公开(公告)号：WO2011052923A2

公开(公告)日：2011-05-05

申请号：PCT/KR2010/007205

申请日：2010-10-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SIM, Tae Bo ,  HAM, Young Jin ,  YOO, Kyung Ho ,  OH, Chang Hyun ,  HAH, Jung Mi ,  CHOI, Hwan Geun ,  KIM, Hwan ,  JUN, Eun Jin

Inventor： SIM, Tae Bo ,  HAM, Young Jin ,  YOO, Kyung Ho ,  OH, Chang Hyun ,  HAH, Jung Mi ,  CHOI, Hwan Geun ,  KIM, Hwan ,  JUN, Eun Jin

IPC: C07D403/04 ,  C07D209/04 ,  A61K31/40 ,  A61P35/00

CPC classification number: C07D403/04 ,  A61K31/404 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

Abstract translation: 公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

公开(公告)号：WO2010128737A1

公开(公告)日：2010-11-11

申请号：PCT/KR2009/005961

申请日：2009-10-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHO, Eun Ae ,  IM, Seok Hui ,  LIM, Tae Hoon ,  OH, In Hwan ,  NAM, Suk-Woo ,  YOON, Sung Pil ,  LEE, Sang Yeop ,  KIM, Hyoung-Juhn ,  JANG, Jong Hyun ,  KIM, Soo-Kil

Inventor： CHO, Eun Ae ,  IM, Seok Hui ,  LIM, Tae Hoon ,  OH, In Hwan ,  NAM, Suk-Woo ,  YOON, Sung Pil ,  LEE, Sang Yeop ,  KIM, Hyoung-Juhn ,  JANG, Jong Hyun ,  KIM, Soo-Kil

IPC: H01M4/88

CPC classification number: H01M4/8814 ,  H01M4/8668 ,  H01M4/8828 ,  H01M4/8882 ,  H01M4/8896 ,  H01M4/92 ,  H01M4/926 ,  H01M8/1004 ,  H01M8/1023 ,  H01M8/1025 ,  H01M8/1027 ,  H01M8/103 ,  H01M8/1032 ,  H01M8/1048 ,  H01M8/106 ,  Y02P70/56

Abstract: Provided is a method for producing a membrane-electrode assembly for a full cell, comprising: preparing catalyst ink slurry from a catalyst, an ion conductive polymer and a solvent; applying the catalyst ink slurry onto a support film, followed by vacuum drying; and transferring the support film to either surface or both surfaces of an electrolyte membrane to form a catalyst layer on the electrolyte membrane. A membrane-electrode assembly obtained by the method and a fuel cell including the membrane-electrode assembly are also provided. The method provides a membrane-electrode assembly having increased porosity, and thus the membrane-electrode assembly shows significantly reduced mass transfer resistance. Therefore, the output density and the quality of the fuel cell including the membrane-electrode assembly prepared therefrom can be improved.

Abstract translation: 本发明提供一种全电池用膜电极接合体的制造方法，其特征在于，包括：由催化剂，离子传导性聚合物和溶剂制备催化剂墨水浆料; 将催化剂油墨浆料涂布在支撑膜上，然后进行真空干燥; 并将支撑膜转移到电解质膜的任一表面或两个表面，以在电解质膜上形成催化剂层。 还提供了通过该方法获得的膜 - 电极组件和包括膜 - 电极组件的燃料电池。 该方法提供了具有增加的孔隙率的膜 - 电极组件，因此膜 - 电极组件显示出显着降低的传质阻力。 因此，可以提高包括由其制备的膜 - 电极组件的燃料电池的输出密度和质量。

公开(公告)号：WO2010016634A2

公开(公告)日：2010-02-11

申请号：PCT/KR2008/005022

申请日：2008-08-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  RYU, Jae-Chun ,  KIM, Youn-Jung ,  SONG, Mi-Kyung ,  JEON, Hee-Kyung

