Abstract:
Disclosed is a system for diagnosing the pathological change in lipids in blood vessels using coherent anti-strokes raman microscopy which can image lipids abnormally deposited on the deep intima of blood vessels and analyze the components of the imaged lipids, without labeling or destroying blood vessels, to diagnose minute pathological changes in the blood vessels, whereby the stage of progression of lipid-related diseases can be determined.
Abstract:
The present disclosure provides for a method for analyzing treated fingerprints on a document. A sample document is provided. A digital image of the sample document is obtained. The sample document is treated with a reagent and a hyperspectral image of the document is obtained. The hyperspectral image of the document is analyzed to determine a region of interest and a hyperspectal image is obtained of the region of interest. The present disclosure also provides for a system comprising a carrier frame, an imaging station for obtaining a digital image of the sample document, a first processing station for treating the document and a second processing station for developing the treated document, a second imaging station for obtaining a hyperspectral image of at least one of the document and a region of interest of the document, and a robotic subsystem for transporting the document through the system.
Abstract:
A scanning optical apparatus includes a light source unit, an objective lens, a scanning device, an imaging optical system, a confocal aperture, a plurality of photodetectors, a spectrum decomposing element, and a light-deflecting microelement array. The light source unit is located at the position where illumination light from the light source unit is incident through the light-deflecting microelement array on the confocal aperture. Each of light-deflecting microelements constituting the light-deflecting microelement array has deflection angles for selectively deflecting light passing through the confocal aperture toward the plurality of photodetectors and a deflection angle for deflecting the light from the light source unit toward the confocal aperture so that each of the light-deflecting microelements is capable of selecting one of these deflection angles.
Abstract:
A microscopic spectrometer having a separate optical path for masking light from a sample for spectrometric measurements. In the preferred embodiment, a beam splitter is disposed behind an object lens to form two branched optical paths. One of the optical paths is provided with masks at a point of focus along the path, allowing part of the image to be masked. The second optical path allows optical throughput and observation of the entire image. These two optical paths are rejoined, and a final image is obtained for visual inspection by synthesizing the two optical paths.
Abstract:
A confocal measuring microscope including a spectrometer and autofocus system sharing common optical elements in which the intensity of light entering the spectrometer from a particular spot on a workpiece is used to determine a focus condition for the same spot. The microscope includes at least one light source, an illumination field stop, and a microscope objective that images the stop onto a workpiece supported by a movable platform. The objective also forms an image of the illuminated portion of the object. An aperture in a second stop and intersecting the image plane passes light from part of the image to the spectrometer, while viewing optics are used to view the image. In one embodiment, a detector is placed at the zero order position, while in another embodiment a laser is placed at the zero order position. In the later embodiment an integrator circuit connected to the detector array replaces the zero order detector for measuring the total intensity of light entering the spectrometer. A best focus condition occurs when the total intensity is a maximum for a positive confocal configuration, i.e. where source and detector are on opposite sides of their respective field stops from said workpiece, and a minimum for a negative confocal configuration, i.e. where the source and workpiece are on the same side of a reflective illumination field stop with aperture. The movable platform may be scanned axially to achieve and maintain object focus as the object is scanned transversely.
Abstract:
A colorimetry device includes an integrating sphere having a measurement opening part and a trap hole, a trap disposed to be able to open and close the trap hole, a lid that is non-reflective and disposed to be able to open and close the trap hole, an imaging means disposed at a position that allows taking, through the trap hole, an image of a specimen facing the measurement opening part, and a display means that displays an image taken by the imaging means. The trap is to move to a position at which the trap hole is closed by the trap at a time of measurement of light with an SCI method, the light being reflected from the specimen, and the lid is moved to a position at which the trap hole is closed by the lid at a time of measurement of the light with an SCE method.
Abstract:
A Raman spectroscopy apparatus comprises an imaging optical system that transmits light from an object to a spectrograph along an optical path. A scanning device intersects, and is movable with respect to, the optical path. Light is directed onto the scanning device to illuminate the object at a plurality of illumination points. The imaging optical system transmits Raman scattered light emitted from the object at the illumination points to an intermediate image plane, the scanning device being located at the intermediate image plane, and transmits the Raman scattered light from the intermediate image plane to the spectrograph. In comparison with conventional confocal Raman spectroscopy, the apparatus can perform Raman analysis of a sample more quickly, and in comparison with conventional line scan Raman spectroscopy the apparatus can perform Raman analysis more accurately.
Abstract:
In some embodiments, a system comprises a head-mounted frame removably coupleable to the user's head; one or more light sources coupled to the head-mounted frame and configured to emit light with at least two different wavelengths toward a target object in an irradiation field of view of the light sources; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering the target object; and a controller operatively coupled to the one or more light sources and detectors and configured to determine and display an output indicating the identity or property of the target object as determined by the light properties measured by the detectors in relation to the light properties emitted by the light sources.
Abstract:
A method for identification of biochemical markers associated with cervical remodeling over the course of pregnancy of humans includes obtaining Raman signals from the cervix of each of a group of humans with pregnancy at each phase of pregnancy; finding Raman signatures corresponding to each type of cervical tissue from the obtained Raman signals; and identifying biochemical markers associated with cervical remodeling at each phase of pregnancy corresponding to the Raman signatures.
Abstract:
In one implementation, a spectral microscope may comprise a substrate with a planar lens, the planar lens including a phase profile including an axial focus and an oblique focus, a light source to excite a signal of a particle among a plurality of particles, and a detector to receive light generated from the light source from the axial focus of the planar lens and a spectral color component of the excited signal of the particle from the oblique focus of the planar lens.