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    Alleviator for radiation disorder
    237.
    发明专利
    Alleviator for radiation disorder 有权
    辐射障碍的病人

    公开(公告)号：JP2012121914A

    公开(公告)日：2012-06-28

    申请号：JP2012048534

    申请日：2012-02-17

    Applicant: Hayashibara Biochem Lab Inc ,  株式会社林原生物化学研究所

    Inventor： CHAEN HIROTO ,  MIYAKE TOSHIO

    IPC: A61K31/7048 ,  A61K9/08 ,  A61K9/16 ,  A61K47/12 ,  A61P39/00

    CPC classification number: C07H17/04 ,  A23K20/174 ,  A23L33/15 ,  A61K8/676 ,  A61K31/7034 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide an alleviator for radiation disorders which can reduce or prevent hematopoietic suppression, fiberization of internal organs, genetic influences, atrophic skin, accelerated senescence and further cancers, which are caused by radiation exposure, and is further safe even when administered to a living body, and a compound containing the alleviator.SOLUTION: The alleviator for radiation disorders contains α-D-glucopyranosyl-(1→2)-L-ascorbic acid as an active ingredient. A composition containing the alleviator is also provided.

    Abstract translation: 要解决的问题：提供减轻或防止造血抑制，内部器官纤维化，遗传影响，萎缩性皮肤，加速衰老和由放射线暴露引起的其它癌症的放射性疾病的缓解剂，并且进一步地 即使施用于生物体也是安全的，以及含有缓解剂的化合物。 解决方案：放射性疾病的缓解剂含有α-D-吡喃葡萄糖基 - （1→2）-L-抗坏血酸作为活性成分。 还提供了含有缓释剂的组合物。 版权所有（C）2012，JPO＆INPIT

    Powder containing anhydrous crystal of 2-o-alpha-d-glucosyl-l-ascorbic acid, process for producing the same, and use thereof
    238.
    发明专利
    Powder containing anhydrous crystal of 2-o-alpha-d-glucosyl-l-ascorbic acid, process for producing the same, and use thereof 有权
    含有2-O-ALPHA-D-葡萄糖-L-抗坏血酸的无水晶体的粉末，其生产方法及其用途

    公开(公告)号：JP2012067064A

    公开(公告)日：2012-04-05

    申请号：JP2010218963

    申请日：2010-09-29

    Applicant: Hayashibara Biochem Lab Inc ,  株式会社林原生物化学研究所

    Inventor： SHIBUYA TAKASHI ,  IZAWA SEISUKE ,  NISHIMOTO TOMOYUKI ,  FUKUDA SHIGEHARU ,  MIYAKE TOSHIO

    IPC: C07H17/04 ,  A23L1/302 ,  A61K8/02 ,  A61K8/60 ,  A61K8/67 ,  A61K31/7048 ,  A61P17/16 ,  A61Q19/02 ,  C12P7/42

    CPC classification number: C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

    Abstract: PROBLEM TO BE SOLVED: To provide a powder containing anhydrous crystals of ascorbic acid 2-glucoside, the powder being significantly less prone to caking than existing general-purpose quasi-drug-class powders containing anhydrous crystals of ascorbic acid 2-glucoside, to provide a method for producing the same, and to provide uses thereof.SOLUTION: There are provided a powder containing anhydrous crystals of ascorbic acid 2-glucoside, which contains, in terms of anhydride content, greater than 98.0 mass% and less than 99.9 mass% of ascorbic acid 2-glucoside, and in which the crystallinity of the anhydrous crystals of ascorbic acid 2-glucoside is at least 90%, as calculated on the basis of a powder X-ray diffraction profile, or after free moisture has been removed from the provided powder in a nitrogen stream, the dynamic amount of moisture absorbed by the powder after 12 hours at a temperature of 25°C and a relative humidity of 35% is no more than 0.01 mass%; a method for producing the same; and uses thereof.

