公开(公告)号：WO2017011919A1

公开(公告)日：2017-01-26

申请号：PCT/CA2016/050864

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KENYA AGRICULTURE AND LIVESTOCK RESEARCH ORGANIZATION (KALRO) ,  INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI)

Inventor： POTTER, Andrew ,  GERDTS, Volker ,  PEREZ-CASAL, Jose ,  WANG, Yejun ,  WESONGA, Hezron ,  SOI, Reuben ,  NAESSENS, Jan ,  JORES, Joerg

IPC: C12N15/31 ,  A61K39/02 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/30 ,  C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  C12N15/70

CPC classification number: C07K14/30 ,  A61K39/0241 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/00

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

Abstract translation: 免疫原性蛋白质，包括支原体支原体亚种 金丝桃和M.cocoides subsp。 编码多核苷酸的capri蛋白，用于产生所述蛋白质的方法，以及使用组合物来防止M.mycoides subsp。 披露了金丝雀感染。

公开(公告)号：WO2016191885A1

公开(公告)日：2016-12-08

申请号：PCT/CA2016/050637

申请日：2016-06-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： ADAMKO, Darryl ,  EL-ANEED, Anas

IPC: G01N33/48 ,  A61B5/00 ,  G01N33/483 ,  G01N33/493 ,  G06F19/00 ,  A61B5/08

CPC classification number: A61B5/08 ,  G01N33/493 ,  G01N33/6893 ,  G01N2570/00 ,  G01N2800/122 ,  G06F19/00 ,  G16H10/40

Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.

Abstract translation: 描述了使用代谢组学数据来诊断哮喘病状态或慢性阻塞性肺疾病（COPD）状态的方法和用途。 进一步描述了使用代谢组学数据来区分哮喘和COPD的方法。 特别地，使用尿代谢组学谱来进行哮喘和COPD的鉴别诊断。

公开(公告)号：WO2015192216A1

公开(公告)日：2015-12-23

申请号：PCT/CA2015/000399

申请日：2015-06-19

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： WILSON, David G.

IPC: A61K39/02 ,  A61P37/04

CPC classification number: A61K39/092 ,  A61K39/02 ,  A61K39/116 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/57 ,  A61K2039/58 ,  A61K2039/70

Abstract: The disclosure relates to immunogenic and vaccine compositions comprising Streptococcus exotoxins and/or bacterial thermolysins from M4 protease family. Also provided are kits, methods and uses of said compositions for treating or preventing laminitis in a hooved animal.

Abstract translation: 本公开涉及包含来自M4蛋白酶家族的链球菌外毒素和/或细菌嗜热菌蛋白酶的免疫原性和疫苗组合物。 还提供了用于治疗或预防蹄动物中的扁桃体炎的所述组合物的试剂盒，方法和用途。

公开(公告)号：WO2015079414A1

公开(公告)日：2015-06-04

申请号：PCT/IB2014/066408

申请日：2014-11-27

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： OLKOWSKI, Andrew A. ,  LAARVELD, Bernard

IPC: C08L1/02 ,  A61K9/107 ,  C07C407/00 ,  C08B3/04 ,  C08J3/075 ,  C07C409/24

CPC classification number: A61K47/48961 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/107 ,  A61K31/4164 ,  A61K47/38 ,  A61K47/46 ,  A61K47/6949 ,  C07C407/00 ,  C08B3/04 ,  C08H8/00 ,  C08J3/03 ,  C08J3/075 ,  C08J2391/00 ,  C08J2401/02 ,  C08L1/04 ,  C08L91/00 ,  C08L2201/52 ,  C08L2203/02 ,  C09B69/10 ,  Y02A50/411 ,  C07C409/24

Abstract: Crystalline cellulose gels useful in the stabilization of emulsions, including nanoemulsions, and for acting as cryptands or clathrates, and methods for their use and production are provided. In some embodiments, the emulsion is an oil-in-water emulsion. In some embodiments, such emulsions and/or vesicles produced in such emulsions, and/or the crystalline cellulose gel itself 15 are useful in the fields of drug delivery, pharmaceuticals, cosmetics, feed and food, paints and coatings, mining, or oil and gas recovery.

Abstract translation: 提供了可用于稳定乳液（包括纳米乳剂）和作为穴状物或包合物的结晶纤维素凝胶及其使用和生产方法。 在一些实施方案中，乳液是水包油乳液。 在一些实施方案中，在这种乳液中生产的这种乳液和/或囊泡和/或结晶纤维素凝胶本身15可用于药物递送，药物，化妆品，饲料和食品，油漆和涂料，采矿或油的领域，以及 天然气回收。

公开(公告)号：WO2015000057A1

公开(公告)日：2015-01-08

申请号：PCT/CA2014/000535

申请日：2014-07-03

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KARLSRUHER INSTITUT FUR TECHNOLOGIE

Inventor： TAYFEH ALIGODARZ, Mohammadreza ,  RASHIDIAN, Atabak ,  KLYMYSHYN, David Mathew ,  SCHULZ, Michael ,  BOERNER, Martin ,  HANEMANN, Thomas

