公开(公告)号：US10662206B2

公开(公告)日：2020-05-26

申请号：US16304662

申请日：2017-05-24

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Chinmoy Kumar Hazra ,  Narasimhulu Gandhamsetty

IPC: C07F7/08 ,  B01J31/14

Abstract: The present invention relates to a method for preparing various silane derivatives by subjecting various furan derivatives to hydrosilylation in the presence of a borane catalyst. The method for preparing silane derivatives according to the present invention is a very efficient method for converting, into high value-added silane derivatives, various furan derivatives derived from biomass.

公开(公告)号：US20190242028A1

公开(公告)日：2019-08-08

申请号：US16317332

申请日：2017-07-12

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Rodney S. RUOFF ,  Sunghwan JIN

IPC: C30B1/02 ,  C30B29/02 ,  C30B25/18 ,  C22F1/08 ,  C22F1/10

CPC classification number: C30B1/02 ,  C22F1/00 ,  C22F1/08 ,  C22F1/10 ,  C30B25/14 ,  C30B25/18 ,  C30B29/02

Abstract: The present invention relates to a manufacturing method for single crystalline metal foil including: thermally treating poly-crystalline metal foil positioned to be spaced apart from a base to manufacture single crystalline metal foil, and a single crystalline metal foil manufactured thereby. According to the present invention, single crystalline metal foil having a large area may be obtained by thermally treating the poly-crystalline metal foil under a condition at which stress applied to the poly-crystalline metal foil is minimized.

公开(公告)号：US20190214644A1

公开(公告)日：2019-07-11

申请号：US16352334

申请日：2019-03-13

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hee Cheul CHOI ,  Hyungki KIM

IPC: H01M4/38 ,  C22F1/16 ,  C22C28/00

CPC classification number: H01M4/386 ,  C22C28/00 ,  C22F1/16 ,  H01M4/134 ,  H01M4/38 ,  H01M10/0525

Abstract: The disclosure describes a nanowire for an anode material of a lithium ion cell and a method of preparing the same. The nanowire includes silicon (Si) and germanium (Ge). The nanowire has a content of the silicon (Si) higher than a content of the germanium (Ge) at a surface thereof, and has the content of germanium (Ge) higher than the content of the silicon (Si) at an inner part thereof.

公开(公告)号：US20190200589A1

公开(公告)日：2019-07-04

申请号：US16095414

申请日：2017-04-21

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE

Inventor： Hong Gil NAM ,  Gyoo Yeol JUNG ,  Seung Jae LEE ,  Woo Seon HWANG ,  Gi Won SHIN ,  Mi Hwa SEO

IPC: A01K67/033 ,  C12N15/89 ,  A61K49/00 ,  C12N15/113

CPC classification number: A01K67/0336 ,  A01K67/027 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A61K49/0008 ,  C12N15/113 ,  C12N15/85 ,  C12N15/89 ,  G01N33/50

Abstract: The present invention relates to: a transgenic Caenorhabditis elegans in which a glutamine tRNA 5′ terminus-derived fragment (Gln 5′-tsRNA) is overexpressed; a preparation method therefor; and a method for screening for aging-associated factors by using the transgenic Caenorhabditis elegans. A transgenic Caenorhabditis elegans model provided in the present invention is an animal model in which Gln 5′-tsRNA is overexpressed such that aging is inhibited. When the model of the present invention is used, anti-aging mechanisms can be easily investigated, thereby significantly contributing to various research fields such as that of developing new anti-aging drugs and screening for age-inducing materials.

公开(公告)号：US20180119213A1

公开(公告)日：2018-05-03

申请号：US15656811

申请日：2017-07-21

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： V. Narry KIM ,  Jaechul LIM ,  Hyeshik CHANG

IPC: C12Q1/68

CPC classification number: C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2525/301 ,  C12Q2531/113 ,  C12Q2565/514 ,  C12Q2565/519

Abstract: The present disclosure provides a new protocol for sequencing the 3′ end of messenger RNA (mRNA). The present disclosure can be very favorably used in analyzing the repetitive sequences of nucleic acids, which are difficult to analyze by current sequencing methods, especially, homopolymeric sequences (poly[A] sequence) of mRNA. The present disclosure has significantly improved sensitivity to mRNA compared with an existing method, thereby obtaining a lot of genetic information from a small amount of sample. The method of the present disclosure reduces the time and cost for sequencing the 3′ end of mRNA and can be applied to various samples, and thus, can be used as a useful tool in the study of RNA synthesis/degradation and protein production in association with all life phenomena, including embryogenesis, cancer, and neurotransmission.

