公开(公告)号：WO2012045179A1

公开(公告)日：2012-04-12

申请号：PCT/CA2011/050633

申请日：2011-10-07

Applicant: UNIVERSITY OF SASKATCHEWAN ,  REANEY, Martin J.T. ,  HAAKENSEN, Monique ,  KORBER, Darren ,  TANAKA, Takuji ,  RATANAPARIYANUCH, Kornsulee

Inventor： REANEY, Martin J.T. ,  HAAKENSEN, Monique ,  KORBER, Darren ,  TANAKA, Takuji ,  RATANAPARIYANUCH, Kornsulee

IPC: C12N1/20 ,  C12P7/18 ,  C12P7/54

CPC classification number: C12P7/18 ,  C12P7/54 ,  C12R1/225

Abstract: The present application includes a process and a microorganism of the genus Lactobacillus that converts glycerol to 1,3-propanediol. The conversion is accomplished by a proprietary microorganism that is easily cultured in glycerol rich waste products of ethanol production, such as thin stillage.

Abstract translation: 本申请包括将甘油转化为1,3-丙二醇的乳酸杆菌属的方法和微生物。 转化是通过一种专有的微生物完成的，该微生物易于在富含甘油的乙醇生产废物中培养，如稀酒糟。

公开(公告)号：WO2011022809A1

公开(公告)日：2011-03-03

申请号：PCT/CA2010/001253

申请日：2010-08-30

Applicant: UNIVERSITY OF SASKATCHEWAN ,  VUJANOVIC, Vladimir

Inventor： VUJANOVIC, Vladimir

IPC: C12N15/31 ,  A01N63/04 ,  A01P3/00 ,  C07K14/37 ,  C12N1/14 ,  C12N15/63 ,  C12N15/80 ,  C12Q1/68

CPC classification number: A01N63/04 ,  C12N1/14 ,  C12R1/645

Abstract: The present invention relates to a novel ascomyceteous fungus, Sphaerodes mycoparasitia strain IDAC 301008-01, for controlling Fusarium plant pathogens, disease symptoms, and mycotoxins in planta and ex planta . Uses, methods, compositions, sequences, and products are also disclosed herein.

Abstract translation: 本发明涉及一种用于控制植物病原体镰孢属植物病原体，疾病症状和植物和外来植物中真菌毒素的新颖的小型真菌真菌Sormorodes mycoparasiaia菌株IDAC 301008-01。 本文还公开了用途，方法，组合物，序列和产物。

公开(公告)号：WO2010043039A1

公开(公告)日：2010-04-22

申请号：PCT/CA2009/001463

申请日：2009-10-15

Applicant: UNIVERSITY OF SASKATCHEWAN ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  DALHOUSIE UNIVERSITY ,  INTERNATIONAL VACCINE INSTITUTE ,  VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  . KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

Inventor： VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  . KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

IPC: C07K7/08 ,  A61K39/10 ,  A61K39/155 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract translation: 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。

公开(公告)号：WO2009135295A1

公开(公告)日：2009-11-12

申请号：PCT/CA2009/000603

申请日：2009-05-11

Applicant: UNIVERSITY OF SASKATCHEWAN ,  HAYES , Sidney

Inventor： HAYES , Sidney

IPC: C12N15/34 ,  C12N15/73 ,  C12N7/00 ,  C40B50/06 ,  A61K39/12 ,  A61K35/76 ,  A61K48/00 ,  C04B40/02

CPC classification number: C12N15/1037 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/735 ,  C12N7/00 ,  C12N2795/10321 ,  C12N2795/10322 ,  C40B40/02

Abstract: Bacteriophages in genera! and lambda phage in particular are powerful, flexible reagents who have yet to be exploited to their full potential. As discussed herein, the lambda phage head and/or genome comprises an easy to use and highly efficient delivery vehicle for delivering the expression products of a gene of interest systemically or to a particular tissue.

