公开(公告)号：EP0181291A2

公开(公告)日：1986-05-14

申请号：EP85810508.3

申请日：1985-11-04

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Ringrose, Anthony ,  Sutherland, Ranald M. ,  Dähne, Claus ,  Place, John F.

IPC: G01N21/03 ,  G01N21/77 ,  G01N33/53 ,  G01N35/02 ,  G01N21/13

CPC classification number: G01N21/7703 ,  G01N21/03 ,  G01N2021/0325 ,  G01N2201/04 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/81

Abstract: An apparatus responsive to optical changes in a waveguide when the latter is contacted with an analyte capable of reacting with a specific reactant thereto attached to the surface of said guide involves, for containing the analyte, an interchangeable round bottomed cuvette temporarily held by a suitably shaped carrier in working relationship with the optical components of the apparatus, this arrangement ensuring a correct optical orientation thereof relative to said component whenever the exact positioning of the cuvette.

Abstract translation: 当波导中的光学变化与能够与附着在所述导向件的表面上的特定反应物反应的分析物接触时，波导中的光学变化的装置包括用于容纳分析物的可互换的圆底比色皿，其被暂时保持在适当形状 载体与设备的光学部件处于工作关系中，这种布置确保了相对于所述部件的正确的光学取向，无论比色杯的确切位置如何。

公开(公告)号：EP0129450A3

公开(公告)日：1986-04-23

申请号：EP84400840

申请日：1984-04-25

Applicant: LE MATERIEL BIOMEDICAL Société à Responsabilité Limitée dite:

Inventor： David, Pierre ,  Jarricot, Jean Alain

IPC: G01N21/82 ,  G01N21/25 ,  G01N33/80

CPC classification number: G01N21/82 ,  G01N2021/5934 ,  G01N2201/04 ,  Y10S436/805

公开(公告)号：EP0160568A2

公开(公告)日：1985-11-06

申请号：EP85303055.9

申请日：1985-04-30

Applicant: ORTHO DIAGNOSTIC SYSTEMS, INC.

Inventor： Gershman, Russell J. ,  Hoffman, Robert A. ,  O'Connell, Garland J.

IPC: G01N15/14

CPC classification number: G01N15/1456 ,  G01N21/59 ,  G01N2021/4704 ,  G01N2201/04

Abstract: Samples are prepared and applied to a cuvette, and the cuvette is translated in a given direction. Laser light is coupled to the sample through a Bragg cell, which causes the beam to scan the sample transversely to the given direction. Select optical parameters are monitored, and when they occur, the scan is stopped or slowed for a more complete analysis of the illuminated cell.

公开(公告)号：EP0110610A2

公开(公告)日：1984-06-13

申请号：EP83306928.9

申请日：1983-11-14

Applicant: THE UNIVERSITY OF BIRMINGHAM

Inventor： Whitehead, Thomas Paterson ,  Thorpe, Gary Harold Gregory Henry ,  Kricka, Larry Jan ,  Gibbons, John Edwin Charles ,  Bunce, Roger Abraham

IPC: B01L3/02 ,  G01N21/76

CPC classification number: G01N21/76 ,  B01L3/021 ,  G01N2201/04

Abstract: A dispensing device, for dispensing reagent into an array of reaction wells (16) in a photographic recording apparatus, comprises an array of tubes (28) which are mounted in a support (23). The support (23) contains a common chamber (29) into which the tops of all the tubes (28) open. The chamber (29) is connected with atmosphere via an opening (32) which is sealable manually to retain liquid in the tubes (28) when the latter are immersed in a reservoir (40) and which is unsealed to dispense the liquid. The recording apparatus has a housing (10) closable at the top by part of the support (23). A plate (11) having an array of holes (15) therethrough rests on a shutter (13) disposed above a photographic film holder (12). The plate (11) carries the reaction wells (16) in the holes (15).

公开(公告)号：EP2293066A1

公开(公告)日：2011-03-09

申请号：EP10177052.7

申请日：2001-04-06

Applicant: Life Technologies Corporation

Inventor： Empedocles, Stephen A. ,  Watson, Andrew R.

