026 ,  A61N1/3606 ,  A61N1/36114 ,  A61N5/045 ,  A61N5/0622 ,  A61N7/02 ,  A61N2007/0026 ,  G06F19/00 ,  G06F19/34

Abstract: Systems and methods for informing and evaluating neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a guidewire having a proximal portion, a distal portion configured to be positioned at a target site in a blood vessel of a human patient, and a sensing element positioned along the distal portion. The sensing element can be a pressure sensing element, a flow sensing element, an impedance sensing element, and/or a temperature sensing element. The system can further include a controller configured to obtain one or more measurements related to a physiological parameter of the patient via the sensing element. Based on the measurements, the controller can determine the physiological parameter and compare the parameter to a predetermined threshold. Based on the comparison, the controller and/or the operator can assess the likelihood of the patient benefitting from neuromodulation therapy.

Abstract translation: 本文公开了用于通知和评估神经调节疗法的系统和方法。 根据本技术的实施例配置的系统可以包括例如导丝，该导丝具有近侧部分，被配置为定位在人类患者的血管中的目标位置处的远侧部分以及沿着 远端部分。 感测元件可以是压力感测元件，流量感测元件，阻抗感测元件和/或温度感测元件。 该系统还可以包括控制器，该控制器被配置为经由感测元件获得与患者的生理参数有关的一个或多个测量值。 基于测量结果，控制器可以确定生理参数并将该参数与预定阈值进行比较。 基于比较，控制器和/或操作员可以评估患者从神经调节疗法中受益的可能性。

公开(公告)号：WO2017021971A1

公开(公告)日：2017-02-09

申请号：PCT/IL2016/050855

申请日：2016-08-04

Applicant: ART HEALTHCARE LTD.

Inventor： ELIA, Liron ,  IDDAN, Gavriel J.

IPC: A61B5/20 ,  A61M5/168

CPC classification number: A61B5/208 ,  A61B5/14507 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/201 ,  A61B5/412 ,  A61B5/743 ,  A61B5/746 ,  A61B5/7475 ,  A61B2562/0295 ,  A61M25/0017

Abstract: There is provided a urine analysis device for bed side monitoring of a patient, comprising: an inlet sized and shaped for fluid communication with a urine collecting tube that receives urine from a patient; a drip chamber through which the urine flows towards an outlet; at least one sensor that analyzes each drop of urine and estimates a respective volume of each drop; a timing element that measures a reference time for each drop; a program store storing code; and at least one processing unit coupled to the program store for implementing the stored code, the code comprising: code to calculate a urine output flow rate of the urine output flowing through the chamber according to the estimated volume of each drop of the urine and the reference time for each drop; and code to output the urine output flow rate.

Abstract translation: 提供了一种用于患者的床侧监测的尿液分析装置，包括：入口，其大小和形状用于与从尿管接收尿液的尿液收集管流体连通; 滴水室，尿液通过其流向出口; 至少一个传感器，其分析每一滴尿液并估计每个液滴的相应体积; 测量每一滴的参考时间的定时元件; 程序存储代码; 以及至少一个处理单元，其耦合到所述程序存储器以实现所存储的代码，所述代码包括：根据每一滴尿液的估计体积计算流过所述腔室的尿液输出的尿液输出流量的代码， 每滴参考时间; 并输出尿液输出流量的代码。

公开(公告)号：WO2016022437A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/043317

申请日：2015-07-31

Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

Inventor： NADKARNI, Girish ,  GOTTESMAN, Omri ,  ELLIS, Stephen Bartlett ,  BOTTINGER, Erwin P.

IPC: G06F19/00

CPC classification number: G16H50/20 ,  A61B5/201 ,  A61B5/7275 ,  A61B2218/00 ,  G06F19/00 ,  G06F19/324 ,  G16H10/60

Abstract: An example method of diagnosing chronic kidney disease (CKD) includes obtaining an electronic medical record for a patient having medical data. The medical data includes an indication if the patient had been previously diagnosed with CKD, an indication if the patient had previously undergone a kidney transplant, an indication if the patient had previously undergone a renal dialysis procedure, an indication if the patient had previously been diagnosed with another type of kidney disease, one or more glomerular filtration rate (GFR) measurements associated with the patient, an indication if the patient has type 2 diabetes, and/or an indication if the patient has hypertension. The method also includes automatically determining that the patient has CKD or does not have CKD based on the medical data in the electronic record.

Abstract translation: 诊断慢性肾脏疾病（CKD）的示例性方法包括获得具有医疗数据的患者的电子病历。 医学数据包括患者以前是否曾被诊断患有CKD的指征，患者以前是否接受了肾移植的指征，患者以前是否接受过肾透析手术的指征，患者以前是否被诊断过的指示 与另一种类型的肾脏疾病，与患者相关联的一种或多种肾小球滤过率（GFR）测量，患者是否具有2型糖尿病的指征，和/或患者是否具有高血压的指征。 该方法还包括基于电子记录中的医疗数据自动确定患者具有CKD或不具有CKD。

公开(公告)号：WO2015138702A1

公开(公告)日：2015-09-17

申请号：PCT/US2015/020140

申请日：2015-03-12

Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL ,  MOLITORIS, Bruce, A. ,  WANG, Exing ,  SANDOVAL, Ruben, M.

Inventor： MOLITORIS, Bruce, A. ,  WANG, Exing ,  SANDOVAL, Ruben, M.

IPC: G01N33/49 ,  A61K49/10 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61K49/0054 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/4875 ,  A61B5/4881 ,  A61K49/0041

Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV-TVPV.

Abstract translation: 本发明一般涉及动物受试者体液体积的测量。 感兴趣的体液体积包括细胞外液体积（ECFV），总血管血浆体积（TVPV）和间质液体体积（IFV）。 这些方法对于患有肾功能衰竭的受试者尤其是肾透析患者特别有益。 可以通过施用第一分子来测量ECFV，所述第一分子是血管系统的血管壁的非代谢和可渗透的，其中第一分子分布在总血管空间以及间质空间内。 TVPV可以通过施用第二分子来测量，所述第二分子是非代谢的并且不渗透血管系统的血管壁，其中第二分子仅分布在血管空间内。 然后可以使用IFV = ECFV-TVPV等式计算IFV。