公开(公告)号：US09823196B2

公开(公告)日：2017-11-21

申请号：US14371890

申请日：2013-01-09

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Reinhold Wimberger-Friedl ,  Johan Lub ,  Pieter Jan Van Der Zaag

IPC: C12M1/34 ,  G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6486 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00711 ,  B01J2219/00722 ,  C12Q1/6874 ,  C12Q2523/319 ,  C12Q2525/186 ,  C12Q2565/601 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/648 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/103

Abstract: The present invention relates to DNA sequencing with reagent cycling on the wiregrid. The sequencing approach suggested with which allows to use a single fluid with no washing steps. Based on strong optical confinement and of excitation light and of cleavage light, the sequencing reaction can be read-out without washing the surface. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moietys. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked.

公开(公告)号：US09784700B2

公开(公告)日：2017-10-10

申请号：US14611668

申请日：2015-02-02

Applicant: Hitachi High-Tech Science Corporation

Inventor： Masahiro Sakuta

IPC: G01N23/22 ,  G06F1/16 ,  G06F3/033 ,  G06F3/048 ,  G01N23/223 ,  G06F3/0354 ,  G06F3/01 ,  G06F3/041 ,  G06F3/0484

CPC classification number: G01N23/223 ,  G01N2201/103 ,  G01N2201/125 ,  G01N2223/076 ,  G01N2223/304 ,  G01N2223/306 ,  G01N2223/408 ,  G01N2223/427 ,  G06F1/1692 ,  G06F3/017 ,  G06F3/03547 ,  G06F3/03548 ,  G06F3/0416 ,  G06F3/0484 ,  G06F3/04842 ,  G06F3/04845 ,  G06F3/04847 ,  G06F2203/04104

Abstract: A fluorescent X-ray analyzer includes a sample stage, an X-ray source that irradiates a sample with primary X-rays, a detector that detects secondary X-rays generated from the sample, a position adjustment mechanism that adjusts relative positions of the sample stage and the primary X-rays, an observation mechanism that obtains an observation image of the sample, and a computer having a display unit and an input unit. The computer has a function of, in response to a pointer being moved from a central region of the observation screen to a certain position by dragging the input unit while maintaining a state in which an input element of the input unit is held, moving the sample stage in a movement direction and at a movement speed corresponding to a direction and a distance of the certain position relative to the central region.

公开(公告)号：US09423397B2

公开(公告)日：2016-08-23

申请号：US14194437

申请日：2014-02-28

Applicant: iNDx Lifecare, Inc.

Inventor： Reuven Duer

IPC: G01N21/00 ,  G01N33/543 ,  G02B6/42 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N33/54373 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0819 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N33/56988 ,  G01N2021/6439 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/103 ,  G02B6/4226 ,  Y10T436/143333

Abstract: The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.

Abstract translation: 本发明提供了使用空间扫描光源在一个或多个波导中产生光脉冲的方法和装置。 还提供了检测系统，其使用方法和用于检测生物活性分析物分子的试剂盒。 该系统包括扫描光源，包括多个波导的基板和与基板的一个或多个波导光学通信的多个光学感测位置，耦合到基板并与光学连接的检测器，以及装置 用于空间地平移从所述扫描光源发射的光束，使得所述光束在沿其扫描路径的某点处耦合到所述衬底的波导并与所述衬底的波导光通信。 使用扫描光源允许以简单且成本有效的方式将光耦合到衬底的波导中。

公开(公告)号：US20160238533A1

公开(公告)日：2016-08-18

申请号：US15025464

申请日：2014-09-30

Applicant: RENISHAW PLC

Inventor： Thomas Anthony MASON

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0248 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/2826 ,  G01N2201/025 ,  G01N2201/06113 ,  G01N2201/103 ,  G01N2201/11 ,  G01N2201/117 ,  G01N2201/122

Abstract: This invention concerns spectroscopy apparatus comprising a light source arranged to generate a light profile on a sample, a photodetector having at least one photodetector element for detecting characteristic light generated from interaction of the sample with light from the light source, a support for supporting the sample, the support movable relative to the light profile, and a processing unit. The processing unit is arranged to associate a spectral value recorded by the photodetector element at a particular time with a point on the sample predicted to have generated the characteristic light recorded by the photodetector element at the particular time based on relative motion anticipated to have occurred between the support and the light profile.

