公开(公告)号：WO1993012715A1

公开(公告)日：1993-07-08

申请号：PCT/US1992010966

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KHALIL, Gamal-Eddin ,  BROWN, David, P.

IPC: A61B05/02

CPC classification number: G01N21/27 ,  G01N2021/3144 ,  G01N2201/1211 ,  G01N2201/126

Abstract: A method for converting a partial pressure of oxygen (pO2) value in blood at a measurement temperature to a corresponding value at a reference temperature (37 °C). A pO2 value is determined by measurements made in a partient's blood stream using a phosphorescent compound sensitive to oxygen concentration. The compound is illuminated with a short pulse of light, causing a phosphorescent emission having a rate of decay that varies as the function of the pO2 in the blood. A detector (34) produces an electrical signal corresponding to the intensity of the emission, and the signal is converted to a corresponding digital value for input to a microcomputer (12). Supplied to the microcomputer in digital form is a signal indicative of the temperature at the measurement site where the compound is disposed. The microcomputer determines phosphorescent decay rate and from that determines pO2 at the measurement site for measurement temperature.

公开(公告)号：WO1993012668A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011020

申请日：1992-12-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, B. ,  NARDELLI, Christy, A. ,  HOGARTH, Arthur, J., C., L. ,  DAAB-KRZYKOWSKI, Andre

IPC: A23J01/14

CPC classification number: A23J1/14 ,  A23L11/34 ,  A23L33/21

Abstract: A method for separating phytate and manganese from protein and dietary fiber involves treatment of an aqueous slurry of phytate-containing material at a low pH with insoluble alumina. In a batch treatment process the pH of the solution is increased, leaving phytate units attached to the alumina while freeing the protein and dietary fiber. In a column treatment process, the column containing alumina is rinsed, after the low pH treatment, with dilute acid and water to recover the protein and/or dietary fiber. This method may be employed either during the manufacture of protein and fiber isolates from flour or flakes, or for removing phytate from commercially available protein and fiber commodities. The spent alumina may be readily regenerated and reused. The method of separating manganese from rice protein using this same technology is also discussed.

公开(公告)号：WO1993012002A1

公开(公告)日：1993-06-24

申请号：PCT/US1992010918

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GRABENKORT, Richard, W.

IPC: B65B03/04

CPC classification number: A61J1/20

Abstract: A system accommodates the transfer or withdrawal of liquid from a bulk supply. The system includes a connector (50) connected to the supply container (20), a first conduit (56) extending from the first connector, a second connector (116) on the first conduit connected to a syringe (120), a second conduit (132) having an end connected with the first conduit and another end connected to a receptacle (140), a first check valve (102) in the first conduit prevents flow into the supply container, a second check valve (150) in the second conduit prevents flow out of the receptacle (140), and a flexible, open-mouthed barrier (80) penetrated by the conduits and sealed about the conduits. The barrier is bag-like and accommodates an arrangement permitting access to the first connector and container. The bag (80) can be arranged in extended orientations enclosing the first connector and container. The bag is sealable in the extended orientation to form a protection system around the supply container and receptacle.

公开(公告)号：WO1993010458A1

公开(公告)日：1993-05-27

申请号：PCT/US1992009281

申请日：1992-10-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ANAWIS, Mark, A. ,  ARAI, Hiroyasu ,  KOYAMA, Hiromi ,  KOYAMA, Hiromi

IPC: G01N33/563

CPC classification number: G01N33/6854

Abstract: A method and composition useful for the detection of anti-milk-protein IgE antibodies patient in body fluids. A composition of milk protein extract, casein and beta -lactoglobulin is useful for the detection of anti-milk-protein IgE antibodies. The furher addition of bovine gamma globulin to the composition improves the detection of such IgE antibodies. The method involves applying to a solid phase an amount of the composition in solution and drying. The solid phase is placed in contact with a patient test sample and the presence or amount of anti-milk-protein IgE antibodies is determined.