Inventor： RYU, Jae-Chun ,  KIM, Youn-Jung ,  SONG, Mi-Kyung ,  JEON, Hee-Kyung

IPC: C12N15/10

CPC classification number: C12Q1/6876 ,  C12Q2600/158

公开(公告)号：WO2010011016A1

公开(公告)日：2010-01-28

申请号：PCT/KR2009/001897

申请日：2009-04-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Dae-Young

Inventor： LEE, Dae-Young

IPC: B01J20/00

CPC classification number: B01J20/26 ,  A61L9/00 ,  B01J20/046 ,  B01J20/261 ,  B01J20/262 ,  B01J20/3208 ,  B01J20/3236 ,  B01J2220/68

Abstract: Disclosed are a desiccant having a Superabsorbent Polymer (SAP) and a hygroscopic salt, in which the SAP includes a first element having an electrostatic repulsion and a second element having a hydrophilic property, a dehumidifying element using the same and methods for fabricating the same.

Abstract translation: 公开了具有超吸收聚合物（SAP）和吸湿盐的干燥剂，其中SAP包括具有静电排斥性的第一元素和具有亲水性的第二元素，使用该吸湿性聚合物的除湿元件及其制造方法。

公开(公告)号：WO2010005148A2

公开(公告)日：2010-01-14

申请号：PCT/KR2008/005784

申请日：2008-10-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHO, Yong Seo ,  PAE, Ae Nim ,  CHOO, Hyunah ,  LEE, Jae Kyun ,  OH, You Na ,  SHIN, Hee Sup ,  KIM, Dong Jin ,  HAHN, Hoh Gyu ,  CHOI, Kyung Il ,  NAM, Ghilsoo ,  SHIN, Kye Jung ,  KANG, Soon Bang ,  ROH, Eun Joo ,  SHIN, Dong Yun ,  SEO, Seon Hee ,  RHIM, Hyewhon ,  KEUM, Gyo Chang ,  KIM, Key-Sun ,  CHEONG, Chan Seong ,  KIM, Eunice Eun-Kyeong ,  LEE, Cheolju ,  KIM, Youngsoo ,  CHOI, Kee Hyun ,  NAM, Kee Dal ,  PARK, Woong Seo ,  KANG, Yong Koo ,  CHUNG, Hye Jin

Inventor： CHO, Yong Seo ,  PAE, Ae Nim ,  CHOO, Hyunah ,  LEE, Jae Kyun ,  OH, You Na ,  SHIN, Hee Sup ,  KIM, Dong Jin ,  HAHN, Hoh Gyu ,  CHOI, Kyung Il ,  NAM, Ghilsoo ,  SHIN, Kye Jung ,  KANG, Soon Bang ,  ROH, Eun Joo ,  SHIN, Dong Yun ,  SEO, Seon Hee ,  RHIM, Hyewhon ,  KEUM, Gyo Chang ,  KIM, Key-Sun ,  CHEONG, Chan Seong ,  KIM, Eunice Eun-Kyeong ,  LEE, Cheolju ,  KIM, Youngsoo ,  CHOI, Kee Hyun ,  NAM, Kee Dal ,  PARK, Woong Seo ,  KANG, Yong Koo ,  CHUNG, Hye Jin

IPC: C07D403/12

CPC classification number: C07D401/12 ,  A61K31/454

Abstract: Disclosed are isoindolinone derivatives having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient.