Abstract translation: 本发明涉及光谱装置，其包括被配置为在样品上产生光分布的光源，具有至少一个光电探测元件的光电检测器，该光电检测元件用于检测由样品与来自光源的光的相互作用产生的特征光;支撑样品 ，相对于光轮廓可移动的支撑件，以及处理单元。 处理单元被布置为将由特定时间的光电检测器元件记录的光谱值与预测的样品上的点相关联，以在特定时间基于由光电检测器元件记录的特征光，基于预期发生在 支持和光线。

公开(公告)号：US09404843B2

公开(公告)日：2016-08-02

申请号：US14510330

申请日：2014-10-09

Applicant: Caterpillar Inc.

Inventor： Jacob P. Fabrizius ,  Trent A. Simpson ,  Robert E. Sharp ,  Benjamin J. Rasmussen ,  Jarrod D. Moss

IPC: G01B11/28 ,  G01N3/56 ,  G01M15/04 ,  G01B11/22

CPC classification number: G01N3/56 ,  G01B11/22 ,  G01M5/0033 ,  G01M15/02 ,  G01M15/042 ,  G01N21/9515 ,  G01N2201/103

Abstract: A method of determining wear of a worn surface of a machine component includes providing a scanning device at a distance from the worn surface. The method also includes moving at least one of the scanning device and the worn surface relative to the other and generating a set of data points via the scanning device. Each data point of the set of data points is indicative of a depth of a corresponding point on the worn surface relative to a reference plane. The method further includes determining a maximum depth of the worn surface based on the set of data points and comparing the maximum depth to a reference value to determine a next step in a remanufacturing process of the machine component.

Abstract translation: 确定机器部件的磨损表面的磨损的方法包括提供距磨损表面一定距离的扫描装置。 该方法还包括相对于另一扫描装置和磨损表面中的至少一个移动并经由扫描装置产生一组数据点。 数据点集合中的每个数据点表示磨损表面上相对于参考平面的对应点的深度。 该方法还包括基于该组数据点确定磨损表面的最大深度，并将最大深度与参考值进行比较，以确定机器部件的再制造过程中的下一步骤。

公开(公告)号：US20160216216A1

公开(公告)日：2016-07-28

申请号：US14917701

申请日：2014-09-11

Applicant: HITACHI HIGH-TECH FINE SYSTEMS CORPORATION

Inventor： Shigeru SERIKAWA ,  Takayuki ISHIGURO

IPC: G01N21/95 ,  G01N21/88

CPC classification number: G01N21/95 ,  G01N21/8806 ,  G01N21/8851 ,  G01N2201/06113 ,  G01N2201/103 ,  G11B5/84

Abstract: To increase horizontal resolution while preventing the depth of focus, a magnetic disk inspection device is configured: a table part which has a spindle shaft and a stage; a lighting system which irradiates a magnetic disk; a specularly reflected light detection optical system; a scattered light detection optical system; and a signal processing unit which processes outputs from the specularly reflected light detection optical system and the scattered light detection optical system and detects a defect, in which the scattered light detection optical system is provided with a lens system and a photoelectric converter having a plurality of photoelectric conversion elements arranged in an array, and using the lens system, forms an image of the scattered light on the photoelectric converter, which is long in one direction and thinner than the width of the photoelectric conversion element in a direction perpendicular to the direction of the arrangement in an array.