    Abstract translation: 待解决的问题：为了提供含有抗坏血酸2-葡萄糖苷的无水晶体的粉末，该粉末比现有的含有抗坏血酸2-葡萄糖苷的无水晶体的通用准药物级粉末显着更不容易结块 ，以提供其制备方法，并提供其用途。 解决方案：提供含有抗坏血酸2-葡萄糖苷无水结晶的粉末，其含有以酸酐含量计，抗坏血酸2-葡萄糖苷的大于98.0质量％且小于99.9质量％，其中 抗坏血酸2-葡萄糖苷的无水结晶的结晶度为至少90％，根据粉末X射线衍射图计算，或在氮气流中从所提供的粉末中除去游离水分后，动态 在25℃，相对湿度35％下12小时后粉末吸收的水分量不大于0.01质量％; 其制造方法; 及其用途。 版权所有（C）2012，JPO＆INPIT

    Powder containing anhydrous crystal of 2-o-alpha-d-glucosyl-l-ascorbic acid, process for producing the same, and use thereof
    239.
    发明专利
    Powder containing anhydrous crystal of 2-o-alpha-d-glucosyl-l-ascorbic acid, process for producing the same, and use thereof 审中-公开
    含有2-O-ALPHA-D-葡萄糖-L-抗坏血酸的无水晶体的粉末，其生产方法及其用途

    公开(公告)号：JP2012067013A

    公开(公告)日：2012-04-05

    申请号：JP2010195482

    申请日：2010-09-01

    Applicant: Hayashibara Biochem Lab Inc ,  株式会社林原生物化学研究所

    Inventor： SHIBUYA TAKASHI ,  IZAWA SEISUKE ,  NISHIMOTO TOMOYUKI ,  FUKUDA SHIGEHARU ,  MIYAKE TOSHIO

    IPC: C07H15/26 ,  A23L1/302 ,  A61K8/60 ,  A61K31/7048 ,  A61P17/00 ,  A61Q19/02 ,  C12N9/10 ,  C12N9/34 ,  C12N9/44 ,  C12N15/09

    CPC classification number: C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

    Abstract: PROBLEM TO BE SOLVED: To provide a powder containing anhydrous crystals of ascorbic acid 2-glucoside, the powder being significantly less prone to caking than existing general-purpose quasi-drug-class powders containing anhydrous crystals of ascorbic acid 2-glucoside, to provide a method for producing the same, and to provide uses thereof.SOLUTION: There are provided a powder containing anhydrous crystals of ascorbic acid 2-glucoside, which contains, in terms of anhydride content, greater than 98.0 mass% and less than 99.9 mass% of ascorbic acid 2-glucoside, and in which the crystallinity of the anhydrous crystals of ascorbic acid 2-glucoside is at least 90%, as calculated on the basis of a powder X-ray diffraction profile, or after free moisture has been removed from the provided powder in a nitrogen stream, the dynamic amount of moisture absorbed by the powder after 12 hours at a temperature of 25°C and a relative humidity of 35 mass% is no more than 0.01 mass%; a method for producing the same; and uses thereof.

    Abstract translation: 待解决的问题：为了提供含有抗坏血酸2-葡萄糖苷的无水晶体的粉末，该粉末比现有的含有抗坏血酸2-葡萄糖苷的无水晶体的通用准药物级粉末显着更不容易结块 ，以提供其制备方法，并提供其用途。 解决方案：提供含有抗坏血酸2-葡萄糖苷无水结晶的粉末，其含有以酸酐含量计，抗坏血酸2-葡萄糖苷的大于98.0质量％且小于99.9质量％，其中 抗坏血酸2-葡萄糖苷的无水结晶的结晶度为至少90％，根据粉末X射线衍射图计算，或在氮气流中从所提供的粉末中除去游离水分后，动态 在25℃，相对湿度35质量％下12小时后粉末吸收的水分量不大于0.01质量％; 其制造方法; 及其用途。 版权所有（C）2012，JPO＆INPIT

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