公开(公告)号：WO1994018974A1

公开(公告)日：1994-09-01

申请号：PCT/US1993001359

申请日：1993-02-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ARNERIC, Stephen, P. ,  DECKER, Michael, W.

IPC: A61K31/445

CPC classification number: A61K31/445 ,  A61K31/465 ,  A61K2300/00

Abstract: Pharmaceutical compositions comprising a therapeutically effective amount of (+) 2-methylpiperidine and a pharmaceutically-acceptable carrier or diluent, as well as to a method of treating cognitive, neurological and mental disorders, which are characterized by decreased cholinergic function in humans and lower mammals, by administration of (+) 2-methylpiperidine, optionally with a nicotinic agonist.

Abstract translation: 包含治疗有效量的（+）2-甲基哌啶和药学上可接受的载体或稀释剂的药物组合物，以及治疗认知，神经和精神障碍的方法，其特征在于人和下部哺乳动物中的胆碱能功能降低 ，通过（+）2-甲基哌啶的给药，任选地与烟碱激动剂。

公开(公告)号：WO1994016226A1

公开(公告)日：1994-07-21

申请号：PCT/US1993012439

申请日：1993-12-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ABRAHAMSON, Kent, D. ,  OGDEN, John, E.

IPC: F04B43/02

CPC classification number: A61M39/04 ,  A61M5/14224 ,  A61M2205/12

Abstract: A solution pumping system (10) including a disposable pump cassette (12) is disclosed, with the system configured for efficient and accurate preparation of parental admixture solutions. The system includes a pump driver (14) having a reciprocable pump plunger (36) and a plurality of associated valve actuators (32, 34). The disposable pump cassette of the system is configured for removable positioning in operative association with the pump driver, and includes a positive displacement pump (31) configured for operation by the reciprocable pump plunger (36). The pump cassette further includes a plurality of liquid inlets (24), and at least one liquid outlet (26) joined in fluid communication with the inlets. By selective operation of the valve actuators of the pump driver, one or more selected source solutions are drawn through the pump inlets by the positive displacement pump, and directed through the pump outlet to an admixture solution container.

Abstract translation: 公开了一种包括一次性泵盒（12）的溶液泵送系统（10），该系统被配置为有效和准确地制备亲本混合物溶液。 该系统包括具有可往复泵柱塞（36）和多个相关联的阀致动器（32,34）的泵驱动器（14）。 系统的一次性泵盒被构造成与泵驱动器可操作地关联的可拆卸定位，并且包括构造成用于可往复运动的泵柱塞（36）的操作的容积式泵（31）。 泵盒还包括多个液体入口（24）和与入口流体连通的至少一个液体出口（26）。 通过泵驱动器的阀致动器的选择性操作，通过正排量泵将一个或多个选定的源解决方​​案通过泵入口抽吸，并通过泵出口引导到混合溶液容器。

公开(公告)号：WO1994015942A1

公开(公告)日：1994-07-21

申请号：PCT/US1993012560

申请日：1993-12-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SARTHY, Aparna, V. ,  SCHOPP, Cynthia, W.

IPC: C07H17/00

CPC classification number: C12N9/0089 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/61 ,  C12N9/0006 ,  C12N15/81 ,  C12N2795/10022 ,  C12Y101/01014

Abstract: An isolated DNA segment is disclosed which is derived from a Saccharomyces cerevisiae sorbitol dehydrogenase gene and which functions to increase expression of an associated foreign polypeptide when the DNA segment and the gene coding for the foreign polypeptide are operably linked in a vector in such a manner that the vector is replicated and carried by a host yeast cell. The functionally active portion of the segment is under the control: (i) a transcriptional regulatory sequence of the sorbitol dehydrogenase of Saccharomyces cerevisiae, (ii) a translation initiation regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerivisiae, and (iii) a termination regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerivisiae. Yeast cells containing these regulatory sequences linked to a foreign DNA sequence are grown in medium containing sorbitol under conditions permitting a foreign polypeptide to be expressed.

Abstract translation: 公开了分离的DNA片段，其衍生自酿酒酵母山梨糖醇脱氢酶基因，并且当DNA片段和编码外来多肽的基因以可操作地连接在载体中时，其作用可增加相关外源多肽的表达， 载体被宿主酵母细胞复制和携带。 所述片段的功能活性部分是受控制的：（i）酿酒酵母的山梨糖醇脱氢酶的转录调控序列，（ii）Saccharomyces cerivisiae的山梨糖醇脱氢酶基因的翻译起始调节序列，和（iii）终止 Saccharomyces cerivisiae的山梨糖醇脱氢酶基因的调节序列。 将含有与外来DNA序列连接的调节序列的酵母细胞在允许外源多肽表达的条件下，在含有山梨糖醇的培养基中生长。

公开(公告)号：WO1994015850A1

公开(公告)日：1994-07-21

申请号：PCT/US1993012614

申请日：1993-12-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  NORVILLE, James, D. ,  FERNANDO, Juan, V. ,  ELIAS, Allen, M.

