公开(公告)号：WO1986003114A1

公开(公告)日：1986-06-05

申请号：PCT/US1985002334

申请日：1985-11-27

Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  EUTECTIC ELECTRONICS, INC. ,  HUTCHESON, Stanford, J. ,  LUTZ, Richard, W. ,  OBRIST, Paul ,  FLAUGHER, David, J. ,  WATTS, Charles, E.

Inventor： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  EUTECTIC ELECTRONICS, INC.

IPC: A61B05/02

CPC classification number: A61B5/02208

Abstract: A portable computer-based blood pressure monitoring system automatically measures heart rate and blood pressure using the auscultatory method. Measurements are performed at random time intervals to prevent the subject from affecting his blood pressure and heart rate due to the expected onset of measurement. Data representative of Korotkoff sounds and corresponding applied cuff pressures is stored in both digital form in a semiconductor random access memory (132) and in analog form on a serial magnetic tape recorder (112). The system automatically maintains occluding cuff pressure constant for a predetermined period after cuff inflation before performing measurements to prevent pneumatic ringing from affecting blood pressure measurements. After cuff deflation, values are derived which are representatives of the average of the highest Korotkoff sound level peaks and the average of all Korotkoff sound level peaks and serve to define a threshold value in relation to which the points of systolic and diastolic pressure measurements are determined.

Abstract translation: 基于便携式计算机的血压监测系统使用听诊方法自动测量心率和血压。 以随机时间间隔进行测量，以防止受试者由于预期的测量开始而影响他的血压和心率。 代表Korotkoff声音的数据和相应应用的袖带压力以数字形式存储在半导体随机存取存储器（132）中，并以模拟形式存储在串行磁带录像机（112）上。 在执行测量之前，系统在袖带充气之后的预定时间段内自动保持闭塞袖带压力恒定，以防止气动振铃影响血压测量。 袖带通缩后，导出值，这些值代表Korotkoff最高声级峰值的平均值和所有Korotkoff声级峰值的平均值，并用于定义相对于其中确定收缩压和舒张压测量点的阈值 。

公开(公告)号：WO1986000209A1

公开(公告)日：1986-01-16

申请号：PCT/US1985001120

申请日：1985-06-17

Applicant: NORSE INSTRUMENTS, INC.

Inventor： NORSE INSTRUMENTS, INC. ,  LINK, William, Trevor

IPC: A61B05/02

CPC classification number: A61B5/021 ,  A61B5/02108

Abstract: Techniques for determining different parameters associated with an individual's blood pressure in a non-invasive manner. These techniques include generating a blood pressure waveform (16') corresponding to the individual's actual waveform whereby the mean blood pressure of the individual can be readily calculated. This is accomplished by either using a specifically selected cuff pressure (10m') or by ramping the cuff pressure as would be done in taking blood pressure.

Abstract translation: 用于以非侵入性方式确定与个体血压相关的不同参数的技术。 这些技术包括产生对应于个人实际波形的血压波形（16'），从而可以容易地计算个体的平均血压。 这可以通过使用专门选择的袖带压力（10m'）或通过使血压压力升高来实现，就像在服用血压时所做的那样。

公开(公告)号：WO1986000208A1

公开(公告)日：1986-01-16

申请号：PCT/US1985001119

申请日：1985-06-17

Applicant: NORSE INSTRUMENTS, INC.

Inventor： NORSE INSTRUMENTS, INC. ,  LINK, William, Trevor

IPC: A61B05/02

CPC classification number: A61B5/021 ,  A61B5/02116

Abstract: A technique for generating certain arterial blood pressure related curves V/P and dV/dP (42, 43) of a given individual using cuff pressure peak to peak values (curve 40). This is accomplished using only these latter values and the individuals diastolic and systolic blood pressures.

Abstract translation: 使用袖带压力峰值到峰值产生给定个体的某些动脉血压相关曲线V / P和dV / dP（42,43）的技术（曲线40）。 这只是使用这些后续值和个体舒张压和收缩压来实现的。

公开(公告)号：WO1985003855A1

公开(公告)日：1985-09-12

申请号：PCT/US1985000295

申请日：1985-02-25

Applicant: OPTICAL TECHNOLOGIES, INC. ,  EINZIG, Robert, E.

Inventor： OPTICAL TECHNOLOGIES, INC.

IPC: A61B05/02

CPC classification number: A61B5/6853 ,  A61B5/0261 ,  G01F1/363 ,  G01F1/661 ,  G01L11/025

Abstract: An optical fiber fluid flow device is provided for in vivo determination of blood flow in arteries. The device includes a fiber optical fluid pressure measuring device having at least first and second optical fiber sensors which optical fiber sensors are positioned in the blood passage and in a restricted flow area in the blood passage and the two fiber optical pressure fluid sensors are connected to an interferometer associated with an opto-electronic demodulator which has an output signal representing the differential pressure between the two sensed areas. The device also has utility in industrial applications.