公开(公告)号：US20180078620A1

公开(公告)日：2018-03-22

申请号：US15661300

申请日：2017-07-27

Applicant: INSTITUTE FOR BASIC SCIENCE ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

Inventor： Jin-Soo KIM ,  Jeong Hun KIM ,  Sung Wook PARK ,  Kyoungmi KIM

IPC: A61K38/46 ,  C12N15/11

CPC classification number: A61K38/465 ,  A61K48/00 ,  C12N15/102 ,  C12N15/11 ,  C12N15/1136 ,  C12N2310/20 ,  A61K2300/00

Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.

公开(公告)号：US20180055951A1

公开(公告)日：2018-03-01

申请号：US15807850

申请日：2017-11-09

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dong Wook KIM ,  Jin Soo KIM ,  Chul Yong PARK ,  Duk Hyoung KIM ,  Jung Eun KIM ,  Jiyeon KWEON

IPC: A61K48/00 ,  C12N5/074 ,  C12N9/22 ,  C12N15/11 ,  A61K35/545

CPC classification number: A61K48/005 ,  A61K35/12 ,  A61K35/545 ,  A61K48/00 ,  C07K14/755 ,  C12N5/0696 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  C12N2310/20 ,  C12N2501/73 ,  C12N2506/09

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

公开(公告)号：US20170327795A1

公开(公告)日：2017-11-16

申请号：US15328628

申请日：2015-08-06

Applicant: College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo KIM ,  Dong Youn HWANG

IPC: C12N5/074 ,  C12Q1/68 ,  C07K14/74 ,  C12N5/0735

CPC classification number: C12N5/0696 ,  C07K14/70539 ,  C12N5/0603 ,  C12N5/0606 ,  C12N2501/50 ,  C12N2501/70 ,  C12N2510/00 ,  C12Q1/6881 ,  C12Q2600/156

Abstract: The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method

公开(公告)号：US20170312313A1

公开(公告)日：2017-11-02

申请号：US15145823

申请日：2016-05-04

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Taeg Hwan HYEON ,  Seung Hoon LEE ,  Min SOH ,  Chi Kyung KIM

IPC: A61K33/24 ,  A61K9/51

CPC classification number: A61K33/24 ,  A61K9/0019 ,  A61K9/5146

Abstract: Disclosed is a ceria-zirconia nanoparticles comprising a core layer consisting of particles made of ceria-zirconia; and a surfactant layer formed by binding a surfactant on the surface of the core layer so as to easily react in vivo, and more particularly, to applying a ceria-zirconia nano complex to an application field as an activator and a sepsis treating agent.

公开(公告)号：US20170167851A1

公开(公告)日：2017-06-15

申请号：US15160871

申请日：2016-05-20

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Min-Ki LEE ,  Young-Kwon KIM ,  Yong-Woo JO ,  Jong-Wan CHOI ,  Woo-Kang KIM ,  Hee-Tae KIM

IPC: G01B11/02 ,  G01B11/00 ,  H05H5/03

CPC classification number: G01B11/028 ,  G01B11/002 ,  G01B11/27 ,  G01B11/272 ,  H05H5/03 ,  H05H7/00 ,  H05H2007/008

Abstract: A system for measuring displacement of an accelerating tube by using a micro-alignment telescope, which includes a vacuum chamber; a hollow accelerating tube in the vacuum chamber; a sighting target attached to a surface of the accelerating tube while protruding from the surface of the accelerating tube; the micro-alignment telescope spaced apart from one side surface of the vacuum chamber; a first lens device interposed between the micro-alignment telescope and the vacuum chamber; and a second lens device spaced apart from an opposite side surface of the vacuum chamber by a distance, wherein the vacuum chamber includes first and second viewports placed on the surfaces of the vacuum chamber in correspondence with each other, and the micro-alignment telescope, the first lens device, the first viewport, the sighting target, the second viewport and the second lens device are aligned on a same axis in one direction.