公开(公告)号：US4554257A

公开(公告)日：1985-11-19

申请号：US489734

申请日：1983-04-29

Applicant: Frederick J. Aladjem ,  Padmasini K. Ayengar

Inventor： Frederick J. Aladjem ,  Padmasini K. Ayengar

IPC: A61K39/00 ,  G01N15/10 ,  G01N21/82 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N33/54313 ,  G01N15/10 ,  G01N21/82 ,  G01N2201/0446 ,  G01N2201/0461 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/827

Abstract: The disclosed methods improve conventional agglutination processes for assaying immunoreactive and like substances, primarily by improving the measurement of the agglutination itself. Suspensions containing agglutinated particles are automatically inspected, preferably intermittently during the agglutinating reaction, and the resulting data are processed to identify individual particle aggregates of a selected limited class, which may, for example, comprise aggregates having sizes within a limited size interval. The numbers of such aggregates are compared with corresponding reference values obtained with standard solutions and suitable controls to evaluate the concentration of one of the reactive substances, or other information. The aggregate size intervals and other parameters which are used to define aggregate classes are preferably selected with attention to the detailed behavior of each test system.

Abstract translation: 所公开的方法改进了用于测定免疫反应性和类似物质的常规凝集方法，主要通过改进凝集本身的测量。 自动检查含有凝集颗粒的悬浮液，优选在凝集反应期间间歇地进行检查，并且对所得数据进行处理以鉴定所选择的有限类别的单个颗粒聚集体，其可以例如包含尺寸在有限尺寸间隔内的聚集体。 将这些聚集体的数量与用标准溶液和合适的对照获得的相应参考值进行比较，以评估其中一种反应物质或其它信息的浓度。 用于定义聚合类的聚合大小间隔和其他参数优选地被选择，注意每个测试系统的详细行为。

公开(公告)号：US4415809A

公开(公告)日：1983-11-15

申请号：US289155

申请日：1981-08-03

Applicant: John Shields

Inventor： John Shields

IPC: G01J1/24 ,  G01N21/03 ,  G01N21/25 ,  G01N33/04 ,  G01N21/01

CPC classification number: G01N21/253 ,  G01N21/03 ,  G01N21/251 ,  G01N33/04 ,  G01J1/24 ,  G01N2201/0446 ,  G01N2201/127 ,  Y10S250/91

Abstract: Electro-optical apparatus for measurement of fat, protein, lactose and water or solids in milk wherein a milk sample is pumped by a homogenizer into an optical measurement cell. The specimen in the cell is then irradiated with reference and measurement beams at differing wavelengths for fat, protein, lactose and water respectively, and signals are stored indicative of uncorrected concentrations. A scaling and correction circuit includes cross-correction circuitry for compensating the effects on each reading caused by the other constitutents. The signals so corrected are then provided in percentage by weight or weight over volume on suitable digital displays.

Abstract translation: 用于测量乳中脂肪，蛋白质，乳糖和水或固体的电光装置，其中将牛奶样品通过均化器泵送到光学测量单元中。 然后分别用脂肪，蛋白质，乳糖和水分别以不同波长的参考和测量光束照射细胞中的样品，并且存储指示未校正浓度的信号。 缩放和校正电路包括交叉校正电路，用于补偿由其他组成部分引起的每次读数的影响。 然后如此校正的信号以合适的数字显示器上的体积重量或重量的百分比提供。

公开(公告)号：EP3353535A1

公开(公告)日：2018-08-01

申请号：EP16892853.9

申请日：2016-02-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： SHKOLNIKOV, Viktor ,  ROGACS, Anita

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01N21/253 ,  G01N21/65 ,  G01N21/658 ,  G01N35/00 ,  G01N35/0099 ,  G01N35/04 ,  G01N2021/651 ,  G01N2035/00356 ,  G01N2035/0437 ,  G01N2201/0446

Abstract: An apparatus includes a sample carrier having wells. Each of the wells has sides and a floor forming an interior. A surface enhanced Raman spectroscopy (SERS) structure is within the interior of each of the wells. A pneumatic port is connected to the interior of each of the wells. A pneumatic passage is connected to the pneumatic ports.

