公开(公告)号：WO1998006322A1

公开(公告)日：1998-02-19

申请号：PCT/US1997012875

申请日：1997-07-22

Applicant: NELLCOR PURITAN BENNETT INCORPORATED

Inventor： NELLCOR PURITAN BENNETT INCORPORATED ,  LEVINSON, Mitchell ,  MANNHEIMER, Paul ,  NIERLICH, Steven, L. ,  PALMER, Phillip, S.

IPC: A61B05/00

CPC classification number: A61B5/1464 ,  A61B5/14542 ,  A61B5/6834 ,  A61B5/6859 ,  A61B5/6882 ,  A61B2503/02

Abstract: A fetal pulse oximeter sensor in which a sensor head (10) is held against the fetus (14) by the action of a securing means (20, 24) which is remote from the sensor head. The securing means is sufficiently remote so that light detected by the light detector (48) in the sensor head does not scatter through tissue which may be deformed by the securing mechanism. The securing mechanism could deform the tissue by applying pressure, to exanguinate the tissue, or could attach to the tissue by vacuum, penetration, or glue, etc.

Abstract translation: 一种胎压脉搏血氧饱和度传感器，其中传感器头（10）通过远离传感器头的固定装置（20,24）的作用抵靠胎儿（14）。 固定装置足够遥远，使得由传感器头中的光检测器（48）检测到的光不会通过可能被固定机构变形的组织散射。 固定机构可以通过施加压力使组织变形，排出组织，或者可以通过真空，穿透或胶水等附着到组织上。

公开(公告)号：WO1998005252A1

公开(公告)日：1998-02-12

申请号：PCT/US1997012715

申请日：1997-07-21

Applicant: NELLCOR PURITAN BENNETT INCORPORATED

Inventor： NELLCOR PURITAN BENNETT INCORPORATED ,  MANNHEIMER, Paul, D.

IPC: A61B05/00

CPC classification number: A61B5/02444 ,  A61B5/14552 ,  A61B5/6829 ,  A61B2503/06

Abstract: An improved infant/neonatal pulse oximeter sensor substrate which is preferably conforming to the shape of the infant or neonate's foot. In one embodiment, the pad (10) conforms to the heel of the infant, with the emitter (14) and detector (20) preferably being mounted in the region of the calcaneus bone (26). The heel pad can be held in place with a stretchable sock (52). In an alternate embodiment, the conformable pad is a sock (52) with recesses or pockets (54, 56) cut in it for holding the emitter (14) and detector (20).

Abstract translation: 改进的婴儿/新生儿脉搏血氧计传感器基底，其优选地符合婴儿或新生儿足部的形状。 在一个实施例中，垫（10）符合婴儿的跟部，发射器（14）和检测器（20）优选地安装在跟骨骨骼（26）的区域中。 鞋跟垫可以用可拉伸的袜子（52）保持在适当位置。 在替代实施例中，贴合垫是具有切入其中用于保持发射器（14）和检测器（20）的凹部或凹穴（54,56）的袜子（52）。

公开(公告)号：WO1998004190A2

公开(公告)日：1998-02-05

申请号：PCT/US1997013267

申请日：1997-07-30

Applicant: DTR DERMAL THERAPY (BARBADOS) INC. ,  ELDEN, Harry, Richardson ,  WICKETT, R., Randall

Inventor： DTR DERMAL THERAPY (BARBADOS) INC.

IPC: A61B05/00

CPC classification number: A61B5/14532

Abstract: Method and apparatus for non-invasively determining glucose level in fluid of subject, typically blood glucose level. A particular device (10) is mounted on the skin of the patient for a fixed period of time. The device (10) is mounted on the skin such that a substrate such as paper (12) or gel or an aqueous glucose solution carried by the device are in contact with the patient's skin. Water and/or glucose migrates between the substrate (12) or the aqueous glucose solution of the device. The degree of migration of the substance in question is monitored, for example the amount of glucose remaining in an aqueous solution of the device is measured at the end of the fixed period. This can be done by a conventional or other spectrophotometric method, for example. The glucose level is determined based on the degree of migration of the migrating substance. That is, the degree of migration is correlated with previously determined fluid glucose levels based on directly measured fluid glucose levels. In another approach, impedance of skin tissue is measured and the measurement is used with impedance measurements previously correlated with directly determined glucose levels to determine the glucose level from the newly measured impedance. It is thus possible to routinely non-invasively determine fluid glucose levels.