Abstract translation: 用于检测体液中抗乳蛋白IgE抗体患者的方法和组合物。 乳蛋白提取物，酪蛋白和β-乳球蛋白的组合物可用于检测抗乳蛋白IgE抗体。 牛γ球蛋白向组合物中的较轻添加改善了这种IgE抗体的检测。 该方法包括向溶液中施加一定量的溶液中的组合物并干燥。 将固相与患者测试样品接触，测定抗乳蛋白IgE抗体的存在或量。

公开(公告)号：WO1993007526A1

公开(公告)日：1993-04-15

申请号：PCT/US1992003802

申请日：1992-05-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SIBLEY, Murray, Jack

IPC: G02C13/00

CPC classification number: G02C13/008

Abstract: A device (10) for cleaning contact lenses has a soft tip applicator (20) affixed to a container (12) of lens cleaning solution and is used to apply the solution to the lenses. A cap (25) having threads (26) is adapted to engage threads (15) on the container (12). A dust cover (29) is detachably affixed to the cap (25).

Abstract translation: 用于清洁隐形眼镜的装置（10）具有固定到透镜清洁溶液的容器（12）上的软尖端涂抹器（20），并用于将溶液施加到透镜。 具有螺纹（26）的帽（25）适于接合容器（12）上的螺纹（15）。 防尘罩（29）可拆卸地固定到盖（25）上。

公开(公告)号：WO1993007494A1

公开(公告)日：1993-04-15

申请号：PCT/JP1992001281

申请日：1992-10-02

Applicant: ALOKA KABUSHIKI KAISHA ,  ABBOTT LABORATORIES ,  KAWANABE, Junichi ,  TAKEDA, Masaaki ,  KATAGI, Hitomi ,  KATO, Yuko ,  BIELARCZYK, Gregory, A. ,  MAGEE, Rosie, L.

Inventor： ALOKA KABUSHIKI KAISHA ,  ABBOTT LABORATORIES

IPC: G01N35/06

CPC classification number: G01N35/1016 ,  G01N33/491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/103

Abstract: This invention is directed to suck as quickly as possible an erythrocyte component as a highly viscous liquid when a blood plasma component and the erythrocyte component are pipetted from a blood sample in which the blood plasma component and the erythrocyte component are separated into upper and lower fractions by centrifugal separation. A nozzle portion (32) consists of a nozzle base (35) and a disposable chip (36) and is transferred vertically and horizontally by an XYZ robot (34). Pipetting of the blood plasma component in the blood sample place into a test tube (62) by the nozzle portion (32) is first carried out and after the inner wall of the disposable chip (36) is coated by the blood plasma, pipetting of the erythrocyte component is then carried out.

Abstract translation: 本发明涉及当将血浆成分和红细胞成分从其中将血浆成分和红细胞成分分离成上部和下部血液的血液样品中移取血浆成分和红细胞成分时，尽快吸入作为高粘度液体的红细胞成分 通过离心分离。 喷嘴部分（32）由喷嘴基座（35）和一次性芯片（36）组成，并由XYZ机器人（34）垂直和水平地传送。 首先在血液样本中将血液成分吸入试管（62）中，并且在一次性芯片（36）的内壁被血浆涂覆之后，移液 然后进行红细胞成分。

公开(公告)号：WO1993006820A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008622

申请日：1992-10-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HADAWAY, Michelle, A. ,  KRAMER, David, E. ,  BEST, Robert, J.

IPC: A61K09/14

CPC classification number: A23G3/563 ,  A61J7/003 ,  A61J2205/30 ,  A61K9/0056

Abstract: A stick-like holder (18) and packaging (16), including an overcap (20) and a sealed, light, moisture and tamper resistant foil pouch, for a hardened, medicated matrix (26) affixed to one end (24) of the holder (18) including detent means for releasably mounting the overcap on the matrix (26) end of the holder and with the holder having a flat, label receiving handle (28) at its other end and a circular flange (32) to prevent swallowing of the holder when placed in a patient's mouth to medicate or pre-medicate the patient, also includes a cylindrical rod like member (22), a handle, pressure sensitive mylar label (30), spaced annular rounded grooves (34), tubular body portion (36), closed end (38), open end (40), collar (42), a cylindrical wall portion (46), retaining bumps (48) and ribs (54).