公开(公告)号：EP3230719A1

公开(公告)日：2017-10-18

申请号：EP15868139.5

申请日：2015-12-08

Applicant: Molecular Devices LLC

Inventor： ATZLER, Josef, J. ,  KATZLINGER, Michael ,  KRONBERGER, Georg ,  SCHINWALD, Bernhard

IPC: G01N21/64 ,  G01N21/01 ,  G01N1/14 ,  G01V3/08

CPC classification number: G01N21/76 ,  G01J3/02 ,  G01N21/15 ,  G01N21/253 ,  G01N21/763 ,  G01N27/223 ,  G01N35/028 ,  G01N2021/015 ,  G01N2021/155 ,  G01N2035/1025 ,  G01N2201/0225 ,  G01N2201/0245 ,  G01N2201/0446 ,  G01N2201/0806

Abstract: In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.

Abstract translation: 在样品分析装置中，注射器组件将试剂注入到样品上，并且来自样品的发光被传送到检测器。 该组件可以朝向和远离样品移动。 该组件可以包括与供应试剂或其他液体的一个或多个储存器连通的一个或多个针。 该组件可以包括用于与检测器通信的光导。 可以提供盒，其中设置有组件，一个或多个储存器以及一个或多个泵。 盒和/或装置可以被构造成能够在装置外部进行冲洗或灌注。 盒和/或装置可以包括一种或多种类型的传感器，其被配置用于检测例如装置和/或盒的一个或多个位置中是否存在液体或气泡。

公开(公告)号：EP3092474A4

公开(公告)日：2017-10-04

申请号：EP15806517

申请日：2015-06-12

Applicant: AXION BIOSYSTEMS INC

Inventor： CLEMENTS ISAAC PERRY ,  PREYER AMANDA JERVIS ,  RAJARAMAN SWAMINATHAN ,  MILLARD DANIEL CHRISTOPHER ,  ROSS JAMES DAVID

IPC: G01N21/00 ,  C12N5/00 ,  G01N33/483

CPC classification number: G01N33/4836 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/01 ,  G01N21/75 ,  G01N2021/015 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/062

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 该系统还包括至少一个电极组，该电极组靠近多个井的相应一个设置，其中电极组包括至少一个电极，该至少一个电极被配置为收集与相应井的至少一部分相关联的电信号。 该系统还包括发光元件组，该发光元件组对应于各自的一个井并且被配置为将光学刺激传送到相应井的至少一部分。

公开(公告)号：EP2778231A1

公开(公告)日：2014-09-17

申请号：EP12847822.9

申请日：2012-10-23

Applicant: Hamamatsu Photonics K.K.

Inventor： SUGIYAMA Norikazu ,  KATAOKA Takuji ,  ARATA Ikuo

IPC: C12Q1/02 ,  C12M1/34 ,  C12N5/071 ,  G02B21/06

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

Abstract translation: 一种用于通过在观察装置1包括，放置在培养皿11干细胞C，经由水13上的波导21安装培养皿11发射照明光L1到波导管21和发射照明光L1观察干细胞的方法 经由水在培养皿11中的干细胞-C 13和检测的散射光L2，散射光L2是所述照明光L1射出到干单元C都通过干单元C的散射和通过了波导管通过 21.然后，在光图像由所述散射光L2的检测手段，做了一个区域是明显地比其它区域被识别为在状态朝向分化倾向是更暗。

公开(公告)号：EP2422184A1

公开(公告)日：2012-02-29

申请号：EP10721546.9

申请日：2010-04-23

Applicant: Avacta Limited

Inventor： WEBSTER, Simon

IPC: G01N21/03

CPC classification number: G01N21/03 ,  G01N21/0332 ,  G01N2021/0346 ,  G01N2201/0446

Abstract: A unit is provided comprising an array (2) of sample containers (1), said containers, being connected together and arranged in a planar configuration, each container having multiple optically transparent windows arranged such that the sample contained therein can be interrogated using simultaneous multiple optical analytical techniques, the array of containers being configured so as to allow optical access to the windows of each container in the array. Also provided is an apparatus comprising such a unit, a system comprising a combination of such an apparatus and unit and a method of analysing multiple samples by introducing each individual sample into an individual container of such an apparatus, illuminating the samples and detecting and analysing light emerging therefrom.