IPC: B65D47/36

CPC classification number: B65D51/002 ,  A61M39/04

Abstract: A closure (10) for sealing the open end of a container and usable with a blunt entry device includes a resilient body having a central diaphragm portion (14), peripheral flange portion (16), and a hollow plug portion (18). The plug portion (18) depends from the circumference juncture of the flange and diaphragm portions and sealingly engages the interior of the open end of the container. The diaphragm portion (14) is configured for minimal entry force by the blunt entry device. A metal ferrule (36) which secures the stopper to the container has an annular skirt portion for engagement with the exterior of the container.

Abstract translation: 用于密封容器的开口端并可用于钝进入装置的封闭件（10）包括具有中心隔膜部分（14），周边凸缘部分（16）和中空插塞部分（18）的弹性体。 插头部分（18）从凸缘和隔膜部分的圆周接合部分，并密封地接合容器开口端的内部。 隔膜部分（14）被配置为通过钝进入装置的最小进入力。 将止动件固定到容器的金属套圈（36）具有用于与容器的外部接合的环形裙部。

公开(公告)号：WO1994014841A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012196

申请日：1993-12-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HAVIV, Fortuna ,  GREER, Jonathan ,  SWENSON, Rolf, E. ,  SAUER, Daryl, R.

IPC: C07K07/00

CPC classification number: C07K7/23 ,  A61K38/00

Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substituted-amino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substituted-amino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

Abstract translation: 一类有效的LHRH十肽拮抗剂具有N-烷基化氨酰基残基，其中残基的侧链部分是4-（取代的 - 氨基）苯丙氨酰基，4-（取代的 - 氨基）环己基丙氨酰或OMEGA - （取代的 - 氨基） 烷基，另外第5位的氨酰基残基在肽骨架的氮原子上进行N-烷基化。

公开(公告)号：WO1994013155A1

公开(公告)日：1994-06-23

申请号：PCT/US1993007446

申请日：1993-08-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  NARDELLI, Christy, Ann ,  MAZER, Terrence, Bruce ,  HOGARTH, Arthur, James, Clancy, Lewis ,  SUH, John, Dongbin ,  DAAB-KRZYKOWSKI, Andre ,  PICKETT, Leona, Marie ,  KELLER, Harold, William ,  NELSON, William, Jr.

IPC: A23J01/14

CPC classification number: A23J1/14

Abstract: A process for the removal of phytate from protein using ion exchange has been developed. The process involves the upflow passage of a protein slurry at an elevated temperature through a strong base anion exchanger in the chloride form. The weak base anion sites inherent to the resin have been converted to the free base form. The anion exchange material can easily be regenerated. The process can be used on-line, yields phytate removal of greater than 90 %, has high (greater than 90 %) protein recovery, is cost-effective, and is environmentally friendly.

Abstract translation: 已经开发了使用离子交换从蛋白质中除去植酸盐的方法。 该方法包括蛋白质浆液在升高的温度下通过氯离子形式的强碱阴离子交换剂。 树脂固有的弱碱阴离子位点已经转化为游离碱形式。 阴离子交换材料可以容易地再生。 该过程可以在线使用，产生植酸盐去除率大于90％，具有高（大于90％）的蛋白质回收率，具有成本效益，是环保的。

公开(公告)号：WO1994011838A1

公开(公告)日：1994-05-26

申请号：PCT/US1993010525

申请日：1993-11-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KILLIAN, William, R.

IPC: G06F15/42

CPC classification number: G01N35/00732 ,  G01N2035/00752 ,  G01N2035/00881 ,  G05B19/4183 ,  G06F19/00 ,  G06F19/325 ,  G06F19/3418 ,  G16H10/40 ,  G16H10/60 ,  G16H15/00 ,  Y02P90/10 ,  Y02P90/18

Abstract: A system (10) for automatically testing biological fluids includes a network database (26) which holds test protocols and test results for identified samples. The system (10) tracks the samples by their identifier through the system to testing equipment (16) which is also coupled to the network (24). The system (10) records the tests performed and the times they were performed and monitors any reagents used in the test being run. In addition, the system (10) monitors any incubation of the samples and any results indicated by the test equipment (16). Information on the tests run on a particular sample, the reagents used and the results produced by the tests, are maintained a database and may be formatted into a report.