Abstract translation: 公开了对T型钙通道具有抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其的作为活性成分的药物组合物。

公开(公告)号：WO2009148201A1

公开(公告)日：2009-12-10

申请号：PCT/KR2008/004267

申请日：2008-07-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Woo Sub ,  KANG, Sung Chul ,  KIM, Mun Sang ,  CHOI, Jun Ho ,  CHUN, Chang Mook

Inventor： LEE, Woo Sub ,  KANG, Sung Chul ,  KIM, Mun Sang ,  CHOI, Jun Ho ,  CHUN, Chang Mook

IPC: B25J19/06

CPC classification number: B25J19/06 ,  F16D7/10

Abstract: The present invention relates to a device for generating limit torque, which generates a rotational displacement to protect a rotating device and automatically returns to the initial position when an external force is eliminated, and a rotating device using the same. The device includes a flexible member that is vertically connected to a rotating shaft and of which the length can be varied in an inward and outward direction with respect to the rotating shaft; an elastic member that is connected to the flexible member and causes the flexible member to receive an elastic force in the outward direction with respect to the rotating shaft; and a cam member that is rotatably connected to the rotating shaft and delivers a rotating force of the rotating shaft to a rotating member. The cam member has a through-hole in which a rotational displacement is generated and through which the flexible member returns to the initial position. According to the present invention, the device for generating limit torque can generate limit torque with a relatively simple structure, and can secure stability.

Abstract translation: 本发明涉及一种用于产生限制转矩的装置，其产生旋转位移以保护旋转装置，并且当外力被消除时自动返回到初始位置，以及使用其的旋转装置。 该装置包括垂直连接到旋转轴的柔性构件，其长度可以相对于旋转轴在向内和向外的方向上变化; 弹性构件，其连接到所述柔性构件，并使所述柔性构件相对于所述旋转轴在向外的方向上受到弹力; 以及可旋转地连接到旋转轴并将旋转轴的旋转力传递到旋转构件的凸轮构件。 凸轮构件具有其中产生旋转位移的通孔，并且柔性构件通过该通孔返回到初始位置。 根据本发明，用于产生极限转矩的装置可以以相对简单的结构产生极限转矩，并且可以确保稳定性。

公开(公告)号：WO2009104849A1

公开(公告)日：2009-08-27

申请号：PCT/KR2008/005331

申请日：2008-09-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHO, Yong Seo ,  KIM, You Seung ,  LEE, Jae Kyun ,  CHOO, Hyunah ,  PAE, Ae Nim

Inventor： CHO, Yong Seo ,  KIM, You Seung ,  LEE, Jae Kyun ,  CHOO, Hyunah ,  PAE, Ae Nim

IPC: C07D309/04

CPC classification number: C07D309/06

Abstract: Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in the presence of trimethylsilyltriflate. The tetrahydropyran derivatives with cis-substituents at both C2 and C6 positions of the tetrahydropyran ring are useful as intermediates for use in the synthesis and development of therapeutically effective, naturally occurring compounds.

Abstract translation: 公开了顺式-2,6-二取代四氢吡喃衍生物及其制备方法。 四氢吡喃衍生物可以通过Prins-在三甲基甲硅烷基三氟甲磺酸酯存在下将四氢吡喃衍生物与高官能醇衍生物反应来制备。 在四氢吡喃环的C2和C6位上具有顺式取代基的四氢​​吡喃衍生物可用作合成和开发治疗有效的天然存在的化合物的中间体。

公开(公告)号：WO2009093772A1

公开(公告)日：2009-07-30

申请号：PCT/KR2008/001275

申请日：2008-03-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SHIN, Hee Sup ,  LEE, Sukchan ,  KIM, Hui-su ,  CHOI, Sukwoo ,  HONG, Ingie

Inventor： SHIN, Hee Sup ,  LEE, Sukchan ,  KIM, Hui-su ,  CHOI, Sukwoo ,  HONG, Ingie

IPC: A01K67/027

CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

Abstract: The present invention relates to a use of a PLCβ4 (Phospholipaseβ4 ) knock-out animal, more precisely, a use or a method of using a PLCβ4 knock-out animal as an anxiety disorder animal model and a method for screening a preventive and therapeutic agent for treating anxiety disorder using the animal model. The mouse model for anxiety disorder of the present invention has normal learning ability, long-term memory and living activity but has a severe defect in memory extinction, therefore it can be effectively used for the screening of a therapeutic agent for anxiety disorder.