Abstract translation: 属中的噬菌体 特别是λ噬菌体是强大的，灵活的试剂，尚未被充分利用。 如本文所讨论的，λ噬菌体噬菌体头和/或基因组包含易于使用和高效的递送载体，其用于将感兴趣的基因的表达产物全部或特定组织递送。

公开(公告)号：WO2009117828A8

公开(公告)日：2009-10-01

申请号：PCT/CA2009/000394

申请日：2009-03-26

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  UNIVERSITY OF SASKATCHEWAN ,  HICKIE, Robert ,  BALSEVICH, John ,  RAMIREZ-EROSA, Irving ,  DUNLOP, Donna ,  BISHOP, Greg ,  DEIBERT, Leah ,  ARNISON, Paul

Inventor： HICKIE, Robert ,  BALSEVICH, John ,  RAMIREZ-EROSA, Irving ,  DUNLOP, Donna ,  BISHOP, Greg ,  DEIBERT, Leah ,  ARNISON, Paul

IPC: A61K36/36 ,  A61K31/575 ,  A61P35/00

Abstract: A saponin extract from Saponaria vaccaria and its use for stimulating apoptosis in cancer cells and treating cancer is described. The saponin extract may be isolated from Saponaria vaccaria seed. The saponin extract may comprise one or more than one triterpene saponin. The triterpene saponin may comprise a bisdesmosidic saponin having a molecular weight selected from the group consisting of molecular weight 1448, 1464, 1422, 1526, 1596 and 1688. Bisdesmosidic saponin of molecular weight 1448, 1464, 1422, 1526, 1596 and 1688 isolated from Saponaria vaccaria seed may be used to treat human cancer including prostate cancer, human breast cancer and colon cancer. Also disclosed is a method of isolating the saponin extract.

公开(公告)号：WO2009100530A1

公开(公告)日：2009-08-20

申请号：PCT/CA2009/000170

申请日：2009-02-12

Applicant: UNIVERSITY OF SASKATCHEWAN ,  GORDON, John, R.

Inventor： GORDON, John, R.

IPC: A61K38/20 ,  A61K38/16 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  A61P9/10

CPC classification number: A61K38/2053

Abstract: Described herein is the use of a modified human chemokine, GS-CXCL8 (3-73) K11R/G31P or G31P in the treatment of a number of diseases or disorders, including but by no means limited to pulmonary disorders, inflammatory diseases and disorders, cancers and surgical/ischemia reperfusion applications.

Abstract translation: 本文描述了修饰的人趋化因子GS-CXCL8（3-73）K11R / G31P或G31P在治疗许多疾病或病症中的用途，包括但不限于肺部疾病，炎性疾病和病症， 癌症和手术/缺血再灌注应用。

公开(公告)号：WO2009073963A1

公开(公告)日：2009-06-18

申请号：PCT/CA2008/002132

申请日：2008-12-12

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KENDALL, Edward, J. ,  BARNETT, Michael, Gordon

Inventor： KENDALL, Edward, J. ,  BARNETT, Michael, Gordon

IPC: G06T7/00 ,  A61B6/00

CPC classification number: G06T7/0012 ,  A61B6/502 ,  A61B6/5217 ,  G06T7/42 ,  G06T2207/10116 ,  G06T2207/20064 ,  G06T2207/30068

Abstract: A method and apparatus for classifying an image is proposed. The image is first preprocessed by for example adjusting its orientation, selecting an area of interest and removing artifacts, and normalizing the brightness. Subsequently the image is processed by applying a wavelet decomposition and values for a scalar feature of the wavelet decomposition are measured. This value is binned and probabilities for different classifications of the image are determined based on the number of images from a training set that fall into the same bin that have each classification. Improved classifiers are constructed by aggregating the results for different features, and a network of improved classifiers, in which images are processed by later classifiers according to the results from earlier classifiers, is used.

Abstract translation: 提出了一种用于分类图像的方法和装置。 首先通过调整图像的方向，选择感兴趣的区域和去除伪像，以及对亮度进行归一化来预处理图像。 随后，通过应用小波分解来处理图像，并测量小波分解的标量特征的值。 该值被分档，并且基于来自具有每个分类的相同仓的训练集合的图像的数量来确定图像的不同分类的概率。 改进的分类器是通过聚合不同特征的结果构建的，并且使用改进的分类器网络，其中根据来自早期分类器的结果的后续分类器处理图像。

公开(公告)号：WO2009067809A1

公开(公告)日：2009-06-04

申请号：PCT/CA2008/002091

申请日：2008-12-01

Applicant: UNIVERSITY OF SASKATCHEWAN ,  REANEY, Martin, J.T. ,  SHEN, Jianheng ,  SOVERAN, Douglas, W.

