Biodegradable copolymer, and polymeric micelle composition containing the same
    205.
    发明公开
    Biodegradable copolymer, and polymeric micelle composition containing the same 有权
    可生物降解的共聚物,以及这些共聚物含有聚合物胶束组合物

    公开(公告)号:EP1550680A1

    公开(公告)日:2005-07-06

    申请号:EP03029295.7

    申请日:2003-12-22

    Abstract: A biodegradable copolymer with a core block comprising bioresorbable hydrophobic polyester segment and from 3 to 10 shell blocks comprising hydrophilic polyethylene glycol segment. The hydrophobic polyester segment and each of the hydrophilic polyethylene glycol segments are linked by a urethane linkage. A polymeric micelle composition containing the copolymer is also provided. The copolymer forms micelles when the concentration of the copolymer in a dispersing medium reaches or exceeds the critical micelle concentration. The micelles possess good drug and bioactive agent delivery characteristics and are suitable for use in drug delivery or cosmetic applications.

    Abstract translation: 一种可生物降解的共聚物与核心块,包括生物可吸收的疏水性聚酯链段和3到10个壳块包括亲水性聚乙二醇链段。 疏水性聚酯链段和各所述亲水性聚乙二醇链段的由氨基甲酸乙酯键连接。 因此,提供含有该共聚物的聚合物胶束组合物。 当共聚物的在分散介质中的浓度达到或超过临界胶束浓度的共聚物形成胶束。 胶束具有良好的药物和生物活性剂的递送特性和适合用于药物递送或化妆品应用中使用。

    Adhesive composition containing a vinyl acetate ethylene copolymer and production thereof by polymerisation
    206.
    发明授权
    Adhesive composition containing a vinyl acetate ethylene copolymer and production thereof by polymerisation 失效
    一种粘合剂组合物,包含乙酸乙烯酯 - 乙烯的共聚物和它的生产通过聚合。

    公开(公告)号:EP0385734B1

    公开(公告)日:1994-08-03

    申请号:EP90302092.3

    申请日:1990-02-27

    Abstract: A dispersant is prepared by mixing in water by weight (i) 1.0 to 1.9 parts of polyvinyl alcohol saponified to less than 96% (preferably at least 70%) with (ii) 1.0 to 3.0 parts of a polyoxyethylene non-ionic surfactant, of HLB 16.5 to 17.5 to make a solution (D) containing 2.5 to less than 5.0 parts of dispersant; and a reducing agent part of a redox catalyst; 40 to 90% of 100 parts of the vinyl acetate (VA) to be polymerized is added to (D) and stirred to make a dispersion stable for at least 10 hours, and a polymerization is performed by subjecting the dispersion to ethylene at pressure of 98 - 980 Pa at 30 - 80 DEG C and adding the remaining 10 to 60% of the VA and an oxidizing agent part of the catalyst; optionally up to 30% of the dispersant (D) is added in this step. A third monomer having a functional group may be copolymerized in amount of 10 to 100 parts by weight of the VA. There is obtained an aqueous dispersion ("emulsion") of particles of not larger than 0.9 mu m of a copolymer of ethylene and vinyl acetate together with said dispersant; the dispersion has a good properties as an adhesive on a variety of substrates.

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