IPC: H01B3/12 ,  B32B18/00 ,  B32B27/04 ,  C08J3/20 ,  C08K3/00 ,  C08L33/12 ,  H01B3/30 ,  H01Q1/38 ,  H01Q9/04

CPC classification number: H01B3/30 ,  B32B27/08 ,  B32B27/20 ,  B32B27/308 ,  B32B2264/107 ,  B32B2307/204 ,  B32B2457/00 ,  C04B35/4682 ,  C04B35/48 ,  C04B35/488 ,  C04B35/634 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5454 ,  C04B2235/6026 ,  C04B2235/75 ,  C08K3/013 ,  C08K3/24 ,  C08K2003/2244 ,  C08K2201/002 ,  H01B3/10 ,  H01Q9/0485

Abstract: Composite materials with dielectric properties for use in microwave applications, and methods of fabrication, are described. The composite materials include a filler, for example a ceramic, with high relative permittivity and a polymer constituent. The resulting composite material has a relative permittivity suitable for use in microwave applications. Dielectric resonator antennas using the composite material are also described.

Abstract translation: 描述了用于微波应用的具有介电特性的复合材料以及制造方法。 复合材料包括具有高相对介电常数的聚合物成分的填料，例如陶瓷。 所得复合材料具有适用于微波应用的相对介电常数。 还描述了使用复合材料的介质谐振器天线。

公开(公告)号：WO2014191961A1

公开(公告)日：2014-12-04

申请号：PCT/IB2014/061826

申请日：2014-05-29

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： OLKOWSKI, Andrew A. ,  LAARVELD, Bernard ,  TANINO, Karen K.

IPC: A01N59/16 ,  A01C1/06 ,  A01H1/04 ,  A01H3/04 ,  A01H5/00 ,  A01H5/10 ,  A01H7/00 ,  A01N59/00 ,  A01P1/00 ,  A01P21/00 ,  A01P3/00

CPC classification number: A01N59/20 ,  A01C1/02 ,  A01N59/00 ,  A01N59/16 ,  A01N25/00 ,  A01N25/08 ,  A01N25/22

Abstract: The present application pertains to compositions for enhancing or controlling the germination of seeds. The compositions comprise i) a transition metal catalyst such as nanoparticulate catalyst bearing one or more transition metals, a carbon nanotube impregnated with Fe, Cu, Mo, Rh or Co, or a transition metal salt (FeS0 4 , CuS0 4 or a cobalt salt) and ii) an oxidant such as hydrogen peroxide. The composition may further comprise a buffer. Methods of enhancing or controlling the germination of seeds using the composition are also disclosed.

Abstract translation: 本申请涉及用于增强或控制种子萌发的组合物。 组合物包括：i）过渡金属催化剂，例如载有一种或多种过渡金属的纳米颗粒催化剂，浸渍有Fe，Cu，Mo，Rh或Co的碳纳米管，或过渡金属盐（FeSO 4，CuSO 4或钴盐）和 ii）氧化剂如过氧化氢。 组合物还可以包含缓冲剂。 还公开了使用该组合物增强或控制种子发芽的方法。

公开(公告)号：WO2014176680A1

公开(公告)日：2014-11-06

申请号：PCT/CA2014/000392

申请日：2014-04-30

Applicant: UNIVERSITY OF SASKATCHEWAN ,  MARCINIUK, Kristen ,  TASCHUK, Ryan ,  NAPPER, Scott ,  POTTER, Andrew ,  CASHMAN, Neil

Inventor： MARCINIUK, Kristen ,  TASCHUK, Ryan ,  NAPPER, Scott ,  POTTER, Andrew ,  CASHMAN, Neil

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/395 ,  A61P37/04 ,  C07K16/18 ,  C07K19/00 ,  C07K7/06 ,  C12N15/12 ,  C12N15/85 ,  G01N33/53

CPC classification number: C07K7/06 ,  A61K39/0007 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K14/001 ,  C07K14/285 ,  C07K14/47 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/20134 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/001 ,  G01N2800/24 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。

公开(公告)号：WO2014169395A1

公开(公告)日：2014-10-23

申请号：PCT/CA2014/050390

申请日：2014-04-17

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： ADAMS, Gregg Patrick ,  YAPURA, Maria Jimena ,  PIERSON, Roger A. ,  BADEA, Ildiko

IPC: A61K9/00 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/5575 ,  A61K47/24 ,  A61K47/28 ,  A61K47/44 ,  A61P15/00

CPC classification number: A61K31/4196 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/127 ,  A61K31/437 ,  A61K31/5575 ,  A61K38/24 ,  A61K45/06 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00

