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公开(公告)号：KR1020100046668A
公开(公告)日：2010-05-07
申请号：KR1020080105619
申请日：2008-10-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An evaluation method is provided to objectively measure the relief effect of sensory skin irritation by quantifying the relief effect of sensory skin irritation about various anti-irritants through the change of concrete threshold. CONSTITUTION: A sensory skin irritation relief effect evaluation method comprises a step of measuring the change of a threshold before and after spreading an anti-irritant to a stimulus applied to the skin sensory nerve. The evaluation method quantitatively measures the change of the threshold by using a device. The evaluation method measures the change of the threshold value about a stimulus applied to at least one skin sensory nerve which is selected in a group which includes Aα, Aβ, Aδ, and C-fiber type. The evaluation method measures the change of the threshold value about a stimulus which is applied to the skin sensory nerve of Aδ or C-fiber type.
Abstract translation: 目的：通过改变混凝土阈值，量化消除各种抗刺激剂对皮肤刺激的缓解作用，提供评估方法，客观地测量感觉皮肤刺激的缓解作用。 构成：感官皮肤刺激缓解效果评估方法包括测量在将抗刺激剂涂抹于皮肤感觉神经的刺激之前和之后的阈值变化的步骤。 评价方法通过使用装置定量地测量阈值的变化。 评估方法测量关于施加到包括Aα，Aβ，Aδ和C纤维类型的组中选择的至少一种皮肤感觉神经的刺激的阈值变化。 评估方法测量施加于Aδ或C纤维类型的皮肤感觉神经的刺激的阈值变化。
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232.发明公开ＰＲＰ19 및 ＣＬＩＣ 단백질간의 상호작용을 저해하는물질을 검색하는 방법 및 검색된 물질을 포함하는 조성물 有权筛选能够抑制PRP19和CLIC蛋白之间的相互作用的物质和包含筛选物质的组合物的方法
公开(公告)号：KR1020090057780A
公开(公告)日：2009-06-08
申请号：KR1020070124511
申请日：2007-12-03
Applicant: (주)아모레퍼시픽
IPC: A61K38/00 , G01N33/53 , G01N33/533
CPC classification number: A61K36/185 , A61K8/97 , A61K2236/331 , A61K2236/333 , A61K2236/35 , A61Q19/00 , Y10S514/909
Abstract: A method for searching materials inhibiting the interaction between PRP19 and CLIC protein is provided to inhibit the formation of adipose, prevent and treat the disease mediated by the interaction between PRP19 and CLIC protein. A method for searching a material which inhibits the interaction between PRP19 and CLIC protein comprises: a step of reacting PRP19 protein or it U-box domain and CLIC protein; a step of measuring the amount of probe; and a step of selecting candidate material which decreases the amount of probe. A cosmetic composition contains 0.0001-20 weight% Elaeocarpus sylvestrisvar.ellipticus (Thunb.)Hara extract as an active ingredient. A pharmaceutical composition for preventing and treating obesity contains 0.0001-100 weight% of Elaeocarpus sylvestrisvar.ellipticus (Thunb.)Hara extract.
Abstract translation: 提供了一种搜索抑制PRP19和CLIC蛋白相互作用的材料的方法，以抑制脂肪的形成，预防和治疗由PRP19和CLIC蛋白之间的相互作用介导的疾病。 用于搜索抑制PRP19和CLIC蛋白质相互作用的材料的方法包括：使PRP19蛋白或其U盒结构域和CLIC蛋白质反应的步骤; 测量探针量的一个步骤; 以及选择减少探针量的候选材料的步骤。 化妆品组合物含有0.0001-20重量％的El螨（Thunb。）Hara提取物作为活性成分。 用于预防和治疗肥胖症的药物组合物含有0.0001-100％（重量）的El螨（Thonb。）Hara提取物。
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公开(公告)号：KR1020080067823A
公开(公告)日：2008-07-22
申请号：KR1020070005217
申请日：2007-01-17
Applicant: (주)아모레퍼시픽
Abstract: A transgenic mouse is provided to show obese-inhibiting characteristic by over-express an isocitrate dehydrogenase 3 alpha(IDH3A), there by being used as a model animal for treating and studying obesity. An expression vector pcDNA-IDH3A comprises: a CMV promoter; an IDH3A gene; and a polyadenylated sequence. A method for preparing a transgenic Mus musculus comprises the steps of: (a) preparing the expression vector pcDNA-IDH3A; and (b) micro-injecting the expression vector into a pronucleus of a Mus musculus fertilized egg. Further, the IDH3A gene is cDNA synthesized from mRNA derived form human heart.