Abstract translation: 为了在防止焦深的同时提高水平分辨率，磁盘检查装置被构造成：具有主轴和台的台部; 照射系统，照射磁盘; 镜面反射光检测光学系统; 散射光检测光学系统; 以及信号处理单元，其处理来自镜面反射光检测光学系统和散射光检测光学系统的输出，并且检测散射光检测光学系统设置有透镜系统的缺陷和具有多个 以阵列布置的光电转换元件，并且使用透镜系统，在与光电转换元件的方向垂直的方向上在一个方向上长并且比光电转换元件的宽度更薄的光电转换器上形成散射光的图像 阵列中的排列。

公开(公告)号：US20160216214A1

公开(公告)日：2016-07-28

申请号：US15006976

申请日：2016-01-26

Applicant: CHENG MEI INSTRUMENT TECHNOLOGY CO., LTD.

Inventor： Chao-Yi YEH ,  Pin-Chuan SU ,  Shang-Iun YANG ,  Chih Yuan LIU

IPC: G01N21/89 ,  G01N21/88

CPC classification number: G01N21/8914 ,  G01N21/8806 ,  G01N2021/8841 ,  G01N2021/9513 ,  G01N2201/103

Abstract: A panel inspection apparatus is provided. The panel inspection apparatus has a support platform, a delivery platform and a panel inspection assembly. The delivery platform is disposed on the support platform, and the delivery platform has a push module for delivering the panel. The panel inspection assembly includes a plurality of light source modules and a plurality of image-taking modules corresponding to the light source modules. The light source modules include a front light source, a first horizontal light source, and a back light source. The image-taking modules include a front light image-taking module, a first horizontal light image-taking module, and a back light image-taking module. The push module delivers the panel across the support platform so that a plurality of light beams emitted from the light source modules can scan the panel to finish the panel inspection process.

Abstract translation: 提供面板检查装置。 面板检查装置具有支撑平台，输送平台和面板检查组件。 输送平台设置在支撑平台上，并且输送平台具有用于输送面板的推动模块。 面板检查组件包括多个光源模块和对应于光源模块的多个摄像模块。 光源模块包括前光源，第一水平光源和背光源。 摄像模块包括前光摄像模块，第一水平光摄像模块和背光摄像模块。 推模块将面板传递到支撑平台上，使得从光源模块发射的多个光束可以扫描面板以完成面板检查过程。

公开(公告)号：US20160178520A1

公开(公告)日：2016-06-23

申请号：US14973306

申请日：2015-12-17

Applicant: Singulex, Inc.

Inventor： Richard Livingston ,  Michele Gilbert ,  Jacqueline Felberg ,  Jeffrey Bishop

IPC: G01N21/64 ,  G01N33/536 ,  G01N33/68 ,  G01N33/53

CPC classification number: G01N21/6428 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6452 ,  G01N33/5302 ,  G01N33/536 ,  G01N33/58 ,  G01N33/6845 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0612 ,  G01N2201/103 ,  G01N2201/104 ,  G01N2201/105

Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.

Abstract translation: 本文公开了包括用于确定多个标签种类的分析器，使用分析仪和分析仪系统分析样品的方法的分析仪和分析仪系统。 分析仪包括一个或多个电磁辐射源，以将一个或多个荧光团物质的激发带内的波长处的电磁辐射提供给通过样品翻译的询问空间，以检测不同目标分析物的分子的存在或不存在。 分析器还可以包括被配置为检测从一个或多个荧光团物种发射的电磁辐射的一个或多个检测器。 用于确定本文提供的多种靶分子物质的分析仪可用于诊断，因为可以在单个样品中和单个系统中确定多种目标分子的浓度。