Abstract translation: 用于自动测试生物流体的系统（10）包括一个网络数据库（26），其保存所识别样品的测试协议和测试结果。 系统（10）通过系统将它们的标识符跟踪测试设备（16），测试设备（16）也耦合到网络（24）。 系统（10）记录执行的测试和执行的时间，并监视在运行测试中使用的任何试剂。 此外，系统（10）监测样品的任何温育和由测试设备（16）指示的任何结果。 有关测试的信息在特定样品上运行，使用的试剂和测试产生的结果都保存在数据库中，并可能格式化为报告。

公开(公告)号：WO1994011256A1

公开(公告)日：1994-05-26

申请号：PCT/US1993007472

申请日：1993-08-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GYGAX, Ralph, Allen

IPC: B65D01/42

CPC classification number: B65D1/0276

Abstract: A retortable plastic container (50) has a bottom wall having resting surface which surrounds a primary recessed portion (51). The primary recessed portion surrounds a secondary recessed portion (52). When the bottom wall of the container is viewed head-on the primary recessed portion (51) has an outline which is circular, while the secondary recessed portion (52) has an outline which is non-circular. The secondary recessed portion has major and minor axes which are mutually perpendicular and intersect one another on a longitudinal axis of the container. The distance (B) across the secondary recessed portion along the major axis divided by the distance (C) across the secondary recessed portion along the minor axis is greater than 1 but not greater than 3.

Abstract translation: 可蒸煮塑料容器（50）具有包围初级凹部（51）的搁置面的底壁。 初级凹陷部分包围二次凹陷部分（52）。 当容器的底壁在主凹部（51）的正面观察时具有圆形轮廓，而副凹部（52）具有非圆形轮廓。 副凹陷部分具有相互垂直并且在容器的纵向轴线上彼此相交的主轴和短轴。 沿着长轴的副凹陷部分之间的距离（B）除以次要凹陷部分沿着短轴的距离（C）大于1但不大于3。

公开(公告)号：WO1994008642A1

公开(公告)日：1994-04-28

申请号：PCT/US1993006724

申请日：1993-07-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ROSS, Jeffrey, R. ,  MACCAMISH, Mark, Anthony ,  SENOKOZLIFF-ENGLEHART, Andrea, Lyne ,  DANIS, Roger, Girard

IPC: A61M05/00

CPC classification number: A61J15/0023 ,  A61B17/0469 ,  A61B17/3415 ,  A61B17/3474 ,  A61B50/33 ,  A61B2017/0416 ,  A61B2017/0417 ,  A61B2017/0479 ,  A61B2050/0065 ,  A61B2050/314 ,  A61J15/0007 ,  A61J15/0069 ,  A61J2205/00

Abstract: A laparoscopic gastrostomy instrumentation kit (10) includes means for securing a patient's stomach in apposition to the abdominal wall, means for creating a stoma, a gastrostomy tube (24) and a container for containing the components of the instrumentation kit (10). In preferred embodiments the instrumentation kit (10) includes T-Fasteners assemblies (18), syringes (15, 17 and 27) and a gastrostomy tube (24).

Abstract translation: 腹腔镜胃造口术仪器套件（10）包括用于将患者胃固定到腹壁上的装置，用于产生造口的装置，胃造口管（24）和用于容纳仪器套件（10）的组件的容器。 在优选实施例中，仪器套件（10）包括T型紧固件组件（18），注射器（15,17和27）和胃造口管（24）。

公开(公告)号：WO1994008047A1

公开(公告)日：1994-04-14

申请号：PCT/US1993008359

申请日：1993-09-07

Applicant: ABBOTT LABORATORIES ,  BOUMA, Stanley, R. ,  GORDON, Julian ,  HSIEH, Wang-Ting ,  JOU, Tsung-Hui ,  BEAUDET, Arthur, L. ,  FANG, Ping

Inventor： ABBOTT LABORATORIES

IPC: C12Q01/68

CPC classification number: C12Q1/6862 ,  C12Q2527/125

Abstract: The present invention involves methods of detecting small mutations in target nucleic acid using the Ligase Chain Reaction (LCRTM). Detectable small mutations include single base deletions, insertions and changes, as well as multiple mutations (deletions, insertions and changes) where the size of the mutation is less than about 15 % of the average probe length. The methods include high concentrations of monovalent cations, especially Na+, K+ and NH4+; and/or relatively high initial mixing temperatures. The methods also include probe designs having deliberate mismatches with respect to target, the mismatches being near the 5' ends. Also claimed are several sets of probe sequences for detection of mutations associated with cystic fibrosis.

Abstract translation: 本发明涉及使用连接酶链反应（LCRTM）检测靶核酸中的小突变的方法。 可检测的小突变包括单碱基缺失，插入和变化，以及突变大小小于平均探针长度的约15％的多重突变（缺失，插入和变化）。 这些方法包括高浓度的一价阳离子，特别是Na +，K +和NH4 +; 和/或相对较高的初始混合温度。 这些方法还包括具有相对于靶的故意错配的探针设计，该错配在5'端附近。 还要求的是用于检测与囊性纤维化相关的突变的几组探针序列。