IPC: G01N33/53

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Improved devices, systems (14), and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of independently identifiable spectral codes can be generated by quite small bodies (12a, 12b), and a plurality of such bodies or probes (12a, 12b) may be present within a detection region. Simultaneously imaging of identifiable spectra (60) from throughout the detection region allows the probes (12a, 12b) to be identified. As the identifiable spectra can be treated as being generated from a point source within a much larger detection field, a prism, diffractive grading, holographic transmissive grading, or the like (56) can spectrally disperse the images of the labels across a sensor surface. A CCD (18) can identify the relative wavelengths of signals making up the spectra. Absolute signal wavelengths may be determined by determining positions of the labels, by an interval wavelength reference within the spectra (60), or the like.

Abstract translation: 改进的设备，系统（14）以及用于感测和/或识别来自信号检测区域内的信号的方法非常适用于识别频谱码。 可以由相当小的体（12a，12b）产生大量可独立识别的光谱代码，并且多个这样的主体或探针（12a，12b）可以存在于检测区域内。 同时从整个检测区域成像可识别的光谱（60）允许识别探针（12a，12b）。 由于可识别的光谱可被视为从大得多的检测区域内的点源生成，所以棱镜，衍射分级，全息透射分级等（56）可以通过传感器表面对标签的图像进行光谱分散。 CCD（18）可以识别构成光谱的信号的相对波长。 绝对信号波长可以通过确定标签的位置，频谱（60）内的间隔波长参考等来确定。

公开(公告)号：EP2267451A2

公开(公告)日：2010-12-29

申请号：EP10180073.8

申请日：2001-04-06

Applicant: Life Technologies Corporation

Inventor： Empedocles, Stephen A. ,  Treadway, Joseph A. ,  Watson, Andrew R.

IPC: G01N33/53

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

Abstract translation: 物质的装置，系统，方法和组合物可以跟踪和/或识别元件库，特别是用于流体，微粒，细胞等。 来自一个或多个半导体纳米晶体的信号可以被组合以限定光谱代码。 专用波长范围或窗口内的信号波长分离有助于光谱码的微分，而光谱码内的校准信号可以避免歧义。 基于先前测试的建模可以帮助导出可接受代码的库。

公开(公告)号：EP1872110A4

公开(公告)日：2010-01-27

申请号：EP06758285

申请日：2006-04-06

Applicant: UNIV WASHINGTON

Inventor： CHINOWSKY TIMOTHY M ,  GROW MICHAEL S ,  TRITZ JARED ,  FURLONG CLEMENT E ,  KAUFFMAN PETER C ,  SOELBERG SCOTT D ,  YEE SINCLAIR S ,  NAIMUSHIN ALEXEI N

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N2201/04

公开(公告)号：EP1899067A1

公开(公告)日：2008-03-19

申请号：EP06739539.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William D., ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: B01L7/00

CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

公开(公告)号：EP0547114B1

公开(公告)日：2002-03-27

申请号：EP91916125.7

申请日：1991-09-06

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY

Inventor： KIDWELL, David, A.

IPC: G01N21/03 ,  G01N31/20 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N33/94

CPC classification number: G01N33/54386 ,  B01L3/5023 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/29 ,  G01N21/76 ,  G01N21/78 ,  G01N33/525 ,  G01N2201/04 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/967 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

Abstract: A microassay card (10) includes an upper layer (12) containing wells (14) for receiving a liquid sample (16). A second layer (20) of the card (10), beneath the first layer (12), includes a supporting surface (223) bound to a reactive species (114). A third layer (26) includes a superabsorbent support (26) impregnated with an indicator (228). Typically, the indicator (228) is a substrate (228) for an enzyme (16), such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme (116), upon the substrate to cause a spectral change in the absorbent layer (26). By selecting the structure of the first (12) and second (20) layers, the card (10) can be formatted for a displacement assay or a competitive assay. The microassay card (10) of the present invention is particularly useful for drug testing.

公开(公告)号：EP0538830B1

公开(公告)日：1996-02-21

申请号：EP92118011.3

申请日：1992-10-21

Applicant: HITACHI, LTD.

Inventor： Yoshida, Kasumi ,  Shindo, Isao ,  Kai, Susumu ,  Kimura, Yutaka

IPC: G01N35/00

CPC classification number: G01N35/00029 ,  G01N2035/00108 ,  G01N2035/0441 ,  G01N2035/1025 ,  G01N2201/04 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165