PRODUCTION OF CARBOXYLIC ACID AMIDE
    203.
    发明专利

    公开(公告)号:JPS5665852A

    公开(公告)日:1981-06-03

    申请号:JP14119479

    申请日:1979-11-02

    Applicant: TOKYO DAIGAKU

    Abstract: PURPOSE:To condensation reaction of a single compound bearing carboxyl and amino groups or a plurality of compounds bearing these groups in different molecules is effected in the presence of an organophosphorous compound to produce the titled compound used as a medicine in various application. CONSTITUTION:In the presence of an organophosphorus compound of the formula (R , R are alkyl; R is aryloxy; X is S, O), a condensation reaction of a single compound bearing a carboxylic and an amino group such as an aminocarboxylic acid or between plural compounds bearing carboxyl and amino groups in different compounds such as carboxylic acid and organic amine or its salt is effected to produce a carboxylic acid amide. EFFECT:The objective compounds are obtained under mild reaction conditions by simple operations in a short time. The racemization can be prevented in the production of peptides. The starting materials are inexpensive, easy-to-handle because its crystallinity.

    208.
    发明专利
    失效

    公开(公告)号:JPS49132094A

    公开(公告)日:1974-12-18

    申请号:JP4359273

    申请日:1973-04-19

    210.
    发明专利
    失效

    公开(公告)号:JPS4924799B1

    公开(公告)日:1974-06-25

    申请号:JP9005970

    申请日:1970-10-15

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