Inventor： REANEY, Martin, J.T. ,  SHEN, Jianheng ,  SOVERAN, Douglas, W.

IPC: C07C29/70 ,  B01J31/02 ,  C07C31/30 ,  C07C67/02

CPC classification number: C11C3/003 ,  B01J31/0212 ,  B01J2231/49 ,  B01J2531/11 ,  B01J2531/12 ,  B01J2531/13 ,  B01J2531/14 ,  C07C29/70 ,  C07C29/94 ,  C07C31/30 ,  C07C67/03 ,  C07C69/24 ,  C07C69/52

Abstract: The present disclosure relates to a process for the production of a base complex catalyst comprising reacting a hydroxide base with a polyalcohol, under vacuum pressure, at a temperature in the range of about 60°C to about 220°C, wherein the mole ratio f the hydroxide base to the polyalcohol is greater than about 2:1.

Abstract translation: 本公开内容涉及一种制备碱性配合物催化剂的方法，包括在真空压力下，在约60℃至约220℃的温度下使氢氧化物碱与多元醇反应，其中摩尔比f 多元醇的氢氧化物碱大于约2:1。

公开(公告)号：WO2009012589A1

公开(公告)日：2009-01-29

申请号：PCT/CA2008/001354

申请日：2008-07-23

Applicant: UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  FERNANDO, Ursla

Inventor： POTTER, Andrew, A. ,  FERNANDO, Ursla

IPC: A61K39/02 ,  A61K39/106 ,  A61P31/04 ,  A61P37/04 ,  A61K39/39

CPC classification number: A61K39/105 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  Y02A50/47

Abstract: Methods for the treatment or prevention of Gram negative bacterial infection in a vertebrate subject are provided. The methods provide administering an antagonist of bacterial flagellar protein biosynthesis to the vertebrate subject in an amount effective to reduce or eliminate the bacterial infection. Methods for the treatment or prevention of Campylobacter jejuni infection in an avian species or a mammalian species are provided.

Abstract translation: 提供了在脊椎动物受试者中治疗或预防革兰氏阴性细菌感染的方法。 所述方法提供以有效减少或消除细菌感染的量向脊椎动物受试者施用细菌鞭毛蛋白生物合成拮抗剂。 提供了用于治疗或预防禽类物种或哺乳动物物种的空肠弯曲杆菌感染的方法。

公开(公告)号：WO2007045096A1

公开(公告)日：2007-04-26

申请号：PCT/CA2006/001724

申请日：2006-10-23

Applicant: UNIVERSITY OF SASKATCHEWAN ,  SINGH, Malvinder, Pal ,  CHATTERJEE, Manashi, Nithar

Inventor： SINGH, Malvinder, Pal ,  CHATTERJEE, Manashi, Nithar

IPC: C07D487/14 ,  A61K31/4985 ,  A61P31/00 ,  A61P35/00 ,  C07D471/04 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C07D403/14 ,  C07D471/04 ,  C07D487/14

Abstract: The present invention provides a novel class of oligoheteroaromatic assemblies with luminescence characteristics and composition based on integrated polyheterocyclic polyamide oligomers of multiple nitrogen-containing heteroaromatic of the general formula (I) This novel class of compounds of the present invention is capable of binding to targeted DNA sequence in the minor groove, and thus is useful for genomics applications. In particular, the compounds of the invention binds to the DNA at a binding stoichiometry of 2: 1 ternary complexation with very high affinity and sequence selectivity.

Abstract translation: 本发明提供了一种具有发光特性和基于通式（I）的多个含氮杂芳族的整体多杂环聚酰胺低聚物的组成的新型低聚异氰酸酯组合物。本发明的这类新颖化合物能够结合靶向的DNA 序列在小槽中，因此对于基因组学应用是有用的。 特别地，本发明的化合物以非常高的亲和力和序列选择性以2:1的三元络合的结合化学计量结合DNA。