公开(公告)号：US20230416695A1

公开(公告)日：2023-12-28

申请号：US18342666

申请日：2023-06-27

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  C12N15/86 ,  B01D15/38 ,  B01J20/281 ,  C12N15/864 ,  G01N21/33

CPC classification number: C12N7/02 ,  C12N15/86 ,  B01D15/3804 ,  B01J20/281 ,  C12N15/8645 ,  G01N21/33 ,  C12N2750/14151 ,  B01J41/05

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US11759774B2

公开(公告)日：2023-09-19

申请号：US16067031

申请日：2016-12-16

Applicant: Dow Global Technologies LLC

Inventor： Kaoru Ohba ,  Kenji Takano ,  Masonori Iida ,  Shinnosuke Abe ,  Takashi Masudo ,  Osamu Kishizaki ,  Ryo Ishibashi ,  Yusuke Yamashita

IPC: B01J47/04 ,  B01J39/05 ,  B01J41/05 ,  B01D15/36 ,  B01J39/18 ,  B01J41/12 ,  C07C41/36

CPC classification number: B01J47/04 ,  B01D15/362 ,  B01D15/363 ,  B01J39/05 ,  B01J39/18 ,  B01J41/05 ,  B01J41/12 ,  C07C41/36

Abstract: Methods for the removal of ionic contaminants from a hydrophilic organic solvent by a mixed bed of ion exchange resins are described. A mixed bed of ion exchange resins with gel-type strong-acid cationic ion exchange resin with a specific moisture holding capacity and gel-type anionic ion exchange resin is used in some embodiments of such methods.

公开(公告)号：US20230278895A1

公开(公告)日：2023-09-07

申请号：US18179882

申请日：2023-03-07

Applicant: CALGON CARBON CORPORATION

Inventor： Charles B. Drewry, III

IPC: C02F1/42 ,  B01J41/05 ,  B01J41/12 ,  B01J49/57

CPC classification number: C02F1/42 ,  B01J41/05 ,  B01J41/12 ,  B01J49/57 ,  C02F2101/163

Abstract: A method as described herein may include contacting a fluid with a single resin to cause the single resin to bond to nitrates and perchlorates contained in the fluid. The method may regenerate the single resin by a regeneration process comprising contacting the single resin with a salt solution, wherein regenerating removes a substantial portion of the nitrates contained within the single resin but does not remove a substantial portion of the perchlorates contained within the single resin, wherein the single resin comprises a nitrate-specific resin and does not comprise a perchlorate-specific resin.

公开(公告)号：US11732245B2

公开(公告)日：2023-08-22

申请号：US17379359

申请日：2021-07-19

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  C12N15/86 ,  B01D15/38 ,  B01J20/281 ,  C12N15/864 ,  G01N21/33 ,  B01J41/05 ,  B01D15/16 ,  B01D15/36 ,  B01J41/20

CPC classification number: C12N7/02 ,  B01D15/3804 ,  B01J20/281 ,  C12N15/86 ,  C12N15/8645 ,  G01N21/33 ,  B01D15/166 ,  B01D15/363 ,  B01J41/05 ,  B01J41/20 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US20230219075A1

公开(公告)日：2023-07-13

申请号：US17995639

申请日：2021-04-06

Applicant: Brown University

Inventor： KURT PENNELL ,  Chen Liu

IPC: B01J47/018 ,  B01J41/05 ,  B01J41/12 ,  B01J41/07 ,  B01D15/36 ,  C02F1/42 ,  C02F1/56 ,  C02F1/54

CPC classification number: B01J47/018 ,  B01J41/05 ,  B01J41/12 ,  B01J41/07 ,  B01D15/361 ,  C02F1/42 ,  C02F1/56 ,  C02F1/547 ,  C02F2001/422 ,  C02F2101/36

Abstract: This invention relates to an aqueous composition comprising, (a) an ion-exchange resin (IXR) comprising microporous beads having a particle size ranging from about 200 um to about 1000 um; (b) a water soluble surfactant having a molecular weight ranging from about 7,500 to about 15,000 Da; and (c) a buffer component; wherein the pH of the aqueous composition ranges from about 5 to about 8, and a process for isolating chemical contaminants using the aqueous composition.

公开(公告)号：US11649299B2

公开(公告)日：2023-05-16

申请号：US17344217

申请日：2021-06-10

Applicant: CYCLOLAB CYCLODEXTRIN RESEARCH AND DEVELOPMENT LABORATORY LTD.

Inventor： Tamas Sohajda ,  Gabriella Hirschbergne Szejtli ,  István Puskás

IPC: C08B37/16 ,  C08B37/00 ,  B01J39/05 ,  B01J41/05

CPC classification number: C08B37/0012 ,  B01J39/05 ,  B01J41/05 ,  C08B37/0003

Abstract: Present invention relates to a process to reduce butane sultone hydrolysis products (4-hydroxybutane-1-sulfonic acid, and bis(4-sulfobutyl) ether disodium) in sulfobutylether cyclodextrin reaction mixtures achieved with the combined use of a strong anion exchange resin having dialkyl 2-hydroxyethyl ammonium hydroxide functionality and a cation exchange resin.

