公开(公告)号：KR1020130134565A

公开(公告)日：2013-12-10

申请号：KR1020120058167

申请日：2012-05-31

Applicant: (주)아모레퍼시픽

Inventor： 홍용덕 ,  노호식 ,  남미희 ,  신송석 ,  박영호

IPC: A61K36/296 ,  A61K31/353 ,  A61K31/35 ,  A61K8/97

CPC classification number: A61K36/296 ,  A61K8/498 ,  A61K8/97 ,  A61K31/704 ,  A61K31/7048 ,  A61Q19/02

Abstract: Provided is a composition containing epimedin extracted from genus epimedium plant as an active ingredient. According to the composition containing epimedin of the present invention, extracted epimedin A, epimedin B and epimedin C suppress the activity of DPPH, the generation of MMP-1 and the generation of tyrosinase to present anti-aging effect and skin lighting effect, so that the composition of the present invention can be effectively used in skin external applications, cosmetics compositions and medicinal compositions for preventing the generation of wrinkles, frenkles, and pigmentation.

Abstract translation: 提供含有从淫羊藿植物提取的epimedin作为活性成分的组合物。 根据本发明的含有epimedin的组合物，提取的epimedin A，epimedin B和epimedin C抑制DPPH的活性，MMP-1的产生和酪氨酸酶的产生，以呈现抗衰老作用和皮肤照明效果，使得 本发明的组合物可以有效地用于皮肤外用，化妆品组合物和药物组合物中，用于防止产生皱纹，皱纹和色素沉着。

公开(公告)号：KR1020130134480A

公开(公告)日：2013-12-10

申请号：KR1020120058022

申请日：2012-05-31

Applicant: (주)아모레퍼시픽

Inventor： 홍용덕 ,  남미희 ,  고재영 ,  신송석 ,  박영호

IPC: A61K36/13 ,  A61K8/97 ,  A61K38/46 ,  A61Q19/00

Abstract: The present invention relates to a torreya sp. plant treated with enzyme. The torreya sp. plant is selected from a group composed of torreya californica, torreya fargesii, torreya grandis, torreya jackii, torreya nucifera, and torreya taxifolia. [Reference numerals] (AA) Voltage [mV];(BB) Time [min]

Abstract translation: 本发明涉及一种torreya sp。 植物用酶处理。 torreya sp。 植物选自由torreya californica，torreya fargesii，torreya grandis，torreya jackii，torreya nucifera和torreya taxifolia组成的组。 （标号）（AA）电压[mV];（BB）时间[min]

公开(公告)号：KR1020080052024A

公开(公告)日：2008-06-11

申请号：KR1020060123982

申请日：2006-12-07

Applicant: (주)아모레퍼시픽 ,  크리스탈지노믹스(주) ,  연세대학교 산학협력단

Inventor： 홍용덕 ,  강승현 ,  김연준 ,  변경희 ,  우병영 ,  박미영 ,  주영협 ,  김정주 ,  장두옥 ,  태진성 ,  신동규 ,  김용은 ,  천영훈 ,  이재일 ,  현영란 ,  노성구 ,  조중명

IPC: C07D487/04 ,  A61K31/4162

CPC classification number: C07D487/04

Abstract: Triazolopyridazine derivatives are provided to inhibit acetyl-CoA carboxylase 2(ACC2), so that the compounds are useful for prevention and treatment of obesity, diabetes, hyperlipidemia and metabolic syndrome-related disease. Triazolopyridazine derivatives represented by the formula(1) have inhibitory effects on acetyl-CoA carboxylase 2, wherein X is hydrogen, pyridyl, thiophenyl, furanyl or phenyl optionally substituted by C1-5 alkyl, C1-5 alkoxy, hydroxy or halogen; Y is pyridine, thiophene or NHR2; Z is O, S, NH, methylene, ethylene or -CH(CH3)-; R1 is methyl, hydroxy or hydroxy methyl; R2 is hydrogen, C1-7 alkyl, C3-8 cycloalkyl optionally substituted by hydroxy or C1-7 alkyl, or phenyl optionally substituted by C1-5 alkyl; R3 is hydrogen, hydroxy, C1-5 alkyl, C1-5 alkoxy or halogen; R4 is hydrogen, hydroxy, C1-5 alkyl, C1-5 alkoxy, trifluoromethyl, C1-5 alkoxycarbonyl or halogen; and W is bond, C1-2 alkylene, alkenylene or alkynylene.

Abstract translation: 提供三唑并哒嗪衍生物以抑制乙酰辅酶A羧化酶2（ACC2），使得该化合物可用于预防和治疗肥胖症，糖尿病，高脂血症和代谢综合征相关疾病。 由式（1）表示的三唑并哒嗪衍生物对乙酰辅酶A羧化酶2具有抑制作用，其中X为氢，吡啶基，噻吩基，呋喃基或任选被C 1-5烷氧基，羟基或卤素取代的苯基; Y为吡啶，噻吩或NHR2; Z是O，S，NH，亚甲基，亚乙基或-CH（CH 3） - ; R1是甲基，羟基或羟基甲基; R 2为氢，C 1-7烷基，任选被羟基或C 1-7烷基取代的C 3-8环烷基，或任选被C 1-5烷基取代的苯基; R3是氢，羟基，C1-5烷基，C1-5烷氧基或卤素; R4是氢，羟基，C1-5烷基，C1-5烷氧基，三氟甲基，C1-5烷氧基羰基或卤素; W是键，C1-2亚烷基，亚烯基或亚炔基。