Abstract translation: 提供了一种单元，其包括样品容器（1）的阵列（2），所述容器连接在一起并布置成平面构造，每个容器具有多个光学透明窗口，其布置使得其中容纳的样品可以使用同时多个 光学分析技术，容器阵列被配置为允许光学访问阵列中的每个容器的窗口。 还提供了包括这种单元的装置，包括这种装置和单元的组合的系统以及通过将每个单独样品引入这种装置的单独容器中来分析多个样品的方法，照亮样品并检测和分析光 从中出现。

公开(公告)号：EP2159567A1

公开(公告)日：2010-03-03

申请号：EP09179076.6

申请日：2004-09-10

Applicant: WALLAC OY

Inventor： Kivelä, Petri

IPC: G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/13

CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

Abstract translation: 本发明涉及基因集会生化实验室仪器的领域有关E.G.测量样品的性质的不同的应用程序 微量滴定板和相应的样品载体。 本发明的目的是通过提供对光学测量仪器worin的样品（281-285）被激活（212AS，218AS）取得并且在检测到发射（291，292），测量样品的活化和检测阶段之间worin ，之后，移动在样本的装置（218）之间的相对位置由引导所述激活辐射到样品，以及在样品和接收来自样品的发射辐射的装置（293）之间的相对位置。 例如，这可以被实现 通过移动（299）的样品测定板和/或样品的活化和发射相之间的测量头。 本发明允许一个第一样本的同时激活和检测发射从从而提高了测量的效率的第二样品。

公开(公告)号：EP2112497A2

公开(公告)日：2009-10-28

申请号：EP09158687.5

申请日：2009-04-24

Applicant: Ushio Denki Kabushiki Kaisha

Inventor： Tomita, Mamoru

IPC: G01N21/07 ,  G01N21/59

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion (22) having an aperture (23) which allows light to pass therethrough and holding a µ-TAS chip for holding a measurement liquid; a rotary body (25) on which the chip holding portion (22) is mounted; a light source (41); and a light-receiving unit (43). A measurement position of the rotary body (25) at which the measurement liquid is to be measured with the light from the light source (41) is set by: rotating the rotary body (25) to obtain a light value of light which is emitted from the light source (41) and received by the light-receiving unit (43) through the aperture (23); and setting a rotational position of the rotary body (25) where the light value is a threshold value or more, as the measurement position.

Abstract translation: 提供血液分析装置。 血液分析装置包括：具有孔（23）的芯片保持部（22），其允许光通过并保持用于保持测量液体的μ-TAS芯片; 旋转体（25），其上安装有芯片保持部分（22）; 光源（41）; 和光接收单元（43）。 用来自光源（41）的光测量测量液体的旋转体（25）的测量位置通过以下方式设定：旋转体（25）旋转以获得发射的光的光值 从所述光源（41）通过所述孔（23）被所述光接收单元（43）接收; 并且将光值为阈值以上的旋转体（25）的旋转位置设定为测定位置。

公开(公告)号：EP1992936A1

公开(公告)日：2008-11-19

申请号：EP08008946.9

申请日：2008-05-14

Applicant: Hitachi High-Technologies Corporation

Inventor： Adachi, Sakuichiro

IPC: G01N21/25 ,  G01J3/04 ,  G01J3/42 ,  G01N35/00

CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

Abstract: A light amount is increased and an analyzing accuracy can be increased in accordance with an enlargement of a load angle.. However, scattered light tends to be loaded into a light receiving element in an analysis accompanied by scattered light, and the dynamic range of a concentration which can be measured becomes narrow. In the invention, light is dispersed by a light dispersing portion (20), a load angle of the received light is changed per wavelength, the load angle is made larger for light of a wavelength having a small light amount, and the load angle is made smaller for light of a wavelength having a large light amount and used for an analysis accompanied by scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanied by scattered light, while increasing the light amount and maintaining the analyzing accuracy.

Abstract translation: 光量增加，并且可以根据负载角度的增大来提高分析精度。然而，散射光倾向于在伴随散射光的分析中被加载到光接收元件中，并且动态范围 可测量的浓度变窄。 在本发明中，光被光分散部分（20）分散，每波长改变接收光的负载角，对于具有小光量的波长的光，负载角度变大，负载角为 对于具有大光量的波长的光而较小，并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。