公开(公告)号：US20190210003A1

公开(公告)日：2019-07-11

申请号：US15520390

申请日：2015-10-01

Applicant: JNC CORPORATION

Inventor： Natuki OKANIWA ,  Tsuyoshi NAKAMA ,  Eri IWAMOTO ,  Shuji SASAKI ,  Takuo IKEDA

IPC: B01J20/24 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  B01D15/36 ,  B01J41/16 ,  B01J41/07 ,  C08B15/00 ,  C08B15/06 ,  C08J9/28 ,  B01J20/281

CPC classification number: B01J20/24 ,  B01D15/361 ,  B01J20/28042 ,  B01J20/281 ,  B01J20/285 ,  B01J20/30 ,  B01J20/305 ,  B01J20/3085 ,  B01J41/05 ,  B01J41/07 ,  B01J41/16 ,  B01J2220/52 ,  C07K1/16 ,  C07K1/18 ,  C08B15/005 ,  C08B15/06 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2301/12 ,  G01N30/482 ,  G01N30/88 ,  G01N2030/484

Abstract: Provided is a manufacturing method for monolithic structure that is a porous body formed of polysaccharide being a naturally-occurring polymer, has continuous pores with an average pore diameter suitable for biomolecule separation, and allows formation into arbitrary shape. The polysaccharide monolithic structure is manufactured by a method including a first step of obtaining a polysaccharide solution by dissolving polysaccharide into a mixed solvent of a first component and a second component at temperature lower than a boiling point of the mixed solvent, and a second step of obtaining polysaccharide monolithic structure by cooling the polysaccharide solution, wherein the first component is a solvent selected from lactate, and the second component is a solvent selected from water, lower alcohol, and a combination thereof. The monolithic structure obtained is a porous body having continuous pores with an average pore diameter of 0.01 to 20.0 micrometers, and a thickness of 100 micrometers or more.

公开(公告)号：US20180326323A1

公开(公告)日：2018-11-15

申请号：US15776838

申请日：2016-11-22

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  ROHM AND HAAS COMPANY

Inventor： Stephen Pease ,  Daryl J. Gisch ,  Collin H. Martin ,  Bianca F. Martins

IPC: B01D15/36 ,  C07C51/47

CPC classification number: B01D15/363 ,  B01J41/05 ,  C07C51/47 ,  C07C53/122 ,  C12P7/52

Abstract: A method for chromatographically separating propionic acid from a liquid feed mixture including propionic acid and a carbohydrate by passing the liquid feed mixture through a bed including a strong base anion exchange resin.

公开(公告)号：US10010829B2

公开(公告)日：2018-07-03

申请号：US15046621

申请日：2016-02-18

Applicant: Carbon Sink, Inc.

Inventor： Allen B. Wright ,  Klaus S. Lackner ,  Burton Wright ,  Matt Wallen ,  Ursula Ginster ,  Eddy J. Peters

IPC: B01D53/04 ,  B01D53/02 ,  B01D53/22 ,  B65G5/00 ,  B01D53/96 ,  B01D53/62 ,  B01D61/44 ,  B01D71/10 ,  B01D71/28 ,  B01D71/54 ,  B01D71/82 ,  B01J41/05

CPC classification number: B01D53/228 ,  B01D53/02 ,  B01D53/025 ,  B01D53/04 ,  B01D53/62 ,  B01D53/96 ,  B01D61/445 ,  B01D71/10 ,  B01D71/28 ,  B01D71/54 ,  B01D71/82 ,  B01D2252/1035 ,  B01D2253/206 ,  B01D2253/25 ,  B01D2253/34 ,  B01D2257/504 ,  B01D2258/06 ,  B01D2325/42 ,  B01J41/05 ,  B65G5/00 ,  Y02C10/04 ,  Y02C10/08

Abstract: The present invention is directed to methods for removing CO2 from air, which comprises exposing sorbent covered surfaces to the air. The invention also provides for an apparatus for exposing air to a CO2 sorbent. In another aspect, the invention provides a method and apparatus for separating carbon dioxide (CO2) bound in a sorbent.

公开(公告)号：US09963359B2

公开(公告)日：2018-05-08

申请号：US14763700

申请日：2014-01-27

Applicant: BROMINE COMPOUNDS LTD.

Inventor： Emanuel Korngold ,  Mordechai Cohen ,  Mira Bergstein Freiberg ,  Sharon Krumbein Rubin

IPC: C02F1/42 ,  B01J41/05 ,  C02F101/12 ,  C02F103/18

CPC classification number: C02F1/42 ,  B01J41/05 ,  C02F2001/422 ,  C02F2101/12 ,  C02F2103/18 ,  C02F2303/16 ,  C02F2303/185

Abstract: The invention relates to a process for recovering bromide from a halide-containing aqueous stream, comprising the steps of: providing a feed of halide-containing aqueous stream; contacting an anion-exchange resin with said feed, to form halide-loaded resin; treating said halide-loaded resin with a regenerant and subsequently with a rinse to produce, in succession, a chloride-rich solution, a mixed chloride/bromide solution, a bromide-rich solution and an essentially halide-free solution; directing said mixed chloride/bromide solution to said feed; processing said bromide-rich solution to recover one or more bromide products; and utilizing said essentially halide-free solution for regenerant dilution and/or rinsing of said resin. An apparatus for carrying out the process is also disclosed.