公开(公告)号：WO1993006247A1

公开(公告)日：1993-04-01

申请号：PCT/US1992007813

申请日：1992-09-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LESNIEWSKI, Richard, R. ,  LEUNG, Tat, K.

IPC: C12Q01/70

CPC classification number: G01N33/5767

Abstract: The present invention provides an improved assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with at least one polypeptide containing at least one epitope of an HCV antigen. Preferred assay formats include a confirmatory assay, a combination assay, a synthetic polypeptide-based assay, an immunodot assay and a competition assay.

Abstract translation: 本发明提供了一种用于通过使样品与至少一种含有HCV抗原的至少一个表位的多肽接触来检测样品中HCV抗原的抗体的改进的测定法。 优选的测定形式包括确认测定，组合测定，基于合成多肽的测定，免疫斑点测定和竞争测定。

公开(公告)号：WO1993004680A1

公开(公告)日：1993-03-18

申请号：PCT/US1992007600

申请日：1992-09-08

Applicant: ABBOTT LABORATORIES ,  LULY, Jay, R. ,  KAWAI, Megumi ,  OR, Yat, Sun ,  WIEDEMAN, Paul ,  WAGNER, Rolf

Inventor： ABBOTT LABORATORIES

IPC: A61K31/395

CPC classification number: C07D487/14 ,  C07D513/14 ,  C07F7/1804 ,  C07F9/6561 ,  C07H19/01

Abstract: Immunomodulatory macrocylic compounds having the formula (VII) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae (Ia), (Ib) and (Ic), as well as pharmaceutical compositions containing the same.

Abstract translation: 具有式（VII）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中X选自式（Ia），（Ib）和（Ic）之一，以及含有其的药物组合物 。

公开(公告)号：WO1993004284A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006586

申请日：1992-08-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  NATWICK, Vernon, R. ,  LAWLESS, Michael, W. ,  DOLL, Joseph, E. ,  WU, Chung-You, Charles

IPC: F04B43/12

CPC classification number: F04B43/084 ,  A61M5/14228 ,  A61M5/16854 ,  A61M2205/14 ,  F04B43/082 ,  F04B43/123 ,  F04B49/065

Abstract: A volumetric pump (30) includes a motor (146) that rotatably drives a cam assembly (142), which actuates a plunger (48), causing it to compress a pumping portion (34b) of a flexible tubing (34). Compression of the tubing displaces fluid trapped within the pumping portion, causing it to flow past an outlet cracking valve (52). A proximal pressure sensor (44) and a distal pressure sensor (56) each produce signals indicative of the pressure within the proximal portion and distal portion of the flexible tubing, which are used to determine whether a proximal or distal occlusion of the flexible tubing has occurred. Both pressure sensors comprise strain gauges connected to flexures that apply a spring-biased force against the proximal and distal portions of the flexible tubing. These sensors thereby respond to the cross-sectional size (diameter) of the tubing, as affected by fluid pressure therein. Proximal and distal pressures are thus monitored without violating the integrity of the flexible tubing.

Abstract translation: 容积泵（30）包括可旋转地驱动凸轮组件（142）的马达（146），其驱动柱塞（48），使其压缩柔性管道（34）的泵送部分（34b）。 管道的压缩将捕获在泵送部分内的流体置换，使其流过出口裂解阀（52）。 近端压力传感器（44）和远端压力传感器（56）各自产生指示柔性管的近端部分和远端部分内的压力的信号，其用于确定柔性管的近端或远端闭塞是否具有 发生。 两个压力传感器都包括连接到挠性件的应变计，该挠曲件对柔性管的近端部分和远端部分施加弹簧偏压力。 这些传感器因此受到其中流体压力的影响而对管道的横截面尺寸（直径）作出响应。 因此监测近端和远端压力，而不会违反柔性管的完整性。