Abstract translation: 提供一种光纤流体流动装置，用于体内测定动脉血流量。 该装置包括具有至少第一和第二光纤传感器的光纤流体压力测量装置，光纤传感器位于血液通道中并且在血液通道中的限制流动区域中，并且两个光纤压力流体传感器连接到 与光电解调器相关联的干涉仪，其具有表示两个感测区域之间的压差的输出信号。 该器件还可在工业应用中实现。

公开(公告)号：WO1984002641A1

公开(公告)日：1984-07-19

申请号：PCT/US1983002031

申请日：1983-12-27

Applicant: PORGES, Stephen, W.

IPC: A61B05/02

CPC classification number: A61B5/4362 ,  A61B5/02411 ,  H03H17/02

Abstract: A method and apparatus for detecting amplitude variations in the rhythmic oscillations of a physiological response pattern in a frequency range of interest. A sensor (1) is used to detect an occurrence of an event in the cycle of a physiological response and the interval between each reoccurring event is timed and placed in a buffer (9). The output from the buffer (9) is read out at predetermined time intervals and fed to a filter (90) which determines the aperiodic portion of the signal and substracts that aperiodic portion to output a residual data signal. The residual data signal is fed to a band pass filter (94) which filters in a region determined by the predetermined frequency range of interest and which outputs to a calculation and display device (96) wherein the variance of the rhythmic oscillation is calculated and displayed.

公开(公告)号：WO1982004182A1

公开(公告)日：1982-12-09

申请号：PCT/SE1982000187

申请日：1982-05-26

Applicant: KAROLINSKA INST ,  HALLEN BOERJE ,  RIBBE TOMMY ,  LINNARSSON DAG

Inventor： KAROLINSKA INST

IPC: A61B05/02

CPC classification number: A61B7/023 ,  A61B5/02055 ,  A61B5/0421

Abstract: A monitoring probe of tubular cross-section is arranged to be inserted into the oesophagus of a patient and there temporarily orientated during, for example, surgical work. The probe is provided with means for monitoring and indicating one or more functions or conditions of the body of the patient. Indicating means for indicating the body functions via conductors form together with the probe casing an inseparable unit, and the indicating means are arranged within an area determined by the cylindrical outer surface of the probe. The heart functions are arranged to be monitored and externally indicated by an accelerometer which is arranged in a damping fluid and which is also operative to monitor lung sound, and by two mutually spaced electrodes, each electrode and the accelerometer forming separate units, each of which is connected to the plastic casing of the probe in a manner such as to be inseparable therefrom, and in that a thermistor is arranged within the probe.

Abstract translation: 管状横截面的监测探针被布置成插入到患者的食道中，并且在例如外科手术期间临时定向。 探针设置有用于监测和指示患者身体的一个或多个功能或状况的装置。 用于通过导体指示身体功能的指示装置与探针套管一起形成不可分离的单元，并且指示装置布置在由探针的圆柱形外表面确定的区域内。 心脏功能被布置成被加速度计监测和外部指示，加速度计布置在阻尼流体中并且还可操作以监测肺声，并且通过两个相互间隔开的电极，每个电极和加速度计形成分离的单元，每个单元 以与其不可分离的方式连接到探针的塑料外壳，并且热敏电阻布置在探针内。

公开(公告)号：WO1982001642A1

公开(公告)日：1982-05-27

申请号：PCT/US1981001526

申请日：1981-11-17

Applicant: ULTRA MED INC

Inventor： ULTRA MED INC ,  RASOR JULIA S ,  TICKNER ERNEST G

IPC: A61B05/02

CPC classification number: A61K49/223 ,  A61B8/06 ,  A61B8/481

Abstract: Des micro-bulles sont formees dans un liquide, p.ex. du sang de maniere a modifier leurs caracteristiques de transmission en ondes electromagnetiques et soniques transmises au travers de celui-ci, en dissolvant dans le sang un materiau particulaire solide, de preference une suspension dans un liquide porteur dans lequel le materiau particulaire est au moins temporairement stable, et dont les particules sont sensiblement exemptes de micro-bulles et ont une pluralite de vides remplis de gaz communiquant avec la surface des particules et constituant des noyaux pour la formation des micro-bulles, le rapport entre la masse des particules et le volume de gaz dans les vides etant suffisant pour rendre le liquide dans lequel le materiau particulaire est dissout supersature par rapport au gaz se trouvant dans les vides dans la zone du liquide entourant les micro-bulles lorsqu'elles sont formees.