Abstract translation: 提供转基因小鼠以通过过表达异柠檬酸脱氢酶3α（IDH3A）来显示肥胖抑制特征，其被用作用于治疗和研究肥胖症的模型动物。 表达载体pcDNA-IDH3A包含：CMV启动子; IDH3A基因; 和多聚腺苷酸化序列。 一种制备转基因小鼠的方法包括以下步骤：（a）制备表达载体pcDNA-IDH3A; 和（b）将表达载体微注射到小家鼠受精卵的原核中。 此外，IDH3A基因是从人心脏衍生的mRNA合成的cDNA。
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234.发明授权ＩＤＨ３Ａ 프로모터 및 루시퍼라제 함유 벡터로형질전환된 세포주, 및 그를 이용한 비만억제 후보물질검색방법 失效与含有IDH3 ALPHA促进剂和促生长素的载体转染的细胞系以及使用其的肥料控制材料的搜索方法
公开(公告)号：KR100821457B1
公开(公告)日：2008-04-11
申请号：KR1020060117066
申请日：2006-11-24
Applicant: (주)아모레퍼시픽
Abstract: A transformed cell line is provided to identify a chemical material controlling expression of an IDH3A gene at a transcription step and also find out an anti-obese material such as genistein. An expression vector pIDH3A comprises: a kanamycin resistant gene(Kana+) and a neomycin resistant gene(Neo+); a luciferase gene(LUC+); and an IDH3A promoter of SEQ ID : NO. 1 and has a structure depicted in Fig. 2. A cell line PRDC IDH3A transformed by the expression vector is deposited as a deposition no. KCTC 10981BP. A method for searching an obesity controlling material comprises the steps of: (a) treating the cell line with an obesity controlling candidate material; and (b) detecting the fluorescence emitting reaction, wherein the obesity controlling candidate material is treated with at least two concentrations.
Abstract translation: 提供转化细胞系以鉴定在转录步骤中控制IDH3A基因表达的化学物质，并且还可以找到抗肥胖材料如染料木素。 表达载体pIDH3A包含：卡那霉素抗性基因（Kana +）和新霉素抗性基因（Neo +）; 荧光素酶基因（LUC +）; 和SEQ ID NO：1的IDH3A启动子。 具有图1所示的结构。 由表达载体转化的细胞系PRDC IDH3A沉积为沉积物。 KCTC 10981BP。 用于搜索肥胖控制材料的方法包括以下步骤：（a）用肥胖控制候选物质处理细胞系; 和（b）检测荧光发射反应，其中以至少两种浓度处理肥胖控制候选物质。
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公开(公告)号：KR102212626B1
公开(公告)日：2021-02-08
申请号：KR1020170083707
申请日：2017-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61Q19/00 , A61K36/534 , A61P17/00 , A23L33/105 , A23L29/00
Abstract: 본명세서에는박하초추출물을유효성분으로포함하는피부외용제조성물로서, 피부장벽약화를일으키는자극원에의해발현량이영향을받는피부세포내 유전자인 S100A7(NM_002963), IL-36G(NM_019618) 및 LCE3D(NM_032563)로이루어진군에서선택되는하나이상의발현량을정상수준으로조절하는피부장벽강화용조성물이개시된다. 상기피부장벽강화용조성물을이용함으로써, 피부장벽약화를일으키는자극원에의해변화되는유전자발현량을정상수준으로되돌려피부세포의손상을저하시킬수 있다.
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Patent Agency Ranking
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公开(公告)号：KR102152753B1
公开(公告)日：2020-09-07
申请号：KR1020170128175
申请日：2017-09-29
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K36/82 , A23L33/105 , A61Q19/00
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公开(公告)号：KR102083438B1
公开(公告)日：2020-03-03
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
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