Abstract: Described herein is an intravaginal device that provides biologically active circulating concentrations of an aromatase inhibitor for at least about of 4 days. Three compounds with estradiol inhibitory capability (letrozole, anastrozole and fenbendazole) were tested in vitro using bovine granulosa cell culture. Letrozole was found to be the most efficient and potent inhibitor. Liposome-based and a wax-based formulations were used to assess letrozole diffusion through bovine vaginal mucosa in a diffusion chamber study. Samples were collected over a 24 h period. The wax-based vehicle was selected for further development of a letrozole intravaginal device based on its steady release rate. In an in vivo study in cattle, 3 different intravaginal devices containing 3 g of letrozole were tested: Wax (with 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine, DOPE) + gel coat (n=2), Wax + gel coat (n=4) and Wax (n=4). Blood samples were collected serially from time 0 to 120 h, and daily thereafter to measure circulating concentrations of letrozole by LC/MS/MS. The addition of a letrozole-containing gel coating improved initial absorption and hastened the increase on plasma concentrations of the active ingredient, while the letrozole-containing wax-based vehicle maintained prolonged delivery from the intravaginal device.

Abstract translation: 本文描述的是提供至少约4天的芳香酶抑制剂的生物活性循环浓度的阴道内装置。 使用牛颗粒细胞培养体外测试了具有雌二醇抑制能力的三种化合物（来曲唑，阿那曲唑和芬苯达唑）。 来曲唑被发现是最有效和最有效的抑制剂。 在扩散室研究中，使用基于脂质体的蜡和基于蜡的制剂来评估通过牛阴道粘膜的来曲唑扩散。 在24小时内收集样品。 基于其稳定释放速率，选择蜡基载体进一步开发来曲唑阴道内装置。 在牛的体内研究中，测试了含有3g来曲唑的3种不同的阴道内装置：蜡（含1,2-二油酰-sn-甘油-3-磷酸乙醇胺，DOPE）+凝胶涂层（n = 2），蜡+ 凝胶涂层（n = 4）和蜡（n = 4）。 从0到120小时连续收集血液样品，然后每天通过LC / MS / MS测量来曲唑的循环浓度。 添加含有来曲唑的凝胶涂层改善了初始吸收并加快了活性成分血浆浓度的增加，而来曲唑的蜡基载体保持了从阴道内装置延长的递送。

公开(公告)号：WO2014140703A1

公开(公告)日：2014-09-18

申请号：PCT/IB2013/056087

申请日：2013-07-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： LIN, Yen-Han

IPC: C12Q3/00 ,  C12M1/36 ,  C12P1/00 ,  C12P7/06 ,  C12P7/46 ,  C12Q1/02 ,  G01N33/00

CPC classification number: C12P7/06 ,  C12M41/34 ,  C12P7/46 ,  Y02E50/17

Abstract: A concentration of a control parameter in a fermentation broth can be monitored to monitor and/or control microbial fermentation. In some embodiments, a level of a control parameter present in the fermentation broth is controlled to improve microbial fermentation. In some embodiments, the control parameter is dissolved carbon dioxide concentration. In some embodiments, an abrupt drop in dissolved carbon dioxide concentration indicates the feed in the fermentation broth has been completely or nearly completely utilized.

Abstract translation: 监测发酵液中控制参数的浓度以监测和/或控制微生物发酵。 在一些实施方案中，控制存在于发酵液中的控制参数的水平以改善微生物发酵。 在一些实施方案中，控制参数是溶解的二氧化碳浓度。 在一些实施方案中，溶解的二氧化碳浓度的突然下降表明发酵液中的饲料已被完全或几乎完全利用。

公开(公告)号：WO2014012182A1

公开(公告)日：2014-01-23

申请号：PCT/CA2013/050556

申请日：2013-07-18

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： RANGACHARYULU, Chilakamarri

IPC: G01T1/164 ,  G01T1/169

CPC classification number: G01T1/1603 ,  A61B6/037 ,  G01T1/2985

Abstract: Systems and methods for determining an approximate location of a radionuclide at a time of its radioactive decay are described. In one embodiment, the method comprises introducing into a target region a radionuclide that, at the time of its radioactive decay, emits a positron and a primary photon, detecting the primary photon at a first one of a plurality of photon detectors and detecting at least one secondary photon emitted from an annihilation of the position at least a second one of the plurality of photon detectors, and determining the approximate location of the radionuclide at the time of its radioactive decay based on a location of the first one of the plurality of photon detectors, a location of the second one of the plurality of photon detectors, and a presumed common point of origin of the detected primary photon and the detected at least one secondary photon.

Abstract translation: 描述了在放射性衰变时确定放射性核素的近似位置的系统和方法。 在一个实施例中，该方法包括向放射性核素引入放射性核素，放射性核素在其放射性衰变时发射正电子和主光子，检测多个光子检测器中的第一个的主光子并至少检测 从所述多个光子检测器中的至少第二光子检测器的位置的湮灭发射的一个次级光子，并且基于所述多个光子中的第一个的光子的位置来确定放射性核素在其放射性衰变时的大致位置 检测器，多个光子检测器中的第二个光电探测器的位置，以及所检测到的一次光子和检测到的至少一个次光子的推定公共点。