Abstract translation: 本发明涉及使用PLCß4（Phospholipase4）敲除动物，更确切地说，涉及使用或使用PLCβ4敲除动物作为焦虑症动物模型的方法和用于筛选预防和治疗剂的方法 用于使用动物模型治疗焦虑症。 本发明的焦虑症小鼠模型具有正常的学习能力，长期记忆力和生活活动性，但是在记忆丧失方面存在严重的缺陷，因此可以有效地用于筛查焦虑症的治疗剂。

公开(公告)号：WO2009057878A1

公开(公告)日：2009-05-07

申请号：PCT/KR2008/003695

申请日：2008-06-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PARK, Jeong Hyun ,  PARK, Jae Gwan ,  CHOI, Kyoung Jin ,  KIM, Dong-Wan ,  CHOI, Young jin ,  LEE, Hang-Won

Inventor： PARK, Jeong Hyun ,  PARK, Jae Gwan ,  CHOI, Kyoung Jin ,  KIM, Dong-Wan ,  CHOI, Young jin ,  LEE, Hang-Won

IPC: H01B3/12

CPC classification number: H01B3/12 ,  C03C8/04 ,  C04B35/117 ,  C04B35/16 ,  C04B35/20 ,  C04B35/22 ,  C04B2235/3201 ,  C04B2235/3203 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3222 ,  C04B2235/3227 ,  C04B2235/3232 ,  C04B2235/3244 ,  C04B2235/3248 ,  C04B2235/3284 ,  C04B2235/3409 ,  C04B2235/3418 ,  C04B2235/3436 ,  C04B2235/3445 ,  C04B2235/3454 ,  C04B2235/3481 ,  C04B2235/36 ,  C04B2235/5436 ,  C04B2235/656 ,  C04B2235/77

Abstract: The present invention relates to a dielectric ceramic composition comprising a glass frit and a filler with a predetermined proportion, wherein the glass frit or the dielectric ceramic composition comprises a nucleating agent, thereby forming a specific crystal structure and providing low dielectric constant, low dielectric loss, high Q-value and high strength. As such, the low temperature fired dielectric ceramic composition having high strength and high Q-value according to the present invention can increase the size and improve the performance of a multilayered substrate for low temperature sintering and enable modulation of electronic parts with good impact resistance.

Abstract translation: 本发明涉及包含玻璃料和预定比例的填料的电介质陶瓷组合物，其中玻璃料或介电陶瓷组合物包含成核剂，从而形成特定的晶体结构并提供低介电常数，低介电损耗 ，Q值高，强度高。 因此，根据本发明的具有高强度和高Q值的低温烧结介电陶瓷组合物可以增加用于低温烧结的多层基板的尺寸和性能，并且能够调节具有良好抗冲击性的电子部件。

公开(公告)号：WO2009054653A3

公开(公告)日：2009-04-30

申请号：PCT/KR2008/006183

申请日：2008-10-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Ji-Hoon ,  KIM, Dong-Jin ,  PARK, Woong-Seo ,  KANG, Yong-Goo ,  YOO, Kyung-Ho ,  LEE, Hyu-Ji ,  MOON, Dae-Hyuk ,  OH, Seung-Jun

Inventor： LEE, Ji-Hoon ,  KIM, Dong-Jin ,  PARK, Woong-Seo ,  KANG, Yong-Goo ,  YOO, Kyung-Ho ,  LEE, Hyu-Ji ,  MOON, Dae-Hyuk ,  OH, Seung-Jun

IPC: C07D209/48

Abstract: The present invention relates to isoindolone compounds having high binding affinity to beta-amyloid fibrils, thereby being useful for an early diagnosis of degenerative cerebral diseases including dementia, and prevention and treatment of such diseases, its use and a method for preparing the same.