Abstract translation: 微泡形成在液体中，例如血液中，以便通过将固体颗粒材料，优选作为悬浮液溶解在其中颗粒材料至少为载体的载体液体中，将透射特性改变为透过其的电磁波和声波 暂时稳定，其颗粒基本上不含微泡，并且具有与颗粒表面连通的多个气体填充空隙，并提供用于微泡形成的核，并且颗粒质量与气泡体积的比率 当形成微泡的液体区域中的空隙中的气体时，空隙足以使颗粒材料溶解过的液体过饱和。

公开(公告)号：WO1981003606A1

公开(公告)日：1981-12-24

申请号：PCT/EP1981000063

申请日：1981-06-05

Applicant: HYNDMAN B

IPC: A61B05/02

CPC classification number: A61B5/02241 ,  A61B5/02433 ,  A61B5/0285

Abstract: A non-invasive continuous blood pressure meter that reproduces the arterial blood pressure waveform, comprising an inflatable flexible finger cuff (2) which incorporates an infrared transmitter (3) and receiver (5), and electronic circuitry (20) connected to the transmitter and receiver and controlling a dynamic compressor (18). The dynamic compressor (18) comprises a bellows (10) which is compressed by a linear motor (8), electrically activated by the electronics (20). The bellows (10) is connected to the inflatable cuff (2) by a flexible tube (14), to which is also attached an electronic pressure transducer (15), in such a way that the hollow spaces of the bellows (10), tubing (14), electronic pressure transducer (15), and cuff (2), form one complete closed air-filled space. When the inflatable cuff (2) is wound around the finger (1) and the electronics (20) are properly adjusted, the signal from the electronic pressure transducer (15) will very nearly correspond to instantaneous arterial blood pressure.

Abstract translation: 一种非侵入式连续血压计，其再现动脉血压波形，包括包含红外发射器（3）和接收器（5）的可充气柔性指套（2）和连接到发射器的电子电路（20） 接收器和控制动态压缩机（18）。 动态压缩机（18）包括由线性电机（8）压缩的波纹管（10），由电子器件（20）电激活。 波纹管（10）通过柔性管（14）连接到可充气箍（2），柔性管（14）也附接有电子压力传感器（15），使得波纹管（10）的中空空间， 管道（14），电子压力传感器（15）和袖带（2），形成一个完全封闭的空气填充空间。 当可充气袖带（2）缠绕在手指（1）周围并且电子装置（20）被适当地调节时，来自电子压力传感器（15）的信号将几乎对应于瞬时动脉血压。

公开(公告)号：WO1981002664A1

公开(公告)日：1981-10-01

申请号：PCT/US1981000402

申请日：1981-03-30

Applicant: UNIVERSITY PATENTS INC

Inventor： UNIVERSITY PATENTS INC ,  APPLE H ,  DAUCHOT P

IPC: A61B05/02

CPC classification number: A61B7/023 ,  A61B5/037 ,  A61M25/1002 ,  A61M25/1011

Abstract: An esophageal cardiac pulse probe (10) includes a lumen (12) for insertion into the esophagus, the end of the lumen preferably being closed by a flexible diaphragm (24). Pressure variations imparted to the fluid within the lumen in response to sounds from the heart and the lungs are transmitted to an electrical transducer (46) which produces an electrical signal proportional to the time-varying frequency and intensity of the pressure variations. This signal is selectively filtered (60, 62) to effectively eliminate signal components due to respiratory noise and audible heart sounds and the resulting signal is fed to an appropriate visual display apparatus (68). Direct acoustic cardiac sound monitoring is also achievable with an earpiece (50) connected to the lumen (12). Several probe geometries and a method of cardiac pulse waveform monitoring are also disclosed.

公开(公告)号：WO1980000005A1

公开(公告)日：1980-01-10

申请号：PCT/JP1979000143

申请日：1979-06-07

Applicant: MATSUSHITA ELECTRIC WORKS LTD ,  YAMAMURA Y ,  ICHINOMIYA T ,  TERASHIMA O

Inventor： MATSUSHITA ELECTRIC WORKS LTD

IPC: A61B05/02

CPC classification number: A61B5/02208 ,  A61B5/02233

Abstract: A blood pressure measurement system includes a cuff, an automatic inflation-deflation device for supplying compressed air to the cuff, electronic circuits for discriminating Korotokov sounds, and display means for indicating both the maximum (systolic) and minimum (diastolic) values of blood pressure. The cuff is divided into two portions, namely a blood choking cuff portion and a sound collecting cuff portion. The variation of air pressure in the sound collecting cuff portion may be detected by a microphone sensor which is provided outside the cuff. The detected sounds are once separated into Korotokov sounds and heart sounds. Then both sounds are compared to confirm the simultaneous occurrence. These coincident sounds may be judged to be Korotokov sounds and used to measure blood pressure.

Abstract translation: 血压测量系统包括袖带，用于向压缩袋供应压缩空气的自动充气 - 放气装置，用于鉴别Korotokov声音的电子电路和用于指示血压的最大（收缩）和最小（舒张）值两者的显示装​​置 。 袖带被分成两部分，即血液阻塞箍部分和收集胶囊部分。 收集袖带部分中的空气压力的变化可以由提供在袖带外部的麦克风传感器来检测。 检测到的声音曾经被分离成Korotokov的声音和心脏的声音。 然后将两个声音进行比较以确认同时发生。 这些重合的声音可能被判断为Korotokov声音，并用于测量血压。