Abstract translation: 用于非侵入性地测定受试者流体中的葡萄糖水平（通常为血糖水平）的方法和装置。 特定装置（10）被安装在患者的皮肤上一段固定的时间。 装置（10）安装在皮肤上，使得诸如纸（12）或凝胶的基质或由装置携带的葡萄糖水溶液与患者的皮肤接触。 水和/或葡萄糖在基质（12）或装置的葡萄糖水溶液之间迁移。 监测所述物质的迁移程度，例如在固定期限结束时测量残留在装置的水溶液中的葡萄糖的量。 这可以通过例如常规或其它分光光度法来完成。 葡萄糖水平基于迁移物质的迁移程度来确定。 也就是说，基于直接测量的流体葡萄糖水平，迁移程度与先前确定的流体葡萄糖水平相关。 在另一种方法中，测量皮肤组织的阻抗，并且测量使用先前与直接测定的葡萄糖水平相关的阻抗测量值，以从新测量的阻抗确定葡萄糖水平。 因此，可以常规地非侵入性地确定流体葡萄糖水平。

公开(公告)号：WO1997049328A1

公开(公告)日：1997-12-31

申请号：PCT/US1997010381

申请日：1997-06-12

Applicant: VITA INSITE, INC.

Inventor： VITA INSITE, INC. ,  FLAHERTY, Bryan, Patrick ,  SHER, Mark, Henry ,  CARO, Richard, G.

IPC: A61B05/00

CPC classification number: A61B5/022 ,  A61B5/02133

Abstract: A blood pressure can be obtained by supplying an external pressure to a portion of an artery. The external pressure is preferably between the systolic and diastolic pressure. An event which occurs at least once a cycle can then be identified. This event can be, for example, a peak in the arterial compliance that occurs at a transmural pressure approximately equal to zero. A pair of signals, one that is an arterial volume-indicating signal, and one that is an arterial pressure-indicating signal can be used to identify this event. Alternately, a small signal high-frequency exciter component can be placed upon the pressure or volume of the artery and detected to determine the time that the transmural pressure is equal to zero.

Abstract translation: 通过向动脉的一部分供给外部压力可以获得血压。 外部压力优选在收缩压和舒张压之间。 然后可以识别发生至少一次循环的事件。 该事件可以是例如在大约等于零的透壁压力下发生的动脉顺应性的峰值。 可以使用一对信号，一个是动脉体积指示信号，另一个是动脉压指示信号，用于识别该事件。 或者，可以将小信号高频激励器部件放置在动脉的压力或体积上，并检测以确定透壁压力等于零的时间。

公开(公告)号：WO1997048331A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010729

申请日：1997-06-19

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  RICHARDS-KORTUM, Rebecca ,  RAMANUJAM, Nirmala ,  MAHADEVAN-JANSEN, Anita ,  MITCHELL, Michele, Follen

Inventor： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

IPC: A61B05/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61B5/7264 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6484

Abstract: The present invention involves the use of fluorescence spectroscopy in the diagnosis of cervical cancer and precancer. Using multiple illumination wavelengths, it is possible to (i) differentiate normal or inflamed tissue from squamous intraepithelial lesions (SILs) and (ii) to differentiate high grade SILs from non-high grade SILs. The detection may be performed in vitro or in vivo. Multivariate statistical analysis was employed to reduce the number of fluorescence excitation-emission wavelength pairs needed to re-develop algorithms that demonstrate a minimum decrease in classification accuracy. Fluorescence at excitation-emission wavelength pairs was used to redevelop and test screening and diagnostic algorithms that have a similar classification accuracy to those that employ fluorescence emission spectra at three excitation wavelengths. Both the full-parameter and reduced-parameter screening algorithms discriminate between SILs and non-SILs with a similar specificity and a substantially improved sensitivity relative to Pap smear screening and differentiate high grade SILs from non-high grade SILs.