公开(公告)号：US09372160B2

公开(公告)日：2016-06-21

申请号：US14876192

申请日：2015-10-06

Applicant: GII ACQUISITION, LLC

Inventor： Michael G. Nygaard

IPC: G01B11/24 ,  G01N21/952

CPC classification number: G01N21/952 ,  B07C5/342 ,  F42B35/00 ,  G01B11/2425 ,  G01B11/2433 ,  G01N21/909 ,  G01N21/9515 ,  G01N2201/02 ,  G01N2201/0621 ,  G01N2201/0638 ,  G01N2201/103 ,  G01N2201/12

Abstract: A method and system for optically inspecting the ends of a manufactured part at a single inspection station having a measurement axis are provided. The system includes a fixture assembly having a rotatable first fixturing component and a rotatable second fixturing component mating with and removably connected to the first fixturing component to transmit torque from the first fixturing component to the second fixturing component. The second fixturing component has a device for holding the part in a generally horizontal orientation and permit rotation of the horizontally held part between first and second angular positions about the measurement axis. The system also includes an actuator assembly, an illumination device, a lens and detector assembly and at least one processor to process electrical signals generated by the lens and detector assembly to determine at least one geometric dimension or any visual defects at the ends of the part.

Abstract translation: 提供了一种用于在具有测量轴的单个检查站上光学地检查制造部件的端部的方法和系统。 该系统包括具有可旋转的第一夹紧部件和可旋转的第二夹紧部件的夹具组件，该可旋转的第二夹紧部件配合并可拆卸地连接到第一夹持部件，以将力矩从第一夹持部件传递到第二夹持部件。 第二固定部件具有用于将部件保持在大致水平取向并允许水平保持部分围绕测量轴线在第一和第二角度位置之间旋转的装置。 该系统还包括致动器组件，照明装置，透镜和检测器组件以及至少一个处理器，用于处理由透镜和检测器组件产生的电信号，以确定部件端部处的至少一个几何尺寸或任何视觉缺陷 。

公开(公告)号：US09239296B2

公开(公告)日：2016-01-19

申请号：US14217848

申请日：2014-03-18

Applicant: Corning Incorporated

Inventor： Joseph Henry Citriniti ,  Parasuram Padmanabhan Harihara

IPC: G01N21/00 ,  G01N21/89 ,  G01N21/95 ,  B28B17/00 ,  B28B19/00 ,  G01N21/952

CPC classification number: B28B19/0023 ,  B01D46/2418 ,  B01D2279/30 ,  B28B17/0072 ,  B28B19/0038 ,  C04B38/0006 ,  C04B41/009 ,  C04B41/5076 ,  C04B41/85 ,  G01N21/8422 ,  G01N21/8914 ,  G01N21/95 ,  G01N21/952 ,  G01N21/95692 ,  G01N2201/06113 ,  G01N2201/103

Abstract: An in situ inspection system and method to inspect a honeycomb body skin in a skinning system. The inspection system includes a line illuminator to generate a line illumination on the skin perpendicular to an axial direction of the honeycomb body travel, and a detector to detect the line illumination scattered from the skin and generate a signal based on the detected line illumination. A controller is configured to receive the signal generated by the detector, compare the received signal to a previously stored defect free signal in real-time, and control at least one skinning process parameter based on the comparison. The method includes in situ inspecting the skin and controlling at least one skinning process parameter based on the inspection. In the method, the in situ inspection includes illuminating a line of the skin perpendicular to the axial direction and detecting the illuminated line scattered from the skin.

Abstract translation: 一种在皮肤系统中检测蜂窝体皮肤的原位检查系统和方法。 该检查系统包括：垂直于蜂窝体行进轴向的皮肤上产生线照明的线照明器;检测器，用于检测从皮肤散射的线照明，并根据所检测的线照明产生信号。 控制器被配置为接收由检测器产生的信号，将接收到的信号与先前存储的无缺陷信号进行实时比较，并且基于该比较来控制至少一个剥皮处理参数。 该方法包括基于检查原位检查皮肤并控制至少一个剥皮过程参数。 在该方法中，原位检查包括照射垂直于轴向的皮肤线并检测从皮肤散射的照明线。