Abstract translation: 本发明涉及在宫颈癌和癌前期诊断中使用荧光光谱。 使用多个照明波长，可以（i）区分正常或发炎的组织与鳞状上皮内病变（SIL）和（ii）区分高等级SIL和非高等级SILs。 检测可以在体外或体内进行。 采用多元统计分析方法，减少重新开发算法所需的荧光激发 - 发射波长对数，证明其分类精度最小。 激发 - 发射波长对的荧光被用于重建和测试筛选和诊断算法，其具有与使用三个激发波长的荧光发射光谱相似的分类精度。 全参数和简化参数筛选算法都区分SIL和非SILs，具有相似的特异性，并且相对于Pap涂片筛选具有显着改善的敏感性，并且区分高等级SIL和非高级SILs。

公开(公告)号：WO1997048330A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010666

申请日：1997-06-20

Applicant: MEDTRONIC, INC.

Inventor： MEDTRONIC, INC. ,  DEEM, Mark, E.

IPC: A61B05/00

CPC classification number: A61M25/09 ,  A61M2025/09091 ,  A61M2025/09175

Abstract: A guidewire (10) comprises a core wire (12) having a coil tip at its distal end. The coil tip includes a helically wound filament (28) having adjacent turns spaced apart by a preselected distance. The guidewire (10) is coated with a polymeric material (54), typically a hydrophilic polysaccharide, such as hyaluronic acid or chondroitin sulphate. By properly selecting the spacing between adjacent turns of the coil tip (16), the hydrophilic coating (54) will adhere to the coil tip (16) in a manner which does not penetrate the coil and which does not significantly interfere with flexibility and bend ability of the coil tip.

Abstract translation: 导线（10）包括在其远端具有线圈末端的芯线（12）。 线圈尖端包括螺旋缠绕的细丝（28），其具有以预定距离间隔开的相邻匝。 引导线（10）涂覆有聚合材料（54），通常为亲水性多糖，例如透明质酸或硫酸软骨素。 通过适当选择线圈尖端（16）的相邻匝之间的间隔，亲水涂层（54）将以不穿过线圈并且不显着干扰柔性和弯曲的方式粘附到线圈尖端（16） 线圈尖端的能力。

公开(公告)号：WO1997048327A1

公开(公告)日：1997-12-24

申请号：PCT/SE1997001108

申请日：1997-06-19

Applicant: GROTH, Torgny ,  ELLENIUS, Johan

IPC: A61B05/00

CPC classification number: G01N33/6887 ,  G01N2800/324 ,  G16H50/20 ,  Y10S128/924

Abstract: The overall invention categorizes patients with suspected acute myocardial infarction (AMI) with regard to a) AMI/non-AMI; b) infarct size (e.g. Major/Minor); c) time since onset of infarction; and d) non-AMI with/without minor myocardial damage (MMD). Generally, the above categorization is based on frequent timed blood sampling and measurement of selected biochemical markers of AMI with different rates of appearance in circulating blood. The computations are performed by using specially designed artificial neural networks. According to a first main aspect of the invention, early, i.e. generally within 3 hours from admission of the patient, detection/exclusion of acute myocardial infarction is provided. Furthermore, early prediction of the infarct size and early estimation of the time from onset are also provided.

Abstract translation: 总体发明分类为AMI /非AMI的疑似急性心肌梗死（AMI）患者; b）梗死面积（例如Major / Minor）; c）梗死发作后的时间; 和d）具有/没有轻微心肌损伤（MMD）的非AMI。 一般来说，上述分类是基于循环血液中不同出血率的AMI选定生物化学标记的频繁定时取血和测量。 通过使用专门设计的人工神经网络进行计算。 根据本发明的第一个主要方面，早期，即一般在入院后3小时内，提供了急性心肌梗塞的检测/排除。 此外，还提供了梗死面积的早期预测和从发病时间的早期估计。

公开(公告)号：WO1997040740A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006901

申请日：1997-04-25

Applicant: OHMEDA INC.

Inventor： OHMEDA INC. ,  PETTERSON, Michael, T. ,  TAYLOR, James, H.

IPC: A61B05/00

CPC classification number: A61B5/14552 ,  A61B5/6829 ,  A61B5/6833 ,  A61B46/10

Abstract: The present invention is directed to a pulse oximeter sensor (24) and an attached flexible carrier (28) for measuring the oxygen saturation of a patient's blood. The carrier includes a compressible material (56) such as foam, for contacting the patient's skin and the sensor that applies a substantially uniform pressure to the skin.

Abstract translation: 本发明涉及一种用于测量患者血液的氧饱和度的脉搏血氧计传感器（24）和附接的柔性载体（28）。 载体包括诸如泡沫的可压缩材料（56），用于接触患者的皮肤和向皮肤施加基本均匀的压力的传感器。

公开(公告)号：WO1997036538A1

公开(公告)日：1997-10-09

申请号：PCT/CH1997000125

申请日：1997-03-26

Applicant: KONTRON INSTRUMENTS AG ,  PHILIPP-SCHÖLLERMANN, Thea +hf ,  EBERHARD, Patrick

Inventor： KONTRON INSTRUMENTS AG ,  PHILIPP-SCHÖLLERMANN, Thea +hf ,  SCHÖLLERMANN, Hans +di

IPC: A61B05/00

CPC classification number: A61B5/02433 ,  A61B5/02422 ,  A61B5/14552

Abstract: The invention concerns a method of detecting parasitic signals caused by movements of the patient or his environment during pulsoxymetric measurement of the saturation with oxygen of the arterial blood. According to this method, the intensity of the light emerging from the object to be measured is measured using two photodiodes (7, 8). The signals (S1, S2) generated at these photodiodes (7, 8) are normalized to the same level of their DC portions. Finally, the differences ( DELTA Sn) of these normalized signals (S1n, S2n) are formed in order to detect parasitic signals caused by movement.

Abstract translation: 在用于检测所引起的患者的运动或他的动脉血氧饱和度的血氧噪声测量环境疾病所提出的方法中，光从与光测量对象出现的强度是两个光电二极管（7,8）进行了测定。 在产生这些光电二极管（7,8）（S1，S2）的信号被归一化到其DC分量的相等的水平。 最后，这些归一化信号（S1N，S2N）的差异（DELTA Sn）的形成所造成的噪声的运动的检测。

公开(公告)号：WO1997035512A1

公开(公告)日：1997-10-02

申请号：PCT/US1996004275

申请日：1996-03-27

Applicant: UROQUEST MEDICAL CORPORATION

Inventor： UROQUEST MEDICAL CORPORATION ,  DAVIS, Richard, C.

IPC: A61B05/00

CPC classification number: B01L3/502 ,  A61B10/0045

Abstract: An analytical specimen cup system (10) includes a lid (14) comprising outer and inner partitions (42, 40) for defining a test space (44) having a chemical test strip (30) mounted therein. The inner partition defines a raised test-strip shelf (61) on which the chemical test strip is mounted, a sump (64) with a floor (62) positioned substantially below the raised shelf, and an opening-defining member (48) for defining an opening (50) to allow test fluid to be transferred from an analytical specimen cup (12) to the test space. A mouth (60) of the opening is vertically positioned intermediate the raised test-strip shelf and the sump floor. In one embodiment the analytical specimen cup has a membrane (24) covering its mouth (18) and is sterilized separately from the lid. The inner partition includes a specimen-release device (52) for uncovering the opening of the opening-defining member as well as for piercing the membrane. A peel-off-label color chart (36) can be marked to indicate the chemical test strip's color and placed on a patient's chart.

Abstract translation: 分析标本杯系统（10）包括盖（14），盖（14）包括用于限定安装在其中的化学测试条（30）的测试空间（44）的外隔板和内隔板（42,40）。 内部分隔件限定了一个凸起的测试条架（61），化学测试条被安装在其上，一个底部（64），底板（62）基本上位于凸起的架子的下方，以及一个开口限定构件 限定开口（50）以允许测试流体从分析样本杯（12）转移到测试空间。 开口的口（60）垂直定位在升高的测试条搁板和集水器底板之间。 在一个实施例中，分析样本杯具有覆盖其口部（18）的膜（24）并与盖子分开灭菌。 内隔板包括用于露出开口限定构件的开口以及用于刺穿隔膜的试样释放装置（52）。 剥皮标签颜色图（36）可以标记为表示化学测试条的颜色并放置在患者的图表上。